Mechanical Damage Research Articles

Role of the ROS/NLRP3/caspase-1 pathway in NiSO4-induced cellular pyroptosis and apoptosis in H9c2 cells

According to comprehensive research, the cardiovascular system is damaged by nickel exposure. The present study selected rat cardiomyocytes (H9c2 cells) and subjected them to varying doses of sodium nickel sulfate (NiSO4) for 24 hours to better understand the mechanism of cardiovascular damage caused by NiSO4 exposure. The relevant indicators were detected employing biochemical analysis, real-time quantitative polymerase chain reaction (RT-qPCR), and western blot, and flow cytometry was used to detect the cell apoptosis rate. The study revealed that the survival rate of H9c2 cells fell significantly when the concentration of NiSO4 exposure rose. Moreover, it caused oxidative stress in H9c2 cells by raising the expression of reactive oxygen species and the concentration of LDH in the cell supernatants. After NiSO4 exposure, the levels of ASC, NLRP3, gasdermin D, and caspase-1 in H9c2 cells increased, suggesting that H9c2 cells underwent pyroptosis induced by NiSO4. In addition, NiSO4 exposure also led to inflammation, with increased levels of interleukin [IL]-18, IL-1β. After adding the antioxidant N-Acetyl-L-cysteine (NAC), the level of ROS indicated that the oxidative stress level in H9c2 cells was reduced, western blot inhibited inflammation, the level of pyroptosis was reduced, and the activity of the NLRP3/caspase1 signaling pathway was reduced. To examine the connection between pyroptosis and apoptosis, the cells were treated with the caspase1 inhibitor Z-YVAD-Fluoromethyl Ketone (Z-YVAD-FMK, YVAD), which resulted in a significant decrease in the rate of cell apoptosis as well as a reduction in the activity of the related protein in the signaling pathway, which in turn decreased the level of pyroptosis. NiSO4 could induce pyroptosis in H9c2 cells through the ROS/NLRP3/caspase-1 axis. Furthermore, NiSO4-induced apoptosis and pyroptosis were found to be reduced by the addition of the caspase-1 inhibitor.

Study on the Microscopic Pore Characteristics and Mechanisms of Disturbance Damage in Zhanjiang Formation Structural Clay

To investigate the microscopic pore evolution characteristics of Zhanjiang Formation structural clay during the disturbance process, unconfined compressive strength tests, scanning electron microscopy (SEM), and X-ray diffraction (XRD) were conducted on disturbed samples subjected to various disturbance conditions after vibrational disturbance. Based on the evolution characteristics of the microstructure, the microscopic pore characteristics of the disturbance damage of Zhanjiang Formation structural clay were examined. The results indicate the following. (1) The porosity in three-dimensional visualization images of the microstructure reconstructed by ArcGIS 10.1 increases with the disturbance degree, showing a linear growth trend. (2) The correlation analysis between macroscopic mechanics and microscopic pores shows that the unconfined compressive strength of Zhanjiang Formation structural clay is mainly affected by its porosity, with a significant linear negative correlation. Based on this, a reasonable regression model between the microscopic porosity and the unconfined compressive strength has been established. The model can rapidly estimate the unconfined compressive strength from porosity data, facilitating the assessment engineering properties of the soil. (3) The microscopic pore structure of Zhanjiang Formation structural clay exhibits prominent Menger fractal characteristics. The three-dimensional pore fractal dimension has a certain positive correlation with the disturbance degree, and can be utilized to characterize the pore structure and complexity, serving as a significant parameter for the quantitative evaluation of the pore structure characteristics of Zhanjiang Formation structural clay. Consequently, the complexity of the pore structure of the engineering soil can be evaluated by the pore fractal dimension. (4) The impact of disturbance on soil is primarily manifested in the structural changes in secondary clay minerals, transitioning from a relatively intact to a fully adjusted state. During this process, interparticle pores continuously increase, pore structure complexity increases, and interparticle cementation weakens, resulting in the continuous degradation of unconfined compressive strength. This study contributes to a deeper understanding of the disturbance damage characteristics of Zhanjiang Formation structured clays from a microscopic pore perspective, providing a theoretical basis for the engineering construction and operational maintenance in regions with Zhanjiang Formation structural clay.

Zinc Deficiency Leads to Reproductive Impairment in Male Mice Through Imbalance of Zinc Homeostasis and Inflammatory Response.

Zinc is an essential trace element crucial for growth and development and plays a significant role in male reproductive function. The aim of this study was explore the mechanism of male reproductive damage caused by different degrees of zinc deficiency. Thirty male ICR mice were randomly assigned to three groups: zinc-normal diet group (ZN, n = 10, Zn content = 30mg/kg), low zinc-deficiency diet group (LZD, n = 10, Zn content = 15mg/kg), and high zinc-deficiency diet group (HZD, n = 10, Zn content = 7.5mg/kg). The mice were maintained for 8weeks. At the end of the experiment, they were sacrificed, and their blood, testicular, and epididymal tissues were collected for further study. Zinc-deficient diet led to weight loss, testicular structural disorder, decreased semen quality, imbalance of zinc homeostasis, and inflammatory damage in mice. Semen quality, testosterone, serum Zn, testicular tissue Zn, testicular free Zn ions, Zrt-, Irt-like protein8 (ZIP8), Zrt-, Irt-like protein5 (ZIP5), and interleukin-10 (IL-10) were significantly decreased; zinc transporter 4(ZnT4), NF-κB p65, P-NF-κB p65, NLRP3, Caspase-8, and Caspase-3 were significantly increased in both LZD and HZD group mice. While compared with the LZD group, Zrt-, Irt-like protein13 (ZIP13), TNF-α, NF-κB p65, P-NF-κB p65, NLRP3, Caspase-1, and GSDMD were significantly increased in the HZD group. Both low and high zinc-deficiency diets can disrupt zinc homeostasis in mice, leading to heightened inflammatory responses, the activation of the NF-κB pathway, and increased apoptosis in testicular cells. Notably, a high zinc-deficiency diet led to an up-regulation of ZIP13 expression, exacerbated inflammation, and induced testicular pyroptosis, resulting in more severe reproductive damage in male mice.

A two‐scale numerical analysis of intra‐yarn hybrid natural/synthetic woven composites

AbstractThis paper investigates how combining natural and synthetic fibers within yarns, altering the degree of hybridisation, and varying weave architectures affect the homogenized elastic properties and stress distributions in 2D woven composite laminae using a two‐scale homogenization scheme. The novelty lies in integrating a micro‐scale representative volume element model with a meso‐scale repeating unit cell model to capture intra‐yarn natural/synthetic fiber hybridisation. The study focuses on 2/2 twill and 5‐harness satin woven laminae with flax/E‐glass, hemp/E‐glass and basalt/E‐glass hybrid yarns, all with a total fiber volume fraction of 0.6. Fiber distributions are created through a random sequential expansion algorithm for hybrid RVEs, while periodic meso‐structures are used to define weave architectures for RUCs. Results show that yarn‐level fiber hybridisation significantly influences matrix stress distributions, with variations of up to 22%. In contrast, weave architecture has a minimal effect, with variations in homogenized properties below 2%. Varying fiber types, degrees of hybridisation and weave architectures allow for the tailoring of yarn and lamina properties and altering the stress distributions at micro‐ and meso‐scales and potentially influencing damage mechanisms. The modeling approach for analyzing the mechanical behavior of intra‐yarn hybrid natural/synthetic woven laminae could potentially be used to tailor their tolerance to damage.Highlights Two‐scale homogenization integrates RVE and RUC for 2D woven hybrid composites. Analyzed flax/E‐glass, hemp/E‐glass, basalt/E‐glass in twill and satin weaves. Intra‐yarn hybridisation significantly affects properties and stress fields. Hybridizing fibers offers tailored properties and may improve damage tolerance.

Investigation of amyl acetate sorption impact on high‐density polyethylene bottle properties

AbstractThermoplastics based on polyolefins, including polypropylene, high‐density polyethylene and low‐density polyethylene, are extensively utilized across various packaging sectors. The selection of these materials for specific applications is influenced by multiple factors, such as the polymer's absorption characteristics and the impact on its mechanical properties when in contact with the packaged product. This study presents an experimental methodology designed to simulate the effects of absorption on the macroscopic and microscopic properties of high‐density polyethylene bottles in contact with amyl acetate. Macroscopic degradation was evaluated by modeling mechanical damage using unified theory and the energy method. Analytical techniques such as gravimetric analysis, scanning electron microscopy and Fourier transform infrared spectrometry were employed. The findings of this research provide valuable insights for suppliers and industries to experimentally determine the usability and safety intervals of plastic packaging through comprehensive macroscopic and microscopic analyses within relatively short timescales. © 2024 Society of Chemical Industry.

Designing a Brushed DC Motor Driver with a Novel Adaptive Learning Algorithm for the Automotive Industry

In this study, a stepper driver, which is suitable for use in the automotive industry, designed for general use, capable of adaptive learning in the systems in which it is used, and with CAN and universal asynchronous receiver–transmitter (UART) communication options, was designed. This design was made with a PIC18F25K22 microcontroller unit (MCU). Rotor speed, armature current, and terminal voltage can be measured on the proposed brushed DC motor drive system. It gives the desired response by evaluating obstacles and other situations in which high currents are drawn from the source. The speed measurement of the vehicle and the open and closed status of an automatic door can be monitored. The main contribution of the designed PCB is an adaptive learning algorithm (ALA) that uses the pulses of the encoder, estimates the position of the step, and manages the operation process to prevent mechanical damage at the final point of the motor. Furthermore, unexpected hitting and pinching which are defined as obstacles to the driver can be controlled by monitoring the current value drawn from the driver. The benefit of this method is that the life of the mechanical step is increased due to the management of the forward and backward step operation, preventing potential accidents.

Wood Surface-Embedding of Functional Monodisperse SiO2 Microspheres for Achieving Robust, Durable, Nature-Inspired, Programmable Superrepellent Interfaces.

Nature-inspired, robust, durable, liquid-repellent interfaces have attracted considerable interest in the field of wood biomimetic intelligence science and technology application. However, realizing green environmental protection and low maintenance and replacement cost wood surfaces constructed with micro/nanoarchitectures is not an easy task. Aiming at the problem of poor waterproof performance of wood, a silicon dioxide/polydimethylsiloxane (SiO2/PDMS) self-cleaning programmable superhydrophobic coating was biomimetically constructed on the wood substrate by surface-embedded dual-dipping design based on the "substrates + nanoparticles" hybrid principle of the lotus leaf effect. This robust, durable, nature-inspired, self-cleaning, programmable superhydrophobic coating was found to have no observable impact on the original color and texture of the natural wood. The SiO2/PDMS/wood prepared exhibited exceptional liquid repellency and a high static water contact angle (WCA) of 158.5° and a low slide angle (SA) of 10°, including everyday general-purpose droplets, indicating that the introduction of the monodisperse SiO2 microspheres can effectively enhance the superhydrophobic properties of the hydrophilic wood. We applied this strategy to a variety of substrates, including wood-cellulose aerogel and wood-cellulose paper, and demonstrated that the liquid-repellent nature of the self-cleaning superhydrophobic coating remained unchanged. Moreover, the superhydrophobic surface of SiO2/PDMS/wood was preserved even after harsh abrasion conditions, including mechanical damage (sandpaper, sharp steel blade, and tapes), thermal damage (UV irradiation and low/high-temperature exposure such as steaming and freezing), chemical damage, and solvent corrosion (immersion in acid, alkali), demonstrating robust stability of the superhydrophobic coating. Furthermore, the SiO2/PDMS programmable superhydrophobic coating exhibits exceptional exciting self-cleaning and stain-resistant properties, making it offer greater possibilities in terms of scientific challenges and real-world problem-solving at biomimetic smart superhydrophobic interfaces in wood.

Effect of multi‐angle lamination on mechanical properties and damages behavior of carbon fiber reinforced resin matrix composites

AbstractCarbon fiber reinforced resin matrix composites, when subjected to multi‐angle delamination during vacuum hot pressing, suffered from defects such as uneven fiber distribution, resin‐rich zones, and voids. These defects caused varied damage and failure behaviors in the composites, seriously affecting their mechanical properties. In this paper, the defect distribution, tensile and flexural properties, and damage behaviors of multi‐angle lay‐up specimens prepared in an autoclave were studied. The results indicated that irregularly shaped voids in laminates with a 0° angle difference primarily led to local stress concentration. Elliptical and elongated voids in laminates with a 90° angle difference were mainly susceptible to delamination. The [0/90]8 layer exhibited the best overall mechanical properties. The proportion of 0° laminates had a direct impact on the mechanical properties, with 0° contact laminates on the bending‐compression side capable of withstanding higher bending loads. The [+45/−45]8 plyer demonstrated pseudo‐delayed behavior, enabling the laminate to show better toughness under load. Variations in damage due to the proportions and positions of the laminates influenced the mechanical properties and damages behavior of multi‐angle laminates.Highlights Angular differences were observed to affect void and resin distribution. The best overall mechanical properties were attributed to [0/90]8 laminates. Pseudo‐delay behavior was exhibited by [+45/−45]8 laminates. Proportion of 0° layers impacted mechanical properties. Greater bending loads were withstood by the 0° contact layer.

Analysis of shear creep damage model of slope rock mass under the influence of coupled damage effects (DBSM)

Abstract This article reveals the evolution law of shear creep damage of carbonaceous shale (weak interlayer of slope) under dynamic load from a mechanical perspective by combining indoor experiments and theoretical research. Firstly, a coupled damage variable D BSM was established for the initial damage D 0 and dynamic disturbance shear creep damage D BS of rock mass based on the theory of damage mechanics. Secondly, according to the fractional calculus operator theory and considering the influence of coupled damage variable D BSM on the viscosity coefficient of rock mass in the viscoelasticity and viscoplasticity creep stages, a shear creep damage model of rock mass was established. At the same time, combined with the shear creep test data under the influence of dynamic loads, the damage evolution law of shear creep in carbonaceous shale (weak interlayer of slope) was revealed, and the accuracy of the established shear creep damage model was verified. Finally, the damage evolution law of carbonaceous shale was quantitatively analyzed. Results show that: The shear creep damage model established in this article has unique advantages. The greater the initial damage, the more likely shear creep failure is to occur under the influence of dynamic disturbance and shear creep loads. Dynamic disturbance accelerates the damage of weak interlayers of slope. The cumulative coupling damage of carbonaceous shale (D ma ≤0.18) under dynamic disturbance and multi-stage shear creep loads exhibits an S-like evolution pattern. The shear creep damage mechanism of carbonaceous shale is characterized by obvious initial damage effect, dynamic disturbance damage effect, and stress response characteristics.

An Attempt to Predict Transparent Armor Ballistic Performance through Quasi-Static Punch Shear Test

Abstract Background Transparent armor systems are traditionally designed following a trial-and-error approach, which involves high development costs associated with ballistic testing. This research article presents a novel methodology, termed quasi-static multi-punch shear testing, within the domain of transparent armor systems. Objective The primary aim is to establish a correlation between multi-hit ballistic tests at Level III-A according to the NIJ 0108.01 standard, achieved through an adaptation of the single-shot ballistic limit methodology, and the quasi-static multi-punch shear testing. The objective is to utilize a simple experimental methodology that provides insights into the multi-hit ballistic behavior of transparent armors. Methods Parameters such as absorbed energy and observed damage mechanisms were utilized to assess the potential relationship between these tests. Transparent armor samples that underwent testing using the quasi-static multi-punch shear test were subsequently cross-sectioned using a water jet cutting machine to facilitate visualization of material damage. In addition, drawing on insights from quasi-static multi-punch shear testing results, the K-means clustering algorithm was employed to predict the likelihood of a specific transparent armor system passing a multi-hit ballistic test. Results Various damage mechanisms were observed as a function of the punch displacement, and correlations were made with the load–displacement curves. Furthermore, the implementation of the K-means clustering algorithm successfully classified transparent armor into two groups: those that passed the ballistic test and those that did not. Conclusions This research significantly advances understanding of transparent armor system behavior under multi-hit conditions and offers a promising predictive tool for evaluating their performance through straightforward and cost-effective experimentation.

Pulmonary Flora-Derived Lipopolysaccharide Mediates Lung-Brain Axis through Activating Microglia Involved in Polystyrene Microplastic-Induced Cognitive Dysfunction.

Microplastics (MPs) have been detected in the atmospheric and the human respiratory system, indicating that the respiratory tract is a significant exposure route for MPs. However, the effect of inhaled MPs on cognitive function has not been adequately studied. Here, a C57BL/6 J mouse model of inhalation exposure to polystyrene MPs (PS-MPs, 5 µm, 60 d) is established by intratracheal instillation. Interestingly, in vivo fluorescence imaging and transmission electron microscopy reveal that PS-MPs do not accumulate in the brain. However, behavioral experiments shows that cognitive function of mice is impaired, accompanied by histopathological damage of lung and brain tissue. Transcriptomic studies in hippocampal and lung tissue have demonstrated key neuroplasticity factors as well as cognitive deficits linked to lung injury, respectively. Mechanistically, the lung-brain axis plays a central role in PS-MPs-induced neurological damage, as demonstrated by pulmonary flora transplantation, lipopolysaccharide (LPS) intervention, and cell co-culture experiments. Together, inhalation of PS-MPs reduces cognitive function by altering the composition of pulmonary flora to produce more LPS and promoting M1 polarization of microglia, which provides new insights into the mechanism of nerve damage caused by inhaled MPs and also sheds new light on the prevention of neurotoxicity of environmental pollutants.

Regulation of ferroptosis in osteoarthritis and osteoarthritic chondrocytes by typical MicroRNAs in chondrocytes

Osteoarthritis (OA) is a progressive degenerative disorder impacting bones and joints, worsened by chronic inflammation, immune dysregulation, mechanical stress, metabolic disturbances, and various other contributing factors. The complex interplay of cartilage damage, loss, and impaired repair mechanisms remains a critical and formidable aspect of OA pathogenesis. At the genetic level, multiple genes have been implicated in the modulation of chondrocyte metabolism, displaying both promotive and inhibitory roles. Recent research has increasingly focused on the influence of non-coding RNAs in the regulation of distinct cell types within bone tissue in OA. In particular, an expanding body of evidence highlights the regulatory roles of microRNAs in OA chondrocytes. This review aims to consolidate the most relevant microRNAs associated with OA chondrocytes, as identified in recent studies, and to elucidate their involvement in chondrocyte metabolic processes and ferroptosis. Furthermore, this study explores the complex regulatory interactions between long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in OA, with an emphasis on microRNA-mediated mechanisms. Finally, critical gaps in the current research are identified, offering strategic insights to advance the understanding of OA pathophysiology and guide therapeutic developments in this field.

Internal shear damage evolution of CFRP laminates ranging from −100 °C to 100 °C using in-situ X-ray computed tomography

Carbon Fiber Reinforced Polymer (CFRP) composites have been widely used in aerospace due to their high specific stiffness, strength, and fatigue properties. However, the ambient temperature significantly influences CFRP's mechanical properties and damage evolution, deriving from the temperature effect on the microstructural behavior and the mesoscopic damage evolution. In this study, the temperature-dependent in-plane shear failure behavior of CFRP composites was investigated. In-situ X-ray Computed tomography (CT) tensile experiments of laminates ([45°/-45°]2s) at RT, −100 °C, and 100 °C were carried out to study the in-plane shear failure mechanisms. The 3D fracture morphology was extracted with internal damage evolution process estimated and quantified. The in-situ 3D deformation fields of critical regions were acquired using the Digital Volume Correlation (DVC) method. The effect of temperature on strain field and the correlation between the high-strain region and the fracture location were analyzed. The results revealed the temperature correlations and failure mechanisms of CFRP's mechanical characteristics and internal damage evolution process. Compared to room temperature (RT), the delamination damage area of the sample increased by 80 % at 100 °C. Meanwhile, the shear modulus of CFRP decreases by 78.4 % from −100 °C to 100 °C, and the fracture strain increases by 95 % from RT to 100 °C. The DVC results indicated a dispersion of high-strain regions at −100 °C, reflecting the brittle damage characteristics, while an extensive ductile deformation region was captured at 100 °C. Fiber-matrix debonding is the dominant failure mode of composites under shear loading, whereas significant matrix cracking was observed at −100 °C and partial fiber pullout occurred at 100 °C.

Investigation of Ductility and Damage Behavior of C/GFRP Composite Laminates under Bending Loads

Carbon and glass fabric reinforced polymer (C/GFRP) composites are extensively used in aerospace and sports industry because of their exceptional properties. However, during service, static and dynamic bending loads can ensue damage in composites affecting their strength, stiffness and energy absorption. Carbon fiber composites, being inherently brittle, are prone to sudden catastrophic fracture without ductile-like behavior of metals. This study investigates mechanical behavior and damage mechanisms of woven C/GFRP composites in on- and off-axis orientations during bending. Initially, bending tests with quasi-static loading were performed, followed by dynamic ones using an Izod impact testing apparatus. Results showed distinct behavior in on-axis CFRP laminates with brittle fracture. Off-axis CFRP samples and both on- and off-axis GFRP laminates showed signs of damage and non-linear behavior, yet they retained their ability to bear loads. Significantly, off-axis specimens of both types and on-axis GFRP laminates exhibited enhanced energy absorption capabilities without experiencing fracture, undergoing pseudo-ductile deformation. CFRP specimens were analyzed with micro-computed tomography (micro-CT), provided insights into prevalent damage modes such as matrix mircocracking, debonding of tows, delamination and breakage of fabric. While on-axis CFRP laminates experienced brittle fracture, off-axis specimens exhibited a ductile-like response attributed to matrix plasticity, cracking and fiber trellising before eventual failure.

Simulation and Experimental Analysis of Surface Crack Propagation in Oscillating Bearings

: This study investigates the propagation of surface cracks in bearings under oscillating conditions. Voronoi elements are employed to simulate the microstructure of bearings, and combined with a cohesive zone model of continuum damage mechanics to simulate the propagation of cracks. A new type of oscillating contact fatigue test machine was designed to conduct experiments on contact crack propagation under oscillating conditions, and the experimental results were analyzed. By comparing the simulation results with experimental data, the validity of the theoretical analysis was confirmed.

Lightning ablation damage and residual bending performances of scarf-repaired composite laminates with copper mesh protection

The copper mesh provides effective lightning strike protection for composite structures, while its efficiency can be compromised in scarf-repaired composite structures. In this study, after verified by test results, a numerical analysis procedure was employed to predict the lightning ablation damage and residual bending performances of scarf-repaired composite laminates with copper mesh protection. Initially, the ablation damage and bending damage mechanisms of good repaired and poor repaired composite laminates were analyzed. Then, the impact of lightning strike attachment position and repair design parameters including overlap length and thickness of adhesive layer on the lighting protection performances was investigated. The results indicate that ablation damage of composite and adhesive materials near the repair area significantly compromises structural integrity and reduces the bending strength. The predominant bending failure mode of scarf-repaired woven composite laminates after lightning strike is fiber failure in warp direction, accompanied by small areas of matrix failure and delamination failure. The reestablishment level of the electrical path varies with overlap length and thickness of adhesive layer, subsequently affecting the ablation damage area and depth. This study can provide a reference for the design and process control of scarf-repair in copper mesh protected composite structures.

Investigations of high-speed projectile impact on symmetric sandwich structures containing solid propellant with core perforations

The response of solid rocket motors (SRMs) to high-speed fragment impacts is crucial for their safety design and operational use in scenarios such as rocket launches and space applications. The visualized Burn to Violent Reaction (BVR) test is used to observe intense reactions induced by high-speed projectile impacts. Employing a two-stage light gas gun and optical diagnostic techniques including high-speed schlieren imaging and direct photography, the impact-induced deflagration/explosion behavior, and reaction growth behavior were investigated. The damage mechanisms of the casing and propellant samples were assessed, and the reaction growth and afterburn effects of the impact-induced fragment cloud were quantitatively analyzed. The results indicate that the ignition delay time is inversely correlated with the impact velocity, decreasing from ms to μs scale. Across a wide range of velocities (1050–2058 m/s), higher projectile velocities induce more sustained and vigorous combustion reactions within the propellant. Furthermore, increasing the propellant air gap to 7.8 cm does not trigger further reactions under the studied configurations. The reaction mechanisms are closely linked to the characteristics of the fragment cloud induced by the impact. The developed Smoothed Particle Hydrodynamics (SPH) method, incorporating material constitutive models, ignition criteria, and reaction growth models, was used to study the influence of projectile velocity on the reaction mechanisms. The simulation results were compared with experimental data, demonstrating satisfactory accuracy.

Study on the Damage Mechanism of an H62-Cu/7075-Al Tribo-Pair Under the Influences of Current Direction and Density

In the present study, we used 7075 Al-H62 Cu and H62 Cu-7075 Al pairs to study the effects of current density and direction on their tribological properties and on the damage caused by the current-carrying friction and wear. We found that, when the current density increased from 0 A/mm2 to 79.61 A/mm2, the coefficients of friction for both pairs decreased. Results obtained after wear indicate that the current direction influences the electromigration between the two tracks, leading to different kinds of damage on the worn surface. In the case of the 7075 Al-H62 Cu pair, damage mainly involved mechanical wear at low current densities. As the current density increased, electro-erosion damage gradually became more dominant. Under the action of a large electric arc, the material surface was severely eroded, and a dense oxide film formed on the material contact surface, ultimately leading to the failure of electrical conduction between the materials. In the case of the H62 Cu-7075 Al pair, damage mainly involved mechanical wear. A layer of copper film was found on the surface of the worn aluminum pin, which caused its mass to be greater than it was before wear.

Low-Velocity Impact Behaviour of Titanium-Based Carbon-Fibre/Epoxy Laminate.

This study investigated the low-velocity impact response of titanium-based carbon-fibre/epoxy laminate (TI-CF FML). A comprehensive experimental study was carried out with impact energies ranging from 16.9 J to 91.9 J. Finite element analysis, performed using ABAQUS, was employed to elucidate the failure mechanisms of the laminate. Three distinct damage modes were identified based on the impact energy levels. The energy absorption characteristics of the TI-CF FML were analysed, revealing that maximum energy absorption is achieved and remains constant after penetration occurs. The relationship between impact force and displacement was also explored, showing that the laminate can withstand a peak force of 13.1 kN. The research on the impact resistance, damage mechanisms and energy absorption capacity of TI-CF FML provides an in-depth understanding of the impact behaviour of the laminate and its suitability for various industrial applications.

Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult.

IOP-induced mechanical insult on retinal ganglion cell axons within the optic nerve head (ONH) is believed to be a key factor in axonal damage and glaucoma. However, most studies focus on tissue-level mechanical deformations, overlooking that axons are long and thin, and that their susceptibility to damage likely depends on the insult's type (e.g. stretch/compression) and orientation (longitudinal/transverse). We propose an axon-centric approach to quantify IOP-induced mechanical insult from an axon perspective. We used optical coherence tomography (OCT) scans from a healthy monkey eye along with histological images of cryosections to reconstruct the axon-occupied volume including detailed lamina cribrosa (LC) pores. Tissue-level strains were determined experimentally using digital volume correlation from OCT scans at baseline and elevated IOPs, then transformed into axonal strains using axon paths estimated by a fluid mechanics simulation. Axons in the LC and post-LC regions predominantly experienced longitudinal compression and transverse stretch, whereas those in the pre-LC and ONH rim mainly suffered longitudinal stretch and transverse compression. No clear patterns were observed for tissue-level strains. Our approach allowed discerning axonal longitudinal and transverse mechanical insults, which are likely associated with different mechanisms of axonal damage. The technique also enabled quantifying insult along individual axon paths, providing a novel link relating the retinal nerve fiber layer and the optic nerve through the LC via individual axons. This is a promising approach to establish a clearer connection between IOP-induced insult and glaucoma. Further studies should evaluate a larger cohort.