We successfully demonstrate a 106.25-Gbps PAM-4 bidirectional optical sub-assembly for optical access networks, including a driver amplifier and an electro-absorption modulated laser for a transmitter, a photodiode and transimpedance amplifier for a receiver, and an optical filter block. For its implementation, we propose design strategies providing an in-line arrangement of optical and electrical interfaces while ensuring optical alignment tolerance for easy assembly and reducing electrical crosstalk between the transmitter and receiver. Measured receiver sensitivity was <-11.4 dBm for the KP4 forward error correction limit during transmitter operation, and measured power penalty of 10-km single-mode fiber transmission was <0.9 dB.