Development of lateral pulvinar resting state functional connectivity and its role in attention

Abstract

ObjectiveThe lateral pulvinar nucleus (LPN) has a well-established role in visual attention. Oscillatory activity of the LPN is critical for cortico-cortical communication within and among occipital and temporal visual processing regions. However, the functional development of the LPN and its role in attention deficits is not understood. This study examined the development of thalamic functional connectivity and its relation to attention abilities. MethodResting state functional Magnetic Resonance Imaging images from 950 participants (ages 8–21) in the Philadelphia Neurodevelopmental Cohort (PNC) were used to examine age effects. Follow-up General Linear Models were performed to examine brain-behavior effects with Attention Deficit Hyperactivity Disorder (ADHD) symptom ratings and D-prime scores from the Penn Continuous Performance Task, a behavioral measure of selective attention. ResultsLPN functional connectivity with ventral visual stream regions of the occipital and temporal cortices decreased with age, while LPN functional connectivity with the supplementary motor area increased with age.Weaker LPN connectivity in the inferior parietal lobule, supramarginal gyrus, posterior insula, and inferior frontal gyrus was associated with more ADHD symptoms; stronger pulvinar-cerebellar connectivity was also associated with more ADHD symptoms. Better D-prime scores were associated with greater connectivity between the pulvinar and superior parietal gyrus; better D-prime scores were associated with weaker pulvinar connectivity with striatal, middle temporal gyrus, and medial prefrontal cortex regions. ConclusionThese findings implicate the LPN in the development of the ventral visual processing stream between late childhood and early adulthood and suggest that LPN connectivity with higher order attention networks is important for attention abilities.