Measures Of Selective Attention Research Articles

NrCAM-deficient mice exposed to chronic stress exhibit disrupted latent inhibition, a hallmark of schizophrenia.

The neuronal cell adhesion molecule (NrCAM) is widely expressed and has important physiological functions in the nervous system across the lifespan, from axonal growth and guidance to spine and synaptic pruning, to organization of proteins at the nodes of Ranvier. NrCAM lies at the core of a functional protein network where multiple targets (including NrCAM itself) have been associated with schizophrenia. Here we investigated the effects of chronic unpredictable stress on latent inhibition, a measure of selective attention and learning which shows alterations in schizophrenia, in NrCAM knockout (KO) mice and their wild-type littermate controls (WT). Under baseline experimental conditions both NrCAM KO and WT mice expressed robust latent inhibition (p = 0.001). However, following chronic unpredictable stress, WT mice (p = 0.002), but not NrCAM KO mice (F < 1), expressed latent inhibition. Analyses of neuronal activation (c-Fos positive counts) in key brain regions relevant to latent inhibition indicated four types of effects: a single hit by genotype in IL cortex (p = 0.0001), a single hit by stress in Acb-shell (p = 0.031), a dual hit stress x genotype in mOFC (p = 0.008), vOFC (p = 0.020), and Acb-core (p = 0.032), and no effect in PrL cortex (p > 0.141). These results indicating a pattern of differential effects of genotype and stress support a complex stress × genotype interaction model and a role for NrCAM in stress-induced pathological behaviors relevant to schizophrenia and other psychiatric disorders.

Interference and Facilitation Effects on Stroop‐like Tasks in Older Adults

AbstractBackgroundThe effect of aging on susceptibility to interference on Stroop‐like tasks is not clearly understood. Some previous studies have suggested slowed reaction time explains age‐related diminution on Stroop performance, while more recent meta‐analyses suggest that disproportionate interference effects are seen with aging, regardless of slower reaction times. In addition, other variables such as education and IQ have been suggested to mediate Stroop‐like effects in older participants.MethodIn the current study, we assessed the relationship between age and Stroop effects in 348 participants, aged 40‐89, with a wide range of educational achievement. The Stroop tasks were administered as part of a novel computerized neuropsychological battery that utilizes advanced automatic speech recognition and transcription software, the California Cognitive Assessment Battery (CCAB). We are currently utilizing the CCAB to track changes in cognition associated with aging, including evolution of mild cognitive impairment (MCI) and dementia, in an ongoing longitudinal study.ResultMultiple regression analysis showed that age independently predicted both Stroop interference (incongruent minus neutral response times) and facilitation effects (neutral minus congruent response times). However, other variables including gender and vocabulary also independently predicted Stroop facilitation, while gender also independently predicted Stroop interference.ConclusionIn summary, while aging has a significant impact on interference and facilitation effects on Stroop‐like tasks, additional variables such as gender and vocabulary (a proxy for IQ) also play a role in performance on these measures of selective attention.

51 Impact of Blast Exposures on the Cognitive Abilities of Warfighters

Objective:There is growing evidence to indicate that blast exposure military personnel experience throughout their career can have a negative impact on their brain health. The majority of research in the area of blast related neurotrauma has been focused on traumatic brain injury (TBI); however, the blast exposure may often be independent of TBI. It is common in both active duty military and veterans to report years of blast exposure from combat and training. The objective of this study was to explore the relationship between blast exposure and cognitive functioning in military personnel seeking treatment for a mild TBI.Participants and Methods:Participants were recruited from a military hospital while enrolled in a multidisciplinary treatment program for TBI. All patients had at least one diagnosed mTBI as well as persistent cognitive complaints. Exclusion criteria included invalid performance on a performance validity test and a symptom validity test. 97 participants were included in the analysis with an average age of 34.0 (SD = 7.9) and average 4.0 combat deployments (SD = 3.6). Blast exposure history was measured by the overall score from the Blast Exposure Threshold Survey (BETS) which assessed the frequency and duration of use of various blast sources. Outcomes included the Neurobehavioral Symptom Inventory (NSI) and the Global Deficit Scale (GDS) an objective measure of cognitive deficiency. GDS was calculated from seven measures: Hopkins Verbal Learning Test-Revised Total and Delayed Recall (HVLT-TR and HVLT-DR); DKEFS System Color-Word Condition 3 Inhibition (CW3), Color-Word Condition 4 Switching (CW4) and Trail Making Condition 3 Letter Sequencing (TM3), Paced Auditory Serial Addition Test (PASAT), and the Symbol Digit Modality Test (SDMT). Demographically corrected t-scores (M=50, SD = 10) were converted to deficit scores and averaged to calculate GDS. To adjust for nonnormal distributions, non-parametric statistics were examined.Results:The BETS was not related to GDS (rho = -.055); however, there was a significant correlation between higher levels on the BETS and better performance on measures of selective attention (PASAT rho = .307) and processing speed (SDMT rho = .218). The correlation between BETS and the other neuropsychological measures were not meaningful (all rho’s &lt;.10). Those with an impaired GDS, did not differ from others on the BETS. BETS was also not associated with neurobehavioral symptoms (rho = .125). BETS had moderate correlations with number of combat deployments (rho =.483), severity of combat exposure (rho =.556). It was not related to education (rho = .004) or pre-morbid intelligence (rho =-.029).Conclusions:The BETS was not related to GDS (rho = -.055); however, there was a significant correlation between higher levels on the BETS and better performance on measures of selective attention (PASAT rho = .307) and processing speed (SDMT rho = .218). The correlation between BETS and the other neuropsychological measures were not meaningful (all rho’s &lt;.10). Those with an impaired GDS, did not differ from others on the BETS. BETS was also not associated with neurobehavioral symptoms (rho = .125). BETS had moderate correlations with number of combat deployments (rho =.483), severity of combat exposure (rho =.556). It was not related to education (rho = .004) or pre-morbid intelligence (rho =-.029).

The functional relevance of visuospatial processing speed across the lifespan

Visuospatial processing speed underlies several cognitive functions critical for successful completion of everyday tasks, including driving and walking. While it is widely accepted that visuospatial processing speed peaks in early adulthood, performance across the lifespan remains incompletely characterized. Additionally, there remains a lack of paradigms available to assess visuospatial processing speed in unsupervised web-based testing environments. To address these gaps, we developed a novel visuospatial processing speed (VIPS) task adapted from two tests sensitive to visuospatial processing speed declines in older adults, the Useful Field of View paradigm and the PERformance CEntered Portable Test. The VIPS task requires participants to make a central orientation discrimination and complete a simultaneous peripheral visual search task. Data were collected from 86 in-lab volunteers (18–30 years) to compare performance to traditional neuropsychological measures. Consistent with previous literature, performance on the novel VIPS task significantly correlated with measures of selective attention, executive functioning, visual speed, and working memory. An additional 4395 volunteers (12–62 years) were recruited on TestMyBrain.org to establish lifespan trajectories of visuospatial processing speed and associations with functional disability. VIPS task performance peaked in the early 20’s, and steadily decreased such that thresholds doubled in 60-year-olds relative to 20-year-olds (817 ms vs. 412 ms). VIPS task performance significantly correlated with self-reported cognitive functioning deficits broadly across the lifespan but was specifically related to mobility issues in middle-age. These findings have important implications for early detection of cognitive decline and provide insights into potential early intervention targets for younger and middle-aged adults.

Brain-Derived Neurotrophic Factor Val66Met Genotype Modulates Latent Inhibition: Relevance for Schizophrenia.

Latent inhibition (LI) is a measure of selective attention and learning relevant to Schizophrenia (SZ), with 2 abnormality poles: Disrupted LI in acute SZ, thought to underlie positive symptoms, and persistent LI (PLI) in schizotypy and chronic SZ under conditions where normal participants fail to show LI. We hypothesized that Brain-Derived Neurotrophic Factor (BDNF)-Met genotype shifts LI toward the PLI pole. We investigated the role of BDNF-Val66Met polymorphism and neural activation in regions involved in LI in mice, and the interaction between the BDNF and CHL1, a gene associated with SZ. No LI differences occurred between BDNF-wild-type (WT) (Val/Val) and knock-in (KI) (Met/Met) mice after weak conditioning. Chronic stress or stronger conditioning disrupted LI in WT but not KI mice. Behavior correlated with activation in infralimbic and orbitofrontal cortices, and nucleus accumbens. Examination of LI in CHL1-KO mice revealed no LI with no Met alleles (BDNF-WTs), PLI in CHL1-WT mice with 1 Met allele (BDNF-HETs), and PLI in both CHL1-WTs and CHL1-KOs with 2 Met alleles (BDNF-KIs), suggesting a shift to LI persistence with the number of BDNF-Met alleles in the CHL1 model of acute SZ. Results support a role for BDNF polymorphisms in gene-gene and gene-environment interactions relevant to SZ. BDNF-Met allele may reduce expression of some acute SZ symptoms, and may increase expression of negative symptoms in individuals with chronic SZ. Evaluation of (screening for) SZ phenotypes associated with mutations at a particular locus (eg, CHL1), may be masked by strong effects at different loci (eg, BDNF).

Inconsistent flanker congruency effects across stimulus types and age groups: A cautionary tale.

The flanker task is a common measure of selective attention and response competition across populations, age groups, and experiential contexts. Adapting it for different uses often involves changing methodological features that are rarely empirically compared with the previous design. This paper presents an example of how typical methodological changes can differentially elicit congruency effects across age groups. We compared two flanker tasks, using direction stimuli on a laptop versus color stimuli on a tablet, in young children (2-7 years; Experiment 1), older children (6-10 years; Experiment 2a), and adults (19-23 years; Experiment 2b). Young children showed the expected congruency effects in the direction task, and one year later a subset of the sample completed the color task, also showing congruency effects. Longitudinal comparisons showed no difference in the congruency effect across tasks, but nearly half of the sample was excluded due to high error rates. To avoid excluding children with few correct trials, we modified a new measure, signed residual time, to incorporate correctness and reaction time per trial. With the larger sample, this measure showed no difference in congruency effects across tasks. To compare these tasks when completed within the same session, we tested older children and young adults in both tasks and found congruency effects in the direction task but not the color task. These results raise concern that tasks adapted for young children may not perform comparably in other samples, and we caution researchers to anticipate this possibility when modifying cognitive tasks.

UCancellation: A new mobile measure of selective attention and concentration.

Measuring selective attention in a speeded task can provide valuable insight into the concentration ability of an individual, and can inform neuropsychological assessment of attention in aging, traumatic brain injury, and in various psychiatric disorders. There are only a few tools to measure selective attention that are freely available, psychometrically validated, and can be used flexibly both for in-person and remote assessment. To address this gap, we developed a self-administrable, mobile-based test called “UCancellation” (University of California Cancellation), which was designed to assess selective attention and concentration and has two stimulus sets: Letters and Pictures. UCancellation takes less than 7 minutes to complete, is automatically scored, has multiple forms to allow repeated testing, and is compatible with a variety of iOS and Android devices. Here we report the results of a study that examined parallel-test reliability and convergent validity of UCancellation in a sample of 104 college students. UCancellation Letters and Pictures showed adequate parallel test reliability (r = .71–.83, p < 0.01) and internal consistency (ɑ = .73–.91). It also showed convergent validity with another widely used cancellation task, d2 Test of Attention (r = .43–.59, p < 0.01), and predicted performance on a cognitive control composite (r = .34–.41, p < 0.05). These results suggest that UCancellation is a valid test of selective attention and inhibitory control, which warrants further data collection to establish norms.Supplementary InformationThe online version contains supplementary material available at 10.3758/s13428-021-01765-5.

Comparing the Cognitive Functioning Effects of Aerobic and Pilates Exercises for Inactive Young Adults: A Randomized Controlled Trial.

Aerobic exercises (AE) have been found to have short-term positive effects on certain aspects of cognitive functioning. Pilates exercises (PE) may have similar benefits. In this randomized controlled study, we compared the effectiveness of PE and AE on participants' cognitive functions. We randomly assigned 52 physically inactive young adult volunteers into either a PE group (Mage = 20.85, SD = 2.11years; 18 females and 8 males) or an AE group (Mage = 19.88, SD = 0.91years; 18 females and 8 males). In both groups, participants engaged in a moderately intense exercise program threedays a week for fourweeks. We tested participants on cognitive measures of selective attention and inhibitory control (Stroop test), verbal fluency (verbal fluency tests (letter and category); VFTs), and speed of movement (Nelson's Speed of Movement Test; NSMT). There were no group differences on the Stroop and the VFTs (p>0.05). However, there was a significant pre- to post-exercise difference for participants in both groups with a medium-large effect size (ES) on Stroop sections 1, 3, 4, and 5, respectively (PE: p < 0.001, ES = 0.58, p = 0.001, ES = 0.54, p < 0.001, ES = 0.88, p = 0.001, ES = 0.60; AE: p < 0.001, ES = 0.70, p < 0.001, ES = 0.89, p < 0.001, ES = 0.86, p = 0.006, ES = 0.65). There was a large effect size pre- to post-exercise detected for VFT sections labeled letter (PE: p < 0.001, ES = 1.45; AE: p < 0.001, ES = 1.11), and category (PE: p < 0.001, ES = 1.11; AE: p < 0.001, ES = 0.83), and there was a large ES for NSMT in the PE group (p < 0.001, ES = 1.07). Both PE and AE may lead to short-term improvements in selective attention, verbal fluency, and executive control in inactive young adults, and PE may benefit speed of movement.

Prevention of Morbidity in Sickle Cell Disease Phase II (Improvement of Cognition in children with Sickle Cell Disease with Auto-adjusting Continuous Positive Airways Pressure: Phase II) (POMS 2b paediatric cohort)

▪Background: Complications in sickle cell anemia (SCA, HbSS) include neurocognitive difficulties in attention and processing speed associated with low daytime and night-time oxygen saturation. These effects can be compounded by obstructive sleep apnea (OSA).However, there is concern that oxygen supplementation in SCA may lead to bone marrow suppression. Continuous Positive Airways Pressure (CPAP) is an accepted treatment for OSA in the general population and prevents dips in oxygen saturation.. The aim of this single-blind, randomised, controlled phase II trial is to compare Auto-adjusting CPAP (APAP) with standard care to standard care alone in subjects with HbSS to determine whether the intervention is safe and improves Cancellation, a measure of selective attention and processing speed.Methods: Eligibility criteria included ability to provide informed consent, age >8 and <16 years, diagnosis of HbSS and mean overnight saturation of <90% for <30% of the night. Key exclusion criteria were overnight respiratory support, respiratory or decompensated cardiac failure, chronic transfusion or contra-indications to APAP therapy or MRI.Minimisation/stratification factors were age group (8-11, 12-15 years), silent infarction on MRI, minimum overnight oxygen saturation >90% or <90%, and hydroxyurea (HU) use.APAP adherence was defined as using APAP for an average of 4 hours a night for >50% of the time and was recorded using software documenting hours of use each night. Participant support in terms of appropriate facemask and facilitating adherence were provided by an unblinded sleep physiologist.Full blood counts were obtained at baseline, 2 weeks, 3 months and 6 months.Data were analysed by intention-to-treat. The primary outcome is change in the Cancellation subtest from the Wechsler scales, and secondary outcomes include general cognitive functioning, assessed at baseline and after 6 months of treatment by assessors blind to treatment assignment. Analysis of Covariance (ANCOVA) models, adjusted for minimisation factors, were used to calculate least-square mean changes from baseline to 6 months.Results: 30 children (18 boys; median age 12.5; range 7.9-16 years) with SCA were randomised to standard care + APAP (n=15) or standard care alone (n=15) for 6 months. One child in the standard care alone arm withdrew after 6 weeks, and 8 children in the APAP arm were not adherent to treatment. Increase in cancellation score was numerically greater in the APAP arm (mean 1.46, SE 0.59 vs 1.01, SE 0.61) but this was not significant (mean difference 0.44, 95% CI: -1.42; 2.31; p=0.626). Increase in Cancellation score was greater (mean 2.63; 95%CI: 0.95, 4.30) in those whose adherence was in the highest quartile (> 2.4 hours/night) compared with the other 3 quartiles (mean 0.71, 95%CI: -0.32, 1.75; mean difference 1.91, 95%CI: -0.06, 3.88; p=0.057). In subjects assigned to APAP, cancellation scores were significantly higher with hydroxyurea use (p=0.01). There was no evidence of decline in haemoglobin in either group; hydroxyurea use was associated with an increase in haemoglobin (p=0.01). There were 7 subjects with serious adverse events in the standard care alone arm, compared to 3 in the APAP + standard care arm, all related to hospital admission for pain.Discussion: APAP for 6 months is feasible and safe in children with SCA. Alhough >50% were not adherent by the pre-defined definition, those who were compliant appeared to have more benefit in terms of improvement in attention/processing speed. There appears to be an interaction with HU use, consistent with the importance of oxygen supply and carriage for brain function. If delivery of the intervention can be improved, avoidance of oxygen desaturation with overnight respiratory support alongside HU use may play a role in improving cognition in SCD. DisclosuresNo relevant conflicts of interest to declare.

Development of lateral pulvinar resting state functional connectivity and its role in attention

ObjectiveThe lateral pulvinar nucleus (LPN) has a well-established role in visual attention. Oscillatory activity of the LPN is critical for cortico-cortical communication within and among occipital and temporal visual processing regions. However, the functional development of the LPN and its role in attention deficits is not understood. This study examined the development of thalamic functional connectivity and its relation to attention abilities. MethodResting state functional Magnetic Resonance Imaging images from 950 participants (ages 8–21) in the Philadelphia Neurodevelopmental Cohort (PNC) were used to examine age effects. Follow-up General Linear Models were performed to examine brain-behavior effects with Attention Deficit Hyperactivity Disorder (ADHD) symptom ratings and D-prime scores from the Penn Continuous Performance Task, a behavioral measure of selective attention. ResultsLPN functional connectivity with ventral visual stream regions of the occipital and temporal cortices decreased with age, while LPN functional connectivity with the supplementary motor area increased with age.Weaker LPN connectivity in the inferior parietal lobule, supramarginal gyrus, posterior insula, and inferior frontal gyrus was associated with more ADHD symptoms; stronger pulvinar-cerebellar connectivity was also associated with more ADHD symptoms. Better D-prime scores were associated with greater connectivity between the pulvinar and superior parietal gyrus; better D-prime scores were associated with weaker pulvinar connectivity with striatal, middle temporal gyrus, and medial prefrontal cortex regions. ConclusionThese findings implicate the LPN in the development of the ventral visual processing stream between late childhood and early adulthood and suggest that LPN connectivity with higher order attention networks is important for attention abilities.

Cognitive and behavioral effects of cannabidiol in patients with treatment-resistant epilepsy

PurposeTherapeutic use of cannabidiol (CBD) in intractable epilepsies has increased considerably over the last ten years. As more evidence for the potentially beneficial effects of CBD on different epilepsy types is emerging, it is important to monitor potential cognitive and behavioral side effects. So far, studies including standardized neuropsychological data in the context of treatment with CBD in epilepsy patients are sparse. The present open-label study examines cognitive and behavioral effects of CBD in children and adults with treatment resistant epilepsy. MethodThirty-nine patients with treatment-resistant epilepsy completed the study protocol, i.e. they were tested at baseline (T0) and after three months of CBD treatment (T1). Patients completed standardized neuropsychological tests on memory, executive functions and attention if they were capable. For cognitively impaired patients who could not complete cognitive tests, caregiver interviews were conducted and caregiver questionnaires completed. ResultsSignificant cognitive decline from T0 to T1 was observed on none of the included measures. There was a significant improvement on a measure of selective attention and on a caregiver-rated behavioral measure. More than 89% of all individual test results remained stable or showed reliable improvement from T0 to T1. Cognitive and behavioral changes from T0 to T1 were not significantly correlated with CBD dose. Improvements in short-term/working memory were significantly related to better therapy response. ConclusionNo adverse group-level effects of CBD treatment were detected. On an individual level, most test results remained stable or were improved. Cognitive change was not related to CBD dose. The present results show that, from a cognitive and behavioral point of view, CBD seems to have an encouraging side-effect profile. The results need to be replicated with larger samples.

L-theanine improves neurophysiological measures of attention in a dose-dependent manner: a double-blind, placebo-controlled, crossover study

ABSTRACT Objective: L-theanine, a non-proteinic amino acid found in tea, is known to enhance attention particularly in high doses, with no reported adverse effects. We aimed to determine whether oral administration of L-theanine acutely enhances neurophysiological measures of selective attention in a dose-dependent manner. Methods: In a double-blind, placebo-controlled, counterbalanced, 4-way crossover study in a group of 27 healthy young adults, we compared the effects of 3 doses of L-theanine (100, 200 and 400 mg) with a placebo (distilled water) on latencies of amplitudes of attentive and pre-attentive cognitive event-related potentials (ERPs) recorded in an auditory stimulus discrimination task, before and 50 min after dosing. Results: Compared to the placebo, 400 mg of theanine showed a significant reduction in the latency of the parietal P3b ERP component (p < 0.05), whereas no significant changes were observed with lower doses. A subsequent exploratory regression showed that each 100-mg increase in dose reduces the P3b latency by 4 ms (p < 0.05). No dose–response effect was observed in P3b amplitude, pre-attentive ERP components or reaction time. Discussion: The findings indicate L-theanine can increase attentional processing of auditory information in a dose-dependent manner. The linear dose–response attentional effects we observed warrant further studies with higher doses of L-theanine.

Domain-specific experience determines individual differences in holistic processing.

Holistic processing refers to the processing of objects as wholes rather than in a piecemeal, part-based fashion. Despite a suggested link between expertise and holistic processing, the role of experience in determining holistic processing of both faces and objects has been questioned. Here, we combine an individual differences approach with an experimental training study and parametrically manipulate experience with novel objects to examine the determinants of holistic processing. We also measure object-recognition ability. Our results show that although domain-general visual ability is a predictor of the ability to match object parts, it is the amount of experience people have individuating objects of a category that determines the extent to which they process new objects of this category in a holistic manner. This work highlights the benefits of dissociating the influences of domain-general ability and domain-specific experience, typically confounded in measures of performance or "expertise." Our findings are consistent with those in recent work with faces showing that variability specific to experience is a better predictor of domain-specific effects than is variability in performance. We argue that individual differences in holistic processing arise from domain-specific experience and that these effects are related to similar effects of experience on other measures of selective attention. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

The SwAD-Task - An Innovative Paradigm for Measuring Costs of Switching Between Different Attentional Demands.

Task switching paradigms are frequently used to identify costs of switching between modalities, spatiality, attributes, rules, etc., but switching between different attentional demands has been somehow neglected. The present study introduces an innovative paradigm, that allows to test single attentional demands (such as selective and divided attention), and more importantly the process of switching between these demands. We examined the feasibility of the paradigm by focusing on the demands of selective and divided attention with a sample of 94 people (age: M = 21.44 years, SD = 2.68; 76 women). In addition, we tested correlations between the implemented single attentional demands and commonly used measures of selective and divided attention. Results show no general difference between individual assessments under single demand conditions. Reaction times under divided attention are significantly higher compared to selective attention. In the switching condition, reaction times in both demands increase with increased switching. Furthermore, switching costs significantly increase in selective but not in divided attention. Means of selective and divided attention in single and switching conditions significantly correlate with a commonly used measure of selective attention. Means of divided attention under single demand significantly correlate with performance in a commonly used dual-task paradigm. Summarizing the present findings, it can be stated that the introduced paradigm comprises a feasible way for quantifying the process of switching attention between different demands.

Deep phenotyping of attention impairments and the 'Inattention Biotype' in Major Depressive Disorder.

Attention impairment is an under-investigated feature and diagnostic criterion of Major Depressive Disorder (MDD) that is associated with poorer outcomes. Despite increasing knowledge regarding mechanisms of attention in healthy adults, we lack a detailed characterization of attention impairments and their neural signatures in MDD. Here, we focus on selective attention and advance a deep multi-modal characterization of these impairments in MDD, using data acquired from n = 1008 patients and n = 336 age- and sex-matched healthy controls. Selective attention impairments were operationalized and anchored in a behavioral performance measure, assessed within a battery of cognitive tests. We sought to establish the accompanying neural signature using independent measures of functional magnetic resonance imaging (15% of the sample) and electroencephalographic recordings of oscillatory neural activity. Greater impairment on the behavioral measure of selective attention was associated with intrinsic hypo-connectivity of the fronto-parietal attention network. Not only was this relationship specific to the fronto-parietal network unlike other large-scale networks; this hypo-connectivity was also specific to selective attention performance unlike other measures of cognition. Selective attention impairment was also associated with lower posterior alpha (8-13 Hz) power at rest and was related to more severe negative bias (frequent misidentifications of neutral faces as sad and lingering attention on sad faces), relevant to clinical features of negative attributions and brooding. Selective attention impairments were independent of overall depression severity and of worrying or sleep problems. These results provide a foundation for the clinical translational development of objective markers and targeted therapeutics for attention impairment in MDD.

Effects of Nonaction Videogames on Attention and Memory in Young Adults

Objective: In this intervention study, we investigated the benefits of nonaction videogames on measures of selective attention and visuospatial working memory (WM) in young adults. Materials and Methods: Forty-eight young adults were randomly assigned to the experimental group or to the active control group. The experimental group played 10 nonaction adaptive videogames selected from Lumosity, whereas the active control group played two nonadaptive simulation-strategy games (SimCity and The Sims). Participants in both groups completed 15 training sessions of 30 minutes each. The training was conducted in small groups. All the participants were tested individually before and after training to assess possible transfer effects to selective attention, using a Cross-modal Oddball task, inhibition with the Stroop task, and visuospatial WM enhancements with the Corsi blocks task. Results: Participants improved videogame performance across the training sessions. The results of the transfer tasks show that the two groups benefited similarly from game training. They were less distracted and improved visuospatial WM. Conclusion: Overall, there was no significant interaction between group (group trained with adaptive nonaction videogames and the active control group that played simulation games) and session (pre- and post-assessment). As we did not have a passive nonintervention control group, we cannot conclude that adaptive nonaction videogames had a positive effect, because some external factors might account for the pre- and post-test improvements observed in both groups.

Flanker tasks based on congruency manipulation are biased measures of selective attention in perceptual load studies.

Flanker tasks based on a flanker-target congruency manipulation are widely used in perceptual load studies to investigate under what circumstances task-irrelevant flankers may be processed. An implicit assumption underlying the congruency manipulation is that the three types of flankers (congruent, incongruent, and neutral) attract attention homogeneously. However, in the present study, we provide evidence to demonstrate that this assumption is wrong: We discovered that incongruent/congruent flankers attracted more attention than the neutral flanker did. To avoid this attentional bias induced by the flanker-target congruency manipulation, we developed a new flanker paradigm in which the extent of flanker processing was evaluated by comparing the threshold stimulus exposure durations (TSEDs) for successfully performing a target identification task when a task-irrelevant flanker was presented versus when the flanker was absent. The flanker was processed if the TSED was longer when the flanker was present than when it was absent. This new paradigm provides an unbiased measure of selective attention when neutral flankers are used. The present data, obtained with neutral flankers in the new paradigm, were consistent with the dilution theory of selective attention, but inconsistent with the perceptual load theory of selective attention.

Decoding listener’s attention :Can it be improved with behavioural measure of selective attention?

During the past decade, there has been growing interest in the neural correlates of selective attention to speech. In these studies, listeners were instructed to focus their attention on one of two concurrent speech streams. However, in everyday-life situations, a listener's attention can switch rapidly between different voices. Thus, we have developed a behavioural protocol to infer the dynamics of auditory attention over time. After listening to two simultaneous stories—a target and an interferer—the participants have to find, among a set of words, those present in the target story. The participant’s responses are then used to estimate, retrospectively, when their attention was directed toward the target, or toward the interferer. Neural data, recorded with EEG, and behavioural measures are combined to extract the brain's temporal response function in response to these stimuli. Moreover, to promote attention switches between the two voices, the interferers were uttered by the same talker as the target stories, but the voice parameters were manipulated to parametrically control the similarity of the two voices. We will discuss the results in terms of attentional selection and voice confusion, and suggest possible applications of this dynamic behavioral test of selective auditory attention.

Specific aspects of cognitive impulsivity are longitudinally associated with lower treatment retention and greater relapse in therapeutic community treatment

IntroductionImpulsivity has been consistently associated with poorer addiction treatment outcomes. However, impulsivity is a multifaceted construct and current evidence have failed to unravel which specific aspects explain this relationship. There is also limited research examining long-term outcomes. We aimed to examine the longitudinal association between baseline performance on a comprehensive battery of impulsivity measures and retention and relapse at the end of treatment. MethodsThe sample comprised 68 participants with miscellaneous diagnoses of substance use disorders and polysubstance use patterns, enrolled in public residential therapeutic communities in Andalusia (Spain). At baseline, we applied measures of selective attention (Stroop), response inhibition (Affective Go/No Go), delay discounting (Monetary Choice Questionnaire; MCQ), and decision-making (Iowa Gambling Task; IGT). At the end of treatment (mean = 148.36 days, range = 22–289 days), we collected outcome measures of retention (coded by the clinical team as completion or dropout based on statewide practice guidelines) and relapse (defined as at least two separate alcohol/drug use episodes based on urine analyses). ResultsCox regression models showed that poorer decision-making in the IGT was associated with premature treatment dropout, whereas elevated commission errors in the Affective Go/No Go were associated with higher relapse rates. Selective attention and delay discounting were unrelated to outcomes. ConclusionLong-term based decision-making skills are important to commit to the complex and intensive treatment programs of therapeutic communities. The ability to withhold behavioural responses under positive affect is relevant to prevent relapse. Both skills should be assessed and potentially trained during therapeutic community treatment.

Psychometric Properties of a Flanker Task in a Sample of Patients with Dementia: A Pilot Study

Background/Aims: Reliable and valid neuropsychological tests for patients with dementia are scarce. To improve the assessment of attention and inhibitory control in dementia, we determined the feasibility, test-retest reliability, and validity of a Flanker task. Methods: Participants with all-cause diagnosed dementia (n = 22, mean age 84 years; mean Mini-Mental State Examination [MMSE] score = 19.4) performed a computerized Flanker task twice within 7 days. The Flanker task required participants to indicate the direction of target arrows flanked by congruent or incongruent arrows. Number of completed trials, accuracy, and reaction times (RTs) were recorded, and interference scores were calculated from basic scores. We examined the psychometric properties of the Flanker task and its relationship with the MMSE and Stroop test. Results: The Flanker task was feasible. Test-retest reliability was good for number of correct answers and RTs, and fair to poor for accuracy and the interference scores. The correlation of the Flanker task with Stroop and MMSE performance was fair to poor. Conclusion: The Flanker task appears to be feasible, and a reliable and valid measure of selective attention. Although the test-retest reliability for the Flanker RT interference measure was fair, future studies need to confirm its validity to measure inhibitory control in patients with dementia.