This paper is dedicated to studying the existence results of solutions to the nonlinear coupled system of Hilfer fractional differential equations and inclusions, with multi-strip and multi-point mixed boundary conditions. Through tools such as the Leray-Schauder alternative and the nonlinear alternative of Leray-Schauder type, continuous and measurable selection theorems, along with Leray-Schauder degree theory, the main results can be obtained. The Hilfer fractional differential system has practical implications for specific physical phenomena. Examples are provided to clarify the application of our main results.