Rate Measurements Research Articles

Positioning Imatinib for Pulmonary Arterial Hypertension (PIPAH) study

Abstract Introduction Pulmonary arterial hypertension (PAH) is characterised by pre-capillary pulmonary vascular remodelling. Imatinib, a tyrosine kinase inhibitor, was the first treatment investigated in PAH patients with the primary aim of targeting vascular remodelling. A Phase 3 study showed that imatinib 400mg daily reduces pulmonary vascular resistance and increases exercise capacity but only 43% of patients continued the drug for 6 months. Concerns about safety prevented regulatory approval. Purpose To identify a safe and tolerated dose of oral Imatinib and evaluate efficacy in the dose range 100-400mg daily. Methods Oral Imatinib was added to the background therapy of 17 patients with PAH; prior intracranial haemorrhage was excluded by cross sectional imaging and none were receiving an anticoagulant. The first patient started on 100mg daily. The next 12 patients were recruited serially at a minimum of 4 week intervals and started on 200mg, 300mg or 400mg, according to a Bayesian adaptive design (Continuous Reassessment Method, CRM). Patients 14-17 were recruited as an extension cohort to better understand the safety and tolerability of the 100mg and 200mg doses. The primary endpoint was safety and tolerability at 4 weeks. Imatinib was continued for up to 24 weeks. Thirteen patients had implanted devices that provided remote daily measurements of cardiopulmonary haemodynamics and heart rate and rhythm and physical activity. Non-invasive measures of systemic blood pressure, weight and oxygen saturations were made remotely. We compared the time-haemodynamic response relationship with that produced by licensed treatments in a similar patient cohort. Results The recommended starting dose from the CRM was 200mg daily. The most common side effect was nausea. Imatinib reduced mean pulmonary artery pressure (P<0.01), increased cardiac output (P=0.08) and reduced total pulmonary resistance (TPR, P<0.001, Figure). There was a clear dose-TPR response relationship (r2=0.52, p<0.01). A reduction in TPR was evident within the first week and plateaued at 4-5 weeks. Withdrawal of Imatinib led to an increase to baseline in TPR over 4-5 weeks. This contrasts with a sharp fall in TPR with licensed therapy and rapid increase on treatment withdrawal. There was a small reduction in systemic vascular resistance (P<0.05) with Imatinib that reached plateau before TPR. Conclusions Oral Imatinib 200mg daily is well tolerated and effective as an add-on treatment in PAH. The time course of the initial haemodynamic response and the gradual return to baseline on withdrawal distinguishes Imatinib from licensed treatments and is supportive of a mechanism of action beyond reliance on vasodilation. Remote monitoring enables the safe evaluation of the withdrawal of an investigational drug in patients established on best medical therapy.Figure 1.

Remote management of worsening heart failure events and subsequent rate of emergency department admission

Abstract Background Worsening heart failure (WHF) is the leading cause of hospitalization among individuals aged ≥ 65 years and constitutes a substantial burden for both the patient and the healthcare systems. Moreover, heart failure contributes to exacerbate the pressure on emergency departments which are involved in 64% of heart failure hospital admission (1). Remote management of heart failure as been shown to reduce the number of days lost due to unplanned cardiovascular hospitalizations and all-cause mortality (2, 3), but little is known about the effect on the emergency healthcare use. We aimed to describe the effect of a telemonitoring program on the rate of emergency admissions for WHF in chronic heart failure patients. Methods All patients enrolled in the heart failure remote management program of two French centers between 13 April 2020 and 31 January 2023 were included in the study. Follow-up data were collected until 31 January 2023. Inclusion criteria were chronic heart failure (HF) with New York Heart Association ≥II and an elevated B-type natriuretic peptide (BNP > 100 pg/mL or N-terminal-pro-BNP > 1000 pg/mL). Remote evaluation included measurements of body weight, blood pressure, heart rate, symptoms, biochemical parameters, and data from cardiac implantable electronic devices when available. Results A total of 1,095 patients (72±11.8 years old, 69.7% male), were followed for a median [IQR] of 437 [182; 739] days with a mean adherence to the remote monitoring system of 67.6±30.3%. Over this period, 198 (18.1%) patients had 949 WHF events, the majority of whom were remotely detected: 830 (87.5%). Overall, 246 (26%) of the WHF episodes required hospitalisation and 109 (11%) prompted an emergency department visit. When the WHF event was remotely detected, hospitalization was only required in 127 (15%) cases and the rate of emergency department visit was reduced to 3%. Conclusion In HF patients engaged in a multiparametric remote management program, the rate of emergency department admission is very low. Adopting such a strategy for patients with chronic HF may be useful in reducing emergency department overcrowding.Baseline characteristics of patientsPatients course and use of resources

Effect of renal dialysis session on novel echocardiographic parameters of left and right ventricle in patients with end-stage renal disease

Abstract Introduction Chronic heart disease is among the leading causes of end-stage renal disease (ESR). On the other hand, patients with ESR undergoing dialysis demonstrate often subclinically impaired left and/or right ventricular function according to small studies, and higher prevalence of chronic heart disease. However, data regarding the effect of renal dialysis on novel echocardiographic parameters among renal dialysis patients remain limited.The purpose of our study, was to study the effect of renal dialysis on novel echocardiographic parameters of left and right ventricle. Methods All 50 patients (14 females) of mean age 62.9 years undergoing renal dialysis in our kidney unit regularly were included in our study. Blood pressure, heart rate and weight measurements and heart echocardiogram with measurement of LV GLS, RV GLS, RV FWS, LA ResS, E/e’ ratio, Right Ventricular Systolic pressure (PASP) and inferior vena cava (IVC) diameter, before and after renal dialysis session, were carried out. Results Mean values of body weight (79,9 vs 77,6 kg), heart rate (74,2 vs 73,5 bpm) and blood pressure (131,5/80,6 vs 123,5/76,9 mmHg) were as expected statistically significant reduced after renal dialysis (p<0,001). Values of PASP (36,1 vs 27,8 mmHg), E/e’ ratio (14 vs 12,5) and IVC diameter (1,6 vs 1,3 cm), were statistically significant reduced after renal dialysis (p<0,001). Furthermore, values of RV GLS (-19,3 vs -20,3 %), RV FWS (-21,2 vs -22,6 %) and LA ResS (29,6 vs 30,7%), were statistically significant improved after renal dialysis session (p <0,001), while LV GLS depicted a minor improvement (-17,9% vs 18,2%) not statistically significant. Conclusion In conclusion, renal dialysis session had a beneficial effect on novel echocardiographic parameters of left and right ventricle (RV GLS, RV FWS, LA ResS) due to improvement of hemodynamic parameters (blood pressure, heart rate, PASP and IVC diameter) and intravascular volume reduction. Larger clinical studies should be organized to further investigate the effect of renal dialysis on those parameters and the underlying mechanisms in the chronic setting of hemodialysis.

Physical Heat Cycle Measurement of Resistance Spot Welding

Resistance spot welding (RSW) is still the ideal joining method in the automotive industry. Mostly steel sheets are used in the car body, so overlap and layering are required for welding or riveting, as spot welding provides simultaneous clamping force with interfacial welding to ensure the required strength and quality. A fundamental understanding of heating and cooling rates in thermal distributions is essential for predicting microstructure formation in the weld and the heat-affected zones (HAZ) of RSW joints. The ability to measure the heat cycle in the RSW process can be valuable in weld control and welding parameter optimization. RSW parameters can be optimized through tensile shear tests and microscopic investigations. Heat cycle measurement (HCM) demonstrates the welding consequences in terms of the change in mechanical properties and microstructural formations. The accuracy of cooling rate measurements including t8/5 cooling time is very important to predict the microstructural evolution in the HAZ, however, the thermocouple measurement raises numerous challenges due to the high temperature gradient and small weld and HAZ size. During our investigations heat cycle measurement has been conducted experimentally by a K-type thermocouple. The data logger is connected to the output of the thermocouple for recording the voltage to measure the temperature distributions as a function of both time and position during the welding process. Measurement results of 1 mm thick martensitic MS1400 steel overlapped RSW joints are discussed, and the HCM curve of heating and cooling rates of the spot-welding process is presented. The heat cycle during RSW was measured with two different welding parameter combinations. In addition to welding current, welding time, and electrode force, pulsation has shown disparate curves. Numerous experiments have been attempted to measure the heat cycle in HAZ sub-zones due to the difficulty of positioning the thermocouple accurately, uppercritical HAZ, intercritical HAZ, and subcritical HAZ were investigated and measured in both welding parameter combinations. Difficulties were encountered in the experimental work as a result of the instantaneous welding time and the vibration resulting from the passage of alternating electrical current between the two electrodes. A magnetic field is generated that affects the thermocouple measurement and appears as a noisy curve that is filtered out and smoothed. Joule heat, interfacial heat generation, and cooling effects of electrodes are also considered in the experiment.

Characterization of X-ray Beams: Determination of K\(_{a,e}\) for Comparison with DRLs

Aims: The aim of this experimental study was to quantify the entrance surface air kerma (Ka,e) of X-ray beams in radiographic examinations, and the obtained values were compared with national and international Diagnostic Reference Levels (DRLs). Place and Duration of Study: Sample: Department of Medical Physics and Radiology, Franciscan University (UFN), between June 2023 and August 2024. Methodology: Initially, the main quality control (QC) tests were applied to characterize the radiographic equipment. During the evaluation of the X-ray beam, a dosimetric set was used, and for the same QC geometry, Air Kerma Rate (KAIR) measurements were obtained to determine the output of the X-ray tube. Under the same conditions, a phantom without water and the same filled with water were used to determine the backscatter factor (BSF), which was then used to estimate the Ka,e for the main radiographic examinations. Results: The results of this study are consistent with other studies and identified the region/anatomy with the highest radiation exposure, highlighting the importance of its optimization and verifying that continued professional training should be integrated into best practices to ensure greater safety in procedures. The results obtained evidence the necessity for adjustments in image acquisition protocols, as the Ka,e values found in this study, although within the limits established by the national DRLs, exceed the reference values of countries such as the United Kingdom and Japan in the areas of the skull, abdomen, and lumbar spine. This discrepancy highlights the importance of the periodic review and update of DRLs, in accordance with international recommendations and the technological evolution of equipment. Dose optimization is an ongoing process that involves the evaluation of image quality, the appropriate selection of technical parameters, and the implementation of specific dose protocols. The continuous training of radiology professionals is essential to ensure the correct application of imaging techniques and the minimization of patient exposure to ionizing radiation. Conclusion: This study shows the importance of evaluating radiation dose in diagnostic imaging and the need for a multidisciplinary approach to dose optimization. Implementing quality assurance programs, updating DRLs, and providing ongoing training for professionals are essential to ensure patient safety and high-quality diagnostic imaging. The methodology adopted in this study can contribute to the ongoing education of radiology professionals, promoting the correct application of imaging techniques and reducing patient exposure to ionizing radiation.

Study on interfacial tension, wettability and viscosity in different salinities of synthesized a new polymeric surfactant for improving oil recovery

Over 50% of the original oil in place (OOIP) is immobile or trapped in the reservoir. Therefore, today, more efficient methods have been introduced in the tertiary oil recovery sector as a scheme of enhanced oil recovery (EOR). Due to the decline of conventional hydrocarbon reserves, polymers are increasingly used in EOR methods, such as surfactant-polymer (SP) and alkaline-surfactant-polymer (ASP) flooding. SP flooding has a complex formulation and design, leading to undesirable phase separation if improperly mixed. Polymeric surfactants are a promising alternative to SP flooding. They consist of hydrophobic groups attached to hydrophilic polymers, which help to improve the mobility ratio and reduce interfacial tension (IFT). This paper examines the rheological and synthesis properties of a new polymeric surfactant produced through bond co-polymerization reaction using different hydrolyzed polyacrylamide (HPAM) ratios and a zwitterion hydrophobic group. The synthesized hydrophobically modified zwitterionic polyacrylamide (HMZPAM) was characterized by FTIR and HMNR analysis. HMZPAM performed better than other substances in IFT, viscosity, wettability, oil recovery, and resistance to different one and two-valence cations. The results indicate that HPAM reduced the IFT to 13.65, while HMZPAM reduced it to 0.441 mN/m. Wettability change evaluated on a rock carbonate/crude oil/HMZPAM system that changed the water-wet state of the primary oil-wet rock carbonate to strongly water-wet state as wettability change measurements showed a decrease in contact angle from 62.76 to 21.23 degree. Comparative studies on the effectiveness of HPAM and HMZPAM were also conducted according to the measurement of viscosity and shear rate in the presence of salt, which indicates the higher shear rate and viscosity of HMZPAM. Core flooding tests revealed that HMZPAM resulted in better additional recovery due to microscopic displacement, resulting in a total oil recovery of 84%, compared to 48% of residual oil saturation for HPAM. Also, salts decreased oil recovery in HPAM injection but increased oil recovery in HMZPAM injection.

Gamma Dose Rate Measurements in Northern Spain: Influence of Local Meteorological Scenarios on Radiological “False Alarms” in a Real-Time Radiological Monitoring Network

The present study characterizes gamma dose rate (GDR) concentrations in Bilbao, located in the northern Iberian Peninsula, utilizing a comprehensive 10-min interval database spanning from 2009 to 2018. This station belongs to the radiological environmental monitoring of the Basque Country network. The daily average GDR was found to be 0.07624 ± 0.00004 µSv/h, with the daily 95th percentile averaging 0.08026 ± 0.00007 µSv/h throughout the entire period. Our analysis specifically addresses the impact of precipitation on GDR, revealing a higher correlation coefficient for daily 95th percentile values compared to daily averages. Additionally, the influence of the Galerna (GL) event, a natural meteorological phenomenon in this region, on GDR was investigated, noting that it can develop both with and without precipitation. Understanding the interaction between GDR and this meteorological scenario is vital for the development of more reliable radiological monitoring strategies and for safeguarding public health. For this purpose, 40 GL events were analyzed. The present results indicate that GDR values frequently exceed alarm levels when a GL is formed. These GDR peaks should be considered natural radiological events, necessitating the classification of such GDR peaks as false alarms within the radiological monitoring network. To explain them in detail, 10-min time series of precipitation and radon outdoor concentrations were analyzed. The results demonstrate that the GL event with precipitation is a meteorological scenario that can be associated with false alarms. The present analysis provides a distinct contrast in radon behavior under the same meteorological event in case of being developed with precipitation or without precipitation. The findings from this analysis are crucial for avoiding and understanding false radiological alarms triggered in the monitoring network, thereby enhancing the accuracy of radiological data interpretation and improving public safety measures.

Rain Fade Analysis on High Frequency Signal: A Review

A reliable transmission of high-frequency signal of more than 10 GHz is crucial for various communication systems, especially in the era of advanced technologies and wireless communications. Rain-induced signal fades pose a significant challenge to signal integrity, making accurate rain rate measurement methods essential for system optimization. This review critically examines the existing techniques for measuring rain rate and the applicability in analysing high-frequency signal fades. Several case studies and practical examples are presented to illustrate the significance of accurate rain rate measurements in predicting and mitigating signal degradation. Researchers are working to enhance existing models to better fit local environmental variables based on all the case studies. Having an accurate estimation of the level of rain attenuation in the signal is one of the components to ensuring the quality of service of a communication signal. Signal availability can be ensured with suitable rain attenuation modelling, assuming that all other communication elements are functioning as planned.

A novel wafer defocus measurement method for spot-scanning imaging system using laser triangulation

Abstract For spot scanning dark-field scattering technology, the defocus caused by the change in wafer surface height decreases the defect detection rate and size measurement repeatability. The demand for accurately and rapidly measuring the wafer surface height online is becoming increasingly urgent. The defect detection system integrates scattering, reflection, film thickness, and topography defect detection channels. The integration of laser-triangulation-based defocus measurement into the bright-field optical path is proposed. The laser beam is directed onto the surface of the wafer, and the reflected light is transmitted through a lens onto the photosensitive surface of a four-quadrant detector. This detector captures both the strength and position of the reflected signal simultaneously. In this paper, a triangulation-modified model is established to obtain the height of each inspection spot on the wafer surface through the position signal of the reflected image. When the signal-to-noise ratio of the simulated reflection image position is 20 dB, the signal-to-noise ratio of the height measurement resolved by the triangulation-modified model is 41 dB, and the measurement error is less than 0.2 μm, indicating that the model has a noise suppression effect. The spot-scanning imaging system is established, and the height measurement results of the triangulation measurement model are verified using a laser interferometer. Within the travel range of 69 μm, the system has a measurement accuracy better than ±1 μm and a measurement repeatability better than ±0.2 μm, which meet the measurement requirements of the spot-scanning imaging system. The system is utilized for defect detection and defocus measurement of the wafer surface, along with the motion mechanism, to accurately and rapidly obtain the height distribution of the wafer surface.

Design and Analysis of a Thermal Flowmeter for Microfluidic Applications: A Study on Sensitivity at Low Flow Rates

To address the challenge of precise flow rate measurement in microchannels, this research details the conceptualization and comprehensive evaluation of a thermal flowmeter which works on the principle of calorimetry for measuring small flow rates between 0.1 and 180 mL/h. The thermal flowmeter is composed of a silicone pipe, a heater, three platinum thermal sensors (T1, T2, T3), and water as the working fluid. The flowmeter is strategically placed to monitor the complex thermodynamics between upstream and downstream flows. The analysis revealed a notable decay in the slope of the temperature differences beyond a flow rate of 40 mL/h, indicating the exceptional sensitivity of the device at lower flow rates and making it an ideal choice for medical applications. Parametric analysis was also carried out to place the sensors at optimized locations for better sensitivity.

BaYaka mothers balance childcare and subsistence tasks during collaborative foraging in Congo Basin

Across cultures, mothers balance childcare with other labour. Hunter-gatherer mothers face a daily choice of whether to take infants on foraging trips or leave them with caregivers in the settlement, as well as deciding with whom to forage. Yet, it remains unclear how infant presence affects mothers’ mobility and food returns during group foraging. Using GPS, heart rate measurements, and food return data from 348 foraging trips by 22 BaYaka mothers in the Republic of the Congo, we found that mothers go on longer-duration foraging trips when they take infants along, compared to when they leave them behind. Despite this, infant presence does not affect mothers’ mobility, energy expenditure, or food returns. Mothers also go on longer-duration and longer-distance trips during group foraging, compared to foraging alone. However, they have decreased food returns in larger groups with more adults, possibly due to food competition. Nevertheless, BaYaka mothers maintain their energy expenditure and net food returns in general, regardless of infant presence or group dynamics, likely due to their individual foraging strategies and support from group members. Particularly, children in foraging groups increase mothers’ food returns, aligning with women’s reports of children assisting as caregivers. These findings provide insights into how BaYaka mothers accommodate childcare with subsistence activities during group foraging.

Deriving iceberg ablation rates using an on-iceberg autonomous phase-sensitive radar (ApRES)

Abstract The increase in iceberg discharge into the polar oceans highlights the importance of understanding how quickly icebergs are deteriorating and where the resulting freshwater injection is occurring. Recent advances in quantifying iceberg deterioration through combinations of modeling, remote sensing and direct in situ measurements have successfully calculated overall ablation rates, and surface and sidewall ablation; however, in situ measurements of basal melt rates have been difficult to obtain. Radar has successfully measured iceberg thickness, but repeat measurements, which would capture a change in iceberg thickness with time, have not yet been collected. Here we test the applicability of using an on-iceberg autonomous phase-sensitive radar (ApRES) to quantify basal ablation rates of a large (~800 m long) non-tabular Arctic iceberg during an intensive 2019 summer field campaign in Sermilik Fjord, southeast Greenland. We find that ApRES can be used to measure basal ablation even over a short deployment period (10 d), and also provide a lower bound on sidewall melt. This study fills a critical gap in iceberg research and pushes the limits of field instrumentation.

Associations of Amino Acids with the Risk of Prediabetes: A Case-Control Study from Kazakhstan.

The high global prevalence of prediabetes requires its early identification. Amino acids (AAs) have emerged as potential predictors of prediabetes. This study investigates the association between amino acids and prediabetes in the Kazakh population. In this case-control study, serum AAs levels were measured using the Trace GC 1310 gas chromatography system coupled with the TSQ 8000 triple quadrupole mass spectrometer (Thermo Scientific, Austin, TX, USA) followed by silylation with the BSTFA + 1% TMCS derivatization method. Biochemical parameters, including total cholesterol, HDL-C, LDL-C, triglycerides, fasting glucose, HbA1c, and Creatinine, were assessed for each participant. Trained professionals conducted anthropometric and physical examinations (which included taking blood pressure and heart rate measurements) and family history collection. A total of 112 Kazakh individuals with prediabetes and 55 without prediabetes, aged 36-65 years, were included in the study. Only Alanine and valine showed a significant association with prediabetes risk among the 13 AAs analyzed. Our findings revealed an inverse relationship between Alanine and Valine and prediabetes in individuals of Kazakh ethnicity. A lower serum level of Alanine and Valine may serve as a predictive biomarker for prediabetes in the Kazakh population.

Estimation of the graft failure by current value joint model, and extension to alternative parameterization structures: Cohort study.

In clinical practice, individuals are followed up to predict the outcome event of interest, and their longitudinal measurements are collected on a regular or irregular basis. We aimed to examine the classical approach, joint model (JM), and alternative parameterization structures using data on the effect of time-varying longitudinal measurements on survival. The motivating cohort dataset included 158 consecutive kidney transplant recipients who had baseline and follow-up data. Although the longitudinal log-transformed estimated glomerular filtration rate (log[eGFR]) measurements and graft failure have an association clinically, the 2 processes are analyzed separately in the classical approach. In addition to the extended Cox model, the current value JM, the weighted cumulative effect JM, and dynamic predictions were performed in the study, by taking advantage of R codes. Of the 158 patients, 34.8% were males. The mean age was 29.8 ± 10.9 years, and the median age was 26 years at the time of transplantation. The hazard ratio for graft failure was 8.80 for a 1-unit decrease in log(eGFR) in the extended Cox model, 10.58 in the current value JM, and 3.65 in the weighted cumulative effect JM. The presence of coronary heart disease was also found to be associated with log(eGFR): 0.199 (P = .03) for the current value JM and 0.197 (P = .03) for the weighted cumulative effect JM. The current value JM was identified as a better model than the extended Cox model and the weighted cumulative effect JM based on parameter and standard error comparison and goodness of fit criteria. JMs should be preferred, as they facilitate better clinical decisions by accounting for the varying slopes and longitudinal variation of estimated glomerular filtration rate among patients. Suitable types of models should be practiced depending on baseline biomarker levels, their trends over time, the distribution of the biomarkers, and the number of longitudinal biomarkers.

Overcoming the challenge of obtaining reliable heart and pulse rate measurements in reptiles.

Overcoming the challenge of obtaining reliable heart and pulse rate measurements in reptiles.

Camera-Based Respiratory Imaging System for Monitoring Infant Thoracoabdominal Patterns of Respiration.

Existing respiratory monitoring techniques primarily focus on respiratory rate measurement, neglecting the potential of using thoracoabdominal patterns of respiration for infant lung health assessment. To bridge this gap, we exploit the unique advantage of spatial redundancy of a camera sensor to analyze the infant thoracoabdominal respiratory motion. Specifically, we propose a camera-based respiratory imaging (CRI) system that utilizes optical flow to construct a spatio-temporal respiratory imager for comparing the infant chest and abdominal respiratory motion, and employs deep learning algorithms to identify infant abdominal, thoracoabdominal synchronous, and thoracoabdominal asynchronous patterns of respiration. To alleviate the challenges posed by limited clinical training data and subject variability, we introduce a novel multiple-expert contrastive learning (MECL) strategy to CRI. It enriches training samples by reversing and pairing different-class data, and promotes the representation consistency of same-class data through multi-expert collaborative optimization. Clinical validation involving 44 infants shows that MECL achieves 70% in sensitivity and 80.21% in specificity, which validates the feasibility of CRI for respiratory pattern recognition. This work investigates a novel video-based approach for assessing the infant thoracoabdominal patterns of respiration, revealing a new value stream of video health monitoring in neonatal care.

Psychological resilience in patients with primary Sjögren's syndrome: effect of involvement of major salivary and lacrimal glands.

The aim of this study was to assess whether the involvement of major salivary and lacrimal glands in primary Sjögren's syndrome (pSS) affected the psychological resilience of patients. This cross-sectional study included 116 patients with pSS. Data were collected through clinical examinations, measurement of salivary flow rates (SFRs), and from Schirmer's test, as well as from patient-reported outcome measures (PROMs), such as the European League Against Rheumatism (EULAR) Sjögren's Syndrome Patient Reported Index (ESSPRI), Brief Resilience Scale (BRS), Work Productivity and Activity Impairment (WPAI), Oral Health Impact Profile-14 (OHIP-14), and the Hospital Anxiety and Depression Scale (HADS). Hyposalivation was defined as an unstimulated SFR of≤0.1mL/min. The BRS score (mean±SD=2.60±0.69) was lower in patients with recurrent parotitis (2.11±0.37) than in those without recurrent parotitis (2.67±0.86), in the whole group. In patients with an unacceptable symptom state (ESSPRI score≥5 points), a lower BRS score was observed in patients with both hyposalivation and ocular dryness (2.59±0.69) than in patients with isolated hyposalivation (2.84±0.84). The BRS score was also negatively associated with the WPAI-Daily Impairment and OHIP-14 scores in patients with hyposalivation as well as with HADS-A (the seven items of HADS relating to the anxiety dimension) and HADS-D (the seven items of HADS relating to the depression dimension) in the whole group. The results suggest that psychological resilience in pSS may be affected by recurrent parotitis, the levels of anxiety and depression, as well as hyposalivation with ocular dryness.

Assessment of heart rate measurements by commercial wearable fitness trackers for early identification of metabolic syndrome risk

Metabolic syndrome increases the risks of cardiovascular diseases, type 2 diabetes, and certain cancers. The early detection of metabolic syndrome is clinically relevant, as it enables timely and targeted interventions. In the current study, we aimed to investigate the association between metabolic syndrome and heart rate measured using wearable devices in a real-world setting and compare this association with that for clinical resting heart rate. Data from 564 middle-aged adults who wore wearable devices for at least 7 days with a minimum daily wear time of 20 h were analyzed. The results showed significantly elevated all-day, sleeping, minimum, and inactive heart rates in men with pre-metabolic or metabolic syndrome compared with those in normal individuals, whereas sleeping heart rate and heart rate dips were significantly increased and decreased, respectively, in women with metabolic syndrome. After adjusting for confounders, every 10-beats-per-minute increment in all-day, sleeping, minimum, and inactive heart rates in men corresponded to odds ratios of 2.80 (95% confidence interval 1.53–5.44), 3.06 (1.57–6.40), 4.21 (1.87–10.47), and 3.09 (1.64–6.29), respectively, for the presence of pre-metabolic or metabolic syndrome. In women, the association was significant only for heart rate dips (odds ratio = 0.49 [95% confidence interval 0.25–0.96] for every 10% increment). Models incorporating inactive or minimum heart rate in men and heart rate dip in women demonstrated better fits, as indicated by lower Akaike information criterion values (170.3 in men and 364.9 in women), compared with models that included clinical resting heart rate (173.4 in men and 369.1 in women). These findings suggest that the heart rate indices obtained from wearable devices may facilitate early identification of metabolic syndrome.

Can planktonic food web topology be retraced by biomass measurements without internal and input flows (production and grazing rate) in freshwater marshes?

An accurate way to estimate the planktonic food web topology is to consider biomass and flows. However, measurements of flows, as production and grazing rate, are time-consuming. In this paper, we retrace food web topology based on three different degrees of information: input flows (production), internal flows (grazing rate) and plankton biomass in freshwater marshes. For that, a meta-analysis of datasets from 4 freshwater marshes of the Charente-Maritime (French Atlantic coast) were used, corresponding to 47 stations/dates and thus to different geographical and temporal situations. The main results were that, globally, the biomass can yield good results in terms of characterization of the contrasted topology of food web, as the herbivorous food web, the microbial food web and the multivorous food web. However, in order to properly distinguish weak, ‘normal‘ multivorous and strong multivorous food web, the only measure of biomass did not appear to be sufficient. To better separate these different types of multivorous food webs, measurements of primary productions or heterotrophic prokaryote biomass, which correlated well with primary productions, appear interesting. This approach can be applied in all aquatic ecosystems.

Lithosphere infiltrometer: A low cost, automated infiltrometer (permeameter) for measurement of soil health, infiltration, and hydraulic conductivity

Accurate measurement of infiltration rate and hydraulic conductivity is important for assessing soil physical health, irrigation management and catchment modelling. Commercially available infiltrometers are often expensive, fragile, and require specialist knowledge to operate and perform complex post-measurement calculations. We developed the Lithosphere Infiltrometer (permeameter) to be usable for both experienced soil researchers, and users without prior technical or scientific expertise in soil science. The Lithosphere Infiltrometer is able measure both surface and subsoil infiltration rate and hydraulic conductivity. It is manufactured using 3D-printed parts and off-the-shelf electronic components. It has a robust, quad-leg design that allows for rapid leveling of the device and accurate setting of water depth via a novel 3D-printed bell chamber. The water level is measured using a U85 JRT laser with ±1 mm accuracy connected to an Adafruit Huzzah 32 microcontroller. Infiltration rate and hydraulic conductivity are calculated at 1 to 10 min time steps, and data is presented in real-time on an OLED display. Data is stored on the device and available for download to a mobile device by Wi-Fi.