Measurement Capabilities Research Articles

Design of a low frequency, density profile reflectometer system for the MAST-U spherical tokamak.

Validated and accurate edge profiles (temperature, density, etc.) are vitally important to the Mega Ampere Spherical Tokamak Upgrade (MAST-U) divertor and confinement effort. Density profile reflectometry has the potential to significantly add to the measurement capabilities currently available on MAST-U (e.g., Thomson scattering and Langmuir probes). This work presents the diagnostic requirements, problems, and solutions facing profile reflectometry in spherical tokamaks and MAST-U in particular. Requirements include density measurements near zero electron density in the scrape off layer region, coverage for a broad range of MAST-U plasma parameters, high time (≤10microseconds) and spatial resolutions (≤1cm), reliability, and identification of the plasma start frequency.

A compact and portable gamma-ray spectrometer (GRASP) for inertial confinement fusion and basic science experiments.

A compact and portable gamma-ray spectrometer has been designed to diagnose different components of the inertial confinement fusion-relevant γ-ray spectrum with energies between ∼3.7-17.9MeV. The system is designed to be as compact as possible for convenient transportation and fielding in diagnostic ports on the OMEGA laser, the National Ignition Facility, and other photon-source facilities. The system consists of a conversion foil for Compton scattering in front of four magnetic spectrometer "arms," each covering a different energy range and constructed out of cylindrical permanent magnet Halbach arrays. Monte Carlo simulations have been used to optimize and assess the performance of the conversion foil, and COSY INFINITY ion-optical simulations have been used to optimize the spectrometer magnets. The performance of the design is assessed for a simulated direct-drive γ-ray spectrum. Spanning its total γ-ray energy bandwidth and using a 1.7mm thick boron conversion foil, the system's total energy resolution and efficiency are ∼15.8%-4.5% and 5.4 × 10-7-3.7 × 10-7e-/γ, respectively, with room for improvement. Spectral γ-ray measurements will provide guidance to the inertial confinement fusion program toward achieving high-energy gain relevant to inertial fusion energy and enable new measurement capabilities for basic discovery science.

Attenuation Measurement Using the IF Substitution Method in the Frequency Range of 9 kHz to 10 MHz

Using the intermediate frequency (IF) substitution method, this study establishes a low-frequency attenuation measurement standard operating in the 9 kHz to 10 MHz frequency range. We designed and fabricated a low-frequency attenuation measuring instrument using a mixer that converts the input radio frequency signal into an output IF of 1 kHz. When varying the attenuation of a variable attenuator under test, an attenuation of up to 100 dB was measured. The IF output of the mixer was measured using a spectrum analyzer as the receiver. The receiver's performance was evaluated using an inductive voltage divider whose measurement capability is traceable to the electrical measurement standard. The measurement uncertainty, which accounts for uncertainty sources such as the performance of the receiver, mismatch, and mixer nonlinearity, was evaluated to be 0.005 dB to 0.058 dB (k = 2) in the attenuation range of 10 dB to 100 dB.

Application of acid-activated near-infrared viscosity fluorescent probe targeting lysosomes in cancer visualization

The higher viscosity and lower pH in lysosomes of cancer cells highlight their potential as biomarkers for cancer. Therefore, the development of acid-activated viscosity fluorescent probes is significant for the early diagnosis and treatment of cancer. Based on this, we have designed and synthesized a near-infrared fluorescent probe based on the 2-(2-hydroxyphenyl)benzothiazole (HBT) group, namely HBTH, to monitor the viscosity changes within lysosomes. It has been demonstrated that HBTH was extremely sensitive to viscosity, with a strong linear relationship between fluorescence intensity and log(viscosity) within the range of (logη) = 0–3.06 (a correlation coefficient of 0.98), proving its capability for quantitative viscosity measurement. In particular, the most obvious fluorescence enhancement of HBTH was only efficiently triggered by the combined effect of low pH and high viscosity. Furthermore, HBTH can rapidly localize to lysosomes by wash-free procedure at a low concentration (100 nM) and achieve high-fidelity imaging within 20 s. It can also monitor the dynamic processes of lysosomes in cells, viscosity changes under drug stimuli, and lysosomal behavior during mitophagy. Importantly, HBTH is capable of identifying tumors in tumor-bearing nude mice through in vivo imaging. These features make HBTH a powerful tool for the early diagnosis and treatment of cancer.

Complex network analysis of climate and landscape satellite data to explore spatio-temporal patterns in urban environment: the case of Athens

Motivated by the significance and complexity of exploring spatiotemporal patterns - regions within an urban environment, particularly in the context of extreme heat events- this research analyzes meteorological time series through complex network analysis. The data collected for the examination area is focused on Athens, Greece, and covers sections of the city’s urban landscape. The data was obtained from the Copernicus observation component of the European Union. Initially, the time series are transformed into networks using correlation network methodology, followed by examination of the discriminative capability of the topological measures of networks degree and modularity as community - region detection methods. Of particular interest is that our findings suggest that the proposed complex network analysis can lead to the extraction of spatial urban regions closely linked to land use and building heights in corresponding areas. These results may help investigate the spatial variability of heat in the urban environment and inform urban planning and management strategies in policy decision-making regarding the intensity of urban heat throughout the city and the planning of climate change adaptation strategies.

In Situ Pipe Prover Volume Measurement Method.

To improve the accuracy of in situ measurement of the standard volumes of pipe provers and to shorten the traceability chain, a new method of in situ pipe prover volume measurement was developed alongside a supporting measurement device. This method is based on the geometric dimension approach, which measures the inner diameter and length of a pipe prover to calculate its volume. For inner diameter measurement, a three-probe inner-diameter algorithm model was established. This model was calibrated using a standard ring gauge of Φ313 mm, with the parameters calculated through fitting. Another standard ring gauge of Φ320 mm was used to verify the inner diameters determined by the algorithmic model. A laser interferometer was employed for the segmented measurement of the pipe prover length. The comprehensive measurement system was then used for in situ measurement of the standard pipe prover. The newly developed system achieved an expanded uncertainty of 0.012% (k = 2) in volume measurement, with the deviation between the measured and nominal pipe prover volumes being merely 0.007%. These results demonstrate that the proposed in situ measurement method offers ultra-high-precision measurement capabilities.

A novel silicon PIN photodiode device for radiation exposure monitoring in dental CBCT

This paper presents a versatile and cost-effective system for the monitoring of X-ray exposure during dental cone beam computed tomography procedures based on silicon PIN photodiode detectors. The system, developed and implemented at the University of Pisa's School of Engineering, underwent characterization under a range of operational conditions focusing on full field-of-view 3D protocols used in adult patient examinations. This study was facilitated by the Azienda Ospedaliero Universitaria Pisana, which provided access to a Planmeca ProMax 3D Classic scanner for the research. During the investigation, photodiodes were placed both on the surface and inside an Alderson RANDO phantom head to assess the dose delivered to regions near radiation-sensitive areas such as the salivary glands, thyroid, eye lens, and laryngopharynx. The evaluation process spanned a spectrum of tube voltages, ranging from 60 to 90 kVp, and tube currents, extending up to 16 mA, to ensure a broad and thorough analysis. Furthermore, to reinforce the effectiveness of the silicon photodiodes' measurement capabilities, calibrated GR-200 A-type thermoluminescent dosimeters were positioned within the phantom head inserts to serve as a reference point. Complementing this setup, PCXMC Rotation 2.0 simulations were conducted to further the efficacy of the monitoring system, particularly tailored to the specific dental CBCT protocols being investigated. In conclusion, while the research revealed a generally consistent correlation across PCXMC simulations, photodiode readings, and thermoluminescent dosimeter measurements, it is important to note that a direct comparison was not exactly possible due to limitations in the size and positioning of the systems. Variations up to 20–35% were observed, primarily due to the different positioning of the dosimeters and the unique physical and operational traits of the different measurement methods employed. Nevertheless, the development of an affordable, easily deployable, and scalable dosimetry monitoring system may provide a substantial contribution to enhancing patient safety in dental radiology and aid in the optimization of diagnostic X-ray protocols.

Evaluation of Scale-dependent Kurtosis with HelioSwarm

Plasma turbulence involves complex, nonlinear interactions of electromagnetic fields and charged particles across multiple scales. Studying these phenomena in space plasmas, like the solar wind, is facilitated by the intrinsic scale separations and the availability of in situ spacecraft observations. However, the single-point or single-scale configurations of current spacecraft limit our understanding of many properties of the turbulent solar wind. To overcome these limitations, multipoint measurements spanning a range of characteristic scales are essential. This Letter prepares for the enhanced measurement capabilities of upcoming multispacecraft missions by demonstrating that higher-order statistics, specifically kurtosis, as a baseline for intermittency can be accurately measured. Using synthetic turbulent fields with adjustable intermittency levels, we achieve scale separations analogous to those in the solar wind and apply these techniques to the planned trajectories of the HelioSwarm mission. This approach promises significant advancements in our understanding of plasma turbulence.

High-Fidelity, Multiqubit Generalized Measurements with Dynamic Circuits

Generalized measurements, also called positive operator-valued measures (POVMs), can offer advantages over projective measurements in various quantum information tasks. Here, we realize a generalized measurement of one and two superconducting qubits with high fidelity and in a single experimental setting. To do so, we propose a hybrid method, the “Naimark-terminated binary tree,” based on a hybridization of Naimark’s dilation and binary tree techniques that leverages emerging hardware capabilities for midcircuit measurements and feed-forward control. Furthermore, we showcase a highly effective use of approximate compiling to enhance POVM fidelity in noisy conditions. We argue that our hybrid method scales better toward larger system sizes than its constituent methods and demonstrate its advantage by performing detector tomography of symmetric, informationally complete POVM (SIC POVM). Detector fidelity is further improved through a composite error-mitigation strategy that incorporates twirling and a newly devised conditional readout error mitigation. Looking forward, we expect improvements in approximate compilation and hardware noise for dynamic circuits to enable generalized measurements of larger multiqubit POVMs on superconducting qubits. Published by the American Physical Society 2024

A study of 9 common breath VOCs in 504 healthy subjects using PTR-TOF-MS.

This study employs Proton-Transfer-Reaction Mass Spectrometry (PTR-MS) to analyze exhaled breath profiles of 504 healthy adults, focusing on nine common volatile organic compounds (VOCs): acetone, acetaldehyde, acetonitrile, ethanol, isoprene, methanol, propanol, phenol, and toluene. PTR-MS offers real-time VOC measurement, crucial for understanding breath biomarkers and their applications in health assessment. The study aims to investigate how demographic factors-gender, age, and smoking history-affect VOC concentrations in exhaled breath. The objective is to enhance our understanding of breath biomarkers and their potential for health monitoring and clinical diagnosis. Exhaled breath samples were collected using PTR-MS, measuring concentrations of nine VOCs. The data were analyzed to discern distribution patterns across demographic groups. Males showed higher average VOC levels for certain compounds. Propanol and methanol concentrations significantly increased with age. Smoking history influenced VOC levels, with differences among non-smokers, current smokers, and ex-smokers. This research provides valuable insights into demographic influences on exhaled VOC profiles, emphasizing the potential of breath analysis for health assessment. PTR-MS's real-time measurement capabilities are crucial for capturing dynamic VOC changes, offering advantages over conventional methods. These findings lay a foundation for advancements in non-invasive disease detection, highlighting the importance of considering demographics in breath biomarker research.

Application of Gabor, Log-Gabor, and Adaptive Gabor Filters in Determining the Cut-Off Wavelength Shift of TFBG Sensors

Tilted fibre Bragg gratings are optical fibre structures used as sensors of various physical quantities. Their unique measurement capabilities result from the high complexity of the optical spectrum consisting of several dozen cladding mode resonances. TFBG spectra demodulation methods generate signal features that highlight changes in the spectrum due to changes in the interacting quantities. Such methods should enable the distinction between two slightly different values of the measured quantity. The paper presents an effective method of processing the TFBG spectrum for use in measuring the refractive index of liquids. The use of Gabor and log-Gabor filters and their adaptive version eliminates the problem of discontinuity in determining the SRI value related to the existence of the cladding mode comb. The Gabor filters used make visible the shifting and fading of spectral features related to the decrease in the intensity of leaking modes. Subsequent modifications of the proposed algorithm led to an increase in the quality factor of the processed spectrum.

TTFDNet: Precise Depth Estimation from Single-Frame Fringe Patterns.

This work presents TTFDNet, a transformer-based and transfer learning network for end-to-end depth estimation from single-frame fringe patterns in fringe projection profilometry. TTFDNet features a precise contour and coarse depth (PCCD) pre-processor, a global multi-dimensional fusion (GMDF) module and a progressive depth extractor (PDE). It utilizes transfer learning through fringe structure consistency evaluation (FSCE) to leverage the transformer's benefits even on a small dataset. Tested on 208 scenes, the model achieved a mean absolute error (MAE) of 0.00372 mm, outperforming Unet (0.03458 mm) models, PDE (0.01063 mm) and PCTNet (0.00518 mm). It demonstrated precise measurement capabilities with deviations of ~90 μm for a 25.4 mm radius ball and ~6 μm for a 20 mm thick metal part. Additionally, TTFDNet showed excellent generalization and robustness in dynamic reconstruction and varied imaging conditions, making it appropriate for practical applications in manufacturing, automation and computer vision.

Exploring the gamma counting function in PET for sample activity measurement

With the widespread availability of small animal PET scanners globally, there exists a significant opportunity to enhance their operational utility. Our research introduces a novel utilization pathway by integrating gamma-counting functionalities within PET systems. This approach leverages the shared gamma counting technology between PET systems and traditional gamma counters, enabling direct radioactivity measurement from PET-derived raw count data. We established a correlation between the raw data from all-digital PET and the radioactivity of samples, conducting experiments to assess the system's measurement capabilities. The system demonstrated high accuracy and stability across a detectable range of 25.53–1900.69 kBq in single-photon mode and 19.61–1107.04 kBq in coincidence mode, with the difference between the sample activity and the linear function being no more than 5 %. Due to the multi-channel characteristic of PET detectors, our system exhibits a tenfold higher upper detection limit than that of gamma counters, without dead-time correction. This study demonstrates that all-digital PET can directly measure radioactivity, simplifying nuclear medicine procedures by integrating gamma counting within PET systems. This strategy not only reduces the need for multiple instruments but also has the potential to improve quantitative accuracy by minimizing cross-calibration errors, thereby maximizing the operational utility of existing all-digital PET scanners.

National programme for the reliability of ionizing radiation measurements based on inter-laboratory comparisons (ILCs): ILC n°2 ‘radiopharmaceutical activities’

A national Inter-Laboratory Comparisons (ILCs) programme was organized in Italy in 2022 by the Italian National Institute of Ionizing Radiation Metrology (INMRI), belonging to ENEA (Italian National Agency for New Technologies, Energy and Sustainable Economic Development), under the auspices of the Ministry of Enterprises and Made in Italy (Mimit ex MiSe). Within this ILCs programme, six inter-laboratory comparisons were organized, including the ILC-2 which focused on activity measurements carried out with radionuclide calibrators commonly used in the nuclear medicine departments of the participants.The focus was on three short-lived radionuclides - 99mTc, 18F, 177Lu - commonly employed in nuclear medicine for both diagnostic and therapeutic purposes. All presented results were compared with the reference values provided by ENEA-INMRI to ensure the traceability of measurements to the national primary activity standards. The observed deviation from the reference values of the measured activity were mainly within ± 10% (100% for 18F, 91.7% for 99mTc, 100% for 177Lu). The En statistical estimator was used to assess the participants’ ability to estimate uncertainty in the provided activity values. The obtained values revealed that, in certain instances, the involved laboratories did not achieve the correct results for En (with failure rates of 22.7%, 16.7%, 12.5% for 18F, 99mTc, 177Lu, respectively), despite deviations from the reference values falling within the ± 10%. The aim of ILC-2 was to harmonize the activity measurements in the country within the field of nuclear medicine for the specific radionuclides studied and enhance the measurement capabilities of the participants.

Investigation of intra-fractionated range guided adaptive proton therapy: I. On-line PET imaging and range measurement

Objective. Develop a prototype on-line positron emission tomography (PET) scanner and evaluate its capability of on-line imaging and intra-fractionated proton-induced radioactivity range measurement. Approach. Each detector consists of 32 × 32 array of 2 × 2 × 30 mm3 Lutetium–Yttrium Oxyorthosilicate scintillators with single-scintillator-end readout through a 20 × 20 array of 3 × 3 mm2 Silicon Photomultipliers. The PET can be configurated with a full-ring of 20 detectors for conventional PET imaging or a partial-ring of 18 detectors for on-line imaging and range measurement. All detector-level readout and processing electronics are attached to the backside of the system gantry and their output signals are transferred to a field-programable-gate-array based system electronics and data acquisition that can be placed 2 m away from the gantry. The PET imaging performance and radioactivity range measurement capability were evaluated by both the offline study that placed a radioactive source with known intensity and distribution within a phantom and the online study that irradiated a phantom with proton beams under different radiation and imaging conditions. Main results. The PET has 32 cm diameter and 6.5 cm axial length field-of-view (FOV), ∼2.3–5.0 mm spatial resolution within FOV, 3% sensitivity at the FOV center, 18%–30% energy resolution, and ∼9 ns coincidence time resolution. The offline study shows the PET can determine the shift of distal falloff edge position of a known radioactivity distribution with the accuracy of 0.3 ± 0.3 mm even without attenuation and scatter corrections, and online study shows the PET can measure the shift of proton-induced positron radioactive range with the accuracy of 0.6 ± 0.3 mm from the data acquired with a short-acquisition (60 s) and low-dose (5 MU) proton radiation to a human head phantom. Significance. This study demonstrated the capability of intra-fractionated PET imaging and radioactivity range measurement and will enable the investigation on the feasibility of intra-fractionated, range-shift compensated adaptive proton therapy.

Pulsed-Mode Magnetic Field Measurements with a Single Stretched Wire System.

In synchrotrons, accurate knowledge of the magnetic field generated by bending dipole magnets is essential to ensure beam stability. Measurement campaigns are necessary to characterize the field. The choice of the measurement method for such campaigns is determined by the combination of magnet dimensions and operating conditions and typically require a trade-off between accuracy and versatility. The single stretched wire (SSW) is a well-known, polyvalent method to measure the integral field of magnets having a wide range of geometries. It, however, requires steady-state excitation. This work presents a novel implementation of this method called pulsed SSW, which allows the system to measure rapidly time-varying magnetic fields, as is often needed, to save power or gain beam time. We first introduce the measurement principle of the pulsed SSW, followed by a combined strategy to calculate the absolute magnetic field by incorporating the classic DC SSW method. Using a bending magnet from the Proton Synchrotron Booster located at the European Organization for Nuclear Research as a case study, we validate the pulsed SSW method and compare its dynamic measurement capabilities to a fixed induction coil, showing thereby how the coil calibration must be adjusted according to the field level. Finally, we assess the method's measurement accuracy using the standard SSW as a reference and present an analysis of the primary noise contributors.

A Framework for Selecting and Assessing Wearable Sensors Deployed in Safety Critical Scenarios.

Wearable sensors for psychophysiological monitoring are becoming increasingly mainstream in safety critical contexts. They offer a novel solution to capturing sub-optimal states and can help identify when workers in safety critical environments are suffering from states such as fatigue and stress. However, sensors can differ widely in their application, design, usability, and measurement and there is a lack of guidance on what should be prioritized or considered when selecting a sensor. The paper aims to highlight which concepts are important when creating or selecting a device regarding the optimization of both measurement and usability. Additionally, the paper discusses how design choices can enhance both the usability and measurement capabilities of wearable sensors. The hopes are that this paper will provide researchers and practitioners in human factors and related fields with a framework to help guide them in building and selecting wearable sensors that are well suited for deployment in safety critical contexts.

Novel mining conveyor monitoring system based on quasi-distributed optical fiber accelerometer array and self-supervised learning

Belt conveyors in mining are crucial, with downtime leading to significant losses and safety hazards. Unplanned shutdowns often result from idler failures. To address this, an online monitoring system for continuous idler health assessment is proposed. Considering the large number and dense spatial distribution of idlers over long distances, this work presents a system that utilizes a quasi-distributed optical fiber accelerometer array. This array incorporates phase-sensitive optical time domain reflectometry (Phase-OTDR) interrogation technology and ultra-weak fiber Bragg gratings (UWFBGs) to effectively capture idler vibrations. The designed array achieves high-sensitivity vibration sensing with a sensitivity of 2.4 rad/g and a resolution of 1.7 mg/Hz. After collecting the vibrations of idlers by the designed accelerometer array, an automatic fault classification algorithm based on self-supervised learning (SSL) is introduced, which requires only a small number of labeled samples. By leveraging large amount of unlabeled data in the pretext task, the algorithm efficiently extracts latent features from the quasi-distributed accelerometer array. A diagnosis accuracy of 95.37 % can be achieved on a seven-class classification task with only 3.6 % labeled data (16 samples/class). This system offers a promising solution for idler monitoring, combining high sensitivity, distributed measurement capabilities, enhanced security, and superior fault detection accuracy.

Digital Image Correlation and Ultrasonic Lamb Waves for the Detection and Prediction of Crack-Type Damage in Fiber-Reinforced Polymer Composite Laminates.

The possibility of using the Digital Image Correlation (DIC) technique, along with Lamb wave analysis, was investigated in this study for damage detection and characterization of polymer carbon fiber (CFRP) composites with the help of numerical modeling. The finite element model (FEM) of the composite specimen with artificial damage was developed in ANSYS and validated by the results of full-field DIC strain measurements. A quantitative analysis of the damage detection capabilities of DIC structure surface strain measurements in the context of different defect sizes, depths, and orientation angles relative to the loading direction was conducted. For Lamb wave analysis, a 2D spatial-temporal spectrum analysis and FEM using ABAQUS software were conducted to investigate the interaction of Lamb waves with the different defects. It was demonstrated that the FEM updating procedure could be used to characterize damage shape and size from the composite structure surface strain field from DIC. DIC defect detection capabilities for different loadings are demonstrated for the CFRP composite. For the identification of any composite defect, its characterization, and possible further monitoring, a methodology based on initial Lamb wave analysis followed by DIC testing is proposed.

An In Vivo Assessment of a Novel Temperature Control Flexible Ureteroscope System for Monitoring and Controlling Intrarenal Temperature During Flexible Ureteroscopy

ObjectiveTo evaluate the efficacy of a novel temperature control flexible ureteroscope system in the precise monitoring and control of intrarenal temperature during ureteroscopy. MethodsWe developed a novel temperature control flexible ureteroscope system (PT-Scope), including a temperature-monitoring ureteroscope and a irrigation-suction platform for temperature regulation. A porcine thermometry model was established to observe temperature changes under varying holmium laser powers (10, 20, 30W) and irrigation rates (0, 20, 50 ml/min), utilizing PCN thermometry and PT-Scope measurements, with subsequent evaluation of temperature variations at different distances from the laser fiber tip. A porcine kidney stone model was established while porcine were randomly assigned to two groups: In the temperature control group, PT-Scope was connected to the irrigation-suction platform with temperature regulation, while in the non-temperature control group without temperature regulation. Comparative analysis was performed to evaluate differences in intrarenal temperature between the two groups. ResultsAcross various laser powers and irrigation rates, the temperature measurement capability of the PT-Scope was precise, demonstrating consistency with PCN temperature measurements. The temperature obtained from the PT-Scope reflect the temperature approximately 0.05 cm away from the fiber tip, whereas temperatures close to fiber tip were significantly higher. The peak temperature of the temperature control group vs non-temperature control group were 31.70±2.609℃and 44.37±3.318℃, respectively (p<0.01). The mean temperature of the temperature control group vs non-temperature control group was 27.40±2.107℃ vs 35.9±1.921℃(p <0.01). ConclusionPT-Scope has demonstrated the capability to precisely monitor and control intrarenal temperature within a safe threshold.