You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology (PD27)1 Sep 2021PD27-09 REPEATABILITY OF FILL RATE-DEPENDENT CHANGES IN BLADDER SENSATION CURVES DURING ORAL HYDRATION STUDIES Devina Thapa, Rui Li, William R. Visser, Annika C. King, Lauren N. Siff, John E. Speich, and Adam P. Klausner Devina ThapaDevina Thapa More articles by this author , Rui LiRui Li More articles by this author , William R. VisserWilliam R. Visser More articles by this author , Annika C. KingAnnika C. King More articles by this author , Lauren N. SiffLauren N. Siff More articles by this author , John E. SpeichJohn E. Speich More articles by this author , and Adam P. KlausnerAdam P. Klausner More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002020.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Because of the invasiveness, patient risk, and cost of urodynamic testing, non-invasive oral hydration protocols have been developed to evaluate overactive bladder (OAB). In addition, a tablet-based Sensation Meter has been developed to track real-time bladder sensation during filling. Results from a previous 2-fill hydration study showed faster filling during the second fill and a corresponding right shift in the sensation-%capacity curve (Fig 1). The goal of this study was to validate the repeatability of a changes in bladder sensation curves due to changes in fill rate during multiple visits of a comparative-fill hydration protocol. METHODS: Healthy volunteers with no urgency symptoms based on the International Consultation on Incontinence OAB Questionnaire (ICIq-OAB scores of 0 on question 5a and ≤1 on all others) participated in a hydration study. Participants drank 2L of Gatorade G2 and completed two fill-void cycles while they used a touch-screen Sensation Meter to record real-time bladder fullness sensation from 0 to 100%. The study was repeated during two visits (A & B) one week apart. Abdominal ultrasound imaging was used to measure bladder volume every 5 min during filling. Fill rates were calculated as (void+post void residual)/fill time. Sensation data were sampled at every 5% capacity to develop sensation-%capacity curves (Fig 1). Area-under-the-curve (AUC) analysis for the 2nd plus 3rd quartiles of capacity was used to quantify changes in the sensation-capacity curves due to fill rate and across different visits for each participant. RESULTS: The study included 20 participants (12 women, 8 men). The fill rate for Fill 2 was greater than Fill 1 (17 vs 8 ml/min, p<0.05). Based on AUC analysis, a right shift (decrease in AUC) in the sensation-%capacity curve from Fill 1 to Fill 2 was observed in 18/20 participants in Visit A and in 19/20 participants in Visit B (Fig 1). The expected right shift in the curve was repeatable in 18/20 (90%) participants. CONCLUSIONS: This study validated the repeatability of predicted effects of bladder fill rate on patient-reported real-time bladder sensation during oral hydration studies. This data could potentially be used in the development novel bladder sensation phenotypes. Source of Funding: NIH Grant R01DK101719 © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e447-e447 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Devina Thapa More articles by this author Rui Li More articles by this author William R. Visser More articles by this author Annika C. King More articles by this author Lauren N. Siff More articles by this author John E. Speich More articles by this author Adam P. Klausner More articles by this author Expand All Advertisement Loading ...