Measurement Of hsCRP Levels Research Articles

Association of serum high-sensitivity creactive protein level with metabolic syndrome

Background – Metabolic syndrome is considered as pro inflammatory state, measurement of hsCRP might help in the prediction of onset of CVD. We analyzed the association of serum hsCRP level with metabolic syndrome. Methods- the study included the 140 diagnosed case of metabolic syndrome (Men= 81, Women= 5). We measured the fasting glucose, fasting lipid panel & serum hsCRP level. Serum hsCRP level was compared with the components of metabolic syndrome. Results- High level of hsCRP was found in both men (67.9 %) & women (66.1%) with metabolic syndrome. The most common components of metabolic syndrome were abdominal obesity in women, while high TG, hypertension & low HDL-C was common in men. hsCRP level was found to be significantly increased in metabolic syndrome subjects with diabetes mellitus and obesity. In addition, hsCRP was significantly increased with increasing the number of components of metabolic syndrome. Conclusion- Measurement of hsCRP level indicates the inflammation associated with obesity & diabetes mellitus that might be explained the increasing the risk for development of cardiovascular disease.

Уровни высокочувствительного с-реактивного белка у работающих мужчин молодого и среднего возраста

Cardiovascular diseases remain the leading cause of death in the working age population. In recent decades, more and more attention has been attracted to a subacute chronic inflammatory process as the cause of the progression of atherosclerosis and the development of atherothrombosis. A high-sensitivity C-reactive protein (hs-CRP) is recognized as an independent marker of cardiovascular disease risk, comparable in value to cholesterol or blood pressure. Aim. Measurement of hs-CRP levels in the group of initially healthy young and middle-aged working men. Materials and methods. The study included 349 men aged 28 to 56 years, who undergo periodic medical examination at the Diagnostic and Rehabilitation Center of “Gazprom transgaz Moscow” OOO from November 2018 to February 2020.The examination was carried out according to an employee occupation by order of the Ministry of Health and Social Development of Russia No. 302n. dated 12.04.2011. Additionally, a blood test for hs-CRP was performed. Results. An increase in hs-CRP ≥2 mg/L was found in 26.7% of the men examined. In the majority of cases (89.2%), the increase in CRP ranged between 2 and 5 mg/L, in 7.5% of cases – between 5 and 10 mg/L, and only in 3,2% it exceeded 10 mg/L. All patients with elevated hs-CRP levels showed no signs of an acute inflammatory reaction. A direct correlation of hs-CRP levels with overweight and abdominal obesity, which increases with age, was revealed. In 151 men, hs-CRP levels were assessed in dynamics, of which baseline increase of ≥2 mg / l was noted in 28.5%, and after a year – in 23.2%. When assessing the absolute value of biomarker concentration, an increase in this indicator after a year was registered in 45.3% of men. Conclusion. The high incidence of increased baseline hs-CRP levels in the group of relatively healthy young and middle-aged working men, and the tendency for this indicator to increase after a year in 45.3% of men makes it appropriate to include routine measurement of the basal hs-CRP concentration in men over 40 years of age in screening programs and standards of medical examinations. Keywords: high-sensitivity C-reactive protein, atherosclerosis, cardiovascular diseases For citation: Kirichenko AA, Poliakova OA, Dubovskaia IN. Levels of high-sensitivity C-reactive protein in young and middle-aged working men. Consilium Medicum. 2021; 23 (1): 99–102. DOI: 10.26442/20751753.2021.1.200577

Comparison of hs-CRP level between low calorie high protein to standard protein diet in obese individuals with weight cycling - a randomised trial

Background: Obesity is associated with various health problems. Low-grade inflammation is a condition found in obese people and contributes to the development of various diseases. The objective of this study was to compare the effects of calorie restriction diet with high-protein (HP) or standard protein (SP) to inflammation marker (hs-CRP) in obese individuals with weight cycling. Methods: 61 healthy obese men and women (25 – 49 years old) with a history of weight cycling were recruited and were randomly assigned to one of the intervention groups, HP or SP groups. Both groups were suggested to reduce their daily caloric intake by 1000 kcal with regular physical activity for 56 days. Subjects in HP group were given a daily protein intake of 22-30% from total daily caloric intake, while SP group were prescribed 12-20%. Dietary consultation was conducted through daily reminder by phone and weekly counseling. The measurement of hs-CRP level was performed prior to and at the end of the intervention. Results: 54 subjects completed the program, yet due to several reasons only 32 of them were measured for hsCRP before and after completing the program, 15 from HP group and 17 from SP group. After completing the 56-day diet program, SP group experienced reduction of hs-CRP by -0.446 + 4.239, while HP underwent increase by 0.135 + 2.389. The mean difference of change in hs-CRP level between the two groups were not statistically significant (P=0.094). Conclusion: Low calorie diet with either HP or SP for 8 weeks significantly reduced body weight (P<0.001) and BMI (P<0.001) in healthy obese subjects but the difference of change in the hs-CRP level between them were not significant. The protein composition of a low calorie diet may not affect the inflammatory state of obese individuals with weight cycling. Trial registration number: NCT03374150

Elevated Plasma High Sensitivity C-reactive Protein (hs-CRP) Level is a Predictor of Periprocedural Myocardial Injury during Percutaneous Coronary Intervention (PCI)

Background: Elevated high sensitivity C-reactive protein (hs-CRP) has been well known as a biomarker reflecting inflammatory process for prediction of ischemic events among patients with coronary artery disease. Relatively small studies have identified a heightened and sustained inflammatory response after percutaneous coronary intervention (PCI) to be a predictor of periprocedural events after coronary angioplasty and a marker of increased restenosis risk among patients undergoing coronary stenting. Embolization of atherosclerotic and thrombotic debris can induce myocardial necrosis during PCI. This study was designed to evaluate whether pre procedural hs-CRP level is associated with procedure related distal microembolization producing myocardial injury (assessed by CK-MB level) after PCI.Methods: A total of 310 patients with chronic stable angina and unstable angina, who would undergo elective PCI were evaluated in National Institute of Cardiovascular Disease (NICVD), Dhaka with a view to evaluate the relationship between preprocedural hs-CRP and rise of CK-MB level, before and after PCI. Patients were divided in 2 groups according to hs-CRP: Group I = hs-CRP <3 mg/ L, Group II = hs-CRP >3 mg/L.Results: A total of 310 patients were divided into two groups: Normal CRP group (n = 131) and elevated CRP group (n= 179). Following PCI, CK-MB level rose from baseline in both groups. In normal CRP group, there was no significant elevation of CK-MB level after PCI (Pre-procedural vs. Post-procedural: 18.6 ± 5.4 vs. 29.1 ± 5.6 mg/L, p= ns). In elevated CRP group, there was significant elevation of CK-MB level after PCI (Preprocedural vs. Post-procedural: 19.1 ± 6.7 vs. 52.46 ± 9.4 mg/L, p < 0.01). The mean rise of CK-MB level was higher in group II than group I (33.06±11.62U/L vs. 11.52±9.60 U/L). The findings were statistically significant between the study groups (p>0.05). Also there was a positive linear correlation between preprocediral hsCRP level and rise of CKMB (r=0.22) following procedure and it was statistically significant (p<0.05). Multivariate logistic regression analysis was done among traditional predictors of PCI outcome including advanced age (>50 years), female gender, diabetes mellitus, BMI, hypertension, smoking, dylipidaemia, type C lesion, multiple stents, post dilatation and hsCRP. After removing the effects of the all other variables, hs- CRP was independent predictor of periprocedural myocardial injury during PCI, assessed by CK-MB elevation with OR 1.57 and p=0.001.Conclusion: The inflammatory activity, as represented by hs-CRP level, is associated with procedure related microvascular injury as assessed by CK-MB elevation after PCI. Measurement of hs-CRP levels could provide a rationale for risk stratification before coronary intervention and may be a useful tool to target aggressive antiaggregatory or anti-inflammatory therapy to patients that are exposed to the highest risk for ischemic complications. As distal microembolization is a determinant of short and long term mortality after PCI, specific strategies may be developed to minimize myocardial injury in subjects with elevated hs-CRP level.Bangladesh Heart Journal 2015; 30(1) : 5-12

High-Sensitivity C-Reactive Protein: To Measure or not to Measure?~!2009-10-29~!2009-12-22~!2010-04-08~!

Abstarct: Based on evidence that inflammatory processes play a fundamental role in the development of cardiovascular disease, high sensitivity C-reactive protein (hsCRP) is considered a powerful risk marker for cardiovascular events. Irrespective of a potential role in risk prediction, recent evidence implicates a direct involvement of CRP per se in the pathogenesis of atherosclerotic cardiovascular disease. In the present article we review the literature concerning clinical studies assessing the association between hsCRP concentration and cardiovascular disease. Measurement of hsCRP levels may help guiding medical treatment initiation and adjustment in certain groups of subjects both in the primary and secondary prevention.

Impact of Diabetes Mellitus on Rehospitalization for Heart Failure Among Survivors of Acute Myocardial Infarction in the Percutaneous Coronary Intervention Era

There is little data regarding the clinical impact of diabetes mellitus (DM) on heart failure (HF) among survivors of acute myocardial infarction (AMI) in the percutaneous coronary intervention (PCI) era. The present study group comprised 4,035 survivors who underwent PCI within 24 h of the onset of symptoms. DM was an independent predictor of rehospitalization for HF by multivariate analysis (hazard ratio (HR) 1.576, P=0.010). The risk of rehospitalization for HF was similar between patients with DM who did not have an enlarged left ventricular diastolic diameter (LVDd<51 mm) before discharge and patients without DM who showed an increase in LVDd (>or=51 mm) (HR 1.020, P=0.959). In the DM group, the hemoglobin A1c level before discharge was similar between patients with and without rehospitalization for HF (7.5+/-1.9% vs 7.4+/-1.6%, P=0.455), whereas high-sensitivity C-reactive protein (hs-CRP) was higher in patients with than without rehospitalization for HF (1.80+/-3.63 vs 0.75+/-2.03 mg/dl, P=0.001). DM is an independent predictor of rehospitalization for HF after AMI in the PCI era. Diabetic patients without left ventricular remodeling should be treated as a high-risk group for HF. Measurement of hs-CRP level may be useful for predicting rehospitalization because of HF in diabetic patients after AMI.

C-reactive protein in chronic heart failure: A new predictor of survival

High CRP levels are associated with adverse outcomes in cardiovascular diseases. hsCRP levels increase with the severity of CHF in patients with diastolic HF as well as in systolic HF. This supports a potential role for CRP in immune activation not only in systolic but also in diastolic HF. The measurement of hsCRP levels thus has the potential to play an important role for risk assessment in patients with CHF.

A Quick Test Predicts Acute Coronary Events

Inflammation of the coronary arterial wall plays a major role in atherosclerosis and ultimately thrombosis by contributing to vascular constriction, spasm, and thrombus formation. Measurement of hs-CRP level is a readily available laboratory blood test that serves as a gauge of coronary plaque inflammation. As a result, hs-CRP has become a very useful biological marker for predicting the risk of acute coronary events and for making decisions regarding treatment. It is important to recognize that lipid-lowering therapy decreases plaque inflammation and slows the progression of calcium buildup in the coronary arteries, which is readily verified by reduction in hs-CRP levels. Endothelial dysfunction is a product of plaque inflammation and as such can predict acute CV events. Endothelial function can be assessed during cardiac catheterization by measuring the vasoactive response to pharmacological or physiological stress. However, the routine use of cardiac catheterization to measure drug-induced coronary vasoactivity can have potential adverse effects in patients with unstable coronary disease. Time and costs can also be additional constraints in the routine use of this procedure. Consequently the simple and readily available hs-CRP test is accurate and preferable.