Measles Immunization Research Articles

Measles: A Review

Measles is an acute febrile viral illness of children. It is highly contagious and its incidence has decreased significantly following successful use of vaccine. The measles immunity following vaccination or natural infection is long lasting. The causative virus is highly transmissible aerogenously or by direct contact. The virus affects lympho-reticular systems. The secondary viraemia causes fever coryza cough and conjunctival redness. Erythematous maculopapular rash helps in diagnosing the condition clinically. The condition is selflimiting. However pneumonia encephalitis subacute sclerosing pan encephalitis and death may occur as complications. Vitamin A and antibiotic prophylaxis reduces the morbidity. Measles vaccine prepared from attenuated strains of the virus effectively protects the child against measles.

SSPE in Children Younger than 3 Years

Subacute sclerosing panencephalitis (SSPE) is typically observed in school-going children, adolescents, and young adults. Herein, we report a 3-year-old boy of SSPE and systematically review all such reported cases (age ≤3 years). We searched PubMed database on June 16, 2020 with “English language & Human only” restrictions. Eligible publications were screened and retrieved by three authors (NK, SP, and RU). Variables like author, year of publication, country, age of onset, sex, duration of illness, immunization, history of measles, clinical presentation, neuroimaging, treatment, and outcome were extracted. Neurological outcome was assessed in terms of improvement, static course or death. The defined search criteria resulted in 791 manuscripts (1951 to June 16, 2020). Only 47 manuscripts were eligible for data extraction. Seventy cases were retrieved. The mean age of onset was 26.34 months. The M:F ratio was 3.2:1. Turkey (19 cases), India (10 cases), and Japan (10 cases) collectively comprised more than half cases of SSPE. Only six children were immunized, 17 have no measles immunization, and the rest 47 had insufficient immunization records. Preceding history of measles was present in 27 cases. Most patients presented in stage II/III with altered sensorium, myoclonic jerks, and seizures. The most common reported outcome was death (18/70) followed by vegetative state (10/70). The absence of measles vaccination is frequently associated with childhood SSPE. Early measles vaccination may prevent SSPE in toddlers. Perinatal measles infection results in short onset latency and fulminant course. Outcome was not good in reviewed age group of ≤3 years.

An Analysis of the Costs and Consequences of Routine Immunization for Measles in Anambra State, Southeast Nigeria

Background: Funding measles immunization in a resource constraint setting like Nigeria has been challenging. Nigeria needs a domestic cost data on measles routine immunization to inform measles routine immunization planning. This study assessed the costs and consequences of a dose of measles vaccine to children through routine immunization. Methods: A cross sectional retrospective costing study at twelve Primary health facilities was conducted. Ingredient approach to costing was used to collect data on routine immunization based on providers’ perspective. Costs attributable to measles vaccination were extracted from the data pool considering the fraction of a dose of measles vaccine to a total of ten doses of routine vaccines for a child. Microsoft excel was used for data analysis. Unit costs were calculated and compared between types of health facility. State estimates was computed using volume weighted mean method. Results: Cost per child immunized considering total and operational costs were $1.41 and $1.01 respectively. Personnel time and vaccine contributed 62%and 23% of the total cost respectively. Cost per child immunized and vaccine doses used were higher at the Health Post than Primary health facility. The percentage coverage was 39% and the wastage rate was 14%. Conclusion: The findings will guide the policy makers in planning for efficient and sustainable measles immunization financing.

PENGARUH KARAKTERISTIK IBU BALITA, FAKTOR PEMUDAH DAN PENGUAT TERHADAP PEMBERIAN IMUNISASI DASAR LENGKAP PADA BAYI DI WILAYAH KERJA PUSKESMAS PIJORKOLING KECAMATAN PADANGSIDIMPUAN TENGGARA

Immunization is an effort of giving immunity on infants and children by incorporating the vaccine into the body so that the body makes antibodies to prevent certain diseases. The achievement of fully immunized target based on by National data is around 80-90%, while the achievement of immunization in Padangsidimpuan in 2014 by 47.1% and in Pijorkoling Health Centre in 2014, BCG immunization was obtained 49.5%, DPT / HB3 immunization was obtained 27.6%, polio immunization was obtained 32,4% and measles immunization was obtained 29,3%. The objective of this study is to determine and analyze the influence of the characteristics of mothers (work and parity), predisposing factors (knowledge and belief) and reinforcing (husband's support and the support of health professionals) to complete basic immunization on infants in sub-district Puskesmas Pijorkoling Southeast Padangsidimpuan. This type of research used analytic study with cross sectional approach. The population of this study was all mothers who have infants with sampling proportional sampling technique with a total sample of 81 respondents. Data were collected through medical records and interviews used questionnaires. Data was analyzed by univariate, bivariate used Chi-Square test at the 95% confidence level (p <0.05) and multivariate used logistic regression test. The results showed that the relationship with p value 0.036 and the support of a husband with a p value of 0.001 against the complete basic immunization on infants. In this study, the relationship of parity with p value 0.180 and the support of health professionals with p value 0.377 to complete basic immunization on infants was not found. The influence of knowledge with p value 0.001 and the value of Exp (B) 17.523 and trust with p value 0.044 and the value of Exp (B) 4.460 to complete basic immunization in infants was affected. It is suggested to the workers of Pijorkoling health center to provide counseling persuasion in improving the knowledge and encourage the mothers to give the complete basic immunization on infants. Thus the achievement of immunization target is more increasing.

When more is less: Do information and communication technologies (ICTs) improve health outcomes? An empirical investigation in a non-linear framework

The purpose of our research is to investigate the influence of information and communication technology (ICT) on the physical health outcomes of nations. The covered countries are 185 (54 high-income and 131 low-income countries, also analysed on subsamples) and the period of the analysis is 2005–2018. We use parametric regression analysis of unbalanced panel data and our quadratic models validate the influence of ICT upon life expectancies, mortality rates and measles immunisation rates, controlling for economic prosperity, cultural dimensions and environmental performances. Our results are original within the specialized literature, shedding new light on the ICT infrastructure - health status nexus as they support the inverted U-shaped relationship between internet users and mobile cellular subscriptions as ICTs proxies on the one hand and population health outcomes proxies on the other. We also validate a multiplier effect of ICT proxies upon mortality rates from high-income countries to low-income countries, as follows: the negative effect of Internet access and online information usage is 3.34 times stronger in low-income countries compared to high-income countries. These findings are robust to various estimation techniques, alternative measures of ICT or health and various added controls. The drawbacks are major: in a world in which healthcare programs and policies consider digital inclusion, the limits of using technologies for the benefit of one's health have to be firmly determined. From regular individuals to top policymakers, one should consider when more ICT infrastructure becomes actually less for people's health status.

Data Exploration of Social Determinants of Health, Health Access and Quality in a Global Health Setting.

Diseases have no borders, and global health operates from both within and beyond. Global health informatics can adopt an assets-oriented approach to mitigate concerns by maximizing global health data, principles, and resources combined with geographic information systems' use case mapping. This exploratory study utilizes an assets-oriented approach to analyze four global social determinants of health indicators, including Skilled Birth Attendance, Measles Immunization Coverage, Education (Female), and the Healthcare Access and Quality Index in relation to countries' income and geographical region. Data were extracted and analyzed from two publicly available datasets. Positive trends and variations were detected among all variables aggregated by countries' income category and geographical region. These findings pinpoint potential health assets that the discipline of nursing can leverage to build healthier global health communities.

EFEKTIVITAS ANTARA KOMPRES HANGAT DAN PLESTER KOMPRES DEMAM DENGAN PENURUNAN SUHU TUBUH BAYI TERHADAP IMUNISASI CAMPAK DI WILAYAH KERJA PUSKESMAS TELAGA

The study aimed to determine the effectiveness of warm water compresses and fever compress plasters to reduce baby's body temperature after measles immunization. The study was conducted at Telaga Health Center. This type of research is pre-experiment with pretest-posttest design. There were 20 respodents samples of the research who were taken by using accidental sampling technique. The samples were devided into 2 groups, 10 babies in intervention group were given warm water compress and 10 babies were treated with fever compress plaster. The data were analyzed by using paired t test and independent t test with level of significancy was 5% (α = 0.05). The result showed that warm water compresses (t count = 41,333 and ρ = 0,000) and fever compress plaster (t count = 47,940 and ρ = 0,000). It indicated that warm water and fever plasters are effective in reducing the baby's body temperature after measles immunization at Telaga Health Center. There was no difference in the effectiveness of warm water compresses with fever compress plasters in lowering the baby's body temperature (t count = 0.793 and ρ = 0.438). It is recommended to health care professionals at Telaga Health Center to be able to provide non-pharmacological interventions such as warm water compresses and fever plasters compresses to reduce babies’ body temperature after measles immunization.

PENGARUH KOMPRES DINGIN TERHADAP INTENSITAS NYERI PADA BAYI SAAT IMUNSISASI CAMPAK DI WILAYAH KERJA PUSKESMAS TALAGA JAYA

This research was conducted at Telaga Jaya health centre work area of gorontalo district. The objective was to identification the influence of before and after cold compresses used quasi eksperiment design on the influence of pain intensity in infants during measles immunization. The design used quasi eksperiment one group pretest-postets. The population were the mothers who have 9 months old infants. The samples are 15 respondents. Cold compresses applied 21 times in 3 weeks, the assessment was before and after treatment which used T-test Dependent test on pressure level 95% (𝛼=0,05). The result obtained the enhancement influence before and after cold compresses on pain intensity in infants during measles immunization.

Retraction Note: Air pollution detection based on image recognition and evaluation of measles prevention and immunity effect

This article first studies the image recognition method and some of its current problems and promotes the comparison and selection of existing image recognition algorithms. The article introduces in detail the training principle and process of the restricted Boltzmann machine and the combination of the restricted Boltzmann machine. Based on this point, this paper selects the NO2, SO2, CO, PM2.5, PM10, and other air pollution data of 161 prefecture-level cities monitored by the Ministry of Environment in 2020 and compares the data of 161 prefecture-level cities in 2020. The urban air quality reaches the level to be tested. Analyze air pollution status and detection methods and seasonal and monthly characteristics of pollution (or annual air pollution change characteristics), as well as comparative analysis between regions and differences in air pollution detection between different cities, explaining the impacts on air pollution in different regions of China. This is the main reason for the change. Finally, this article investigates and studies the epidemiological nature and risk factors of measles in S city and the impact of immune effects on measles prevention, to determine the distribution and characteristics of measles in S city, analyze disease risks, and take preventive measures to prevent more reasonably and control measles. Prior to this, a plan was made to provide a reasonable theoretical basis. At the same time, measles antibody testing and related research will be conducted on some healthy permanent residents in city S to understand the immune effect of the floating population and the factors affecting the immune effect, so as to further strengthen the epidemic prevention of the floating population, which laid the foundation for the work of crowd vaccination. This article has realized the rapid development of measles prevention technology by evaluating the effectiveness of measles prevention and resistance based on image recognition and application of air pollution detection results.

Effect of evidence updates on key determinants of measles vaccination impact: a DynaMICE modelling study in ten high-burden countries

BackgroundModel-based estimates of measles burden and the impact of measles-containing vaccine (MCV) are crucial for global health priority setting. Recently, evidence from systematic reviews and database analyses have improved our understanding of key determinants of MCV impact. We explore how representations of these determinants affect model-based estimation of vaccination impact in ten countries with the highest measles burden.MethodsUsing Dynamic Measles Immunisation Calculation Engine (DynaMICE), we modelled the effect of evidence updates for five determinants of MCV impact: case-fatality risk, contact patterns, age-dependent vaccine efficacy, the delivery of supplementary immunisation activities (SIAs) to zero-dose children, and the basic reproduction number. We assessed the incremental vaccination impact of the first (MCV1) and second (MCV2) doses of routine immunisation and SIAs, using metrics of total vaccine-averted cases, deaths, and disability-adjusted life years (DALYs) over 2000–2050. We also conducted a scenario capturing the effect of COVID-19 related disruptions on measles burden and vaccination impact.ResultsIncorporated with the updated data sources, DynaMICE projected 253 million measles cases, 3.8 million deaths and 233 million DALYs incurred over 2000–2050 in the ten high-burden countries when MCV1, MCV2, and SIA doses were implemented. Compared to no vaccination, MCV1 contributed to 66% reduction in cumulative measles cases, while MCV2 and SIAs reduced this further to 90%. Among the updated determinants, shifting from fixed to linearly-varying vaccine efficacy by age and from static to time-varying case-fatality risks had the biggest effect on MCV impact. While varying the basic reproduction number showed a limited effect, updates on the other four determinants together resulted in an overall reduction of vaccination impact by 0.58%, 26.2%, and 26.7% for cases, deaths, and DALYs averted, respectively. COVID-19 related disruptions to measles vaccination are not likely to change the influence of these determinants on MCV impact, but may lead to a 3% increase in cases over 2000–2050.ConclusionsIncorporating updated evidence particularly on vaccine efficacy and case-fatality risk reduces estimates of vaccination impact moderately, but its overall impact remains considerable. High MCV coverage through both routine immunisation and SIAs remains essential for achieving and maintaining low incidence in high measles burden settings.

How Australia's measles control activities have catalyzed rubella elimination

BackgroundBy 2017, rubella had been officially eliminated in Australia. This success was attributed to Australia's longstanding national immunization programme and two enhanced measles immunization activities using measles, mumps, and rubella (MMR) vaccines — the Measles Control Campaign (MCC) and the Young Adult MMR Campaign (YAC). Our study describes the impact of these activities on rubella incidence, and its elimination in Australia. MethodsAggregate national serological survey data were assigned to birth cohorts, and mean, median, and age-group estimates calculated and analyzed against MMR immunization coverage estimates (1998–2018) and rubella notifications (1993–2018). Three-year cumulative incidences were calculated by birth cohort. ResultsThe serological surveys revealed high and stable levels of rubella immunity among females, but estimates for three male cohorts were lower. Since 2007, MMR immunization coverage among children aged 24–27 months has remained above 90% for both doses. The 3-year cumulative incidence of rubella declined across all birth cohorts following the MCC and the YAC. DiscussionUsing MMR vaccines to address measles immunity gaps had the additional benefit of controlling rubella in Australia. Both the MCC and YAC shifted rubella epidemiology, accelerating the interruption of endemic transmission. Countries should consider combined measles and rubella vaccines for all catch-up activities.

Profile of Serious and Non-Serious Adverse Effects Following Immunization (AEFI) of Measles Rubella Vaccine

Background: The measles rubella immunization campaign conducted in 2017 on the island of Java has replaced the previous measles immunization, and its administration is carried out at 9-12 months of age and 18 months of age. As a new vaccine, the administration of MR vaccine cannot be separated from AEFI. Objective: We aimed to study the AEFI profile of MR vaccine administration by passive surveillance from the first campaign of MR vaccine in East Java Province. Methods: Our study was a retrospective observational study (surveillance survey). The research was conducted from January - April 2021. Children who received the first dose of the MR vaccine in the MR campaign at all age were enrolled in the study. We divide the group of serious and non-serious AEFI. The sample were collected using randomized sampling method. A questionnaire was used to collect the demographic details of the children and the characteristic of the AEFI’s symptoms. Results: The total sample is 43 children with serious AEFI, consisted of 22 (51.2%) males and 21 (48.8%) females. The most common AEFI reported was fever (76.7%), followed by gastrointestinal symptoms (60%), local reactions (25%), respiratory tract symptoms (23.2%), central nervous system symptoms (11.6%), and rash (6.9%).Conclusion: Fever is the most frequently reported symptom. Most of the AEFI symptoms didn’t had causal relationship with MR vaccine. Thrombocytopenia is known to have a causal relationship as a reaction to the MR vaccine.

Waning of Maternal Antibodies against Measles Suggests a Large Window of Susceptibility in Infants in Lao People's Democratic Republic.

Introduction: Measles is an endemic but largely neglected disease in Lao People’s Democratic Republic. New-borns are protected by maternal antibodies, but antibody waning before measles vaccination at 9 months of age leaves infants susceptible to infection. In this study, the susceptibility window of infants was determined to generate scientific evidence to assess the national measles immunization strategy. Methods: Between 2015 and 2016, demographic data, medical history, and blood samples were collected from 508 mother-child pairs at the provincial hospital in Vientiane. The samples were screened with a commercial kit detecting anti-measles IgG antibodies. Results: The large majority (95.7%) of the mothers were seropositive for anti-measles IgG and antibody titers of the mothers and infants were highly correlated (p < 0.01). While at birth 97.7% of the infants were seropositive, seropositivity rates decreased to 74.2% two months later to reach only 28.2% four months after birth (p < 0.01). Just before the first dose of the measles-rubella vaccine, scheduled at 9 months of age, was actually given, less than 14% of the infants were seropositive. Conclusion: This alarmingly wide susceptibility gap due to rapid maternal antibody decay leaves infants at risk of measles infection and serious disease complications. A high herd immunity is crucial to protect young infants and can be achieved through improved routine vaccination coverage and (expanded age group) supplementary immunization activities.

2019–2020 measles in the Republic of Guinea: epidemic features and herd immunity

Introduction. In connection with the Ebola epidemic in the West African countries, including the Republic of Guinea, a failure in implementing measles immunization program was noted. A proportion of measles seronegative subjects in 2017 was 52.4% of total examined individuals. In 2018, a high proportion of measles cases among children aged 1–5 years (61.6%) was identified. In order to stop the 2018 outbreak, the Supplemental Immunization Campaign was conducted in the Konakri and Nzerekore prefectures in the Republic of Guinea. The aim of this study was to examine the 2019–2020 measles epidemic situation and assess the measles population immunity in the Republic of Guinea. Materials and methods. Measles-specific antibodies were examined in 1697 blood serum samples collected from residents of different regions of the Republic of Guinea, aged from 7 months to 76 years, obtained in 2019–2020, and tested retrospectively. The ELISA test systems Anti-Measles Virus ELISA (IgM) Euroimmun and Anti-Measles Virus ELISA (IgG) Euroimmun (Germany) were used. The presence of serum IgM measles antibodies was considered as acute measles infection. Statistical analysis was performed using the software package Statistica 6.0. Results. Blood sera (n = 638) were tested for IgM-measles, and in 46.6% of cases the diagnosis was confirmed by laboratory tests. The biggest proportion of the total cases (61.6%) was found in children aged 1–4 years. The second most important age group was 5–9 years of age, the third is children under 1 year: 18.5% and 11.8% of the total number of patients, respectively. Measles infection was registered in vaccinated patients in 7.4% of the total number of laboratory-confirmed cases. 1059 subjects were examined for IgG measles antibody. The lowest seroprevalence rate was found among children under 4 years of age (47.8%). The highest (85.5%) was found among subjects of 40 years old and older. Conclusion. Measles in GR remains a poorly controlled infection. As in the previous years of observation (2017–2018), children under 5 years of age are the most vulnerable cohort of the population, despite the 2018 DI campaign conducted in a number of GR territories. More problems with the measles control in the Republic of Guinea are expected in the period from 2021, as along with the COVID-19 epidemic, Ebola is repeatedly registered in the country. The Republic of Guinea particularly requires assistance from the international community to implement the WHO measles elimination program on a global scale.

Incidence of Measles in Breastfed Infants versus Non-Breastfed Infants

Breast-feeding protects newborn infants against numerous infectious conditions and sicknesses, and can also affect the results of vaccination. The main purpose of this research is to assess breastfeeding defends against CM and find the changed effects of vaccination. This research is designed as a cross-sectional study. It is worth mentioning that the study took almost one year to be completed, and the survey was conducted from May 1, 2020, to May 1, 2021. It is notable that the study was carried out base on librarian and field research methodology, and the information was collected from the newly born infants until five years’ children, and then it was analyzed. The data upon infections of indicative measles and socioeconomic indicators were obtained at ten months period. Breast-feeding has been classified as &lt; 30 days breastfed, 1-3-month breast-food, breast-feeding for over three months, unsure breastfeeding, and no breastfeeding. Regarding the results, it could be said that anti-measles Ig though with a mean value of 5.37 AFU, all 55 colostrum samples were positive. Furthermore, the timing of extraction for breast milk AFU is different, the average AFU value fell to 2.11 among days 6-15 (n=15), but the value fell below the cut-out mark of 1.8–1.48 amongst days fifteen to thirty (n=10). It is being concluded that immunization of measles gives excellent disease resistance. In addition to this, breastfeeding is related to a relatively moderate decrease in the chance of measles diagnosis. Relationships with such a diagnosis of measles were independent of breastfeeding &amp; measles vaccination.

Оценка осведомленности о вакцинации против кори

Актуальность. В условиях пандемии COVID-19 во многих странах происходит снижение уровней охвата вакцинацией, что в дальнейшем может способствовать возникновению новых вспышек вакциноуправляемых заболеваний. Уже сегодня значительное количество детей рискуют не получить необходимую прививку против кори. Цель исследования: оценить грамотность студентов-медиков в вопросах иммунизации против кори, проанализировать их отношение к вакцинации и установить, что влияет на принятие решения, определить основные вопросы, которые беспокоят относительно вакцинации против кори. Материалы и методы. Проведено анонимное онлайн-анкетирование 350 студентов-медиков с помощью Google Forms. Результаты. Согласно Национальному календарю прививок, 80 % участников получили две дозы вакцины против кори, паротита, краснухи (КПК), 2,9 % — одну, 12,9 % — три, 1,4 % оказались непривитыми и 2,9 % не владели точной информацией о вакцинальном статусе. Основные причины, помешавшие иммунизации, следующие: частые заболевания в детстве, наличие хронических заболеваний, отсутствие вакцины, сомнения в качестве вакцины. Во время вспышки студенты вакцинировались по требованию учебного заведения (31 %), собственной инициативе (50 %), совету родителей (17,2 %) и врачей (9,5 %). Среди возможных источников информации студенты выбирали советы врачей (73,9 %), данные интернет-ресурсов (36,9 %) и специальной медицинской литературы (34,2 %). Почти все студенты (95 %) знали схему введения вакцины КПК. Большая часть из них (66,6 %) была осведомлена об условиях хранения, приоритетном месте и пути введения вакцины, но не владела информацией о вспомогательных компонентах, входящих в состав вакцины, ее эффективности и продолжительности иммунитета после иммунизации. Вакцинацию как профилактическое мероприятие поддержали всего 53,3 % студентов. Выводы. Полученные данные указывают на необходимость повышения осведомленности в вопросах вакцинопрофилактики, разработки новых стратегий общения с пациентами о преимуществах иммунизации. Изучение причин отказов от прививок, повышение грамотности иммунизации путем эффективной коммуникации как будущих врачей, так и простых граждан с целью содействия принятию обоснованного решения могут помочь работникам здравоохранения в повышении охвата вакцинацией КПК.

Seroprotection against measles in previously vaccinated children with difficult-to-treat nephrotic syndrome.

Children with nephrotic syndrome (NS) are vulnerable to infections. Measles infection is an important cause of morbidity and mortality in immunosuppressed children. A suboptimal seroprotection against measles has been shown in immunocompromised children. There is limited published literature on measles immunity in children with difficult-to-treat nephrotic syndrome (DTNS). We compared the proportions of children with DTNS and healthy controls who were seroprotected against measles. This was a cross-sectional study. Measles-specific IgG antibodies of 108 children with DTNS (3 to 10years of age) and an equal number of age-matched healthy controls were measured. All children had received two doses of measles-containing vaccine at 9-12 and 16-24months of age under routine immunisation programme. Serum measles IgG antibody titres were measured by indirect ELISA. The assay results were interpreted as (1) > 11 NTU (NovaTec Units), positive/seroprotective titres; (2) 9-11, equivocal; and (3) < 9 NTU, negative. Inter- and intra-group comparisons were made to identify the disease characteristics related to seroprotection status. The proportion of children with protective anti-measles antibodies (n = 70, 65%) was significantly lower in DTNS as compared to controls (n = 88, 81.48%) (p = 0.005). Their median [IQR] antibody titres were also significantly lower than those in controls (14.1 [14] NTU vs. 18.3 [15.2] NTU (p = 0.001). The age, gender, clinical subtype, duration of disease, and type of immunosuppressive therapy were not significantly different between seroprotected and non-seroprotected children with DTNS. A significantly lower percentage of fully vaccinated children with DTNS were seroprotected against measles compared to healthy controls. A higher resolution version of the Graphical abstract is available as Supplementary information.

The Characteristic of Measles Epidemic Process in Kyrgyz Republic

The Characteristic of Measles Epidemic Process in Kyrgyz Republic

Assessment of the State of Anti-Measles Immunity in Medicine Personnel of a Children's Hospital

RelevanceThe epidemiological disadvantage of measles in developed countries reflects the weakening of herd immunity and is caused, first of all, a change in society's attitude to vaccine prevention and the risks of infectious diseases, which requires a revision of the prevention strategyAim:assessment of measles immunity in employees of the regional multidisciplinary children's hospital.Materials &amp; Methods.365 employees were examined at the same time in 2019 on the basis of the regional children's hospital. Investigation of the intensity of immunity to measles by ELISA using the VectoKor-IgG test system (Vector-Best, Russia). The surveyed were divided into 4 age groups (20–29, 30–39, 40–49 and 50 years and older). Statistical processing was carried out using the χ2 test and Spearman's rank correlation.Results.63% of the examined had a protective titer of antibodies. The least protected were medical workers under the age of 40, especially up to 30 years old, with a share of immune persons of 30%. In older age groups, the proportion of seropositive persons was 80.9%. The age of the employees and the levels of measles immunity were highly correlated (r = 0.72). There was no statistically significant effect on the state of measles immunity of professional status, the presence of documentary evidence of vaccination.Conclusions.Thus, the results of the conducted study indicate a high epidemiological risk of measles in medical institutions and when applying to them. The worst indicators of protective immunity were found among young employees. It is advisable to continue serological monitoring in medical institutions, organized vaccination of seronegative individuals, as well as conduct cooperative research

PHI-011 - Current status of hepatitis A virus and measles immunity in secondary hospital workers in South Korea

PHI-011 - Current status of hepatitis A virus and measles immunity in secondary hospital workers in South Korea