Measurement Of Lower Limb Alignment Research Articles

Automatic measurement of lower limb alignment in portable devices based on deep learning for knee osteoarthritis

BackgroundFor knee osteoarthritis patients, analyzing alignment of lower limbs is essential for therapy, which is currently measured from standing long-leg radiographs of anteroposterior X-ray (LLR) manually. To address the time wasting, poor reproducibility and inconvenience of use caused by existing methods, we present an automated measurement model in portable devices for assessing knee alignment from LLRs.MethodWe created a model and trained it with 837 conforming LLRs, and tested it using 204 LLRs without duplicates in a portable device. Both manual and model measurements were conducted independently, then we recorded knee alignment parameters such as Hip knee ankle angle (HKA), Joint line convergence angle (JCLA), Anatomical mechanical angle (AMA), mechanical Lateral distal femoral angle (mLDFA), mechanical Medial proximal tibial angle (mMPTA), and the time required. We evaluated the model’s performance compared with manual results in various metrics.ResultIn both the validation and test sets, the average mean radial errors were 2.778 and 2.447 (P<0.05). The test results for native knee joints showed that 92.22%, 79.38%, 87.94%, 79.82%, and 80.16% of the joints reached angle deviation<1° for HKA, JCLA, AMA, mLDFA, and mMPTA. Additionally, for joints with prostheses, 90.14%, 93.66%, 86.62%, 83.80%, and 85.92% of the joints reached that. The Chi-square test did not reveal any significant differences between the manual and model measurements in subgroups (P>0.05). Furthermore, the Bland-Altman 95% limits of agreement were less than ± 2° for HKA, JCLA, AMA, and mLDFA, and slightly more than ± 2 degrees for mMPTA.ConclusionThe automatic measurement tool can assess the alignment of lower limbs in portable devices for knee osteoarthritis patients. The results are reliable, reproducible, and time-saving.

High survivorship and low complication rate in a single-centre series of 651 medial opening wedge high tibial osteotomy cases with a mean follow-up of 13 years.

This study aimed to report the early to midterm results of medial opening wedge high tibial osteotomy (MOWHTO) from the largest single-centre osteotomy database. The primary outcomes were reporting the radiological corrections and the functional outcomes represented by multiple patient-reported outcome measures (PROMs). The secondary outcomes were to report the complications, revisionsand survivorship up to 10 years postoperatively. A prospectively maintained single-centre database of 1138 knee osteotomies was retrospectively reviewed. Patients who underwent MOWHTO and met the inclusion criteria were included. Those inclusion criteria were moderate to severe knee pain that failed conservative management;varus knee malalignment; and isolated medial osteoarthritis of the knee. A total of 651 cases, with a mean age of 46.7 ± 9 years and a mean body mass indexof 29.6 ± 5.2 kg/m2 , were included. This comprised 71% males (n = 462) and 29% females (n = 189). The mean follow-up was 158.1 ± 45.4 months. Multiple PROMs were recorded preoperatively and serially postoperatively. This included the Knee injury andOsteoarthritisOutcome Scores, the Oxford Knee Score, the Oxford Knee Score-Activity and Participation Questionnaire, the Western Ontario and McMaster University Scores, the Visual Analogue Scale for health and pain, and the EQ-5D, which is a standardised measure of health-related quality of life. All lower limb alignment measurements were recorded pre- and postoperatively. The rates of osteotomy revision, conversion to arthroplasty, complications, and 5- and 10-year survivorship were recorded. A total of 651 cases were followed up to a mean of 158.1 ± 45.4 months. The mean planned correction angle was 7.6° ± 2.9°. The mean planned opening wedge distance was 8.1 ± 3.1 mm. The mean intraoperative anterior and posterior osteotomy gaps opening were 7.7 ± 3.4and 8.9 ± 3.8 mm, respectively. Postoperatively, the mean mechanical tibiofemoral angle improved from -5.7° ± 2.9° varus to 1.3° ± 2.5° valgus, the mean medial proximal tibial angle improved from preoperative 85.5° ± 2.3° to postoperative 91.6° ± 2.7°and the mean Mikulicz point improved from 21.7 ± 12.6% to 54.8 ± 11% (all p values < 0.001). All PROMs significantly improved at 24 months follow-up (all p values < 0.001). The rate of osteotomy revision was 1.1% at a mean of 2 ± 2.5 years postoperatively. The overall rate of arthroplasty conversion was 9.1%. This comprised 5.8% total knee arthroplasty conversion at a mean of 6.9 ± 3.5 years postoperatively and 3.2% unicompartmental knee arthroplasty conversion at a mean of 5.7 ± 2.5 years postoperatively. An overall 10.3% complication rate was recorded. The 5 and 10-year survivorship was 97.2%and 91.9%, respectively. MOWHTOis a radiologically and clinically rewarding procedure with a high survival rate at 5 and 10 years and a low complication rate in experienced hands. MOWHTO should be considered in patients presenting with medial unicompartmental knee pain with an evidence of overload and a varus mechanical coronal plane axis. Level IV, retrospective cohort study.

Effect of limb rotation on radiographic alignment measurement in mal-aligned knees

PurposeLong-leg-radiography (LLR) is commonly used for the measurement of lower limb alignment. However, limb rotations during radiography may interfere with the alignment measurement. This study examines the effect of limb rotation on the accuracy of measurements based on the mechanical and anatomical axes of the femur and tibia, with variations in knee flexion and coronal deformity.MethodsForty-five lower limbs of 30 patients were scanned with CT. Virtual LLRs simulating five rotational positions (neutral, ± 10^{circ }, and ± 20^{circ } internal rotation) were generated from the CT images. Changes in the hip–knee–ankle angle (HKA) and the femorotibial angle (FTA) were measured on each image with respect to neutral values. These changes were related to knee flexion and coronal deformity under both weight- and non-weight-bearing conditions.ResultsThe measurement errors of the HKA and FTA derived from limb rotation were up to 4.84 ± 0.66^{circ } and 7.35 ± 0.88^{circ }, respectively, and were correlated with knee flexion (p < 0.001) and severe coronal deformity (p < 0.001). Compared with the non-weight-bearing position, the coronal deformity measured in the weight-bearing condition was 2.62^{circ } greater, the correlation coefficients between the coronal deformity and the deviation ranges of HKA and FTA were also greater.ConclusionsFlexion and severe coronal deformity have a significant influence on the measurement error of lower limb alignment. Errors can be amplified in the weight-bearing condition compared with the non-weight-bearing condition. When using HKA and FTA to represent the mechanical axis and the anatomical axis on LLR, limb rotation impacts the anatomic axis more than the mechanical axis in patients with severe deformities. Considering LLR as the gold standard image modality, attention should be paid to the measurement of knee alignment. Especially for the possible errors derived from weight-bearing long-leg radiographs of patients with severe knee deformities.

Assessment of micro-dose biplanar radiography in lower limb measurements in children.

To evaluate in children microdose protocol compared with low dose for lower limb alignment (LLA) measurements on biplanar radiography. Children 6 years or older were included. Height, weight and hip width were measured prior to imaging. Hip width allowed classifying children into morphotype M1 (width <25 cm), M2 (25-35 cm) or M3 (>35 cm) corresponding to predefined acquisition parameters (kV, mA, tube speed). Micro- and low-dose protocols were used alternately, with simultaneous acquisition of frontal and lateral radiographs. LLA measurements were performed by two independent observers (n = 526). In 15 children per morphotype, a third observer performed measurements twice (n = 180). Intraclass correlation coefficients and the dose (delivered, absorbed) were calculated. 100 girls and 160 boys (mean age = 11.7 years) were investigated: 74 M1 (mean BMI, 15.7kg/m2), 149 M2 (19.8 kg/m2) and 40 M3 (30.2 kg/m2). With microdose, inter- and intra-observer agreement was >0.90 for lengths whatever the morphotype, 0.75-0.90 (M1) and >0.90 (M2, M3) for valgus/varus and flexion/hyperextension deviations. Dose reduction reached a factor of 8.5 and 5.4 for the delivered and absorbed dose respectively. Microdose could be used for LLA measurements in children and permits a significant dose reduction. • Lower limb lengths of children can be evaluated with microdose biplanar radiography. • Valgus/varus deviations also can be evaluated with microdose biplanar radiography. • Microdose biplanar radiography significantly reduces delivered and absorbed dose in children.

Measurement of lower limb alignment: there are within-person differences between weight-bearing and non-weight-bearing measurement modalities

Purpose Previous studies have compared weight-bearing mechanical leg axis (MLA) measurements to non-weight-bearing measurement modalities. Most of these studies compared mean or median values and did not analyse within-person differences between measurements. This study evaluates the within-person agreement of MLA measurements between weight-bearing full-length radiographs (FLR) and non-weight-bearing measurement modalities (computer-assisted surgery (CAS) navigation or MRI).Materials and methodsTwo independent observers measured the MLA on pre- and postoperative weight-bearing FLR in 168 patients. These measurements were compared to non-weight-bearing measurements obtained by CAS navigation or MRI. Absolute differences in individual subjects were calculated to determine the agreement between measurement modalities. Linear regression was used to evaluate the possibility that other independent variables impact the differences in measurements.ResultsA difference was found in preoperative measurements between FLR and CAS navigation (mean of 2.5° with limit of agreement (1.96 SD) of 6.4°), as well as between FLR and MRI measurements (mean of 2.4° with limit of agreement (1.96 SD) of 6.9°). Postoperatively, the mean difference between MLA measured on FLR compared to CAS navigation was 1.5° (limit of agreement (1.96 SD) of 4.6°). Linear regression analysis showed that weight-bearing MLA measurements vary significantly from non-weight-bearing MLA measurements. Differences were more severe in patients with mediolateral instability (p = 0.010), age (p = 0.049) and ≥3° varus or valgus alignment (p = 0.008).ConclusionThe clinical importance of this study lies in the finding that there are within-person differences between weight-bearing and non-weight-bearing measurement modalities. This has implications for preoperative planning, performing total knee arthroplasty (TKA), and clinical follow-up after TKA surgery using CAS navigation or patient-specific instrumentation.Level of evidenceIII.

Lower limb alignment characteristics are not associated with running injuries in runners: Prospective cohort study

There is conflicting evidence on the association between lower limb alignment characteristics and the incidence of running-related injury (RRI). Therefore, the primary aim of this study was to investigate the association between lower limb alignment characteristics and the incidence proportion of RRI in a convenience sample of recreational runners. A total of 89 recreational runners were included in this prospective cohort study. These participants had been running for at least six months and were injury-free at baseline. Lower limb alignment measurements were conducted in order to calculate lower limb discrepancy, Q-angle, subtalar angle and plantar index. All participants also answered a baseline and biweekly online surveys about their running routine, history of RRI and newly developed RRI over a period of 12 weeks. The prevalence of previous RRI and the 12-week incidence proportion of new RRI were calculated. Logistic regression analysis was performed to estimate the association between lower limb length discrepancy, Q-angle, subtalar angle and plantar ach index with the incidence proportion of RRI. The prevalence of previous RRI was 55.1% (n = 49). The 12-week incidence proportion of new RRI was 27.0% (n = 24). Muscle injuries and tendinopathies were the main types of RRI identified. The lower leg and the knee were the main anatomical regions affected. We did not find significant associations between lower limb length discrepancy, Q-angle, subtalar angle and plantar arch index and injury occurrence.

An augmented reality C-arm for intraoperative assessment of the mechanical axis: a preclinical study.

Determination of lower limb alignment is a prerequisite for successful orthopedic surgical treatment. Traditional methods include the electrocautery cord, alignment rod, or axis board which rely solely on C-arm fluoroscopy navigation and are radiation intensive. To assess a new augmented reality technology in determining lower limb alignment. A camera-augmented mobile C-arm (CamC) technology was used to create a panorama image consisting of hip, knee, and ankle X-rays. Twenty-five human cadaver legs were used for validation with random varus or valgus deformations. Five clinicians performed experiments that consisted in achieving acceptable mechanical axis deviation. The applicability of the CamC technology was assessed with direct comparison to ground-truth CT. A t test, Pearson's correlation, and ANOVA were used to determine statistical significance. The value of Pearson's correlation coefficient R was 0.979 which demonstrates a strong positive correlation between the CamC and ground-truth CT data. The analysis of variance produced a p value equal to 0.911 signifying that clinician expertise differences were not significant with regard to the type of system used to assess mechanical axis deviation. All described measurements demonstrated valid measurement of lower limb alignment. With minimal effort, clinicians required only 3 X-ray image acquisitions using the augmented reality technology to achieve reliable mechanical axis deviation.

Agreement between radiological and computer navigation measurement of lower limb alignment

Accurate and reproducible measurements of limb alignment are necessary for planning, performing and evaluation of reconstructive knee surgery. Aim of this study was the comparison of the alignment measured on long-leg standing radiographs with the intraoperative data from a navigation system. The records of 135 consecutive patients who received computer-assisted TKA were examined. Technical quality of the long-leg radiographs (LLRs) was classified good, acceptable or poor according to the rotation of the leg. The difference between radiographic and navigation measurements of leg alignment was assessed. Preoperative LLRs were rated as good 56.3% (71.1% postoperatively), acceptable in 37.0% (20.0% postoperatively) and poor in 6.7% (8.9% postoperatively). The median difference between radiographic and navigation measurements increased with reduced quality of the LLR [good 1.5° (range 0.0°-9.9°), acceptable 2.5° (range 0.0°-15.0°), poor 4.5° (range 0.2°-9.5°)], but not with greater deformity. Median difference between both measurements in good radiographs was 1.7° (range 0.0°-9.9°) preoperatively and 1.2° (range 0.0°-7.0°) postoperatively. Difference between radiographic and navigation measurements of lower limb alignment is low if the LLR are obtained in neutral rotation. Larger differences between both measurements can occur even under these ideal conditions, and it is still unclear which measurement is closer to reality. Therefore, even if a navigation system is used during surgery, long-leg standing radiographs should currently not be abandoned. III.

Differences in Measurement of Lower Limb Alignment Among Different Registration Methods of Navigation and Radiographs in TKA Using the OrthoPilot System

The purposes of this study were (1) to compare lower limb alignment measurements between radiographs and computer-assisted surgery and (2) to evaluate the discrepancy in lower limb alignment between computer-assisted surgery with a high tibial osteotomy protocol and computer-assisted surgery with a total knee arthroplasty (TKA) protocol in the same knee. Seventy-one TKAs were performed on patients with primary osteoarthritis using computer-assisted surgery. Preoperative lower limb alignment was measured using the mechanical axis during bipedal, weight-bearing, whole-leg anteroposterior radiography (measure 1). The intraoperative mechanical axis was measured with computer-assisted surgery according to the high tibial osteotomy protocol before joint exposure (measure 2). After changing the software and joint exposure, the intraoperative mechanical axis was measured with computer-assisted surgery according to TKA protocol (measure 3). After final TKA implantation, the lower limb mechanical axis was measured with computer-assisted surgery following the TKA protocol (measure 4). Postoperative lower limb alignment was measured using the mechanical axis on whole-leg standing anteroposterior radiographs (measure 5). The mechanical axis and median value from each group were compared. Factors affecting the mechanical axis measurement were also analyzed. The difference in the mechanical axis between measures 1 and 2, measures 1 and 3, and measures 2 and 3 was significant (P<.0001, <.0001, and =.0007, respectively). The difference between measures 4 and 5 was also significant (P<.0001). Factors affecting the mechanical axis measurement, such as age, height, weight, and range of motion, showed no correlation (R(2)=.07244 and adjusted R(2)=.01622). The pre- and postoperative radiological measurements of limb alignment using the mechanical axis were different from the intraoperative measurements with navigation.

Influence of lower limb rotation in navigated alignment analysis: implications for high tibial osteotomies

Inaccurate coronal plane realignment is a common problem after high tibial osteotomy. It has been shown that lower limb rotation has an effect on the two-dimensional measurement of lower limb alignment. Although alignment errors are known to occur due to limb rotation, the magnitude of this effect is unknown. Navigation systems allow for the measurements of coronal plane alignment and dynamically rotational and sagittal plane. Our study evaluated the effect of rotational leg movements on coronal plane alignment as determined by image-free navigation. We hypothesized that a linear relationship exists between rotation and angular measurements. Eight cadavers were used, while three test conditions of the complete lower limbs were established: (1) solid knee arthrodesis, (2) provisional knee arthrodesis and (3) unconstrained knee conditions. Navigated measurements of coronal and sagittal lower limb axis were done initially without knee flexion for defined internal/external rotations of 5 degrees, 10 degrees and maximal values for all test series. Repeated test for the unconstrained knee included stepwise knee flexion of 5 degrees, 10 degrees and 20 degrees. Statistical analysis comparing the test conditions 1, 2 and 3 and comparison between flexion movements of the unconstrained knee were done. Results revealed no significant differences between the different rotations of test condition 1 (mean 0.34 degrees, SD 0.23, range, 0 degrees-0.8 degrees). Condition 2 similarly did not result in significant deviations (mean 0.51 degrees, SD 0.24, range 0.1 degrees-0.9 degrees). Measurement deviations ranging from 0.4 degrees to 4.3 degrees were found for condition 3, the unconstrained knee. However, no statistically different testings from the arthrodesed knee were found (P=0.099-0.410). Knee flexion from 5 degrees, 10 degrees or 20 degrees, showed significant deviations (P<0.05) for all rotations at all degrees of flexion. Rotation and flexion of 5 degrees led to significant alignment errors of 3.4 degrees and 2.8 degrees, respectively, for internal and external rotations. Measurement failures due to the rotational movements of 1 degree-4 degrees might add to additional sources of errors causing relevant under- or over-corrections of the mechanical leg axis. Discrepancies of the axis due to rotational movements as well as flexion of the knee joint can be avoided and corrected immediately with the help of navigation.

Effects of rotation on measurement of lower limb alignment for knee osteotomy

The purposes of this study were to clarify the effects of rotation on two-dimensional measurement of lower limb alignment for knee osteotomy using a three-dimensional method and to determine whether this 3-D simulation method could help with planning of knee osteotomy. We developed computer software to calculate femorotibial angle (FTA) and hip–knee–ankle angle (HKA) and simulate knee osteotomy from a CT-based 3-D bone model of the lower limb. Lower limb rotation on anteroposterior long-standing radiographs was measured by superimposing the 3-D bone models. Changes in alignment with limb rotation were calculated using the software. FTA after virtual closed-wedged osteotomy was measured for a hypothetical case of a rotation error of the osteotomy plane in reattaching the proximal cutting surface to the distal cutting surface. For 31 varus knees in 20 patients with medial compartment arthritis, the mean rotation angle, relative to the epicondylar axis, with variable limb position was 7.4 ± 3.9° of internal rotation (mean ± SD), ranging from 8° of external rotation to 14° of internal rotation; the mean changes in FTA and HKA were 3.5 ± 2.2° (range, 0.4–8.6) and 1.6 ± 1.3° (range, 0.2–4.9), respectively. The FTA “flexion angle” (lateral view alignment from neutral AP) and the absolute HKA “flexion angle” correlated with the change in FTA and HKA with limb rotation, respectively (FTA, R=0.999; HKA, R=0.993). The mean change in FTA after virtual closed-wedged osteotomy was 3.2° for internal and external 10° rotation errors in reattaching the osteotomy plane. Rotation may affect measurement of lower limb alignment for knee osteotomy, and 3-D methods are preferable for surgical planning.