Safety Measures Research Articles

Investigating the Influence of Time Pressure on Risky Riding Behaviour among P-Hailing Riders in Malaysia: The Mediating Role of Moral Disengagement

This study investigates the impact of time pressure on risky riding behaviour among p-hailing riders in Malaysia, with moral disengagement as a mediating factor. Drawing on Bandura's Moral Disengagement Theory and the Job Demand-Resources (JD-R) Model, the research explores how time pressure influences these behaviours. A survey of 200 respondents, selected through stratified convenience sampling, was conducted across three Northern States in Malaysia, namely Perlis, Kedah, and Penang. Data analysis using Partial Least Squares Structural Equation Modelling (PLS-SEM) reveals that time pressure significantly increases risky riding behaviour, with moral disengagement significantly mediates this relationship. The study finds that younger and less experienced riders are particularly susceptible to time pressure effects. Demographic data indicate that 80% of riders are under 35 years old, with 75% having less than three years of experience. Based on these findings, the research emphasises the need for targeted interventions, including specialised training programmes and improved workload management strategies, to mitigate risks associated with p-hailing. The study contributes to a deeper understanding of the role of a cognitive mechanism factor in influencing risky riding behaviours among p-hailing riders and provides valuable insights for enhancing road safety measures. Future research directions are suggested, including exploration of additional cognitive mechanisms that may impact risky riding behaviours in this context.

CONFORMIDADE DE PAINÉIS ELÉTRICOS COM A NR-10 E NBR 5410

As modern industry integrates into the era of automation 4.0, characterized by information exchange and connectivity, there are still industries with outdated processes and equipment. The NBR 5410 and NR-10 standards play crucial roles, stipulating requirements and safety measures for low-voltage electrical installations and protecting the health and safety of workers. Electrical panels, fundamental in this context, regulate industrial processes automatically and without human intervention, ensuring not only efficiency and productivity, but also safety and effective maintenance of operations. In view of the above, the study aims to analyze how electrical panels can be configured and adjusted to comply with Brazilian standards NR-10 and NBR 5410. This study adopts bibliographic methodology, extensively reviewing academic literature, articles, technical standards and relevant related documents the installation of electrical panels. A careful selection of primary and secondary sources will be made to ensure a comprehensive understanding of current and emerging practices in the field. The process includes an analysis of extracted data to identify patterns, challenges and opportunities for innovation, providing a solid basis for discussion and conclusions in the study. In this way, the application of these standards contributes to a cycle of continuous improvement in the electrical industry. By establishing safe and efficient procedures, standards not only protect the individuals directly involved, but also benefit society as a whole by ensuring the integrity and security of critical infrastructures.

Administrating first aid in road traffic accidents in Bulgaria: a cross-sectional study

Abstract Background Bulgaria had the highest road mortality rate among European Union members in 2023, having previously ranked second after Romania. Research has consistently demonstrated that prompt pre-hospital care can significantly reduce the adverse effects of road traffic accidents. Thus, we conducted a cross-sectional study to explore the involvement of trained road traffic casualties and bystanders in administering first aid. Methods The study, carried out between April and December 2021, collected data via an online survey administered to members of the Scientific and Academic Cooperation Council by the State Agency Road Safety. The survey encompassed a range of topics, including first aid training, involvement in traffic accidents, behaviour of bystanders, administration of first aid, and sociodemographics. Results Among the 292 respondents, a sizeable proportion (90%) reported having received first aid training. Of these, 35.1% (95% CI 29.2-41.1%; p < 0.001) had personally experienced a road traffic accident, and 64.5% (95% CI 58.1-70.1%; p < 0.001) had witnessed one. It is noteworthy that a fifth of those involved in accidents had employed the skills acquired from first aid training, which included applying a dressing to a wound, bleeding control, and immobilising a fracture. Correspondingly, an equivalent percentage of bystanders administrated aid, with the majority of them performing basic airway management. However, the findings revealed that a significant proportion of participants (79.3%) did not engage in providing first aid. The primary rationale stated was the assessment that it was nonessential. Conclusions Despite the growing road safety challenges and many respondents witnessing or being involved in accidents, only a quarter of those trained in first aid actually provided assistance. Considering the increasing number of deaths and severe injuries, it is crucial to assess the need for frequent first aid training and the population’s proficiency in first aid. Key messages • Bystanders’ competence in administrating first aid can mitigate the adverse effects of road traffic accidents. • Among other road safety measures, investments in first aid training can be beneficial in reducing fatalities and severe injuries.

Characterization and Prevalence of Antibiotic Resistance Staphylococcus aureus in Street Food: A Public Health Concern

Food samples containing Staphylococcus aureus pose a serious health risk. This study aimed to examine the prevalence of S. aureus strains in various food samples sourced from Mailsi and Multan. Many food samples including yogurt, bakery products, and raw and cooked food were examined for S. aureus. The isolated strains were confirmed through Mannitol agar fermentation, catalase, coagulase, and urease tests. Hemolysis on blood agar and biofilm formation were also assessed to determine toxin production. Antibiotic sensitivity testing was conducted using the Kirby Bauer method on MH agar, and multiple antibiotics were tested. Out of all samples, a total of 50 S. aureus strains were obtained, mainly from milk and milk-based products. Yellow colonies on mannitol salt agar confirmed S. aureus presence, with all isolates testing positive for coagulase, catalase, and urease. The presence of hemolysins: beta, gamma, and alpha were revealed by hemolysis assays. Biofilm assay results showed variation among the strains, with some categorized as strong, moderate, or weak biofilm formers. Regarding antibiotic sensitivity, most strains exhibited multidrug resistance, particularly against certain antibiotics. Vancomycin showed varying susceptibility patterns, some strains showed susceptibility and intermediate resistance, whereas only milk samples showed resistance. This study emphasizes the prevalence of MDR S. aureus strains in food samples. The study underscores the significance of antimicrobial stewardship programs and stringent food safety measures in preventing the spread of antibiotic-resistant strains and reducing foodborne illnesses. Further research is needed to explore the mechanisms behind antibiotic resistance and toxin production in S. aureus strains from food samples.

Students' Satisfaction with the Choice of Public Transport Mobility in UiTM Puncak Alam

Transportation is essential for facilitating movement and contributing to economic development. This study aims to measure student satisfaction with public transportation mobility at UiTM Puncak Alam. Understanding the level of satisfaction derived from transportation services is crucial for enhancing student experiences. The main focus of this research is to identify the factors influencing student satisfaction with public transport services, specifically examining reliability, convenience, frequency, and safety in UiTM Puncak Alam. A correlation study was conducted to explore the relationships between these factors and student satisfaction. The research utilized a non-probability convenience sampling method, distributing a questionnaire to 217 students from the Faculty of Business and Management. Data collection occurred over three months, from October 2022 to December 2022, using online questionnaires. The findings indicate that comfort, frequency, and safety significantly influenced student satisfaction. Numerous students expressed their dissatisfaction with the old buses, inconsistent service schedules, and safety issues. These elements were discovered to influence students' selection of public transportation and their overall contentment. The research also highlighted concerns like bus conditions, driver behavior, and punctuality, all of which affect student satisfaction and academic achievement. Based on these findings, the study suggests increasing the bus fleet, enhancing service frequency, and strengthening safety measures to better address student needs and boost their overall satisfaction with public transportation at UiTM Puncak Alam.

Pattern of Drowning among Autopsies Conducted at Baroda Medical College and S.S.G Hospital

Drowning kills at least 3,72,000 people every year and is the 3rd leading cause of unintentional deaths. In addition to the human tragedy, drowning represents a huge economic problem with direct and indirect costs, including many Disability-Adjusted Life Years. In India, there is limited knowledge about the epidemiology of drowning.The objective of the study was to study the incidence, manner and epidemiology of deaths due to drowning in and around Vadodara region.The present study was conducted from May 2022 to April 2023 in Government Medical College, Baroda on 82 cases to study the various epidemiological parameters of drowning. In this study period, 1989 cases of post-mortem examination were done out of which 82 cases were of drowning deaths. A maximum number of cases were seen in the age group of 21–30 years with 43% cases of males, dominating the study population. 62% of deaths were accidental in nature and occurred during the rainy season. The most common place of occurrence of drowning was river (38%) followed by water canal (31%). Soddening of hands and feet was the most common external feature of drowning followed by the presence of froth at mouth and nostril. Drowning is a most ignored public hazard worldwide with serious implications for the society. Public awareness regarding safety measures and drowning prevention strategies suitable to the needs of geographical region should be adapted.

Enhancing Daily Crash Count Prediction using Deep Learning with Window Size Selection and Seasonality Predictor Integration

The escalating need for proactive safety measures, coupled with advancements in data collection and analytical techniques, has significantly refined the accuracy of crash count predictions, shifting from annual scales to finer daily or hourly estimates. This research places emphasis on recurrent neural networks (RNNs), specifically the long short-term memory (LSTM) model, acknowledged for effectively managing sequential data in time series predictions. Paramount considerations encompass the treatment of input data, including the decision to incorporate temporal features alongside endogenous historical target values, and the establishment of an optimal window size for data input. Despite the critical nature of these facets, exhaustive studies concurrently investigating both under controlled conditions are scarce. This research addresses this gap, assessing diverse scenarios featuring distinct temporal treatments and window sizes, and employing an LSTM model with uniform fine-tuned parameters to ensure a fair comparison. Findings indicate a significant variation in performance among models employing different window sizes and month predictor integration, under identical RNN structures and LSTM configurations. The best model outperformed the least effective by roughly 30% concerning root mean square error (RMSE) and ranking correlation between predicted and actual target crash counts in the test datasets. Unlike seasonality predictor treatment, diverse window size selections did not lead to statistically significant differences in model performance. Generally, a window size of 3 performed worst under most conditions, followed by a size of 14. Sizes of 7 and 28 performed best in nearly an equal numbers of cases.

Augmented reality guidance improves accuracy of orthopedic drilling procedures

In several orthopedic procedures, the accurate use of surgical power tools is critical to avoid damage to surrounding tissues. As such, various guidance techniques and safety measures were developed. Augmented reality (AR) guidance shows promise but requires validation. We evaluated a new approach using an inside-out infrared tracking solution for the HoloLens to compensate for its limited tracking performance. Eighteen participants with varying levels of experience (student, trainee, expert) each drilled twelve trajectories (six perpendicular, six oblique) in equidimensional wooden logs. Three different techniques were evaluated: freehand drilling; proprioception-guided drilling towards the contralateral index finger; and AR-guided drilling using a tracked drill and a virtual overlay of the log with predefined guidance vectors. The angular errors between planned and performed trajectories were compared using a mixed-design ANOVA. The results demonstrated that guidance technique (p < 0.001) and drilling direction (p < 0.001) significantly affected drilling accuracy, while experience (p = 0.75) did not. AR outperformed both other techniques, particularly for oblique trajectories (p < 0.001). For perpendicular trajectories, it only outperformed proprioception guidance (p = 0.04). Target plots revealed an important scatter perpendicular to the longitudinal axis of the log during freehand and proprioception-guided drilling, especially for oblique trajectories. This inaccuracy disappeared during AR-guided drilling. As such, we were able to conclude that AR guidance using inside-out infrared tracking reduced angular uncertainty during directional drilling, resulting in improved drilling accuracy. This improvement was particularly noticeable for complex trajectories and angles. The benefits of AR guidance were observed across all experience levels, highlighting its potential for orthopedic applications. We believe this study opens the way for the methodical evaluation of AR guidance in specific orthopedic use cases.

Knowledge, Attitudes, and Practices Related to Mold Remediation Following Hurricane Ida in Southeast Louisiana

Hurricane Ida, a Category 4 hurricane, made landfall in southern Louisiana in August of 2021, causing widespread wind damage and flooding. The objective of this study was to investigate knowledge, attitudes, and practices related to post-hurricane mold exposure and cleanup among residents and workers in areas of Louisiana affected by Hurricane Ida and assess changes in knowledge, attitudes, and practices that have occurred over the past 16 years since Hurricane Katrina. We conducted in-person interviews with 238 residents and 68 mold-remediation workers in areas in and around New Orleans to ask about their mold cleanup knowledge and practices, personal protective equipment use, and risk perceptions related to mold. Knowledge of recommended safety measures increased since the post-Katrina survey but adherence to recommended safety measures did not. Many residents and some workers reported using insufficient personal protective equipment when cleaning up mold despite awareness of the potential negative health effects of mold exposure.

Knowledge, Attitude and Practice of Nurses and Midwives towards Hepatitis B Infection and Control Measures in Alban Gaded Hospital, Khartoum, Sudan

Purpose: Infection with the hepatitis B virus (HBV) causes severe morbidity and death, burdening world health. Nurses and midwives, among other healthcare professionals, are more likely to contract the illness. Few studies have looked at the knowledge, attitude, and practices (KAP) of healthcare professionals in Sudan with regard to HBV infection, despite the fact that diverse components of KAP have an impact on health-related behaviors. This study's objective was to assess the knowledge, attitude, and practice (KAP) level of nurses and midwives concerning HBV viral infection in, Khartoum, Sudan.  Methods: In the Sudanese state of Khartoum, a public hospital (Alban Gaded Hospital) underwent a cross-sectional descriptive hospital-based study. To assess KAP's understanding of nurses and midwives about HBV infection. Self-administered questionnaires were used and approved by the supervisor for distribution to the population chosen for the study. The data was handed over to the Medical Director whom personally ensured the questionnaires were signed and filled by the Healthcare workers (HCWs) of the chosen criteria at the field. A member of group (23:B) took care of the supervision aside with the medical director, and made sure the data was collected as needed. The data at hand were subjected to statistical analysis using SPSS version 24.0 (Statistical Package for Social Sciences).  Results: 95 samples out of 99 were collected. According to participants’ knowledge: 67.95% have good knowledge about HBV, while 32.05% lack basic knowledge about it. The participants’ attitude towards HBV is above average showing 60.3% safe attitude. Lastly, the study shows excellent practice of the participants’ behavior towards HBV safety measures with a score of 92.3% safe practice. From the hospital, a total of 95 out of 99 nurses and midwives took part in the study. Two thirds of the respondents practiced safety, and the majority of respondents had a positive attitude about HBV preventative measures. More than half of the respondents (58.2%) had an average level of understanding. A minor but serious score of (12.6%) was noticed of the individuals, dealing with patients without wearing gloves. More over half of the nurses and midwives were not vaccinated against HBV; more than 50% of participants had incorrect ideas regarding the symptoms and route of HBV infection and all 95 participants voted (NO) for ever being infected by HBV.  Conclusion: In Alban Gaded hospital, the majority of the nurses and midwives were aware of HBV infection. But a sizeable majority of the participants lacked the necessary understanding of early immunization after birth. The study found a probability of high risk infection due to exposure under the poor level of HBV vaccine coverage rate. Moreover a clear point of limitation was noticed in Table 4 third question, where it asks whether you are or ever was infected by HBV. All the participants denied, showing a sense of partiality. Further occupational exposure prevention measures, training programs on HBV infection, including post-exposure prophylaxis, and increasing the vaccination rate of all HCWS are also strongly encouraged.

Beach Quality Evaluation as a Strategy for Sustainable Coastal Tourism Management

This study evaluates the quality and visitor satisfaction across Anyer Beach, Tanjung Lesung Beach, Carita Beach, and Sawarna Beach in Banten, Indonesia, using the Bath Area Registration and Evaluation (BARE) survey and Importance-Performance (I-P) Matrix analysis. Each beach's attributes, including security, water quality, facilities, litter management, and scenery, are assessed to identify strengths and areas for improvement. The findings reveal varying levels of performance and visitor satisfaction, highlighting notable gaps in safety, medical facilities, showers, waste facilities, and changing rooms. Recommendations include enhancing safety measures, upgrading medical and shower facilities, improving waste management practices, and preserving scenic beauty to enhance visitor experiences and support sustainable tourism practices.

Survival 1.0: A Novel Autonomous Industrial Mobile Warehouse (AIMW) for Industrial Environments

This article presents the design, implementation and start-up of the first AIMW (Autonomous Industrial Mobile Warehouse) in the industry, in particular, in the factory located at Ford España S.L. in Almussafes (Valencia). This first version has been given the name of “Survival”, due to its ability to survive the industrial environment commonly known as “the jungle”. The motivation for the design of the first AIMW was due to the management of spare warehouses for maintenance tasks. In all factories there is a central warehouse where replacement materials with a higher probability of use are placed near the warehouse exit, thus reducing the time to obtain the replacement. However, in large factories, such as automobile manufacturing, the distance between the central warehouse and the place where the breakdown occurs may cause very long delays. For this reason, there are smaller warehouses distributed throughout the plant that replicate the part of the central warehouse where the most used materials are kept. The objective of our research is to make that part of the central warehouse mobile with the AIMW design, thus eliminating the fixed warehouses. In the factory at Ford España S.L. in Almussafes there are 170 of these warehouses distributed in a homogeneous way. In this first proposal of an AIMW, and with the primary objective of reducing costs, Survival 1.0 has been designed based on a commercial AMR. For its choice, commercial AMRs were tested in real situations within the Ford factory (Almussafes). As a result, none of them were able to pass all the tests. In addition, the current regulations for AMRs, the ANSI/ITSDF B56.5:2019 and the EN 1525:1997 standard, only define minimum test standards to describe how manufacturers and users must carry out the safety measurements of AGVs and AMRs. However, from an industry point of view, these regulations are not adequate. Therefore, there are extensions of these regulations generated by the companies themselves that imply additional developments of commercial AMRs. This paper shows the developments made to be able to integrate the first AIMW into the production line, but it also shows the gap between research and standardization of AMRs with respect to the demands and needs of the industry. There are currently three Survival 1.0 AIMWs in operation in the factory at Ford España S.L. in Almussafes.

Multifeatured Electronic Helmet to Enhance Road Safety and Rider’s Comfort

This paper presents a multi-featured electronic helmet designed to tackle critical road safety issues, including accidents, drunk driving, and over-speeding. The design incorporates a global system for mobile communications (GSM) and global positioning system (GPS) modules to accurately capture driver’s current location and send messages to predefined contacts. When encountering an accident, the helmet promptly notifies designated contacts and authorities, ensuring swift assistance. By integrating features for detecting over-speeding, accidents, and drunk driving, the helmet renders real-time alerts to both the driver’s family and traffic police, enhancing accountability and safety measures. Additionally, the helmet includes solar charging functionality for mobile devices receive 100% charged in 3.37 hours, thereby optimizing usability and emergency communication. A rain detection system protects mobile devices, while an internal warming mechanism caters to adverse weather conditions, and proffers enhanced comfort by maintaining internal form temperature between 26-27 ℃ and safety, especially in cold regions or for military personnel.

Chronic traumatic encephalopathy in athletes, players, boxers and military: systematic review

The objective of the study was to demonstrate whether athletes, players, boxers and military personnel can really be victims of CTE, and to elucidate this pathology. In 53 articles, 14 were selected for qualitative synthesis in the results table that addresses CTE in football, soccer and rugby players, boxers and the military. Neuropathologically, CTE shows cerebral atrophy, a pelvic septum cavity with fenestrations, dense diffuse immunoreactive inclusions and a TDP-43 proteinopathy. Microscopically, there are extensive neurofibrillary tangles and spindle-shaped neurites throughout the brain. Thus, CTE is characterized by being a distinct tauopathy and with a clear environmental etiology. American football players, boxers and the military are more likely to trigger CET, due to the constant mechanical shocks from their heads. The most frequent clinical manifestations were: headache, aggressiveness, dementia, executive dysfunction and suicide. CET is definitely diagnosed only at autopsy, there is no specific treatment for it, but support and safety measures can help the patient. Advances to definitively diagnose CTE in living people and specific treatment for this disease are needed.

Video Game-Based Trunk Exercises for Rehabilitation in Chronic Stroke Survivors: A Mixed-Methods Feasibility Study.

Aim: To assess the feasibility of video game-based trunk exercises using the Valedo® system in a chronic stroke population. Method: Ten chronic stroke survivors (eight males and two females, mean age 63 ± 15 years) were asked to complete 18 intervention sessions, each lasting 45 min., over 6-8 weeks. Feasibility was evaluated quantitatively using the Psychosocial Impact of Assistive Devices Scale (PIADS) as well as through recruitment, retention, adherence, and safety measures. Qualitative data on feasibility were collected through post-intervention semi-structured interviews. Descriptive analysis was used to summarize participant characteristics, recruitment, retention, and adherence. Qualitative data were analyzed using thematic analysis of the interviews. Results: Twelve stroke survivors were recruited from Southampton (United Kingdom) and Riyadh (Kingdom of Saudi Arabia), with two participants dropping out after the baseline assessment session. The remaining ten participants completed the study with a mean adherence of 96.11% to the planned sessions. No serious adverse effects were reported, however, four participants did experience trunk muscle tightness and fatigue. Post-intervention interviews revealed that participants encountered some physical and cognitive challenges while playing the Valedo video games. However, they felt that the implementation of trunk exercises using video games was safe, as the exercises were performed in a secure environment and in safe positions. Conclusions: The findings suggest that the Valedo system is feasible for delivering trunk exercises to chronic stroke survivors. Several factors should be considered when implementing this type of intervention in the future.

Effects of fluorine and phosphorus-based flame retardants addition on the lower flammability limit of dimethyl carbonate

This study initially examines the alteration pattern of the lower flammable limit (LFL) of dimethyl carbonate (DMC), a typical electrolyte component in lithium batteries, under the influence of inhibitors, namely di(2,2,2trifluoroethyl) carbonate (DtFEC), perfluorohexanone (C6F12O), and trimethylphosphate (TMP), through experimental investigation. Additionally, the critical inhibitory concentration required for complete inhibition is investigated. Subsequently, numerical simulations and chemical kinetic path analyses reveal how these inhibitors control combustion. Results show that C6F12O and DtFEC initially decrease and then increase the LFL of DMC, while TMP causes a monotonic increase. This is due to the competition between reaction-thermal and reaction-radical effects. Reaction kinetic analysis reveal that when small amounts of C6F12O and DtFEC are added, the fluorine-containing components decomposed by the reaction undergo oxidation, thereby promoting combustion. However, with increased amounts, these components combine with H and OH radicals to form stable substances like HF, inhibiting the combustion process. In the case of TMP, the phosphorus-containing intermediate components produced by cleavage catalyze the recombination of H and OH radicals, thereby inhibiting DMC combustion. The research findings offer a theoretical foundation for the development of safer lithium batteries and provide crucial data references for enhancing battery safety and prevention measures.

Seaweeds and derived bioactive compounds as food alternatives: Current status and future perspective in Africa

The urgency for food security and diversification has necessitated extensive exploration of all potential food options. Seaweeds, now considered potential functional foods are widely consumed across Asia and parts of Europe. In Africa, reports on consumption trends and food-related applications are scarce. About only 1% of the annually harvested ∼120,000 (fresh weight) tonnes of commercially useful eucheumatoids are utilized locally in the continent's top-producing country, Tanzania. Ultimately, the intensification of current efforts shall promote up-scaling of the seaweed industry. In this review, we have discussed the nutritional profile and nutraceutical potential of commercially viable species, paying attention to consumer safety measures. Also, prospective food-related application of seaweeds based on current international and local African consumption trends is reviewed. The review further addresses factors that hinder consumer acceptance in Africa and the up-scaling of the seaweed industry at large. This review aims to provide some theoretical reference for future developments and application of seaweed as food in Africa.

Arsenic Pigments in Libraries – Testing Methods, Contaminated Spaces, and Occupational Safety Measures

Arsenic Pigments in Libraries – Testing Methods, Contaminated Spaces, and Occupational Safety Measures

Efficacy and Safety of Upadacitinib vs Dupilumab in Adults and Adolescents with Moderate-to-Severe Atopic Dermatitis: Week 16 results of an Open-label, Randomized, Efficacy Assessor-Blinded Head-to-Head Phase 3b/4 Study (Level Up).

Atopic dermatitis (AD) is a chronic skin disease characterized by intense itch and eczematous skin lesions. Some patients continue to experience flares and substantial clinical burden despite ongoing systemic treatment. This study assessed the efficacy and safety of once-daily upadacitinib (UPA), initiated at 15 mg and dose-escalated to 30 mg based on clinical response, compared with dupilumab (DUPI) per its label. Week 16 primary analysis results are presented. Level Up is a phase 3b/4 global, randomized, open-label, efficacy assessor blinded study evaluating UPA vs DUPI in adolescents and adults with moderate-to-severe AD who had inadequate response to systemic therapy or when use was inadvisable. Patients were randomized to UPA or DUPI for 16 weeks of treatment (Period 1). Patients on UPA started on 15 mg and were dose-escalated to 30 mg if they did not achieve an Eczema Area and Severity Index reduction of at least 50% (EASI 50) or a ≥4-point Worst Pruritus Numerical Rating Scale (WP-NRS) improvement on/after Week 4, or EASI 75 on/after Week 8. The primary endpoint was simultaneous achievement of EASI 90 and WP-NRS 0/1 at Week 16. Ranked secondary endpoints included skin and itch responses at varying response levels and timepoints. Safety measures were assessed throughout the study. Superior efficacy in achieving simultaneous EASI 90 and WP-NRS 0/1 response at Week 16 was demonstrated with UPA vs DUPI (19.9% vs 8.9%, respectively; p<0.0001). UPA showed superiority vs DUPI for all ranked secondary endpoints, with post-hoc analyses exhibiting higher itch response rates as early as Day 2. No new safety signals were identified during this period. Treatment of moderate-to-severe AD with UPA, initiated at 15 mg and dose escalated based on clinical response, demonstrated superiority vs DUPI per its label for the primary endpoint of simultaneous achievement of near complete skin clearance (EASI 90) and little to no itch (WP-NRS 0/1) at Week 16, with all ranked secondary endpoints demonstrating superiority at varying skin and itch response levels and timepoints. There were no new safety signals identified compared to the previously reported safety profiles of UPA and DUPI.

An example of a field service plan for oceanographic submerged moorings

Oceanographic mooring missions are critical for advancing our understanding of the world’s oceans and their role in the broader Earth system. These missions rely on the deployment and maintenance of complex observing systems, comprising subsurface, profiling, and surface moorings, which are designed to collect valuable data from the ocean interior. The success of these missions depends on meticulous planning and strategic execution, which are facilitated by the use of Field Service Plans (FSPs). FSPs are comprehensive and adaptable planning tools that integrate safety measures, contingency plans, and timelines to ensure the successful and safe recovery, maintenance, and deployment of mooring systems. In this paper, we provide a comprehensive guide to drafting, implementing, and adapting FSPs tailored to the unique challenges posed by oceanographic mooring missions. We highlight the critical role of FSPs in optimizing safety, data quality, and mission success, while also underscoring the need for flexibility and adaptation. Our aim is to provide practical guidance and a template for researchers, expedition leaders, and institutions engaged in oceanographic research.