Aim. The article deals with establishing the correlations between the anthropometric, hemodynamic, and vegetative tone indicators in first and second-year students during their adaptation to university conditions. The morphophysiological status of students was corrected by Selenes+ and additional physical load. Materials and methods. Students aged 17–20 years (n = 60) participated in a longitudinal study. The following physiological methods were used: body length and mass measurement; BMI calculation; detection of selenium in blood serum; systolic and diastolic pressure measurement; heart rate calculation; average dynamic pressure calculation; pulse pressure calculation; stroke volume calculation using Starr’s equation; minute volume blood flow calculation; endurance coefficient calculation according to Kvass’ equation; functional changes index calculation; Kerdo vegetative index calculation. Results. It was established that application of selenium depending on physical load in first-year female students influenced significantly the following indicators: arterial pressure (F = 4.21), heart rate (F = 3.42), minute volume blood flow (F = 3.80), functional changes index (F = 10.65), systolic pressure (F = 4.72; P < 0.05); selenium concentration (F = 93.97; P < 0.001). At the end of the IV stage, statistically significant F-criteria for arterial pressure (F = 3.50), heart rate (F = 4.33), endurance coefficient (F = 4.78; Р < 0.05), systolic pressure (F = 5.92), pulse pressure (F = 5.50; P < 0.01), functional changes index (F = 10.65), selenium concentration (F = 41.11; P < 0.001) were registered. Conclusion. The correlations revealed between the anthropometric, hemodynamic, and vegetative tone indicators in first and second-year students allowed to make a conclusion about the efficiency of the Selenes+ supplement during adaptation to university conditions. The Selenes+ supplement combined with physical exercises contributes to less pronounced stress in the cardiovascular system and provides the physiological optimum of the body.