Mechanism Of Inheritance Research Articles

Mechanisms of slip modes and texture inheritance in Ti60 alloy during plane strain compression: Insights from texture evolution and regulation

Mechanisms of slip modes and texture inheritance in Ti60 alloy during plane strain compression: Insights from texture evolution and regulation

Inheritance mode and metabolic mechanism of bromopropylate resistance in a field strain of Panonychus citri (Acari: Tetranychidae)

ABSTRACT Panonychus citri is a serious pest of citrus orchards all around the world. In this study, biochemical and resistance inheritance mechanisms of bromopropylate were evaluated on a field population of P. citri. The resistance inheritance of bromopropylate in P. citri has been studied by crossing resistant (As) and susceptible (So) populations, derived from collected populations in northern cities of Iran. The resistance ratios were estimated at 11.45, 3.45, 3.49, 3.72, and 6.16- folds in As, F1, F´1, F2, and F´2 in comparison to the So, respectively. The results of the response showed that resistance was inherited as a bromopropylate incomplete recessive inheritance (D = −0.01 and −0.02) that was detected as polygenic autosomal. The DEM, TPP, and PBO synergism assays in the As population reached 2.27, 2.24, and 1.66- folds, respectively. The in vivo enzyme assays suggested minor involvement of cytochrome P450 monooxygenases, esterases, and GSTs in the P. citri population resistance to bromopropylate, with the highest ratio related to esterases.

Mechanisms of Inheritance of Chromatin States: From Yeast to Human

In this article I review mechanisms that underpin epigenetic inheritance of CpG methylation and histone H3 lysine 9 methylation (H3K9me) in chromatin in fungi and mammals. CpG methylation can be faithfully inherited epigenetically at some sites for a lifetime in vertebrates and, remarkably, can be propagated for millions of years in some fungal lineages. Transmission of methylation patterns requires maintenance-type DNA methyltransferases (DNMTs) that recognize hemimethylated CpG DNA produced by replication. DNMT1 is the maintenance enzyme in vertebrates; we recently identified DNMT5 as an ATP-dependent CpG maintenance enzyme found in fungi and protists. In vivo, CpG methylation is coupled to H3K9me. H3K9me is itself reestablished after replication via local histone H3-H4 tetramer recycling involving mobile and nonmobile chaperones, de novo nucleosome assembly, and read-write mechanisms that modify naive nucleosomes. Additional proteins recognize hemimethylated CpG or fully methylated CpG-containing motifs and enhance restoration of methylation by recruiting and/or activating the maintenance methylase.

Exchangeable coalescents beyond the Cannings class

We propose a general framework for the study of the genealogy of neutral discrete-time populations. We remove the standard assumption of exchangeability of offspring distributions appearing in Cannings models, and replace it by a less restrictive condition of non-heritability of reproductive success. We provide a general criterion for the weak convergence of their genealogies to Ξ-coalescents, and apply it to a simple parametrization of our scenario (which, under mild conditions, we also prove to essentially include the general case). We provide examples for such populations, including models with highly-asymmetric offspring distributions and populations undergoing random but recurrent bottlenecks. Finally we study the limit genealogy of a new exponential model which, as previously shown for related models and in spite of its built-in (fitness) inheritance mechanism, can be brought into our setting.

Mapping resistance to Sclerotinia white mold in two pinto bean recombinant inbred line populations.

White mold, caused by the fungus Sclerotinia sclerotiorum (Lib.) de Bary, is a devastating disease affecting common bean (Phaseolus vulgaris L.) production worldwide. Breeding for resistance to white mold is challenging due to its quantitative inheritance and intricate genetic mechanisms. This research aimed to validate and characterize physiological resistance in the pinto dry bean market class through greenhouse straw tests under controlled conditions and field assessments under natural environments. Classical quantitative trait locus (QTL) mapping and Khufu de novo QTL-seq were employed to detect and narrow QTL intervals and identify candidate genes associated with white mold resistance in two pinto bean recombinant inbred line populations, PT9-5-6/USPT-WM-12 (P2) and PT12-37/VCP-13 (P3). Eleven QTL, five in P2 and six in P3, conditioning white mold resistance were identified. New QTL were discovered including WM1.4 and WM11.5 in P2, and WM1.5 and WM7.7 in P3. Existing major-effect QTL were validated: WM5.4 (34%-phenotypic variation explained) and WM7.4 (20%) in straw tests, and WM2.2 (15%) and WM3.1 (27%) under field conditions. QTL for avoidance traits such as resistance to lodging and late maturity overlapped WM2.2 in P2 and WM1.5, WM3.1, WM5.4, and WM7.7 in P3. WM5.4 (Pv05: 7.0-38.7 Mb) was associated with a large Phaseolus coccineus L. genome introgression in the resistant parent VCP-13. These findings offer narrowed genomic intervals and putative candidate genes for marker-assisted selection targeting white mold resistance improvement in pinto beans.

Post-traumatic stress disorder: molecular mechanisms of the intergenerational and transgenerational inheritance

Post-traumatic stress disorder is a mental disorder that is closely associated with dysfunction of the hypothalamic-pituitary-adrenal axis, and for its development is required the experience of a traumatic event that causes negative emotions and memories that persist for quite a long time. The likelihood of development of post-traumatic stress disorder is influenced both environmental factors, and genetic and epigenetic characteristics of the body. In this case epigenetic modifications act as dynamic biomarkers (“nanotags”) of the impact of the environment on the genome (epigenome), which can, under certain conditions, disappear or remain not only in an individual directly exposed to psychogenic trauma, but also transmitted over a number of generations. Review focuses on the possible mechanisms of intergenerational and transgenerational inheritance of the biological effects of post-traumatic and stress-related disorders.

Deciphering and Preserving the Landscape Genes of Handicraft Villages from the Perspective of Production–Living–Ecology Spaces (PLESs): A Case Study of YaoTou Village, Shaanxi Province

The long-term interplay between rural handicraft industries and village development has resulted in imbalances such as the disorder of living spaces, misalignment of production spaces, and ecological space disruptions. Comprehensively analyzing village landscape elements and actively maintaining their coordinated development are the keys to the transformation of handicraft villages. This study firstly introduces the theory of landscape genes and the concept of “Production–Living–Ecology Spaces” (PLESs) and then constructs the identification system of PLES landscape genes. The system starts from the three dimensions of the production, life, and ecology spaces of the village, identifies the landscape elements that have been passed down from generation to generation, and realizes a comprehensive interpretation of the landscape elements of handicraft villages. Using YaoTou Village in Shaanxi Province as a case study, this study illustrates its landscape characteristics, based on the genetic form of PLES landscape genes, using the G1-FCE method to collect evaluation data from both tourists and residents. These data help to identify the genetic status of the PLES landscape genes of YaoTou Village and propose targeted inheritance mechanisms. The results enable the comprehensive identification of production, ecological, and living landscape elements in handicraft villages, evaluating their inheritance status to carry out targeted modern innovative transformation. This study will provide a reference for identifying and preserving the landscape elements of YaoTou Village and more handicraft villages and contribute to rural revitalization.

Shakespearean Spiders and Shakespearean Slime Mold

This article draws on the debts to Shakespeare—in particular Hamlet , Macbeth , The Merchant of Venice and The Tempest —in Adrian Tchaikovsky’s Children of Time (2015–22) novels to illuminate the trilogy’s complex engagement with posthuman identities. It identifies and analyzes a sustained pattern of connections between Tchaikovsky’s allusive processes and the various biological mechanisms of transformation and inheritance which drive the trilogy’s complex plot. The Shakespearean subtext becomes particularly resonant at moments when human survival or identity is challenged by unfamiliar life forms. In response to critical disagreement over whether Tchaikovsky embraces or rejects an anthropocentric view of the universe, it argues that Shakespeare’s own practice of presenting ethical or political debates in utramque partem , on both sides of the question, provides a model for decoding Tchaikovsky’s complex, shifting, and playful exploration of humanity’s encounters with very different life forms.

Research on the Relationship between Obesity and Epigenetics and its Application

Obesity is a complex and persistent disease that has been considered an epidemic with serious implications for public health and the global economy, given the rapid increase in its prevalence across all age groups. Pathogenesis of obesity involves environmental and genetic factors. Environmental factors are essential in modifying the epigenome, which in turn affects gene expression and contributes to obesity. This article provides a concise overview of the current knowledge about the connection between epigenetics and obesity, with a specific emphasis on DNA methylation, histone modifications, and non-coding RNAs. The study also investigates two primary mechanisms of epigenetic transgenerational inheritance, which refers to the phenomenon where environmental damages encountered by one generation can impact the susceptibility to obesity in future generations. The article aims to highlight the importance of epigenetics in obesity development and to propose potential interventions for its prevention and treatment.

Empirical research indicators for family cultural capital

The cultural capital of a family largely defines human resources, especially when it comes to young students (preschoolers, schoolchildren, college students, students of the first two years). The mechanisms of culture inheritance by younger generations are especially peculiar to analyse. The study of family resources is relevant due to the need for thorough human capital analysis, the details of educational and professional choice. The author of the methodological analysis presents a set of indicators relevant to the empirical study of family cultural capital. Among the proposed nine indicators, there are education of parents and the people themselves, parents' professions, family's attitude to higher education, knowledge of foreign languages in the family, the availability of a home library and Internet access. Such indicators as attendance at cultural events, family holidays, and family heirlooms are justified. Several internal characteristics are proposed for each referent. In the developed methodological model, the most appropriate sociological methods are identified, with the help of which it is convenient to analyze various elements of family cultural capital. The proposed indicators can be used in reflexive empirical research, that is, a representative survey, a biographical method, various types of questionnaires, and interviews. The findings of the study are useful for teaching students of sociological and cultural practices. The obtained results can be applied in family and educational policy, as well as analysing the ratio of requests and offers of the modern labour market.

Developmental epigenetics: Understanding genetic and sexually dimorphic responses to parental diet and outcomes following assisted reproduction.

The developmental integrity and wellbeing of offspring are influenced by events that occur in utero, particularly around the time of conception. While extraneous factors such as environmental temperature and exposure to environmental chemicals can each have a bearing on these events, the epigenetic mechanisms that direct cellular differentiation during early development in ruminants are best described for studies which have investigated the effects of parental nutrition or pregnancy outcomes following assisted reproduction. In this article the case is made that the genetic constitution of an individual directs epigenetic responses to environmental stimuli, and consideration in this regard is also given to the origins of sexual dimorphism and mechanisms of germline intergenerational inheritance. These aspects are considered in the context of epigenetic modifications that take place during the normal course of gametogenesis and embryogenesis, and again following either dietary or procedural interventions such as embryo culture. A recurring feature of such interventions, irrespective of species, is that one carbon metabolic pathways are invariably disrupted, and this affects the provision of methyl groups for chromatin and RNA methylation. Inter-specific variation in how these pathways operate, both within the liver and in germ cells, indicates that ruminants may be particularly sensitive in this regard. Recent advances in genomic technologies should enable rapid progress in these areas. Knowledge gained can be integrated into breed improvement programs and used to tailor management practices to specific breeds and strains (including sexes) within breeds. Ultimately, consideration should be given to integrating metagenomics into analyses of genetic-directed epigenetic programming of animal development.

Variation in animal architecture: Genes, environment, and culture.

A new study investigates how stingless bee colonies inherit one of two architecturally distinct types of comb and proposes the primary mechanism of inheritance as stigmergy: among-individual coordination in comb building informed by environmental cues (i.e., social artefacts). These findings highlight the importance of social information in creating and maintaining architectural variance among structures.

Effects of positive mGlu5 modulation on D2 signaling and nicotine-conditioned place preference: Mechanisms of epigenetic inheritance in a transgenerational model of drug abuse vulnerability in psychosis.

The metabotropic glutamate type 5 (mGlu5) receptor has emerged as a potential target for the treatment of psychosis that is suggested to have greater efficacy than antipsychotic medications that are currently utilized. This study sought to elucidate mechanisms of therapeutic action associated with the modulation of the mGlu5 receptor in a disordered system marked by dopamine dysfunction. We further explored epigenetic mechanisms contributing to heritable transmission of a psychosis-like phenotype in a novel heritable model of drug abuse vulnerability in psychosis. F1 generation male and female Sprague-Dawley rats that were the offspring of two neonatal quinpirole-treated (QQ) or two saline-treated (SS) animals were tested on nicotine-conditioned place preference (CPP). Regulators of G protein signaling 9 (RGS9) and β-arrestin 2 (βA2), which mediate dopamine (DA) D2 signaling, were measured in the nucleus accumbens shell, prelimbic and infralimbic cortices. Reduced Representation Bisulfite Sequencing (RRBS) was used to analyze the cytosine methylation in these brain regions. Pretreatment with the mGlu5-positive allosteric modulator 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) 20 min prior to conditioning trials blocked enhanced nicotine CPP and mitigated aberrant G protein-dependent and -independent signaling in QQ animals. RRBS analysis revealed region-specific changes in several pathways, including nicotine addiction, dopamine synapses, and neural connectivity. These results reveal an important region-specific mechanism of action for CDPPB in a system marked by enhanced DAD2 receptor signaling. Results additionally reveal DNA methylation as an epigenetic mechanism of heritability, further validating the current model as a useful tool for the study of psychosis and comorbid nicotine use.

The Study of the Inheritance Mechanisms of Myotonic Dystrophy Type 1 (DM1) in Families from the Republic of North Ossetia-Alania.

Myotonic dystrophy type 1 (DM1) is a multisystem disorder with progressive myopathy and myotonia. The clinical study was conducted in the Republic of North Ossetia-Alania (RNOA), and in it 39 individuals from 17 unrelated families were identified with DM1. Clinical presentations varied, including muscle weakness, fatigue, intellectual disability, hypersomnia, ophthalmological abnormalities, and alopecia. Using clinical and genotyping data, we confirmed the diagnosis and enabled the study of CTG-repeat anticipation and DM1 prevalence in the Ossetian and Ingush populations. CTG expansion correlated with age of onset, with clinical severity, and with offspring showing more severe symptoms than parents. In many families, the youngest child had a more severe DM1 phenotype than older siblings. The prevalence was 14.17 per 100,000 in Ossetians and 18.74 per 100,000 in Ingush people, aligning with global data. Segregation analysis showed a higher frequency of maternal transmission. The study highlights the clinical and genetic heterogeneity of DM1 and its dependence on repeat expansion and paternal and maternal age.

A sperm-enriched 5'fragment of tRNA-Valine regulates preimplantation embryonic transcriptome and development.

Sperm small RNAs have been implicated in intergenerational epigenetic inheritance of paternal environmental effects; however, their biogenesis and functions remain poorly understood. We previously identified a 5' fragment of tRNA-Valine-CAC-2 (tRFValCAC) as one of the most abundant small RNA in mature sperm. tRFValCAC is specifically enriched in sperm during post-testicular maturation in the epididymis, and we found that it is delivered to sperm from epididymis epithelial cells via extracellular vesicles. Here, we investigated the mechanistic basis of tRFValCAC delivery to sperm and its functions in the early embryo. We show that tRFValCAC interacts with an RNA binding protein, heterogeneous nuclear ribonucleoprotein A/B (hnRNPAB), in the epididymis, and this interaction regulates the sorting and packing of tRFValCAC into extracellular vesicles. In the embryo, we found that tRFValCAC regulates early embryonic mRNA processing and splicing. Inhibition of tRFValCAC in preimplantation embryos altered the transcript abundance of genes involved in RNA splicing and mRNA processing. Importantly, tRFValCAC-inhibited embryos showed altered mRNA splicing, including alternative splicing of various splicing factors and genes important for proper preimplantation embryonic development. Finally, we find that inhibition of tRFValCAC in zygotes delayed preimplantation embryonic development. Together, our results reveal a novel function of a sperm-enriched tRF in regulating alternating splicing and preimplantation embryonic development and shed light on the mechanism of sperm small RNA-mediated epigenetic inheritance.

Pesticide exposure triggers sex-specific inter- and transgenerational effects conditioned by past sexual selection.

Environmental variation often induces plastic responses in organisms that can trigger changes in subsequent generations through non-genetic inheritance mechanisms. Such transgenerational plasticity thus consists of environmentally induced non-random phenotypic modifications that are transmitted through generations. Transgenerational effects may vary according to the sex of the organism experiencing the environmental perturbation, the sex of their descendants or both, but whether they are affected by past sexual selection is unknown. Here, we use experimental evolution on an insect model system to conduct a first test of the involvement of sexual selection history in shaping transgenerational plasticity in the face of rapid environmental change (exposure to pesticide). We manipulated evolutionary history in terms of the intensity of sexual selection for over 80 generations before exposing individuals to the toxicant. We found that sexual selection history constrained adaptation under rapid environmental change. We also detected inter- and transgenerational effects of pesticide exposure in the form of increased fitness and longevity. These cross-generational influences of toxicants were sex dependent (they affected only male descendants), and intergenerational, but not transgenerational, plasticity was modulated by sexual selection history. Our results highlight the complexity of intra-, inter- and transgenerational influences of past selection and environmental stress on phenotypic expression.

Tetraniliprole resistance in field-collected populations of Tuta absoluta (Lepidoptera: Gelechiidae) from China: Baseline susceptibility, cross-resistance, inheritance, and biochemical mechanism

Tuta absoluta is one of the most destructive and invasive insect pests throughout the world. It feeds on numerous solanaceous plant species and has developed resistance to most types of popular insecticides. Tetraniliprole is a novel diamide chemical agent that acts as a modulator of the ryanodine receptor. To establish T. absoluta susceptibility to tetraniliprole and to understand potential mechanisms of resistance, we monitored 18 field populations of T. absoluta collected from northern China. One field-evolved resistant population, Huailai (HL), showed moderate resistance to tetraniliprole (36.2-fold) in comparison with susceptible strain YN-S. Assays of cross-resistance, synergism, metabolic enzyme activity, and inheritance of resistance were performed with YN-S strain and HL population. The latter displayed 12.2- and 6.7-fold cross-resistance to chlorantraniliprole and flubendiamide, respectively, but little cross-resistance to broflanilide (1.6-fold), spinosad (2.1-fold), metaflumizone (1.5-fold), or indoxacarb (2.8-fold). Genetic analyses revealed that tetraniliprole resistance in HL population was autosomal, incompletely dominant, and polygenic. Piperonyl butoxide was found to significantly increase tetraniliprole toxicity, and enzymatic activities of P450 monooxygenase and glutathione S-transferase were significantly higher in HL than YN-S population. These results enhance our knowledge of the inheritance and mechanism of tetraniliprole resistance, enabling future optimization of resistance management strategies.

Who do I Look like More, Mom or Dad? An Exploratory Survey about Primary Students’ Ideas about Heredity

Unlike in other countries, heredity and genetics appear first in Spanish science standards in secondary levels. However, some researchers have suggested the need of progressively introducing some basic genetic ideas already from primary education levels. In this context of no formal instruction in early stages, the objectives of our work were to characterize the incipient heredity model of primary school pupils and to evaluate its progression, to identify the most appropriate time to introduce these ideas. We designed a 12-item questionnaire referred to two constructs: (1) the difference between biologically inherited and environmental acquired traits and (2) the mechanism of inheritance. 535 primary school pupils (6–12 years; grades 1–6) took part in the study. In addition, 1–2 pupils per class were interviewed, totalling 30 interviewees. The results showed that pupils clearly identified physical resemblance as inheritable but had more difficulties in assessing physiological traits. Most pupils (84%) correctly identified that accidentally acquired traits were not transmitted to the descendance. However, only 32,2% of them use terms related to inheritance (77,1% of them in G4 – G6). Regarding the mechanism of inheritance, the idea that siblings express traits of both parents becomes more prevalent from grade 3, even suggesting the appearance of new traits or the mixture of previous ones. Older pupils accepted that a trait could skip a generation, although most of them were unable to explain the mechanism, that involves the idea of dominance/ recessiveness. These results allow identifying key leverage points for constructing the inheritance model at Primary levels.

Insights into Fungal Mitochondrial Genomes and Inheritance Based on Current Findings from Yeast-like Fungi.

The primary functions of mitochondria are to produce energy and participate in the apoptosis of cells, with them being highly conserved among eukaryotes. However, the composition of mitochondrial genomes, mitochondrial DNA (mtDNA) replication, and mitochondrial inheritance varies significantly among animals, plants, and fungi. Especially in fungi, there exists a rich diversity of mitochondrial genomes, as well as various replication and inheritance mechanisms. Therefore, a comprehensive understanding of fungal mitochondria is crucial for unraveling the evolutionary history of mitochondria in eukaryotes. In this review, we have organized existing reports to systematically describe and summarize the composition of yeast-like fungal mitochondrial genomes from three perspectives: mitochondrial genome structure, encoded genes, and mobile elements. We have also provided a systematic overview of the mechanisms in mtDNA replication and mitochondrial inheritance during bisexual mating. Additionally, we have discussed and proposed open questions that require further investigation for clarification.

Intergenerational evolution of intangible cultural heritage through tourism development: perspectives of practitioners in Hangzhou China

ABSTRACT As cultural carriers of intangible cultural heritage (ICH), practitioners are key stakeholders in its inheritance and tourism use. Master-apprentice transmission is a major mechanism of generational inheritance. This paper examines ICH masters and apprentices at the Arts & Crafts Museum of Hangzhou, China, and analyzes the cultural composition of handicraft ICH and its intergenerational evolutionary mechanisms. Semi-structured interviews with two generations of practitioners and participant observation were undertaken. Research results reveal that intergenerational evolution involves multifaceted stakeholder interactions centred on practitioners with the support of government, management of the museum and participation of visitors. With patterns of family and master-apprentice inheritance, two generations of practitioners facilitate the evolution of handicraft ICH though both co-creations and conflicts. Second, six cultural attributes for handicraft ICH as of material, pattern, shape, technique, image and system are identified to visualise the process of intergenerational evolution. Third, driven by internal and external factors, ICH evolves through tracks of inheritance, selection and variation as presented through the above six cultural attributes. Moreover, the interdependence of cultural elements highlights the heritage framework of handicraft ICH and reflects the fluidity of authenticity. Accordingly, theoretical contributions and future research directions are offered for the sustainable development of handicraft ICH.