Association of serum high-sensitivity creactive protein level with metabolic syndrome

Abstract

Background – Metabolic syndrome is considered as pro inflammatory state, measurement of hsCRP might help in the prediction of onset of CVD. We analyzed the association of serum hsCRP level with metabolic syndrome. Methods- the study included the 140 diagnosed case of metabolic syndrome (Men= 81, Women= 5). We measured the fasting glucose, fasting lipid panel & serum hsCRP level. Serum hsCRP level was compared with the components of metabolic syndrome. Results- High level of hsCRP was found in both men (67.9 %) & women (66.1%) with metabolic syndrome. The most common components of metabolic syndrome were abdominal obesity in women, while high TG, hypertension & low HDL-C was common in men. hsCRP level was found to be significantly increased in metabolic syndrome subjects with diabetes mellitus and obesity. In addition, hsCRP was significantly increased with increasing the number of components of metabolic syndrome. Conclusion- Measurement of hsCRP level indicates the inflammation associated with obesity & diabetes mellitus that might be explained the increasing the risk for development of cardiovascular disease.