Specific Absorption Rate Measurements Research Articles

Electromagnetic Head-And-Neck Hyperthermia Applicator: Experimental Phantom Verification and FDTD Model

To experimentally verify the feasibility of focused heating in the neck region by an array of two rings of six electromagnetic antennas. We also measured the dynamic specific absorption rate (SAR) steering possibilities of this setup and compared these SAR patterns to simulations. Using a specially constructed laboratory prototype head-and-neck applicator, including a neck-mimicking cylindrical muscle phantom, we performed SAR measurements by electric field, Schottky-diode sheet measurements and, using the power-pulse technique, by fiberoptic thermometry and infrared thermography. Using phase steering, we also steered the SAR distribution in radial and axial directions. All measured distributions were compared with the predictions by a finite-difference time-domain-based electromagnetic simulator. A central 50% iso-SAR focus of 35 +/- 3 mm in diameter and about 100 +/- 15 mm in length was obtained for all investigated settings. Furthermore, this SAR focus could be steered toward the desired location in the radial and axial directions with an accuracy of approximately 5 mm. The SAR distributions as measured by all three experimental methods were well predicted by the simulations. The results of our study have shown that focused heating in the neck is feasible and that this focus can be effectively steered in the radial and axial directions. For quality assurance measurements, we believe that the Schottky-diode sheet provides the best compromise among effort, speed, and accuracy, although a more specific and improved design is warranted.

Low SAR Ferrite Handset Antenna Design

The benefits resulting from the inclusion of ferrite in material loaded antennas are investigated, initially through the use of a spherical analytic model and then through a transmission line matrix simulation tool applied to a rectangular slab geometry. It is observed that a material with equality of relative permittivity and permeability in combination with specific positioning of the antenna in relation to the head, can result in the definitive small-size, high efficiency and bandwidth, low specific absorption rate (SAR) antenna. The accuracy of the simulations is validated both through efficiency and SAR measurements of three material coated monopole samples. Further research into optimizing the above attributes and translating them into a handset antenna leads to a multiband antenna design covering the GSM 1800, 1900, UMTS and Bluetooth bands, with a SAR value reduced by 88% compared to conventional phones and an efficiency of 38% at 1.8 GHz. A tri-band antenna design is also presented, utilizing currently available lossy ferrite material and it is considered as the first step towards the feasibility of the ultimate low SAR multiband ferrite handset antenna, until further material development specifically for antenna applications takes place

Dielectric metrology with coaxial sensors

Coaxial sensors are used in applications that require accurate and traceable measurements of complex permittivity. For example, coaxial sensors are often used for measurement of the complex permittivity of tissue equivalent materials (TEMs) used in specific absorption rate (SAR) measurements of exposure to RF fields. It is therefore important that well-founded metrological techniques for their use are developed and published. Although there are many published papers on coaxial sensors, few discuss the experimental techniques required to obtain the most accurate results. In this paper experimental approaches for obtaining the most accurate measurements are described. Common pitfalls with the technique are discussed. A Monte Carlo modelling (MCM) technique is used to provide estimates of uncertainty which are compared to those of measurements on reference liquids made with 3.5 mm, 7 mm and 15.1 mm diameter sensors. The MCM technique allows uncertainties to be estimated when measuring dielectrics for which there are no reference materials that have comparable properties, for example for TEMs at frequencies below 100 MHz.

Measurement of Specific Absorption Rate and Thermal Simulation for Arterial Embolization Hyperthermia in the Maghemite-Gelled Model

Theoretical models are designed to be applied in hyperthermia treatment planning and to help optimize the surgical treatment procedures. However, it is difficult to obtain every physical parameter of the magnetic field in the living tissue in detail, which is necessary for the calculation. We therefore investigated the simulation of thermal distribution in arterial embolization hyperthermia (AEH) stimulated by the external ferrite-core applicator, and measured specific absorption rate (SAR) of magnetic nanoparticles in the maghemtite-gelled composite model. We used fiber optic temperature sensors (FOTS) to measure the values of SAR, which depend on the microstructure and sizes of particles and the intensity and frequency of external ac magnetic field. Detailed tests indicated that the attenuation of magnetic field was mainly focused on the vertical distance in the aperture of the apparatus. We built a simplified cylindrical phantom containing maghemite particles of 20 nm for thermal field simulation on the basis of SAR measurement. The results of simulation indicated that temperature elevation, induced by nanoparticles inside tumors under ac magnetic field, was dose-dependent. The temperature data acquired from the experiment were compatible with the theoretical results, which demonstrated that the current model considering the inhomogenous heat generation could provide accurate and reliable simulation results and a theoretical and technical basis for controlling temperature during AEH therapy

Near-Field Mapping System Using Fiber-Based Electro-Optic Probe for Specific Absorption Rate Measurement

We have developed a near-field mapping system with a fiber-based electro-optic (EO) probe for microwave antenna characterization. In this probe, an EO crystal is mounted on the tip of an optical fiber through a collimating lens. Since the lens allows the crystal thickness to be lengthened by reducing the loss of an optical beam coupling back to the optical fiber, sensitivity is improved. Because the tip of the EO probe consists of a 1-mm-cubic EO crystal and contains no metallic components, there is very little disturbance of the mapped electric field. Fixing the optical fiber in a thin glass tube provides stable sensitivity during long-term mapping over a large area. The fabricated EO probe has a dynamic range larger than 45 dB, flat sensitivity from 1.95 to 20 GHz, and directivity with cross-axis sensitivity isolation greater than 30 dB, A comparison of the measured and calculated near fields of a dipole antenna showed negligible static or inductive coupling between the EO probe and the dipole antenna. Using a tissue-equivalent phantom to assess the specific absorption rate (SAR), we demonstrated the potential of the EO probe for mapping the electric field with information of amplitude and phase. The EO probe can detect an electric field of less than 0.6 V/m, which corresponds to a SAR of 0.5 mW/kg. This value satisfies the minimum detection limit defined in the regulations for determining SAR. This result shows the potential of the near-field mapping system with the fiber-based EO probe in practical applications.

Comparative evaluation of heating ability and biocompatibility of different ferrite‐based magnetic fluids for hyperthermia application

In this study, lauric acid-coated, superparamagnetic, nanoparticle-based magnetic fluids of different ferrites (Fe(3)O(4), MnFe(2)O(4), and CoFe(2)O(4)) were prepared and compared in terms of heating ability and biocompatibility to evaluate the feasibility of use in hyperthermia treatment of cancer. All the magnetic fluids prepared had particles of average sizes 9-11 nm. Heating ability of these magnetic fluids was evaluated by calorimetric measurement of specific absorption rate (SAR) at 300 kHz frequency and 15 kA/m field. Fe(3)O(4) and MnFe(2)O(4) showed higher SAR (120 and 97 W/g of ferrite, respectively) than CoFe(2)O(4) (37 W/g of ferrite). In vitro study on BHK 21 cell lines showed dose-dependent cell viability for all the magnetic fluids. Threshold-biocompatible ferrite concentration for all the magnetic fluids was 0.1 mg/mL. Above 0.2 mg/mL, CoFe(2)O(4) was more toxic than the other magnetic fluids. On intravenous injection of different doses (50, 200, and 400 mg/kg body weight) of magnetic fluids in mice, no significant changes in hematological and biochemical parameters were observed for Fe(3)O(4) and MnFe(2)O(4). With CoFe(2)O(4), an increase in SGPT levels at a dose rate of 400 mg/kg body weight was observed, indicating its mild hepatotoxic effect. However, histology of different vital organs showed no pathological changes for all the three magnetic fluids. Further, long term in vivo evaluation of biocompatibility of the lauric acid-coated ferrites is warranted. This study shows that lauric acid-coated, superparamagnetic Fe(3)O(4) and MnFe(2)O(4) may be used for hyperthermia treatment and are to be preferred over CoFe(2)O(4).

FDTD calculation of whole-body average SAR in adult and child models for frequencies from 30 MHz to 3 GHz

Due to the difficulty of the specific absorption rate (SAR) measurement in an actual human body for electromagnetic radio-frequency (RF) exposure, in various compliance assessment procedures the incident electric field or power density is being used as a reference level, which should never yield a larger whole-body average SAR than the basic safety limit. The relationship between the reference level and the whole-body average SAR, however, was established mainly based on numerical calculations for highly simplified human modelling dozens of years ago. Its validity is being questioned by the latest calculation results. In verifying the validity of the reference level with respect to the basic SAR limit for RF exposure, it is essential to have a high accuracy of human modelling and numerical code. In this study, we made a detailed error analysis in the whole-body average SAR calculation for the finite-difference time-domain (FDTD) method in conjunction with the perfectly matched layer (PML) absorbing boundaries. We derived a basic rule for the PML employment based on a dielectric sphere and the Mie theory solution. We then attempted to clarify to what extent the whole-body average SAR may reach using an anatomically based Japanese adult model and a scaled child model. The results show that the whole-body average SAR under the ICNIRP reference level exceeds the basic safety limit nearly 30% for the child model both in the resonance frequency and 2 GHz band.

Effect of Amplitude Modulation of the CDMA IS-95 Signal on SAR Measurements

Miniature probes employed for specific absorption rate (SAR) measurements are typically calibrated using a sinusoidal waveform (SW), even though they may be employed to measure a wide variety of communication signals with complex waveforms. This paper shows that the compression produced by the nonlinear response of the probe versus SAR, due to its diode detector, may introduce a significant overestimation of the SAR produced by CDMA IS-95 waveforms when the diode detector operates well into the compression region. This finding is demonstrated theoretically, verified numerically and experimentally, and physically interpreted. The effect is typically small and may be neglected in many practical circumstances involving low-power RF energy emitters, such as mobile phones or two-way dispatch radios

Reliability of temperature and SAR measurements at oesophageal tumour locations

Introduction: For treatment of oesophageal cancer, neo-adjuvant locoregional hyperthermia (HT) has been applied in combination with chemotherapy (ChT) ± radiotherapy (RT) at the institute. Until now, 26 patients were treated within a completed phase I study combining HT with ChT and 29 patients within an ongoing phase II study combining HT with ChT + RT.Methods: HT was given with the 70 MHz AMC-4 waveguide system. Initially, oesophageal temperatures were measured using multi-sensor thermocouple probes (TCs) inside a nasogastric tube (NT), but the question arose whether these measurements were reliable enough to quantify the achieved tumour temperatures accurately. Presently, TCs are mounted on the outside of an inflatable balloon catheter (BC) for better intra-luminal fixation and better contact with the tumour. During 14 treatment sessions in four patients TCs inside a NT and mounted on a BC were used simultaneously. Data from these 14 treatment sessions were used to compare temperature and Specific Absorption Rate (SAR) measurements (‘ΔT-measurements’) using NTs or BCs. To determine the predictive value of the local SAR for the tumour temperatures achieved during treatment, the relation between the initial ΔT and steady state temperature (SST) was evaluated.Results: There was a strong correlation between the temperature measured in the NT (Ttube) and the temperature measured with a BC (Tballoon): R = 0.88 ± 0.13. However, Ttube was on average ∼1°C higher than Tballoon and there was a large variation between the different treatments in the relation between both measurements, rendering Ttube a probably unreliable measure for tumour temperatures. The correlation between the ΔT measured in the NT (ΔTtube) and with a BC (ΔTballoon) was rather weak: R = 0.46 ± 0.25. The correlation between the initial ΔT and the SST was much stronger for the BC measurements, R = 0.78 ± 0.19, than for the NT measurements, R = 0.61 ± 0.23. Thus, ΔTballoon has a higher predictive value for the achieved tumour temperatures than ΔTtube. Both ΔT and SST were generally higher for the NT measurements than for the BC measurements, suggesting an over-estimation of tumour temperatures. Averaged over all treatments in the phase I trial using a NT (20 treatments) or a BC (45 treatments), T90 was significantly higher when measured with a NT.Conclusion: Oesophageal temperature and SAR (ΔT) measurements inside a NT are less reliable than BC measurements. These artefacts are due to bad thermal contact with the tumour tissue and are, therefore, not specific for thermocouple thermometry. For reliable temperature or SAR measurements inside lumina or cavities good thermal contact must be assured, e.g. by using a balloon catheter.

Biological Tissue-Equivalent Agar-Based Solid Phantoms and SAR Estimation Using the Thermographic Method in the Range of 3-6 GHz

In this paper, the electrical constants of a biological tissue-equivalent agar-based solid phantom from 3.0 to 6.0GHz are described. The developed phantom can reproduce the electrical constants of biological tissues from 3.0 to 6.0 GHz, and it is not necessary to change the phantom for each frequency band in the range of 3.0 to 6.0 GHz during the measurements. Moreover, adjustments to the dielectric constants of the phantom at 3.0, 3.8, 5.2, and 5.8 GHz are presented. The constants of this phantom can be adjusted mainly by using polyethylene powder and sodium chloride. The phantom can be used to evaluate the Specific Absorption Rate (SAR) as well as the antenna characteristics in the range of 3.0 to 6.0 GHz. Furthermore, the effect of the electrical constants of the phantom on the SAR is investigated. The investigation of SAR measurements is performed on the phantom at 5.2 GHz using the thermographic method. Calculations using the FD-TD method and the finite difference method based on the heat conduction equation are carried out in order to evaluate the thermal diffusion in the measurements using the thermographic method. The measured and calculated results are in good agreement. There is evidence that the thermal diffusion influences the SAR estimation at 5,2 GHz more than in a lower frequency range even though this method basically does not depend on the frequency.

Influence of Phantom Shell on SAR Measurement in 3-6 GHz Frequency Range

SUMMARY This paper presents the results of an investigation on the effect of a thin low-dielectric material (phantom shell) on measuring the Specific Absorption Rate (SAR) in the frequency range of 3 to 6 GHz. The International Electrotechnical Commission (IEC) has started to develop a SAR measurement procedure in order to cover such frequencies. In the procedure, the SAR is measured in a liquid phantom, which is a shell filled with tissue-equivalent liquid. Although the shell is thin and has low-dielectric properties, the influence of the phantom shell is thought to increase at higher frequencies. Therefore, an investigation using the transmission line model and the Finite-Difference Time-Domain (FD-TD) method was conducted. To verify the FD-TD results, measurements were also carried out. The calculation results using the FD-TD method agree well with the measurement results. If the frequency is higher, the SAR is affected by the shell even though the shell is thinner and has much lower dielectric properties than those of the tissue-equivalent liquid. Specifically, the SAR with the shell is approximately 1.3 times higher than without the shell at 5.2 GHz for the maximum case. The deviations in the loss and the thickness for the shell do not affect the SAR more than the relative permittivity.

Empirical and theoretical dosimetry in support of whole body radio frequency (RF) exposure in seated human volunteers at 220 MHz

This study reports the dosimetry performed to support an experiment that measured physiological responses of seated volunteer human subjects exposed to 220 MHz fields. Exposures were performed in an anechoic chamber which was designed to provide uniform fields for frequencies of 100 MHz or greater. A vertical half-wave dipole with a 90 degrees reflector was used to optimize the field at the subject's location. The vertically polarized E field was incident on the dorsal side of the phantoms and human volunteers. The dosimetry plan required measurement of stationary probe drift, field strengths as a function of distance, electric and magnetic field maps at 200, 225, and 250 cm from the dipole antenna, and specific absorption rate (SAR) measurements using a human phantom, as well as theoretical predictions of SAR with the finite difference time domain (FDTD) method. A NBS (National Bureau of Standards, now NIST, National Institute of Standards and Technology, Boulder, CO) 10 cm loop antenna was positioned 150 cm to the right, 100 cm above and 60 cm behind the subject (toward the transmitting antenna) and was read prior to each subject's exposure and at 5 min intervals during all RF exposures. Transmitter stability was determined by measuring plate voltage, plate current, screen voltage and grid voltage for the driver and final amplifiers before and at 5 min intervals throughout the RF exposures. These dosimetry measurements assured accurate and consistent exposures. FDTD calculations were used to determine SAR distribution in a seated human subject. This study reports the necessary dosimetry to precisely control exposure levels for studies of the physiological consequences of human volunteer exposures to 220 MHz.

Optimization of PIFA-IFA combination in handset antenna designs

As commercial needs have expanded the functions of the wireless cellular handsets, multiantenna development in one handset has become more and more common. This paper addresses a multiantenna solution for the wireless handset application. A planar inverted "F" antenna (PIFA) was designed as the main antenna of the handset to cover the 800 MHz band (824 MHz-894 MHz) and the 1900 MHz band (1850 MHz-1990 MHz). A side-mounted inverted "F" antenna (IFA) was designed as the 1575.42 MHz global positioning system (GPS) antenna. The location of the feed/ground pins of both antennas affected not only the total antenna efficiency, but also the polarization of the GPS IFA. The length of the GPS IFA affected the isolation between the two antennas and the specific absorption rate (SAR) of the PIFA at the 1900 MHz band. A three-dimensional efficiency measurement of the prototypes in both free space and against-head position will be presented. Measurement of SAR and its distribution will also be presented to demonstrate the impact of the IFA on the near field of the PIFA.

Consideration of SAR and TRP in handset antenna designs at 1900-MHz band

This paper compares four planar inverted “F” antenna (PIFA) models designed for the personal communication system (PCS) frequency band (1850–1990 MHz, also refer to as the 1900-MHz band). The ground-plane size, the dielectric substrate, and the feeding pin are fixed for all the antenna models. By moving the ground pin, three different-size patches are tuned to the 1900-MHz band. The fourth model is a dual-band design with a J-shaped slot. The impedance bandwidth and the free-space antenna efficiency are measured. The impact of the presence of a phantom head on the efficiency is also shown and analyzed. A prototype transmitter is then integrated into the antenna models with a mechanical chassis for specific absorption rate (SAR) measurements. The measured SAR distribution shows that by relocating the ground pin of the PIFA, the SAR can be reduced. For each case, the transmit (TX) power is adjusted to normalize the SAR, and then the total radiated power (TRP) is calculated and compared. © 2005 Wiley Periodicals, Inc. Microwave Opt Technol Lett 46: 569–573, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.21054

Faster Determination of Mass-Averaged SAR From 2-D Area Scans

An algorithm is presented that accurately and quickly estimates the peak 1or 10-g averaged specific absorption rate (SAR) in a human phantom when exposed to a wireless device. Instead of performing both an area scan and a zoom scan (as per international standards), only the area scan and knowledge of the transmit frequency are needed. The accuracy of the algorithm has been demonstrated across a broad frequency range (150-2450 MHz) and for both 1- and 10-g averaged SAR using a sample of 264 SAR measurements from 55 wireless handsets. For the sample size studied, the root-mean-squared errors of the algorithm are 1.2% and 5.8% for 1- and 10-g averaged SAR, respectively. It is shown that the algorithm works well in both head and body phantoms.

Effect of Dielectric Properties on the Peak1-and 10-g SAR for 802.11 a/b/g Frequencies 2.45 and 5.15 to 5.85 GHz

Compliance with 1- or 10-g specific absorption rate (SAR) safety guidelines is required in various countries for all newly-introduced personal wireless devices such as Wi-Fi PCs. Even though the dielectric properties of the human tissues are known to be nonuniform and highly variable, relatively rigid adherence to prescribed dielectric properties (/spl epsiv//sub r/,/spl sigma/) is required for compliance testing of such devices. Using some typical near-field radiators, we have examined the effect of dielectric properties for SAR measurement fluids with conductivities varying by 2:1 to show that both 1- and 10-g SARs vary by less than /spl plusmn/2%-4% for the 802.11a band 5.15 to 5.825 GHz and only slightly more at the lower 802.11 b/g frequency of 2.45 GHz. This is due to higher surface SAR but shallower depth of penetration of EM fields for the higher conductivity media resulting in nearly identical SARs for cubical volumes associated with 1- or 10-g of tissue, respectively. Also studied, is the effect of lower /spl epsiv//sub r/ fluids recommended in some standards which results in slightly higher and, thus, a conservative assessment of SAR.

Rapid SAR measurement of mobile phones

Specific Absorption Rate (SAR) designates the electromagnetic power density deposited per unit mass of biological tissues. This paper presents a new approach where SAR calculation for mobile phones is based on a parametric reconstruction of the E-field distribution in the phantom to assess rapid SAR measurements, by means of an ellipsoidal model. The estimation of its parameters is achieved by two ways: using a reduced number of real data points exclusively, and using a combination of real data points and E-field extrapolation with a given expansion model.

Dielectric Properties of Tissue-Equivalent Liquids and Their Effects on Specific Absorption Rate

The radio frequency safety of mobile phones has been evaluated in terms of specific absorption rate (SAR). Standard methods for measurement of the SAR, including recipes for tissue-equivalent dielectric liquids, have recently been the subject of discussion among international standards organizations. Standards currently recommend glycol-type liquids as tissue-equivalent liquids for frequencies above 1 GHz. Although the ingredients are specified in the recipes provided, some fundamental information, such as the stability of dielectric properties, remains unclear. We measured the change of dielectric properties with time and with temperature of tissue-equivalent liquids recommended in the standard documents, and evaluated their effects on SAR. The conductivity decreased with increasing temperature in all glycol-type specimens. The permittivity, on the other hand, was almost constant. With the evaporation of water, the permittivity decreased, although the conductivities remained constant. Experimental results proved that dielectric properties are affected by environmental conditions, and that it is inevitably necessary to adjust the dielectric properties regularly, through the addition of ingredients, in order to follow the standards. The SAR values, however, were not affected significantly by the change in dielectric properties; thus, a larger tolerance of the dielectric properties may be acceptable in practical SAR measurements.

Size of head phantoms for standard measurements of SAR due to wireless communication devices

AbstractIn recent years, a project on the standardization of measurement methods for the head specific absorption rate (SAR) while using cellular phones has been in progress in Japan, Europe, and the United States. In order to achieve international coordination, it is desirable that head phantoms of the same shape be used in all countries; these are based on statistical data on European and American human sizes. However, the validity of application to the Japanese standard head phantoms which are generally of a larger size than the Japanese human size has not been established. Consequently, SAR measurements are made in this study with head phantoms based on the 90th‐percentile values of the head shape statistics of Europeans and Americans (E/A) and head phantoms based on the average Japanese adult male head shape (JP) in order to investigate the dependence of the head SAR on the phantom size. A numerical simulation is also performed, and the effect of the head phantom size on the current distribution on a cellular phone is also investigated. Based on these studies, it is found that the effect of the head phantom characteristics on the head SAR is small compared to the effect of the position of the cellular phone in the measurements, and that the effect on the current distribution on the cellular phone is also small. It is shown that for all three types of cellular phone models, that is, thick, thin, and folding types, that the E/A phantoms have roughly the same or larger maximum local SAR values than the JP phantoms. © 2003 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 87(4): 82–91, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecja.10083

In vitro assessment of tissue heating near metallic medical implants by exposure to pulsed radio frequency diathermy

A patient with bilateral implanted neurostimulators suffered significant brain tissue damage, and subsequently died, following diathermy treatment to hasten recovery from teeth extraction. Subsequent MRI examinations showed acute deterioration of the tissue near the deep brain stimulator (DBS) lead's electrodes which was attributed to excessive tissue heating induced by the diathermy treatment. Though not published in the open literature, a second incident was reported for a patient with implanted neurostimulators for the treatment of Parkinson's disease. During a diathermy treatment for severe kyphosis, the patient had a sudden change in mental status and neurological deficits. The diathermy was implicated in causing damage to the patient's brain tissue. To investigate if diathermy induced excessive heating was possible with other types of implantable lead systems, or metallic implants in general, we conducted a series of in vitro laboratory tests. We obtained a diathermy unit and also assembled a controllable laboratory exposure system. Specific absorption rate (SAR) measurements were performed using fibre optic thermometry in proximity to the implants to determine the rate of temperature rise using typical diathermy treatment power levels. Comparisons were made of the SAR measurements for a spinal cord stimulator (SCS) lead, a pacemaker lead and three types of bone prosthesis (screws, rods and a plate). Findings indicate that temperature changes of 2.54 and 4.88 °C s−1 with corresponding SAR values of 9129 and 17 563 W kg−1 near the SCS and pacemaker electrodes are significantly higher than those found in the proximity of the other metallic implants which ranged from 0.04 to 0.69 °C s−1 (129 to 2471 W kg−1). Since the DBS leads that were implanted in the reported human incidents have one-half the electrode surface area of the tested SCS lead, these results imply that tissue heating at rates at least equal to or up to twice as much as those reported here for the SCS lead could occur for the DBS leads.