Measures Of Psychopathology Research Articles

Relationship Between Religious Attitude and Depression, Anxiety, and Stress Symptoms in University Students in Iran

A considerable proportion of young adults studying at universities have a mental disorder. Previous research has shown a negative relationship between various religiosity and psychopathology measures, with different strengths of this correlation depending on the religiosity measure. The aim of the present study is to investigate the strength of association between religious attitude and depression, anxiety and stress in Iranian university students. Thirty-three students from two Iranian universities filled in the Religious Attitude Scale for University Students (RASUS), the Beck Depression Inventory-II (BDI-II), and the Depression, Anxiety and Stress Scale (DASS-42). Religious attitude correlates negatively with all psychopathological variables with a moderate effect size (e.g., with BDI-II: r = -.47; p = .006). When dividing the sample in low vs. high religious people, there were significantly more students without depression symptoms in the high religious attitude group than in the low group.

Predictors of Treatment Response to a Community-Delivered Group Social Skills Intervention for Youth with ASD.

Group social skills interventions (GSSIs) are among the most commonly used treatments for improving social competence in youth with ASD, however, results remain variable. The current study examined predictors of treatment response to an empirically-supported GSSI for youth with ASD delivered in the community (Ntotal=75). Participants completed a computer-based emotion recognition task and their parents completed measures of broad psychopathology, ASD symptomatology, and social skills. We utilized generalized estimating equations in an ANCOVA-of-change framework to account for nesting. Results indicate differential improvements in emotion recognition by sex as well as ADHD-specific improvements in adaptive functioning. Youth with both co-occurring anxiety and ADHD experienced iatrogenic effects, suggesting that SDARI may be most effective for youth with ASD without multiple co-occurring issues. Findings provide important directions for addressing variability in treatment outcomes for youth with ASD.

Short measures of youth psychopathology: psychometric properties of the brief problem monitor (BPM) and the behavior and feelings survey (BFS) in a Norwegian clinical sample

BackgroundTracking clinical outcomes during therapy can be useful for improving both clinical practice and research. For repeated data collection, short, reliable, and valid measures of central aspects of psychopathology are necessary. The current paper investigates the psychometric properties of two short surveys for measuring central dimensions of psychopathology in youth.MethodsWe investigated the factor structure and validity of the Norwegian translations of the Behavior and Feelings Survey (BFS) and the Brief Problem Monitor (BPM). The BFS has previously shown a two-factor structure and indications of validity as a measure of internalizing and externalizing problems in youth. The BPM has support for a three-factor structure of internalizing, externalizing, and attention problems. In our sample of 503 patients (56% female, age 6 to 18) in a Norwegian outpatient clinic, we conducted confirmatory factor analyses to test the assumed measurement models and further considered the concurrent validity of the measures.ResultsInternal reliability of both measures were good. The results suggest that the assumed measurement models for both questionnaires only partly fit our data but that subscales of the BFS and BPM still indicate convergent validity. Scores on subscales (internalizing and externalizing problems) on both measures converged with relevant subscales as well as with relevant groups of diagnoses.ConclusionsAlternative measurement models, and the usefulness and limitations of these short-form questionnaires for internalizing and externalizing problems, are discussed.

Oral microbiota signatures in post-traumatic stress disorder (PTSD) veterans.

Post-traumatic stress disorder (PTSD) represents a global public health concern, affecting about 1 in 20 individuals. The symptoms of PTSD include intrusiveness (involuntary nightmares or flashbacks), avoidance of traumatic memories, negative alterations in cognition and mood (such as negative beliefs about oneself or social detachment), increased arousal and reactivity with irritable reckless behavior, concentration problems, and sleep disturbances. PTSD is also highly comorbid with anxiety, depression, and substance abuse. To advance the field from subjective, self-reported psychological measurements to objective molecular biomarkers while considering environmental influences, we examined a unique cohort of Israeli veterans who participated in the 1982 Lebanon war. Non-invasive oral 16S RNA sequencing was correlated with psychological phenotyping. Thus, a microbiota signature (i.e., decreased levels of the bacteria sp_HMT_914, 332 and 871 and Noxia) was correlated with PTSD severity, as exemplified by intrusiveness, arousal, and reactivity, as well as additional psychopathological symptoms, including anxiety, hostility, memory difficulties, and idiopathic pain. In contrast, education duration correlated with significantly increased levels of sp_HMT_871 and decreased levels of Bacteroidetes and Firmicutes, and presented an inverted correlation with adverse psychopathological measures. Air pollution was positively correlated with PTSD symptoms, psychopathological symptoms, and microbiota composition. Arousal and reactivity symptoms were correlated with reductions in transaldolase, an enzyme controlling a major cellular energy pathway, that potentially accelerates aging. In conclusion, the newly discovered bacterial signature, whether an outcome or a consequence of PTSD, could allow for objective soldier deployment and stratification according to decreases in sp_HMT_914, 332, 871, and Noxia levels, coupled with increases in Bacteroidetes levels. These findings also raise the possibility of microbiota pathway-related non-intrusive treatments for PTSD.

A Case-Series Study Examining Acceptance and Commitment Therapy for Experiential Avoidance-Related Mixed Anxiety and Depression in a Telehealth Platform

Acceptance and commitment therapy (ACT) is a process-based, transdiagnostic approach to treatment that seeks to increase values-based, adaptive functioning (i.e., engaged living [EL]) in part through attenuating the impact of experiential avoidance (EA). The present case-series study examined EL and EA as mechanisms of change within a 10-week course of individual ACT delivered via a telehealth platform. Participants were two adult women with mental health concerns associated with clinically elevated EA. Throughout the study, we collected (a) daily self-monitored clinically relevant behaviors, (b) daily and weekly measures of EL and EA, and (c) pre-, mid-, post-treatment, and 3-month follow-up measures of psychopathology, quality of life, and ACT-related outcome variables. Results showed support for the efficacy of ACT, with both participants demonstrating slight improvements in clinically relevant behaviors, along with expected improvements in EL and EA. These favorable results were most pronounced for Participant 1. Results are discussed in the context of COVID-19-related adaptations (including telehealth), and within the framework of process-based ACT and its transdiagnostic applicability to a range of mental health concerns.

A comparison of nomothetic and individualized alpha frequency approaches to measuring frontal EEG alpha asymmetry.

Frontal alpha asymmetry (FAA) is considered to be a reliable marker of affective processing and psychopathology. Traditionally, the magnitude of alpha is calculated by taking the average over a nomothetic fixed frequency window (e.g., 8 to 13 Hz). Alternatively, methods have been proposed to extract individualized alpha frequency (IAF) peaks and windows in hopes of improving the reliability and validity of signal detection. However, no study has compared the nomothetic to IAF approaches to examine the reliability and validity of resting FAA in a large well-characterized data set. In this study, we assessed the psychometric performance of the standard fixed window approach, a PZ-alpha based IAF approach and a global-alpha based IAF windows detection approach on a previously collected EEG data set (8 recordings per subject collected on four occasions across two weeks). Our results revealed that resting FAA calculated with these three different methods are highly correlated at all frontal regions (mean r=.98). The stability across the 8 recordings over the two weeks also showed no substantial difference between approaches as indicated by intraclass correlations. Moreover, internal-consistency reliability, validity with respect to measures of emotion and emotion-related psychopathology and state-trait Structure equation model (SEM) fitting were evaluated and yielded no significant differences across methods. Our results supported the overall reliability and validity of two different IAF approaches to assessing resting FAA but fail to find any incremental advantage over nomothetic approaches to defining alpha bands. Guidelines for methods selection for future research are provided.

Inner Peace in a Global Crisis: A Case Study of Supported Spiritual Individuation in Acute Onset Phase of COVID-19.

Emerging-adult undergraduates (ages 18–25) are at increased risk for mental illness, exacerbated by the COVID-19 pandemic. Simultaneously, emerging adults face developmental tasks including identity development, finding meaning and purpose, and spiritual individuation. A case study approach is used to elucidate processes of undergraduates coping with collective trauma as a potential pathway to trauma-related spiritual growth via Awakened Awareness for Adolescents (AA-A) and emerging adults, a spiritual-mind-body wellness intervention. Awakened Awareness for Adolescents fosters enhanced spiritual perception to support spiritual individuation for improved mental health and well-being. Processes of spiritual individuation supported by AA-A during the COVID-19 pandemic from February to May 2020 are presented using students’ qualitative data and self-report measures of psychopathology, spiritual well-being, emotional regulation, and cognition. Shared cohort (N = 15) themes and one in-depth case (1) reveal ideographic processes of personal transformation and spiritual growth, (2) generate hypotheses around pathways of trauma-related spiritual growth and spiritual individuation for future research.

Revising the trait model of the alternative model of personality disorders: Comment on Clark and Watson's structural review.

In their review of examination of the self-report Personality Inventory for Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition (DSM-5; PID-5) factor structure and joint factor analysis of this instrument with other self-report measures of personality and psychopathology, Clark and Watson (2022) make argument for a set of modifications to the DSM-5 alternative model of personality disorders (AMPD)-the AMPD-5.1. In this commentary we offer opinion that their proposed modifications to the AMPD are problematic. In particular, we express concern that their modifications are based solely on research that uses a single instrument to measure the model and that this instrument employs a self-report measure methodology. We argue further that this method of assessment is vulnerable to response bias which could potentially alter the substantive structure of the model. We suggest that any proposed revised model should also be informed by other forms of measurement (e.g., informant report and structured interviews). In addition, we also argue that the best approach to delineating the universe of pathological personality traits should also include clinician input. Such input would maximize the clinical utility of any revised model. We believe that to propose a modified model that is based on self-report only and does not include other sources of information is presumptive and premature. At best, we think that Clark and Watson (2022) have only provided suggestions for a revision and expansion of the Personality Inventory for DSM-5 (i.e., the PID-5.1). (PsycInfo Database Record (c) 2022 APA, all rights reserved).

The joint hierarchical structure of psychopathology and dysfunctional personality domain indicators among community-dwelling adults.

To examine the hierarchical structure of psychopathology and dysfunctional personality domains, 2416 Italian community-dwelling adult volunteers were administered a set of psychometrically sound psychopathology measures and the Personality Inventory for DSM-5 Brief Form+ (PID-5-BF+). Parallel analysis, minimum average partial, and very simple structure results suggested that 1-6 principal components (PCs) should be retained. Goldberg's bass-ackwards model of the joint psychopathology measure and PID-5-BF+ ipsatized domain scale correlation matrix evidenced a hierarchical structure that was consistent with the working model proposed by the Hierarchical Taxonomy of Psychopathology (HiTOP) consortium. Hierarchical agglomerative cluster analysis around latent variables of the psychopathology indicators and PID-5-BF+ domain scales recovered four latent dimensions, which were akin to the corresponding bass-ackwards components and nicely reproduced the HiTOP Internalizing, Externalizing, Thought Disorder, and Eating Pathology dimensions.

The Holistic Recovery Capital in Gambling Disorder index: A pilot study.

Background and aimsRecovery is a challenge for individuals coping with a gambling disorder (GD). Recovery capital (RC) is a conceptual framework describing positive external and internal (e.g., human, social, community and financial) resources that promote recovery. Negative RC relates to external and internal obstacles to recovery. To date, no scale has captured both positive and negative RC items in the gambling field. Based on the RC framework, this pilot study aimed to develop The Holistic Recovery Capital in Gambling Disorder (HRC-GD) instrument, and to explore its associations with recovery status, measures of psychopathology and happiness. We hypothesized that higher HRC-GD scores will be positively related to recovery and subjective happiness, but negatively linked to depression, anxiety, and gambling severity. MethodRecovered and non-recovered individuals with a lifetime DSM-5 GD (n = 164) completed the HRC-GD instrument, the DSM-5 GD diagnostic criteria, and measures of depression, anxiety, and subjective happiness.ResultsThrough a process of item reduction, which included a principal components analysis, 19 items were retained. Since exploratory factor analysis (EFA) yielded uninterpretable findings, an index score reflecting human, financial, community, and social resources and obstacles was calculated. HRC-GD index scores were negatively correlated with anxiety, depression, and GD symptom severity, but positively related with subjective happiness. Index scores were significantly associated with recovery status.ConclusionsThe HRC-GD index holds promise as a new tool for measuring RC in GD. Additional research is needed to validate this index using larger and more ethnically and gender diverse clinical and community samples of individuals with GD.

Tethering theory to timescale: Advances in measuring interpersonal complementarity and covariation

Interpersonal theory suggests interpersonal functioning is healthier when exchanging dominance throughout a conversation (agentic complementarity). However, many research paradigms measure agency across conversations rather than within conversations. This leads to different timescales (minutes vs. seconds) and analyses (between-situation vs. within-situation), complicating how interpersonal complementarity is researched and applied clinically. Interpersonal processes (complementarity, covariation) are examined across different timescales, and a new way to measure within-situation complementarity using EMA data is proposed. Participants across two datasets (n = 186, n = 180) completed 20 social interaction records. New measures of within-situation interpersonal processes were more often and stronger related to measures of psychopathology at baseline and in daily life. I discuss the implications for theory and assessment of interpersonal processes moving forward.

A psychometric evaluation of the tripartite attachment battery

The Tripartite Attachment Battery (TAB) includes scales assessing attachment security, organized insecurity (i.e., anxiety and avoidance), and disorganized attachment. This recently developed series of measures provides expanded options for assessing attachment characteristics (e.g., a scale that directly assesses attachment security) and may improve the assessment of attachment anxiety and avoidance by including items capturing the secondary attachment strategies associated with them (viz., hyperactivation and deactivation). The present study utilized a community sample (N = 386) to evaluate and refine these scales. Factor analyses were conducted to: (a) examine the dimensionality of each TAB scale, and (b) guide the creation of empirically-derived subscales. The Secure Attachment Scale and the Organized Insecurity Scale were multidimensional. The Disorganized Attachment Scale was unidimensional. Most of the empirically-derived measures had internal consistency and test-retest reliability levels in the range considered adequate or better. Their correlations with a measure of psychopathology provided preliminary support for their construct validity. The TAB scales are promising measures of adult attachment characteristics. Further investigation of their psychometric properties is warranted.

Psychometric properties of the Spanish version of the Psychopathy Checklist: Youth Version

The current study examined the psychometric properties (factor structure, reliability and validity) of the Psychopathy Checklist: Youth Version (PCL:YV; Forth et al., 2003) in Spanish samples of male justice-involved youths between 15 and 22-years old. The PCL:YV was administered to two groups of youths who were incarcerated (n = 62; n = 95) and a sample of youth on probation (n = 122). Confirmatory factor analyses showed acceptable-to-good fit for three- and four-factor models. The four-factor hierarchical model with a second-order higher factor representing the whole psychopathy construct was considered for further analyses. PCL:YV scores showed high internal consistency and inter-rater reliability. Low-to-moderate convergence with other measures of psychopathic traits evinced an adequate convergent validity. Convergent and discriminant validity of the PCL:YV total scores were also confirmed considering several measures of psychopathology and personality traits. Importantly, the differential external correlates of the PCL:YV factors provide support for a multidimensional conceptualization of the psychopathy construct. Altogether, these results reveal adequate psychometric properties of the PCL:YV in Spanish population of justice-involved youths and justifies its use to assess psychopathic traits in this kind of populations.

The network structure of paranoia dimensions and its mental health correlates in the general population: The core role of loneliness

Paranoid ideas are the most common abnormal beliefs in the schizophrenia spectrum, are also prevalent in non-clinical populations, and are highly correlated with other mental health problems such as anxiety, depression and low levels of well-being. Two previous studies with the same British population sample used confirmatory factor analysis and network analysis to show that the spectrum of paranoid beliefs is made up of four factors or dimensions (i.e., interpersonal sensitivity, mistrust, ideas of reference and ideas of persecution). The aims of this study are: 1) to explore the distribution and the structure of paranoid beliefs in a Spanish general population by applying the network approach and 2) to use network analysis to explore for the first time whether specific domains of paranoid ideation (i.e., dimensions) are specifically associated with mental health correlates such as depression, anxiety, loneliness, and well-being. We found a continuous distribution of paranoid beliefs among the 1328 individuals constituting the sample (e.g., 29,2 % did not endorse any items, 4.6 % endorsed half of the items, while 0.8 % endorsed all paranoid items). Paranoid ideas form three dimensions; interpersonal sensitivity, mistrust, and ideas of persecution (ideas of reference did not form a separate factor). The network model showed that loneliness has a pivotal role in connecting paranoid ideation with general psychopathology measures (i.e., depression, anxiety, loneliness and well-being). Research and clinical implications derived from our findings are also discussed.

Analyses of Pharmacokinetic, Pharmacogenetic and Psychometrics Correlates of Antidepressants Use during Pregnancy and the Post-Partum Period

IntroductionAbout 15% of women experience a depressive episode during pregnancy, and 19% during the postpartum. Studies on safety of Antidepressants use during pregnancy have given controversial results. Obstetric-gynecological changes of pregnancy determine modifications in the pharmacokinetics of medications, through an altered metabolism of the CYP enzymes. Patient’s therapeutic response might also be influenced by polymorphisms of the genes encoding CYP enzymes.ObjectivesIn this perspective, we evaluated the correlation between pharmacokinetics, pharmacogenetics and psychopathological measures, analyzing SSRIs or SNRIs concentrations during the three trimesters of pregnancy, at birth and at postpartum, in order to define efficacy, tolerability and safety of Antidepressants (ADs) in the treatment of affective and anxiety disorders during pregnancy.Methods87 patients were enrolled at the Depressive Disorders Treatment Centre (CTDD) of the Department of Psychiatry of Sacco University Hospital (Milano, Italy). Plasma concentrations of ADs were measured during first (T1), second (T2), third (T3) trimester, at birth (T4) and at postpartum (T5). Psychometric assessments were carried out. The genotype of hepatic CYP isoforms were also analysed.ResultsADs mainly metabolized by CYP2C19 (es. Sertraline) are less frequently below therapeutic range than ADs metabolized by CYP2D6. In fact, the metabolic activity of CYP2C19 is slowed down during pregnancy. The majority of ADs concentrations below therapeutic range were found in women with an accelerated metaboslism, carrier of a CYP polymorphism.ConclusionsOur results underline that the systematic use of pharmacokinetic and pharmacogenetic analyses during pregnancy could constitute a valid support in the management of therapy in the last phases of pregnancy.DisclosureNo significant relationships.

Associations between neighborhood built, social, or toxicant conditions and child externalizing behaviors in the Detroit metro area: a cross-sectional study of the neighborhood ‘exposome’

BackgroundThe specific ‘active ingredients’ through which neighborhood disadvantage increases risk for child psychopathology remains unclear, in large part because research to date has nearly always focused on poverty to the exclusion of other neighborhood domains. The objective of this study was to evaluate whether currently assessed neighborhood built, social, or toxicant conditions were associated with child externalizing psychopathology outcomes separately, and in a combined model, using data from the Detroit-metro county area.MethodsWe conducted principal components analyses for built, social, or toxicant conditions. Next, we fitted separate multiple regression models for each of the child externalizing psychopathology measures (oppositional defiant and conduct problems) as a function of built, social, or toxicant components.ResultsWe found that built features (more non-profits, churches, and alcohol outlets, and less agriculture and vacant properties) were associated with conduct problems, while toxicant conditions (high percent industrial, toxins released and number of pre-1978 structures) were associated with oppositional defiance problems. There was no significant association between greenspace or social conditions and child externalizing outcomes. When examined simultaneously, only the significant independent association between built conditions and conduct problems remained.ConclusionsBuilt, social, and toxicant neighborhood conditions are not interchangeable aspects of a given neighborhood. What’s more, built features are uniquely associated with child externalizing outcomes independently of other neighborhood characteristics. Future research should consider how changes in the built conditions of the neighborhood (e.g., development, decay) serve to shape child externalizing behaviors, with a focus on identifying potentially actionable elements.

Influence of Identity Development on Weight Gain in Adolescent Anorexia Nervosa.

BackgroundAnorexia Nervosa (AN) typically begins during early adolescence, an important phase of personality development. A substantial proportion of adolescent AN patients shows impaired personality functioning, which might be a relevant but understudied aspect of illness severity. The developmental status of identity as key element of personality is suggested to influence inpatient treatment outcome in adolescents with AN.MethodsThis study analyzed existing data of N = 60 adolescents with AN. Multilevel models assessed the influence of identity functioning, measured by the Assessment of Identity Development in Adolescence (AIDA) at admission, on weight gain [BMI (body mass index), BMI-SDS (BMI standard deviation score)] during 10 weeks of inpatient treatment. Moreover, the influence of other indicators of illness severity, i.e., eating disorders and comorbid psychopathologies, was explored.ResultsAs expected, higher AIDA scores negatively influenced the course of weight gain. A similar effect was observed for other psychopathology measures, especially body image distortion. In general, higher weight at admission was associated with less weight gain. Higher weight at admission was also predicted by higher other psychopathology measures, but not AIDA scores.ConclusionThe course of weight gain during inpatient treatment was hampered in adolescent AN patients who have difficulties developing a stable identity. Unlike other aspects of psychopathology, this was independent of the initial weight. Thus, in addition to the level of underweight and other aspects of psychopathology, difficulties in identity development constitute a relevant aspect of illness severity in AN. This recommends consideration of identity development during treatment.

Fear-potentiated startle predicts longitudinal change in transdiagnostic symptom dimensions of anxiety and depression

BackgroundElevated defensive responding, through startle reflex (SR) and skin conductance response (SCR), may contribute to onset and maintenance of depression and anxiety. Most work examining SR and SCR has predicted psychiatric diagnoses. There is a paucity of research examining links between SR or SCR and dimensional measures of psychopathology. MethodsWe used latent growth curve modeling to predict longitudinal change in three symptom factors (i.e., General Distress, Fears, Anhedonia-Apprehension) from SR and SCR measured during a fear-potentiated startle paradigm among adolescents oversampled for neuroticism (N = 129). ResultsElevated SCR in danger phases before and after an unpleasant muscle contraction predicted increasing Fears over time. Elevated SR in safe phases post-contraction also predicted increasing Fears over time. Attenuated SR in safe phases post-contraction predicted elevated General Distress longitudinally. Attenuated SCR pre-contraction in danger phases predicted elevated Anhedonia-Apprehension over time. LimitationsOur non-clinical sample may limit generalizability of results. Additionally, we did not assess change in SR and SCR over time. ConclusionsThe present study demonstrates that SR and SCR during a fear-potentiated startle paradigm predict longitudinal change in dimensional anxiety and depression symptom factors and relatedly, that SR and SCR may represent risk factors for the exacerbation of symptomatology.

Development and Validation of the Young Parenting Inventory (YPI-R3) for Measuring Past Deviant and Normal Variations in Parenting.

Most measures of past parenting patterns have a restricted range of about two to three negative parenting constructs. The Young Parenting Inventory (YPI-R2) provides a more nuanced framework that measures a fuller spectrum of these negative parenting patterns and, therefore, holds the potential of being a more useful guide to parents and caretakers. The YPI-R2 is made up of six validated subscales. An additional four were identified but were not sufficiently robust to be included. The purpose of this study is to determine if these four scales can be strengthened through the development of additional items and be empirically validated. Using non-clinical, English-speaking community samples from Singapore (n = 592, 628) and Malaysia (n = 222, 229), these revised scales were tested using multiple exploratory factor analyses with fathers and mothers rated separately. After further scale refinement, the final model, which consisted of 10 subscales and 41 items, was then subjected to confirmatory factor analysis using 4 other non-clinical international samples with separate ratings for fathers and mothers—USA (n = 259, 281), South Africa (n = 318, 372), Nigeria (n = 328, 344) and India (n = 277, 289). The results show that the YPI-R3 with 10 subscales is a robust and cross-culturally acceptable model. Correlations and hierarchical multiple regression analyses showed that the YPI-R3 has good convergent validity and predictive capabilities with measures of psychopathology, personality traits, emotional distress, negative schemas and other distal measures of functioning in everyday life—gratitude, humor and satisfaction with life.

The impact of non-infection pandemic stress on depression and anxiety severity: Investigating mediation by intrusive and deliberate rumination

BackgroundSocial restrictions to curb COVID-19's spread have had adverse effects on population mental health. Rumination is one mechanism through which pandemic stress (PS) might translate into psychopathology. In particular, intrusive rumination (IR) is believed to be problematic. In this study, we investigated whether IR and deliberate rumination (DR) mediated the associations between PS and both depression and anxiety severity. Methods1090 participants recruited online and from an undergraduate psychology participation pool completed an assessment of COVID-19 PS, as well as the Event-Related Rumination Inventory, the Beck Depression Inventory-II, and the Beck Anxiety Inventory. Total scores for PS, IR, DR, depression, and anxiety severity were tested in a parallel mediation model. ResultsPS positively predicted IR, DR, depression, and anxiety severity. IR positively predicted 1depression and anxiety severity, whereas DR did not. Indirect effects of PS on depression and anxiety severity were significant for IR, but not DR. Direct effects of PS on anxiety and depression severity were significant. Taken together, IR partially mediated the association between PS and both measures of psychopathology, and DR did not. LimitationsThis study was limited by its cross-sectional design and the lack of assessment of when PS exposure occurred. ConclusionsRegarding PS that is unrelated to infection by COVID-19, IR is one mechanism through which psychopathology may emerge, whereas DR appears to be benign. Promoting a shift from IR to DR may therefore be one strategy for mitigating the negative effects of PS and other stressors on mental health.