Objective: Ascending aortic conduit with mechanical aortic valve prosthesis was the standard therapy for younger people suffering from severe aortic stenosis in combination with aortic aneurysm over many years. In times of TAVI, new concepts of aortic valve therapy are developing. Especially biological valves in younger patients get into focus avoiding lifelong anticoagulation therapy. We report about implantation of a self made bio-conduit using the Edwards INSPIRIS RESILIA biological valve in younger patients. Methods: From 1/2018 until 7/2019 we implanted a self made bio conduit consisting of an Edwards INSPIRIS RESILIA biological valve 23 – 27 mm sewed in a Vascutek vascular prosthesis 2mm oversized onsite in the OR. Patient cohort consisted of 15 patients (11 male, 4 female) aged 55 to 64 years. Conduits were implanted in a typically Bentall procedure with coronary reimplantation. TEE/TTE control examinations were done 7 days and three months after operation. Results: Implantation was uneventful in all patients, intraoperative TEE showed no stenosis, regurgitation or paravalvular leakage. Postoperative course was uncomplicated in 13 cases, we saw one renal insufficiency and one pneumonia, both in regression until discharge. Echo control examinations 7 days and 3 months p.o showed good valve function with low gradients comparable to measured gradients of patients with single AVR using Edwards INSPIRIS RESILIA biological valve. Patients got no anticoagulation therapy with exception of 6 CHD patients treated with ASS. Conclusions: Self made bio-conduit for Bentall procedure using Edwards INSPIRIS RESILIA biological valve in younger patients is a good alternative avoiding need of lifelong anticoagulation therapy, especially in times of TAVI as a low risk redo procedure in case of bioprosthesis failure. KEYWORD: e-PD-39 The authors do not declare any conflict of interest.