Objective: This article explores the concept of meaningful work in a multifaceted context, focusing on the different social positions that act as leaders and the roles played by these leaders. The study, carried out with collaborators from Brazilian startups, adopts an exploratory qualitative approach, combined with descriptive elements to capture the essence of meaningful work from the perspective of participants. Thus, its goal was to investigate the relationships between social positions, leadership roles, and meaningful work experiences, providing insights for leaders, human resource managers, and professionals involved in startups. Method: Qualitative research involved interviews with collaborators from Brazilian startups, exploring significant work experiences. The study adopts a descriptive approach to present the essence of the phenomenon. Results and Conclusions: The results identified several social positions (manager, colleague, working group, family, etc.) and leadership roles (sensei mentor, inspirational example, etc.) that influence positively or negatively the significant work experiences. Leaders play crucial roles in promoting a meaningful work environment, impacting employees’ perception of the value and significance of their work activities. Research Implications: The insights in this study offer opportunities for executives, human resource managers and startup leaders to improve work environments by promoting more meaningful experiences for their employees. It also highlights the importance of developing leadership in organizations. Originality/Value: This study stands out by exploring the intersection between social positions, leadership roles and meaningful work. It contributes to the practical understanding of how different leaders and their functions influence the work experience, offering a valuable and original perspective in the context of Brazilian startups.