Measures Of Endurance Research Articles

Are caffeine effects equivalent between different modes of administration: the acute effects of 3 mg.kg-1 caffeine on the muscular strength and power of male university Rugby Union players.

There is growing interest in the potential of alternative modes of caffeine administration for enhancing sports performance. Given that alternative modes may evoke improved physical performance via distinct mechanisms, effects may not be comparable and studies directly comparing the erogenicity of alternative modes of caffeine administration are lacking. To address this knowledge gap, the present study evaluated the effect of 3 mg·kg-1 caffeine delivered in anhydrous form via capsule ingestion, chewing gum or mouth rinsing on measures of muscular strength, power, and strength endurance in male Rugby Union players. Twenty-seven participants completed the study (Mean ± SD: Age 20 ± 2 yrs; daily caffeine consumption 188 ± 88 mg). Following assessments and reassessment of chest press (CP), shoulder press (SP), Deadlift (DL), and Squat (SQ) 1-repetition maximum (1RM) and familiarization to the experimental procedures, participants completed six experimental trials where they were administered 3 mg.kg-1 caffeine (Caff) or placebo (Plac) capsule(CAP), chewing gum(GUM) or mouth rinse(RINSE) in a randomized, double-blind and counterbalanced fashion prior to force platform assessment of countermovement jump, drop jump and isometric mid-thigh pull performance. Strength endurance was measured across two sets of CP, SP, DL, and SQ at 70% 1RM until failure. Pre-exercise perceptions of motivation and arousal were also determined. Caffeine increased perceived readiness to invest mental effort (p = .038; ηp2=.156), countermovement jump height (p = .035; ηp2=.160) and SQ repetitions until failure in the first set (p < .001; d = .481), but there was no effect of delivery mode (p > .687; ηp2<.015). Readiness to invest physical effort, felt arousal, drop jump height, countermovement jump, drop jump and isometric mid-thigh pull ground reaction force-time characteristics and repetitions until failure in CP, SP and DL were not affected by caffeine administration or mode of caffeine delivery (p > .0.052; ηp2< .136). 3 mg.kg-1 caffeine administered via capsule, gum or mouth rinse had limited effects on muscular strength, power, and strength endurance. Small effects of caffeine on CMJ height could not be explained by changes in specific ground reaction force-time characteristics and were not transferable to DJ performance, and effects specific to the SQ RTP exercise underpin the complexity in understanding effects of caffeine on muscular function. Novel modes of caffeine administration proposed to evoke benefits via distinct mechanisms did not offer unique effects, and the small number of effects demonstrated may have little translation to a single performance trial when data examining direct comparison of each caffeine vehicle compared against a mode matched placebo is considered.

The higher the fraction of maximal oxygen uptake is during interval training, the greater is the cycling performance gain.

It has been suggested that time at a high fraction (%) of maximal oxygen uptake (VO2max) plays a decisive role for adaptations to interval training. Yet, no study has, to date, measured the % of VO2max during all interval sessions throughout a prolonged training intervention and subsequently related it to the magnitude of training adaptations. Thus, the present study aimed to investigate the relationship between % of VO2max achieved during an interval training intervention and changes in endurance performance and its physiological determinants in well-trained cyclists. Twenty-two cyclists (VO2max 67.1 (6.4) mL·min-1·kg-1; males, n=19; females, n=3) underwent a 9-week interval training intervention, consisting 21 sessions of 5×8-min intervals conducted at their 40-min highest sustainable mean power output (PO). Oxygen uptake was measured during all interval sessions, and the relationship between % of VO2max during work intervals and training adaptations were investigated using linear regression. A performance index was calculated from several performance measures. With higher % of VO2max during work intervals, greater improvements were observed for maximal PO during the VO2max test (R2 adjusted=0.44, p=0.009), PO at 4mmol·L-1 [blood lactate] (R2 adjusted=0.25, p=0.035), the performance index (R2 adjusted=0.36, p=0.013), and VO2max (R2 adjusted=0.54, p=0.029). Other measures, such as % of maximal heart rate, were related to fewer outcome variables and exhibited poorer session-to-session repeatability compared to % of VO2max. In conclusion, improvements in endurance measures were positively related to the % of VO2max achieved during interval training. Percentage of VO2max was the measure that best reflected the magnitude of training adaptations.

Development of tongue strength and endurance measurement device: A pilot study in healthy adults

Background: Safe and efficient swallowing relies on adequate tongue strength and endurance. Thus, tongue strength and endurance assessments are essential for swallowing rehabilitation for individuals with swallowing difficulties due to tongue structure and function abnormalities. These tongue functions can be objectively measured using a standard device. However, in Thailand, assessing tongue strength and endurance using standard devices is not widespread in clinical practice due to the high cost of importing these devices. Objective: This study aimed to develop a precise, accurate, and reliable tongue function measurement device for the clinical assessment of tongue strength and endurance. Materials and methods: This study was divided into three phases: 1) Development of a tongue strength and endurance measurement device in a laboratory setting and administration of a satisfaction questionnaire, 2) Trial of the prototype device with six participants, and 3) Assessment of the test-retest reliability of the developed device and investigation of tongue strength and endurance values with twenty participants. Results: As a result of this development, a novel device for measuring tongue strength and endurance was obtained, which provides measurements in units of newtons (N) and kilopascals (kPa) for strength and seconds (s) for endurance. The device’s development cost was significantly lower compared to imported commercially available devices while maintaining the performance standards for medical measurement devices. This was demonstrated by its accuracy ranging from 96.40% to 100%, high precision with a Coefficient of Variation (% CV) of 0.90% to 4.21%, and moderate to excellent reliability with an Intraclass Correlation Coefficient (ICC) of 0.56 to 0.93. Furthermore, statistically significant differences (p&lt;0.01) were observed between genders, especially in anterior tongue strength. Conclusion: The tongue strength and endurance measurement device developed through this study can be utilized for clinical tongue function assessment, giving patients more access to objective evaluations of tongue strength and endurance at a lower examination cost.

High-intensity resistance training improves quality of life, muscle endurance and strength in patients with myositis: a randomised controlled trial

Myositis is associated with reduced quality of life, which is accompanied by significant impairments in muscle endurance and strength, altogether representing cardinal traits in patients with myositis. This randomised controlled trial aimed to investigate the effect of high-intensity resistance training on quality of life in patients with myositis. Thirty-two patients with established, stable myositis were randomised to 16 weeks of high-intensity resistance training (intervention group) or 16 weeks of usual care (control group). Primary outcome was quality of life assessed as the change in the physical component summary score (PCS) of the Short Form-36 health questionnaire from baseline to post-intervention. Secondary outcomes included functional capacity measures, such as functional index 3, and International Myositis Assessment and Clinical Studies Group (IMACS) disease activity and damage core set measures, including manual muscle testing 8 (MMT8). The primary outcome PCS showed an improvement in favour of high-intensity resistance training with a between-group difference of 5.33 (95% CI 0.61; 10.05) (p = 0.03). Additionally, functional index 3 showed a between-group difference indicating greater gains with high-intensity resistance training 11.49 (95% CI 3.37; 19.60) (p = 0.04), along with a between-group improvement in MMT8 1.30 (95% CI 0.09; 2.51) (p = 0.04). High-intensity resistance training for 16 weeks effectively improved quality of life in patients with myositis. Clinical measures of muscle endurance and muscle strength were also found to improve with high-intensity resistance training, while patients stayed in disease remission. Consequently, progressively adjusted high-intensity resistance training is feasible and causes no aggravation of the disease, while benefitting patients with myositis.Clinical trial registration: Clinicaltrials.gov ID: NCT04486261—https://clinicaltrials.gov/study/NCT04486261.

Estimation of minimal clinically important difference for 6-minute walking distance in patients with acute stroke using anchor-based methods and credibility instruments.

Stroke impairs a patient's ability to walk. In patients with acute stroke, a 6-min walking distance (6MWD) is recommended to assess walking function. Minimal clinically important difference (MCID) is used to determine the effectiveness of rehabilitation; however, the MCID for 6MWD has not been adequately validated. This study aimed to estimate the MCID of 6MWD, a measure of walking endurance, in patients with acute stroke using anchor-based methods. Based on the change in 6MWD from baseline to the follow-up measurement 2weeks later, the MCID was estimated using anchor-based methods (receiver operator operating characteristic curves, predictive and adjustment models) with a patient- and therapist-rated global rating of change scale (p-GRC, t-GRC) as external anchors. The accuracy of "meaningful change" was estimated from the area under the curve. Using MCID's credibility instruments, the credibility of each anchor was evaluated. Using the credibility instrument, high credibility was defined as satisfying 3/5 of the Core criteria and 6/9 of all criteria. The analysis included 58 patients. The MCID for each anchor was 78.7-100.0m for p-GRC, and 95.2-99.5m for t-GRC. The p-GRC demonstrated excellent accuracy (area under the curve >0.8). With p-GRC as anchors, over 50% of patients showed improvement. The p-GRC satisfied the core criterion of 3/5 and all criteria of 6/9 on the reliability instrument. The t-GRC demonstrated low reliability and satisfied the core criterion of 2/5 and all criteria of 3/9. Since the percentage of improved groups exceeded 50%, the adjusted model was useful in the anchor-based method. Therapists may not accurately capture patient fatigue and subjective symptoms, potentially affecting the correlation between the 6MWD change score and the t-GRC and, consequently, the reliability instrument. The p-GRC showed high accuracy and reliability; therefore, the MCID was estimated to be 78.7m.

Effectiveness of 12-Week Core Stability Training on Postural Balance in Soccer Players With Groin Pain: A Single-Blind Randomized Controlled Pilot Study.

Core stability training (CST) is effective in improving postural balance, core endurance, and self-reported outcomes in different populations. This study aimed to investigate the effect of CST in soccer players with groin pain (GP). CST would improve postural balance performance, core endurance, and self-reported outcomes in soccer players with GP. Randomized controlled trial. Level 2. Soccer players with GP who met the selection criteria were assigned randomly to a CST (CSTG, n = 10) or a control (CG, n = 10) group. The CG undertook no additional physical activity program besides their usual training. The CSTG performed a 12-week CST comprising 76 ~75 min sessions. Static (force platform) and dynamic (Y-Balance test) postural balance, core endurance (McGill trunk endurance tests), and self-reported outcomes (Copenhagen Hip and Groin Outcome Score [HAGOS]) were assessed before and immediately after the 12-week CST. Significant improvements were seen in dynamic postural balance (P = 0.04 to <0.01), HAGOS scores (P = 0.02 to <0.01), and core endurance measures (P < 0.01) in the CSTG in posttest compared with pretest session and compared with CG. Static bipedal postural balance measures showed significant improvements (eyes open, P = 0.02; eyes closed, P < 0.01) in the CSTG in posttest compared with pretest session. However, no significant differences (P > 0.05) were observed between CSTG and CG after the training period. A 12-week CST improved static (foam surface) and dynamic postural balance, core endurance measures, and HAGOS scores. The beneficial effect of CST on improving postural balance, core endurance, and self-reported outcomes in soccer players with GP suggests that this training would be an important feature of rehabilitation programs for these players. Coaches and clinicians should prioritize CST training when designing rehabilitation programs.

Effectiveness of Circuit and Fartlek Exercises to Increase Aerobic Endurance in Adolescent Futsal Players

Aerobic endurance is an important component in futsal sports games, so it requires an exercise that can increase aerobic endurance. This study aims to evaluate the effectiveness of circuit training with fartlek exercises to increase aerobic endurance futsal players Bina Darma. The research method used was an experiment with the design of the control group pre-test post-test. The study population of 40 Bina Darma futsal players was divided evenly into two groups, namely the circuit training group and the fartlek training group consisting of 20 samples. Each group performed the exercises for 8 weeks with a frequency of 3 times a week. Aerobic endurance measurements were taken before and after the exercise program using the Bleep Test. Analysis Data obtained from VO2 max test will be analyzed using statistical software SPSS 23. Statistical analysis that will be used is an Paired Samples Test to compare the increase in aerobic endurance between circuit training group and fartlek exercise group. The results showed a significant increase in aerobic endurance in all groups after the exercise programme. The results of this study showed that the circuit training group was more significant than the fartlek training group with very high statistical significance (p&amp;lt; .001), showing that the difference between circuit training and fartlek training in improving aerobic endurance was significant. In conclusion, circuit training is a more effective option for improving aerobic endurance in Bina Darma futsal players. Choosing the right type of sport can increase the aerobic endurance of futsal players.

Textured insoles may improve some gross motor balance measures but not endurance measures in children with motor coordination issues. A randomised controlled feasibility trial.

Motor coordination concerns are estimated to affect 5%-6% of school-aged children. Motor coordination concerns have variable impact on children's lives, with gait and balance often affected. Textured insoles have demonstrated positive impact on balance and gait in adults with motor coordination disorders related to disease or the ageing process. The efficacy of textured insoles in children is unknown. Our primary aim was to identify the feasibility of conducting a randomised controlled trial involving children with motor control issues. The secondary aim was to identify the limited efficacy of textured insoles on gross motor assessment balance domains and endurance in children with movement difficulties. An assessor-blinded, randomised feasibility study. We advertised for children between the ages of 5-12years, with an existing diagnosis or developmental coordination disorder or gross motor skill levels assessed as 15th percentile or below on a norm-referenced, reliable and validated scale across two cities within Australia. We randomly allocated children to shoes only or shoes and textured insoles. We collected data across six feasibility domains; demand (recruitment), acceptability (via interview) implementation (adherence), practicality (via interview and adverse events), adaptation (via interview) and limited efficacy testing (6-min walk test and balance domain of Movement ABC-2 at baseline and 4weeks). There were 15 children randomised into two groups (eight received shoes alone, seven received shoes and textured insoles). We experienced moderate demand, with 46 potential participants. The insoles were acceptable, however, some parents reported footwear fixture issues requiring modification. The 6-min walk test was described as problematic for children, despite all but one child completing. Social factors impacted adherence and footwear wear time in both groups. Families reported appointment locations and parking impacting practicality. Underpowered, non-significant small to moderate effect sizes were observed for different outcome measures. Improvement in balance measures favoured the shoe and insole group, while gait velocity increase favoured the shoe only group. Our research indicates that this trial design is feasible with modifications such as recruiting with a larger multi-disciplinary organisation, providing velcro shoe fixtures and using a shorter timed walk test. Furthermore, progressing to a larger well-powered randomised control trial is justified considering our preliminary, albeit underpowered, efficacy findings. This trial was retrospectively registered with the Australian and New Zealand Clinical Trial Registration: ACTRN12624000160538.

Relationship between work posture and core muscle endurance with lower back disability among farmers: a cross-sectional study

Background: Farmers rely on physical performance for their livelihood, and non-ergonomic working postures can lead to lower back pain, reducing core muscle endurance and resulting in lower back disability. This study examines the relationship between work posture and core muscle endurance with lower back disability among farmers. Methods: This research used an analytical observational design with a cross-sectional study. The sampling technique used was simple random sampling. The total sample obtained in this study was 106 participants. Data collection included posture assessment using the rapid entire body assessment (REBA), measurement of core muscle endurance using the prone bridge test, and measurement of lower back disability using the modified Oswestry disability index (MODI). The inclusion criteria for this study were farmers aged 26-45 working as farmers in Pancasari Village, Sukasada District, Buleleng Regency. Conversely, the exclusion criteria were the presence of a history of Spearman's rho and a condition of injury that limits the prone bridge test. Furthermore, the obtained data was analyzed using Spearman's rho test. Results: The non-parametric analysis of work posture on lower back disability obtained a p = 0.000 (p &lt; 0.05) and a correlation coefficient of r = 0.849. Core muscle endurance against lower back disability obtained a value of p = 0.000 (p &lt; 0.05) and a correlation coefficient r = -0.825, which is statistically significant that the higher the work posture score of the subject has means the higher incidence of lower back disability and also the higher of core muscle endurance the subject has, mean lower incidence of lower back disability among farmers. Conclusion: Based on the research results, it can be concluded that there is a significant relationship, with a high correlation, between work posture and core muscle endurance and the occurrence of lower back disability in farmers.

Injury Profiles of Elite, Semielite, and Recreational Golfers, and Their Associated Risk Factors: A Systematic Review

Abstract Garrett, JM, Beaumont, PL, van den Hoek, DJ, Veugelers, K, Schmitz, M, and Bennett, H. Injury profiles of elite, semielite, and recreational golfers, and their associated risk factors: a systematic review. J Strength Cond Res 38(6): 1157–1176, 2024—Golf is one of the most participated sports played worldwide. However, how injury distributions change between different golf populations is unknown, and associated injury risk factors are unclear. Therefore, this review aimed to describe the common musculoskeletal injuries in different golf populations and identify their associated risk factors. A systematic search was performed to identify eligible articles through PubMed, SPORTDiscus, EMBASE, and Scopus up until September 4, 2023. Of the 4643 studies identified, 58 satisfied the inclusion criteria. Data from 10,437 subjects were extracted, with the most common area of injury to all golf populations being the lower back. Different injury distributions were found between populations with elite male golfers (n = 1924 injuries, 62% of all injuries) and recreational male golfers (n = 442 injuries, 45% of all injuries) reporting the trunk as the most injured region, whereas upper-extremity injuries were the most prevalent injury in elite female golfers (n = 890 injuries, 42% of all injuries) and recreational female golfers (n = 178 injuries, 47% of all injuries). Range-of-motion deficits at the hip and spine were identified as risk factors for elite golfers, whereas measures of lower-limb and trunk strength endurance were identified as risk factors for recreational golfers, suggesting areas of focus for golf practitioners. However, there is a paucity of robust studies evaluating the epidemiology of musculoskeletal injuries in all golf populations, and because of the variety of methods and measures used, detailed comparisons and definitive recommendations were difficult to make. Nonetheless, this review provides an overview of the common golf injuries and possible risk factors, which can aid partitioners in developing strategies for injury prevention for all golfing demographics.

A Narrative Review of Intermittent Fasting With Exercise

Intermittent fasting is a dietary pattern that encompasses the 5:2 diet, alternate-day fasting, and time-restricted eating. All 3 involve alternating periods of fasting and ad libitum eating. Like other dietary strategies, intermittent fasting typically induces loss of both fat mass and lean mass. Exercise may thus be a useful adjuvant to promote lean mass retention while adding cardiometabolic, cognitive, mental, and emotional health improvements. In this narrative review, we summarize current evidence regarding the combination of intermittent fasting and exercise and its influence on body weight, body composition, cardiometabolic risk, and muscular and cardiorespiratory fitness. A PubMed search was conducted to identify all trials lasting >4 weeks that combined 5:2 diet, alternate-day fasting, or time-restricted eating with any modality exercise and had body weight as an end point. A total of 23 trials (26 publications) were identified. Evidence suggests that combining intermittent fasting with exercise leads to decreased fat mass regardless of weight status. However, evidence is equivocal for the influence on other aspects of weight loss and body composition, fat-free mass, and cardiometabolic risk factors and may be dependent on weight status or exercise doses (ie, frequency, intensity, duration, and modality). Higher-powered trials are needed to determine the efficacy of combining exercise and intermittent fasting for benefits on body weight and cardiometabolic risk. Current evidence suggests that intermittent fasting does not impair adaptation to exercise training, and may improve explosive strength, endurance, and cardiopulmonary measures such as maximal oxygen consumption. In addition, we discuss limitations in the current evidence base and opportunities for continued investigation. Future trials in this area should consider interventions that have increased sample size, longer intervention duration, broadened inclusion criteria, objective measures of diet and exercise adherence, and diversity of sample population.

Speed- and Endurance-Based Classifications of Community Ambulation Post-Stroke Revisited: The Importance of Location in Walking Performance Measurement

Background Gait speed or 6-minute walk test are frequently used to project community ambulation abilities post-stroke by categorizing individuals as household ambulators, limited, or unlimited community ambulators. However, whether improved clinically-assessed gait outcomes truly translate into enhanced real-world community ambulation remains uncertain. Objective This cross-sectional study aimed to examine differences in home and community ambulation between established categories of speed- and endurance-based classification systems of community ambulation post-stroke and compare these with healthy controls. Methods Sixty stroke survivors and 18 healthy controls participated. Stroke survivors were categorized into low-speed, medium-speed, or high-speed groups based on speed-based classifications and into low-endurance, medium-endurance, or high-endurance groups based on the endurance-based classification. Home and community steps/day were quantified using Global Positioning System and accelerometer devices over 7 days. Results The low-speed groups exhibited fewer home and community steps/day than their medium- and high-speed counterparts (P < .05). The low-endurance group took fewer community steps/day than the high-endurance group (P < .05). Despite vast differences in clinical measures of gait speed and endurance, the medium-speed/endurance groups did not differ in their home and community steps/day from the high-speed/endurance groups, respectively. Stroke survivors took 48% fewer home steps/day and 77% fewer community steps/day than healthy controls. Conclusions Clinical classification systems may only distinguish home ambulators from community ambulators, but not between levels of community ambulation, especially beyond certain thresholds of gait speed and endurance. Clinicians should use caution when predicting community ambulation status through clinical measures, due to the limited translation of these classification systems into the real world.

Influence of Programmed Physical Training on the Performance of Table Tennis Athletes

This study aims to explore the influence of a programmed physical training program on enhancing the performance of table tennis athletes at the local table tennis club level. The study utilizes a quantitative research approach with a case study design. Research participants consist of 30 table tennis athletes from one local table tennis club. Data were collected through physical tests covering measurements of muscle strength, agility, and cardiovascular endurance, as well as direct observation of athlete performance during table tennis training sessions. The results of the study indicate a significant improvement in muscle strength, agility, and cardiovascular endurance of athletes after participating in the programmed physical training program. Regression analysis also confirms a positive relationship between the level of participation in the programmed physical training program and athlete performance improvement. The practical implications of this research are that local table tennis clubs can utilize programmed physical training programs as a strategy to enhance their athletes' performance. However, this study has limitations that need to be considered, including the limited generalizability of the results due to being conducted in only one local table tennis club. Therefore, further research with larger samples and diversification of table tennis clubs is needed to confirm these findings more broadly.

The Calf Raise App shows good concurrent validity compared with a linear encoder in measuring total concentric work.

The linear encoder and the Calf Raise App have been shown to be valid for measurements of plantar flexor muscular endurance in the heel raise test when compared with gold standard equipment. However, the validity of the Calf Raise App has not yet been compared with a linear encoder, an instrument commonly used in clinical and research settings. The purpose of this study was to determine the concurrent validity of the Calf Raise App compared with a linear encoder for the measurement of average heel raise height and total concentric work in the heel raise test. Fifty TeamGym athletes (82% females) from an on-going prospective study were included (mean [SD] age: 20 [7] years; body mass index (BMI) = 21.3 [2.5]). Concurrent validity was analysed with single measures intraclass correlation coefficient (ICC) using a two-way mixed effects, consistency model. Ninety-eight samples were included in the analysis. The mean (SD) average heel raise height and total concentric work measured by the linear encoder and Calf Raise App were 9.9 (1.4) and 7.5 (1.2) cm, and 1728 (584) and 1291 (450) J, respectively. The mean (SD) number of unilateral heel raises was 30 (7.5). The results showed poor to moderate concurrent validity for the measurement of average heel raise height (ICC: 0.62; 95% confidence interval [CI]: 0.48-0.73). Good to excellent concurrent validity was shown for the measurement of total concentric work (ICC: 0.89; 95% CI: 0.84-0.93). The Calf Raise App shows good concurrent validity in the heel raise test compared with a linear encoder in measuring total concentric work but not average height. While caution is recommended when comparing results from the different instruments, each instrument can be used separately to compare between-limb differences or changes over time in plantar flexor muscular endurance in clinical and research settings. Level III.

Longitudinal Evaluation of Physical Fitness in Adults with Cystic Fibrosis in the Era of CFTR-Modulating-Therapies

ABSTRACT Purpose: Maintaining physical fitness plays an important role in the management of people with cystic fibrosis (pwCF). Longitudinal data on the course of physical fitness and the potential impact of the introduction of highly effective CFTR modulator therapy with elexacaftor/tezacaftor/ivacaftor (ETI) in adult pwCF are scarce. Methods: Health-related and skill-related components of physical fitness were assessed using an incremental cycle test (Wpeak), plus forward bend (FB), prone bent knee hip extension (HE), plank leg raise (PLR), standing long jump (SLJ), and standing on one leg (OLS). Relevant disease-specific clinical data (body mass index [BMI] and forced expiratory volume in 1 second [FEV1]) were recorded. Results: Twenty-eight adult pwCF (age 26.0 ± 7.8 years) were followed over 5.6 ± 0.9 years; 21 started ETI therapy during this period. Significant improvements from baseline were noted in BMI (p < 0.001) and health-related fitness components (HE, p = 0.002; PLR, p = < 0.001), whereas Wpeak and FB remained stable over time (all p > 0.05). Skill-related components (SLJ, OLS) showed no change (all p > 0.05). Subgroup analysis revealed significant improvements in BMI, FEV1, and health-related fitness measures of muscular strength and endurance (HE, p = 0.009; PLR, p < 0.001) only in pwCF using ETI. Conclusion: Despite the improvements, the impact of ETI on the individual parameters was small. Other factors than implementation of ETI alone need to be considered on the way to a high level of physical fitness in adult pwCF.

QUALITY BY DESIGN SUPPORTED CONSTRUCTION OF ORAL FAST-DISSOLVING FILMS FOR TELMISARTAN: RECONNOITERING THE QUALITY ATTRIBUTES

Objective: The angiotensin II receptor antagonist telmisartan (TMS) is often used to treat hypertension. The BCS class II antihypertensive drug TMS has a low solubility, poorly absorbed when taken orally. The goal of this study was to formulate an oral fast-dissolving film (OFDF) of TMS. In recent years, the concept of a rapidly dissolving dosage form as an innovative delivery system has gained popularity. By decreasing dosing frequency, maximize therapeutic effectiveness, bioavailability, and stability. It will also prevent the drugs from being metabolized in the first place. This technique allows for faster drug absorption from the gastrointestinal tract (GIT), which might result in a more rapid onset of action. Methods: An experimental design known as Box-Behnken was employed to optimize a OFDF. Mango kernel (100-300 mg), maltodextrin (200-350 mg), and propylene glycol (PG) (15-30%) were chosen as independent variables with the highest preference. Included measurements of T5 tensile strength, disintegration time, folding endurance, elongation, and drug release efficiency as dependent variables. Results: The physical properties of the films were found to be satisfactory, and Fourier transform infrared (FTIR) analysis failed to detect any drug-polymer interaction. F4 was found to have the greatest bioadhesive strength of 49.82 gm and the longest ex-vivo mucoadhesion duration of 189 min. A higher concentration of mango kernel in the formulation resulted in a greater rate of drug release. More than 60% of the drug was discharged within 10 min. Conclusion: The oral mucosa of a rat was used for ex-vivo for irritation studies. Based on the pharmacokinetic plasma parameters, which is made into quick-dissolving films that are taken by mouth, is much better absorbed than aqueous suspensions. Studies of the enhanced formulation's stability showed that F4 may be stored for up to three months without deterioration.

The influence of low resistance respiratory muscle training on pulmonary function and high intensity exercise performance

Background/objectivesRespiratory muscle training (RMT) was recognized as an effective means to improve respiratory muscle (RM) strength and enhance exercise performance. The purpose of this study was to examine the effect of low-intensity RMT on RM strength, pulmonary function, and performance. MethodsFourteen healthy active adults were assigned randomly to either a training or placebo group. The training group completed six weeks of RMT, which consisted of a first week, 1 set of 15 min/d, 5 d/wk at 10–25% of maximal inspiratory pressure (PImax), and the remaining 5 weeks, 2 sets of 15 min/d, 5 d/wk, at 30% PImax. The placebo group followed the same protocol but with almost no additional ventilatory resistance. Measurement of RM strength and endurance, spirometry, and endurance exercise performance were obtained before and after the RMT program. ResultsIn the training group, PImax (+14%) and maximal expiratory pressure (PEmax, +27%), forced vital capacity (FVC, +3.6%), maximal oxygen uptake (VO2max, +11%), and time to exhaustion (Tlim90%, +25%) increased significantly from baseline values (P < 0.05). No significant changes were observed in the placebo group. Also, no significant interaction in maximum voluntary ventilation (MVV12), minute ventilation (VE), and respiratory rate (RR) were detected. ConclusionsThese data suggest that low-intensity RMT is an effective tool to improve RM strength, pulmonary elastic properties and endurance exercise performance.

Heterostructure of Reduced Titanium Dioxide Nanorods and Small Molecules Leads to Photo‐Induced Negative Differential Resistance Behaviors

AbstractNegative differential resistance (NDR) is of considerable interest due to the uncommon characteristic of having a region where the current decreases as the applied voltage bias increases. However, it is difficult to reproduce NDR devices and evaluate their reliability and stability because of the unstable NDR behaviors. In this paper, a highly stable photo‐induced hybrid photonic (HP)‐NDR device is presented for practical applications, which has heterostructure between TiO2‐x nanorods formed by oblique angle deposition and dinaphtho[2,3‐b:2′,3′‐f]‐thieno[3,2‐b]thiophene. The mechanism of NDR behaviors is investigated through morphological analysis, energy band structure, and electrical characteristics. In addition, diverse bias stress and endurance measurements are performed to demonstrate the reliability of the HP‐NDR device. As a result, the NDR behavior lasts up to 1,000 s in each bias stress and 38,850 cycles in the repeated current–voltage (I–V) characteristics Thus, the study has successfully achieved robust HP‐NDR devices with potential for practical applications.

Hip and Trunk Variables in University Students with and without Recurrent Low Back Pain.

Low back pain (LBP) is a leading cause of disability. Recurrent low back pain (rLBP) is defined as two or more episodes of LBP in a 12-month period, each lasting more than 24 hours and separated by at least one pain-free month. Many studies have shown that hip and trunk variables have an influence on LBP. However, most of these are studies of participants with acute or chronic LBP rather than rLBP. To examine the difference between hip and trunk variables of university students with and without rLBP. Cross-Sectional. Participants with and without rLBP between 18 and 35 years of age not currently undergoing clinical orthopedic care were recruited for this cross-sectional study. Bilateral hip range of motion (ROM) and trunk ROM were measured with a goniometer or measuring tape (hip motions in all planes along with trunk flexion, extension, and lateral flexion). Strength of the hip extensors, abductors, and external rotators was measured using a handheld dynamometer, and a single-leg bridge endurance test was performed to assess differences and correlations between outcomes. Twenty-six subjects aged 18 to 35 years with rLBP (n=10) and without rLBP (n=16) participated. Statistically significant differences between the two groups were found for right and left hip flexion (p = 0.029 and 0.039, respectively), right hip adduction (p = 0.043), and right hip extension (p = 0.021). No significant differences were found between groups for strength, endurance, or other ROM measures. The findings of this study show statistically significant although clinically non-meaningful differences in hip flexion, extension, and adduction ROM in the rLBP group compared to the control group. This lack of clinically meaningful difference may be relevant to testing procedures and treatment of patients or athletes with rLBP. This study also suggests that hip strength and endurance may not play a major role in the development or treatment of rLBP. Level of Evidence: 3.

Effect of kettle bells and battle rope training on grip strength and body composition among university volleyball players

The current research is to examine the possible impacts of High-Intensity Interval Training (HIIT) using battle ropes and kettlebells on body composition and grip strength. The aforementioned workout regimen's influence will be assessed by focusing on these two chosen variables, which are considered essential elements of interest. Existing research suggests that HIIT may have a beneficial effect on both body composition and grip strength, based on current hypotheses. The fundamental concept is that HIIT may induce favorable alterations in body composition, such as increases in lean muscle mass and reductions in body fat. This is due to its structure of brief intervals of very vigorous exercise followed by short periods of rest. HIIT has the ability to improve grip strength, which is an important measure of upper body strength and endurance. The experimental design facilitates the examination of many physical attributes by delivering pre- and post-tests to participants in both groups. The factors under investigation include grip strength (measured using handgrip dynamometers), and body composition (measured using skinfold callipers). The rationale behind our study involves the assessment of triceps strength as well as the strength of the left and right hand grips