AbstractThis study aimed to investigate co-seismic stress and aftershock distribution along the Sumatra–Andaman subduction zone (SASZ). The fault parameters of six major earthquakes with an M ≥ 7 that occurred during 2010–2022 along the SASZ, were utilized to determine the Coulomb stress change using numerical modeling techniques calculated on the receiver faults with similar focal mechanisms of the mainshock, strike-slip, thrust, and normal faulting, respectively. The earthquake events were then classified to analyze the aftershocks of major earthquakes in the area. These aftershocks were mapped in order to determine the relationship between the aftershock distribution and the areas of increased or decreased stress. The relationship between the co-seismic stress and distribution of aftershocks in the SASZ was found to mainly depend on the focal mechanism of major earthquakes and the type of receiver fault used for calculation. After a major earthquake in the SASZ, there are two possible patterns that most aftershocks will be generated from in the areas of increased stress. First, a major earthquake is a type of thrust fault calculated on the receiver fault using the focal mechanism of the mainshock. Second, a major earthquake is a type of strike-slip fault calculated on the receiver fault with an optimum-oriented strike-slip fault. This relationship is likely to represent the specific pattern of the seismotectonic stress in the SASZ that can be used to evaluate the risk areas of aftershocks after a major earthquake has occurred. Furthermore, two earthquake events with large magnitudes were generated following the respective major earthquake in the SASZ that were located around the areas of increased stress, indicating that these two earthquake events were likely triggered in areas of increased stress following the respective major earthquake. Therefore, this study concluded that after a major earthquake occurrence in the SASZ, the areas of increased stress have a higher risk of generating both a large number of aftershocks and a new large-magnitude mainshock event. The investigation of co-seismic stress is very important to estimate areas of increased stress after a major earthquake, as this can be useful for monitoring both earthquake and tsunami hazards in the area.