Mechanical Ventilation In Infants Research Articles

Airway Flow Patterns During Mechanical Ventilation of Infants: A Mathematical Model

A mathematical model of flow in a patient-ventilator system is developed. The model is solved for conditions which simulate those which occur during mechanical ventilation of the small infant with lung disease.

Mechanical ventilation of newborn infants. I. The effect of rate and pressure on arterial oxygenation of infants with respiratory distress syndrome.

Extract: This study reports the effect of varying specific parameters of mechanical ventilation on aortic PO2 in six infants with severe respiratory distress syndrome. Twenty-seven studies were performed during the first 168 hours of mechanical ventilation. In each study, arterial oxygen partial pressure was found to vary directly with airway pressure and inversely with respiratory rate. No correlation was found between rate and pressure, or PaO2, PaCO2, and pHa. Oxygenation of infants with severe respiratory distress syndrome can be significantly influenced by variation of specific parameters of mechanical ventilation independently of change in aortic carbon dioxide tension. Speculation: Optimal oxygenation during mechanical ventilation of infants with severe respiratory distress syndrome is dependent upon selection of the specific and appropriate pattern of ventilation.