Measurement Of Volume Changes Research Articles

Regional respiratory inflation and deflation pressure–volume curves determined by electrical impedance tomography

Measurement of regional lung volume changes during a quasi-static pressure–volume (PV) manoeuvre using electrical impedance tomography (EIT) could be used to assess regional respiratory system mechanics and to determine optimal ventilator settings in individual patients. Using this approach, we studied regional respiratory system mechanics in healthy and lung-injured animals, before and after surfactant administration during inflation and deflation PV manoeuvres. The comparison of the EIT-derived regional PV curves in ventral, middle and dorsal regions of the right and left lungs showed not only different amounts of hysteresis in these regions but also marked differences among different landmark pressures calculated on the inflation and deflation limbs of the curves. Regional pressures at maximum compliance as well as the lower and upper pressures of maximum compliance change differed between the inflation and deflation and increased from ventral to dorsal regions in all lung conditions. All these pressure values increased in the injured and decreased in the surfactant treated lungs. Examination of regional respiratory system mechanics using EIT enables the assessment of spatial and temporal heterogeneities in the ventilation distribution. Characteristic landmarks on the inflation and especially on the deflation limb of regional PV curves may become useful measures for guiding mechanical ventilation.

Estimation of Critical State Parameters from One-dimensional Consolidation and Triaxial Compression Tests

Determination of critical state parameters are essential, when critical state soil mechanics based soil models are used for the analysis. Isotropic consolidation test and triaxial tests with accurate measurements of volume change and pore pressure are essential for the direct measurement of critical state parameters. However, in the conventional geotechnical engineering practice, isotropic compression tests are usually not conducted but only one-dimensional consolidation test are performed. The usual parameters reported in most of the soil investigation reports are the shear strength parameters c′ and ϕ′ and the consolidation parameters such as compression index (C c ) and the recompression index (C r ) apart from, the overburden pressure σ 0′ and the corresponding void ratio e0. The critical state parameters are seldom reported in most of the soil investigation reports. This paper explains a procedure to estimate the critical state parameters, in the absence of isotropic compression test data, based on one-dimensional consolidation tests and triaxial compression tests, using the equations of Modified Cam clay state boundary surface. Comparison of the calculated values from the suggested method with the measured values, on three reconstituted soils and one undisturbed soil, lends support to the validity of the proposed procedure.

Monitoring intracellular, interstitial, and intravascular volume changes during fluid management procedures.

The bioimpedance spectroscopic (BIS) analytical algorithm described in this report allows for the non-invasive measurement of intravascular, interstitial, and intracellular volume changes during various fluid management procedures. The purpose of this study was to test clinical use feasibility and to demonstrate the validity of the BIS algorithm in computing compartmental volume shifts in human subjects undergoing fluid management treatment. Validation was performed using volume changes recorded from 20 end stage renal disease patients. The validation procedure involved mathematically deriving post hoc hematocrit profiles from the BIS data-generated fluid redistribution time profiles. These derived hematocrit profiles were then compared to serial hematocrit values measured simultaneously by a CritLine(®) monitor during 60 routine hemodialysis sessions. Regression and Bland-Altman analyses confirm that the BIS algorithm can be used to reliably derive the continuous and real-time rates of change of the compartmental fluid volumes. Regression results yielded a R (2)>0.99 between the two measures of hematocrit at different times during dialysis. The slopes of the regression equations at the different times were nearly identical, demonstrating an almost one-to-one correspondence between the BIS and CritLine(®) hematocrits. Bland-Altman analysis show that the BIS algorithm can be used interchangeably with the CritLine(®) monitor for the measurement of hematocrit. The present study demonstrates for the first time that BIS can provide real-time continuous measurements of compartmental intravascular, interstitial and intracellular fluid volume changes during fluid management procedures when used in conjunction with this new algorithm.

Unsaturated characteristics of undisturbed expansive shale from Saudi Arabia

The aim of this paper is to evaluate the soil water characteristic curves (SWCC) of undisturbed expansive shale identified at different locations of Kingdom of Saudi Arabia. The SWCCs were evaluated for suction ranging from 0.5 to 400 MPa. Based on test results, all SWCCs reveal a bimodal curve indicating the presence of two distinct pore size distributions referred to as small and large micropores. Volume change measurements were performed to evaluate void ratio–suction relationships which confirmed the expansive nature of shale. Similarities between measured SWCCs and void ratio–suction relations developed for expansive shale originating from same geological formation suggests the impact of geological and environmental conditions on the unsaturated behavior of shale samples. Finally, a modified approach based on Mckeen’s classification methodology was proposed to assess the swelling potential using bimodal SWCCs. The modified approach was used to assess the relative contribution of different micropores on the swelling potential of shale.

Assessment of lung volume collapsibility in chronic obstructive lung disease patients using CT

To investigate the collapsibility of the lung and individual lobes in patients with COPD during inspiration/expiration and assess the association of whole lung and lobar volume changes with pulmonary function tests (PFTs) and disease severity. PFT measures used were RV/TLC%, FEV1% predicted, FVC, FEV1/FVC%, DLco% predicted and GOLD category. A total of 360 paired inspiratory and expiratory CT examinations acquired in 180 subjects were analysed. Automated computerised algorithms were used to compute individual lobe and total lung volumes. Lung volume collapsibility was assessed quantitatively using the simple difference between CT computed inspiration (I) and expiration (E) volumes (I-E), and a relative measure of volume changes, (I-E)/I. Mean absolute collapsibility (I-E) decreased in all lung lobes with increasing disease severity defined by GOLD classification. Relative collapsibility (I-E)/I showed a similar trend. Upper lobes had lower volume collapsibility across all GOLD categories and lower lobes collectively had the largest volume collapsibility. Whole lung and left lower lobe collapsibility measures tended to have the highest correlations with PFT measures. Collapsibility of lung lobes and whole lung was also negatively correlated with the degree of air trapping between expiration and inspiration, as measured by mean lung density. All measured associations were statistically significant (P < 0.01). Severity of COPD appears associated with increased collapsibility in the upper lobes, but change (decline) in collapsibility is faster in the lower lobes. • Inspiratory and expiratory computed tomography allows assessment of lung collapsibility • Lobe volume collapsibility is significantly correlated with measures of lung function. • As COPD severity increases, collapsibility of individual lung lobes decreases. • Upper lobes exhibit more severe disease, while lower lobes decline faster.

Development of a laboratory-scale pressuremeter

This paper presents details of the design, fabrication and operation of a laboratory-scale pressuremeter recently built at the University of Western Australia. The device is significantly different to any previously built miniature pressuremeter in that it uses air as the pressurising fluid and the membrane displacement is measured using strain-gauged ‘feeler-arm’ transducers, rather than inferring displacements from measured volume changes in the pressuring fluid. It is believed that the direct measurement of radial cavity displacement removes a number of potential sources of error inherent in the inference of displacement from the volume of hydraulic fluid applied. The requirement for system de-airing is also removed. Preliminary results from stress chamber testing are presented and basic interpretation of results indicates that the device is capable of producing high-quality stress–strain data.

Validation of the automated method VIENA: An accurate, precise, and robust measure of ventricular enlargement

In many retrospective studies and large clinical trials, high-resolution, good-contrast 3DT1 images are unavailable, hampering detailed analysis of brain atrophy. Ventricular enlargement then provides a sensitive indirect measure of ongoing central brain atrophy. Validated automated methods are required that can reliably measure ventricular enlargement and are robust across magnetic resonance (MR) image types. To validate the automated method VIENA for measuring the percentage ventricular volume change (PVVC) between two scans. Accuracy was assessed using four image types, acquired in 15 elderly patients (five with Alzheimer's disease, five with mild cognitive impairment, and five cognitively normal elderly) and 58 patients with multiple sclerosis (MS), by comparing PVVC values from VIENA to manual outlining. Precision was assessed from data with three imaging time points per MS patient, by measuring the difference between the direct (one-step) and indirect (two-step) measurement of ventricular volume change between the first and last time points. The stringent concordance correlation coefficient (CCC) was used to quantify absolute agreement. CCC of VIENA with manual measurement was 0.84, indicating good absolute agreement. The median absolute difference between two-step and one-step measurement with VIENA was 1.01%, while CCC was 0.98. Neither initial ventricular volume nor ventricular volume change affected performance of the method. VIENA has good accuracy and good precision across four image types. VIENA therefore provides a useful fully automated method for measuring ventricular volume change in large datasets. VIENA is a robust, accurate, and precise method for measuring ventricular volume change.

Continuous Noninvasive Monitoring of Lung Recruitment during High-Frequency Oscillatory Ventilation by Electrical Impedance Measurement: An Animal Study

Background: Ventilatory pressures should target the range between the upper and lower inflection point of the pressure volume curve in order to avoid atelecto- and volutrauma. During high-frequency oscillatory ventilation (HFOV), this range is difficult to determine. Quadrant impedance measurement (QIM) has recently been shown to allow accurate and precise measurement of lung volume changes during conventional mechanical ventilation. Objectives: To investigate if QIM can be used to determine a static pressure-residual impedance curve during a recruitment-derecruitment manoeuvre on HFOV and to monitor the time course of alveolar recruitment after changing mean airway pressure (MAP). Methods: An incremental and decremental MAP trial (6 cm H₂O to 27 cm H₂O) was conducted in five surfactant-depleted newborn piglets during HFOV. Ventilatory, gas exchange and haemodynamic parameters were recorded. Continuous measurement of thoracic impedance change was performed. Results: Mean residual impedance (RI) increased with each stepwise increase of MAP resulting in a total mean increase of +26.5% (±4.0) at the highest MAP (27 cm H₂O) compared to baseline ventilation at 6 cm H₂O. Upon decreasing MAP levels, RI fell more slowly compared to its ascent; 83.4% (±19.1) and 84.8% (±16.4) of impedance changes occurred in the first 5 min after an increase or decrease in airway pressure, respectively. Conclusions: QIM could be used for continuous monitoring of thoracic impedance and determination of the pressure-RI curve during HFOV. The method could prove to be a promising bedside method for the monitoring of lung recruitment during HFOV in the future.

Hysteretic soil water characteristics and cyclic swell–shrink paths of compacted expansive soils

The investigation of the hydromechanical behavior of unsaturated expansive soil depends on the determination of hysteretic soil water characteristic curves (HSWCCs). This research investigates the HSWCCs of two natural expansive soils initially compacted at optimum moisture content (OMC) and maximum dry density (MDD) and then saturated to their maximum expansion state to ensure identical capillary history. Filter paper, pressure plate and chilled mirror hygrometer suction measurement techniques were utilized, and corresponding measurements of three-dimensional volume change made. The cyclic swell–shrink paths were deduced in terms of volumetric strain versus either water content or suction. The cyclic three-dimensional volumetric measurements showed a much higher amount of swelling and shrinkage than those determined from one-dimensional measurements. Hydraulic hysteresis rapidly decreased with the swell–shrink cycles as a result of macro-structural stabilization. Under the no/low confining conditions, the swell–shrink cycles generally caused a decrease of global expansion and an increase of global shrinkage. Moreover, a special phenomenon showing a reduction of global shrinkage on significant drying was discovered in the less plastic soil sample.

Towards an Intelligent Predictive Model for Analyzing Spatio-Temporal Satellite Image Based on Hidden Markov Chain

Nowadays remote sensing is an important technique for observing Earth surface applied to different areas such as, land use, urban planning, remote monitoring, real time deformation of the soil that can be associated with earthquakes or landslides, the variations in thickness of the glaciers, the measurement of volume changes in the case of volcanic eruptions, deforestation, etc. To follow the evolution of these phenomena and to predict their future states, many approaches have been proposed. However, these approaches do not respond completely to the specialists who process yet more commonly the data extracted from the images in their studies to predict the future. In this paper, we propose an innovative methodology based on hidden Markov models (HMM). Our approach exploits temporal series of satellite images in order to predict spatio-temporal phenomena. It uses HMM for representing and making prediction concerning any objects in a satellite image. The first step builds a set of feature vectors gathering the available information. The next step uses a Baum-Welch learning algorithm on these vectors for detecting state changes. Finally, the system interprets these changes to make predictions. The performance of our approach is evaluated by tests of space-time interpretation of events conducted over two study sites, using different time series of SPOT images and application to the change in vegetation with LANDSAT images.

SEDIMENT BUDGET FORMULATION VIA EXHAUSTIVE SEARCH METHOD

A regional sediment budget for St. Augustine Inlet and St. Johns County, Florida, was developed for the 1999 to 2010 period. Development of the sediment budget had three main objectives: characterize the transport pathways and magnitudes for the 1999 to 2010 period, compare to an earlier sediment budget for 1974 to 1995 (Srinivas and Taylor 1998), and provide input to numerical modeling of the region (Reports 2 and 3, Beck and Legault 2012a,b). An innovative method was developed to create an inlet sediment budget using high quality measured volume changes for an inlet and beach system. Methods described in the Coastal Engineering Manual (CEM-V-6 2008) and Bodge (1999) were applied to determine the extent of inlet influence along the adjacent beaches, the total inlet sink, and a regional sediment budget for a given set of measured volume changes occurring at St. Augustine Inlet in northeast Florida, U.S.A.

MIRIAD--Public release of a multiple time point Alzheimer's MR imaging dataset.

The Minimal Interval Resonance Imaging in Alzheimer's Disease (MIRIAD) dataset is a series of longitudinal volumetric T1 MRI scans of 46 mild–moderate Alzheimer's subjects and 23 controls. It consists of 708 scans conducted by the same radiographer with the same scanner and sequences at intervals of 2, 6, 14, 26, 38 and 52 weeks, 18 and 24 months from baseline, with accompanying information on gender, age and Mini Mental State Examination (MMSE) scores. Details of the cohort and imaging results have been described in peer-reviewed publications, and the data are here made publicly available as a common resource for researchers to develop, validate and compare techniques, particularly for measurement of longitudinal volume change in serially acquired MR.

Measurement of Orbital Volume after Enucleation and Orbital Implantation

IntroductionThis article reports experience relating to the measurement of orbital volume by means of cone beam computed tomography (CBCT) and Cranioviewer program software in patients who have undergone enucleation and orbital implantation.Patients and MethodsCBCT scans were made in 30 cases, 10 of which were later excluded because of various technical problems. The study group therefore consisted of 20 patients (8 men and 12 women). The longest follow-up time was 7 years, and the shortest was 1 year. In all 20 cases, the orbital volume was measured with Cranioviewer orbital program software. Slices were made in the ventrodorsal direction at 4.8 mm intervals in the frontal plane, in both bony orbits (both that containing the orbital implant and the healthy one). Similar measurements were made in 20 patients with various dental problems. CBCT scans were recorded for the facial region of the skull, containing the orbital region. The Cranioviewer program can colour the area of the slices red, and it automatically measures the area in mm.ResultsIn 5 of the 20 cases, the first 4 or all 5 slices revealed that the volume of the operated orbit was significantly smaller than that of the healthy orbit, in 12 cases only from 1 to 3 of the slices indicated such a significant difference, and in 3 cases no differences were observed between the orbits. In the control group of patients with various dental problems, there was no significant difference between the two healthy orbits. The accuracy of the volume measurements was assessed statistically by means of the paired samples t-test.SummaryTo date, no appropriate method is avaliable for exact measurement of the bony orbital volume, which would be of particular importance in orbital injury reconstruction. However, the use of CBCT scans and Cranioviewer orbital program software appears to offer a reliable method for the measurement of changes in orbital volume.

A Method for Determining Optimal Mean Airway Pressure in High-Frequency Oscillatory Ventilation

"Optimal" mean airway pressure (MAP) during high-frequency oscillatory ventilation (HFOV) can be defined as the pressure that allows for maximal alveolar recruitment while minimizing alveolar overdistension. Choosing a MAP near or just below the point of maximal curvature (PMC) of the volume-pressure characteristics of the lung can serve as a guide to avoid overdistention during HFOV, while simultaneously preventing derecruitment. The purpose of this study was to assess whether optimal MAP at the PMC can be determined by using measures of PaO(2) in patients with acute respiratory distress syndrome (ARDS) undergoing HFOV. We prospectively studied seven patients with ARDS who underwent HFOV after failed conventional ventilation. In addition, 11 healthy subjects were studied to validate measurements of changes in end-expiratory lung volume (∆EELV) using magnetometers. Using this validated method, plots of ∆EELV and MAP were constructed during decremental changes in MAP following a recruitment maneuver in seven ventilated patients with ARDS. The PMC was defined as the point where the slope of the ∆EELV versus MAP curve acutely changed. The MAP at the PMC was compared to that determined from plots of PaO(2) versus MAP. In the healthy cohort, measurements of ∆EELV obtained by magnetometry approximated the line of identity when compared to those obtained by spirometry. The MAP determined using either the ∆EELV or PaO(2) techniques were identical in all seven HFOV ventilated patients. Additionally, there was a significant correlation between the MAP associated changes in PaO2 and the MAP associated changes in ∆EELV (p<0.001). The finding that MAP at the PMC is the same whether determined by measures of ∆EELV or PaO(2) suggest that bedside measures PaO(2) may provide an acceptable surrogate for measures of EELV when determining "optimal" MAP during HFOV.

Discussion of: Theuerkauf, E.J. and Rodriguez, A.B., 2012. Impacts of Transect Location and Variations in Along-Beach Morphology on Measuring Volume Change.Journal of Coastal Research,28(3), 707–718.

Theuerkauf and Rodriguez (2012) utilized terrestrial laser scanning data obtained at Onslow Beach, North Carolina to create digital elevation models and quantify volumetric beach change; and compared their results with data derived from traditional beach profiling. The authors conclude full coverage datasets such as those obtained by terrestrial laser scanning and LIDAR can be used to more accurately quantify volume change, and furthermore are superior to the profile method when measuring storm response, coordinating research and engineering projects, and for other coastal management endeavors. However the inability to capture the dune and offshore environments by these methods is identified as a major shortcoming of the article and the terrestrial laser scanning technique utilized by Theuerkauf and Rodriguez (2012) is further compromised by survey accuracy repeatability issues, and constant on-the-fly changing of the survey boundaries to capture small-scale geomorphic features over large areas of the beach. This conversely augments the value of beach profiling as a suitable method for describing short- and long-term changes over expansive stretches of shoreline such as Bogue Banks, North Carolina for research and coastal management activities.

Respiratory function monitoring using a real-time three-dimensional fiber-optic shaping sensing scheme based upon fiber Bragg gratings

An array of in-line curvature sensors on a garment is used to monitor the thoracic and abdominal movements of a human during respiration. The results are used to obtain volumetric changes of the human torso in agreement with a spirometer used simultaneously at the mouth. The array of 40 in-line fiber Bragg gratings is used to produce 20 curvature sensors at different locations, each sensor consisting of two fiber Bragg gratings. The 20 curvature sensors and adjoining fiber are encapsulated into a low-temperature-cured synthetic silicone. The sensors are wavelength interrogated by a commercially available system from Moog Insensys, and the wavelength changes are calibrated to recover curvature. A three-dimensional algorithm is used to generate shape changes during respiration that allow the measurement of absolute volume changes at various sections of the torso. It is shown that the sensing scheme yields a volumetric error of 6%. Comparing the volume data obtained from the spirometer with the volume estimated with the synchronous data from the shape-sensing array yielded a correlation value 0.86 with a Pearson's correlation coefficient p<0.01.

Monitoring thickness and volume changes of the Dongkemadi Ice Field on the Qinghai-Tibetan Plateau (1969–2000) using Shuttle Radar Topography Mission and map data

This paper presents the first measurement of multi-decadal thickness and volume changes (1969–2000) of the Dongkemadi Ice Field (DIF) in the Tanggula Mountains, central Qinghai-Tibetan Plateau, China, using multi-source remote sensing data. These include the Shuttle Radar Topography Mission (SRTM) Digital Elevation Model (DEM) acquired in February, 2000, a DEM generated by digitising analogue topographic maps from 1969, and Landsat ETM+ imagery from 2000. Digital glacier outlines and GIS-based processing were used to calculate an elevation difference map to evaluate the relative elevation error of these two DEMs over ice-free areas. This method was also used to identify regions of glacier elevation thinning and thickening corresponding to glacier mass loss and gain. Analysis of 67,520 points on flat grass and rock terrain surrounding the DIF, with a slope less than 25°, showed a mean elevation difference of –0.90 m and a standard deviation of 5.58 m. A thickness change error within ±6 m was estimated. Between 1969 and 2000, 76.51% of the whole DIF area appeared to be thinning while 23.49% showed thickening. The average glacier surface thinning was –12.58 m with a standard deviation of 18.29 m and the estimated volume loss was 1.17 km3. The standard deviation of volume change was 0.0006 km3 over the DIF. A thinning rate up to 0.41±0.194 m a−1 or 0.038 km3 a−1 for the volume loss was observed for the whole ice field, which seems to be evidence for the ongoing retreat of glaciers on the Qinghai-Tibetan Plateau. It was found that the spatial thickness change pattern derived from the remote sensing method was consistent with the thickness change results of the Small Dongkemadi Glacier (SDG) from field measurements. The estimated error of the annual thickness change rate was on the order of 5%. The relationship between elevation change and absolute glacier elevation over typical glaciers was also analysed, showing considerable variability. These changes have possibly resulted from increased temperature and decreased precipitation in this region.

Development of Diurnal Micturition Pattern in Mice After Weaning

The development of micturition in mice has been poorly studied because of the minute urine volume voided per micturition. We characterized development of the micturition pattern in young mice. Micturition in young and adult C57BL/6 strain mice, including 5 males and 4 females at age 3 weeks immediately after weaning, and 5 of each gender at ages 9 to 10 weeks, respectively, was recorded by the automated voided stain on paper method. Micturition data were obtained under 12-hour light/dark cycles in young mice for 16 days and in adult mice for 4 days. Diurnal variations were assessed during 8 hours until the first void after lights off and those until lights on. The 24-hour rhythmicity of urinary frequency was calculated for 4-day data at the beginning and at the end on young mice, and for 4-day data on adult mice using a chi-square periodogram and relative power spectral density. Mean frequency was 20 to 30 times per day. Total daily urine volume and mean daily urine volume voided per micturition increased with age. The diurnal rhythm of frequency matured to adult levels with development, which was primarily achieved by maturation of the diurnal variation of urine volume in male mice, followed by female mice. Diurnal variation of urine volume voided per micturition was indistinct at the initial stage and gradually matured toward adult levels. The automated voided stain on paper method was used to record micturition development in young mice. This generated data corresponding to frequency-volume charts in humans. Our findings could lead to the establishment of a mouse model of developmental micturition disorders, such as nocturnal enuresis.

The potential of scanning microcalorimetry for studying thermotropic conformational transitions in biomacromolecules1

General operational principles of a scanning microcalorimeter, methods and approaches to obtaining thermodynamic and kinetic information on the studied transition, and the existence of correlations between the structural features of a macromolecule and the measured thermodynamic parameters of denaturation transitions are considered. The results of studying the domain organization for a number of proteins and transfer poly(ribonucleic acids), the kinetics of heat denaturation, and the nature of the transitional (activated) state of macromolecules are surveyed. The potential of high-pressure scanning microcalorimetry for measuring volume changes during conformational transitions of proteins and lipids is discussed.

Evidence for water-permeable channels in auditory hair cells in the leopard frog

Auditory hair cells in the amphibian papilla (APHCs) of the leopard frog, Rana pipiens pipiens, have a significantly higher permeability to water than that observed in mammalian hair cells. The insensitivity of water permeability in frog hair cells to extracellular mercury suggests that an amphibian homologue of the water channel aquaporin-4 (AQP4) may mediate water transport in these cells. Using immunocytochemistry, we show that an AQP4-like protein is found in APHCs. Rabbit anti-AQP4 antibody was used in multiple-immunohistochemical staining experiments along with AP hair cell and hair bundle markers in leopard frog and mouse tissue. AQP4 immunoreactivity was found in the basal and apical poles of the APHCs and shows uniform immunoreactivity. This study provides the first identification and localization of an AQP4-like protein in the amphibian inner ear. We also report a more direct measure of hyperosmotically-induced volume changes in APHCs that confirms previous findings. The presence of water channels in anuran APHCs constitutes a novel physiological difference between amphibian and mammalian hair cell structure and function.