The Circum-Pacific seismic belt is the region heavily affected by earthquakes in the world. The relationship between earthquake (e.g., the geographic location, occurrence time, magnitude, and focal depth) and ionospheric anomalies in the belt was investigated using 100 M7.0+ earthquakes during 2006–2015. The ground-based GPS measurements and global ionosphere map (GIM) data were used for the analyses of the ionospheric variations preceding the earthquakes. The results indicated that the occurrence rate of total electron content (TEC) anomalies was proportional to the magnitude and inversely proportional to the focal depth to a certain degree, and the occurrence frequency of anomalies had a rising trend with the days getting close to the main shock. The occurrence rate of TEC anomalies in the Southern hemisphere was larger than that in the Northern hemisphere. Besides, the spatial characteristics of TEC anomalies showed that the anomalies in low-middle latitudes did not coincide with the epicenter, sometimes the anomalies were also observed in the corresponding conjugated region. However, the TEC anomalies in the high latitude usually appeared around the epicenter and within the seismogenic zone while no TEC anomalies appeared in the conjugated area. These results may have potential applications to the earthquake prediction in the Circum-Pacific seismic belt.