Soils are good indicators of the stability of environmental systems. In meandering river floodplains, they assess river channel morphology, incision process, groundwater level dynamics, and avulsion processes. The morphological properties and physicochemical attributes give gleysols unique characteristics about formation conditions and evolution degrees related to fluvial dynamics, thus allowing elaborate models of floodplain evolution in meandering rivers. This manuscript aimed to analyze the relationship between gleysols evolution and fluvial dynamics, in the quaternary floodplain of a meandering river, in the Mogi Guaçu River basin in the State of Minas Gerais. We described three profiles, in concave and convex margins of the river, identifying facies and considering the morphological characteristics of the gley horizons. Physicochemical analyses, determination of major and minor elements, and oxides were carried out on the samples of horizons and deposits of the profiles. For the characterization of the river channel, morphometric parameters were measured. Concentrations of silica, titanium dioxide, alumina, ferric and manganese oxides, plus the molar relations of provenance (P), leaching (L), parent material (M1 and M2), oxidation (O), hydrolysis (H), and the alteration geochemical index (CIA-K) were determined to compare the profiles pedological evolution. The three analyzed profiles were classified as typic Dystrophic Tb Haplic Gleysol (P1 and P2) and typic Alic Tb Haplic Gleysol (P3) so that the relation silt/clay demonstrated profile 3 to be the most evolved (weathered). Concentrations and behavior of oxides, associated with molar relations and conditions of the surfaces S II and S III of the flat floodplains morphological, demonstrated that the meandering process, with avulsion linked to erosion and deposition, affects gleysols evolution, suggesting genesis with compound or polygenetic profiles. Under a cyclical interpretation, the evolution of gleysol profiles, with truncation and horizon overlaying, reflects processes of avulsion, incision, and floods, as well as are proxies for interpreting the quaternary evolution of the Mogi Guaçu River meandering process.