Mean Thickness Research Articles

Protective effect of <i>Rosemarinus officinalis</i> on gentamicin-induced acute kidney injury in adult male albino rats

Background: Gentamicin (GN) drug is one of the first-line drugs for managing severe gramnegative bacteria. Its association with acute kidney injury (AKI) has restricted its use due to oxidation damage to kidney architectural structures. Rosmarinus Officinalis (rosemary) is anatural antioxidant available and affordable in many developing countries. Antioxidants can be used to prevent oxidation that causes AKI in GN use. This study was undertaken to evaluate the protective gross morphological effect of Rosmarinus Officinalis (RO) on Gentamicin- induced acute Kidney injury in male albino rats’ species of Rattus norvegicus.
 Methodology: The study was done in Kenya at Maseno University. A posttest true experimental design was used, and a sample size of 25 Albino rats was calculated using a resource-modified equation. Rats were randomly sampled into 5 groups, each with 5 albino rats. The negative control group received a standard rat diet plus water, the positive control received GN100,mg/kg/bwt/i.p, low-dose RO, medium-dose RO, and high-dose RO groups received 100,150 and 200 mg/kg/bwt of RO orally, respectively, and were co-administered with GN 100mg/kg/bwt/i.p. At the end of day seven, they were humanely sacrificed, and gross morphometric were taken.
 Results: It was observed that the mean weight of the rat, weight, and volume of the kidney increased significantly (p= 0.001) in high-dose RO group as compared to the positive control. The mean length and thickness in high-dose RO group increased significantly (p=0.0001) as compared to the positive control.
 Conclusion: This present study shows that co-administration of a high dose of RO has a protective effect on gross morphology against Gentamicin-induced AKI among male albino rats.

Dynamic Quantitative Imaging of the Masseter Muscles in Bruxism Patients with Myofascial Pain: Could It Be an Objective Biomarker?

We aimed to investigate whether the collaboration of shear wave elastosonography (SWE) and B-mode ultrasonography (US) could be offered as diagnostic tools to assess the presence, severity, and progress of bruxism, as well as a biomarker for the effectiveness of treatment in daily clinical practice. The study was designed as a quantitative evaluation of the masseter muscles (MMs) of the clinically diagnosed bruxism patients suffering from myofascial pain and MMs of the healthy individuals. Clinical examinations were made according to the diagnostic criteria for temporomandibular disorders (DC/TMD), and pain was assessed using a visual analog scale (VAS). Painful MMs with VAS scores ≥ 4 were assigned to Group A, and healthy MMs were assigned to Group B. Also, the MMs of the painful bruxers were analyzed based on wearing occlusal splints. Group A was divided into two subgroups as splint users (Group AI) and non-users (Group AII). All the participants were scanned with dynamic US and SWE to quantify the size and stiffness of the MMs. Measurements of each muscle pair while the jaw is in a resting position (relaxation) and clenching position (contraction) were recorded. The significant differences in stiffness and thickness became visible in the relaxation state. Bruxism patients with myofascial pain had significantly harder and thinner MMs than healthy individuals. During the relaxation, the mean thickness and elasticity values were 9.17 ± 0.40 mm and 39.13 ± 4.52 kPa for Group A and 10.38 ± 0.27 and 27.73 ± 1.92 for Group B, respectively. Also, stiffer MMs were measured in Group AII (38.16 ± 3.61 kPa) than in Group AI (26.91 ± 2.13 kPa). In conclusion, the combination of SWE and US using a dynamic examination technique has the potential to be a valuable tool for the management of bruxism patients suffering from myofascial pain.

The utility of high-frequency 18 MHz ultrasonography for preoperative evaluation of acral melanoma thickness in Chinese patients.

Despite the increasing use of preoperative ultrasound evaluation for melanoma, there is limited research on the use of this technique for Acral Melanoma (AM). This retrospective study analyzed the electronic medical records of patients who underwent preoperative evaluation for cutaneous melanoma maximum thickness using an 18 MHz probe and histopathological examination between December 2017 and March 2021 at the Department of Dermatology in Xiangya Hospital, Central South University. A total of 105 patients were included in the study. The mean tumor thickness was 3.9mm (s.d., 2.3), with 63% of the specimens showing ulceration and 44 patients showing lymph node metastasis. The results showed a good correlation between the high-frequency ultrasonography (HFUS) and histopathological thickness measurements, with a Spearman's correlation coefficient of 0.83 [(95% CI 0.73-0.90) (P < 0.001)]. The positive predictive value (PPV) of sonography in identifying tumor thickness was also found to be high. Our study suggests that high-frequency 18 MHz ultrasonography is an effective tool for the preoperative evaluation of AM thickness. The HFUS measurements correlated well with the histopathological thickness measurements, making it a valuable and reliable method for clinicians to assess the thickness of melanoma lesions preoperatively.

Relationships between fluvial dune cross-set thickness, planview width, and trough geometry

Abstract Sedimentary structures provide critical information for the reconstruction of ancient environments of Earth and other planets. Fluvial dune cross sets, structures that record dune migration via the filling of leading troughs along ancient riverbeds, are particularly useful. Most quantitative methods for interpreting cross sets require thickness measurements, but the growth of planview imaging of sedimentary rocks on Earth and Mars has introduced a need for methods to interpret planview exposures of cross sets. Here, we measured 359 cross-set widths exposed along ancient channel belts of the Cretaceous Cedar Mountain Formation exposed in Utah, USA, and compared these widths to published thicknesses (n = 350). We found that the mean cross-set width was 1.29 m, 9.3 times the mean thickness. The normalized distributions of widths and thicknesses were statistically similar and thus contained similar paleoenvironmental information. Numerical experiments representing a series of trough cut-and-fill structures show that cross-set reworking is equally important in setting width as thickness and that the observed cross-set widths could be explained by a gamma-distributed range of trough widths with a mean of 2.96 ± 0.25 m, ~2.3 times cross-set width. Given the similarity of dune-field geometries across depositional settings and planetary boundary conditions, we suggest this cross-set width-to-thickness relationship could be useful for interpreting other cross sets exposed in planview.

Ocular repercussions in COVID-19 patients: structural changes of the retina and choroid

ABSTRACT Background Neurotropic capabilities of SARS-COVs allow viruses to reach the central nervous system by hematogenous neuronal dissemination. The human retina, as an extension of the Central Nervous System, may have some neurodegenerative and/or vascular modifications related to COVID-19. Objectives To evaluate choroidal and inner neural layers in participants previously recovered from COVID-19 compared to the control group using optical coherence tomography. Methods With a cross-sectional approach, the sample (n = 96), constituted by patients who have recovered from COVID-19 (n = 56) and healthy participants control group (n = 40) were ophthalmologically characterized. The neurodegenerative and vascular histological assessment was performed using SD-OCT and the mean thickness was measured in Early Treatment Diabetic Retinopathy Study (ETDRS) subfields. Retinal nerve fiber layer, Ganglion cell layer and subfoveal choroidal thickness were obtained through semi-automatic measurement. Results A total of 40 controls (27 women [67.5%]) and 56 COVID-19 participants (34 women [60.8%]) were included in this first report. There were retinal thickness significant differences in nearly all inner ETDRS subfields: nasal 3 mm (p = .025), I3 (p = .049), and temporal 3 mm (p = .009). Also, a decrease in neural layers was found in the nasal 3 mm (p = .049) and temporal 3 mm (p = .029) during ganglion cell layer assessment. The peripapillary retinal nerve fiber layer thickness was thinner in the COVID-19 group in superior temporal (p = .019), nasal (p = .002), inferior temporal (p = .046) and global (p = .014). Concerning the subfoveal choroidal measurement, an increase was observed in the COVID-19 group (p = .002). Conclusion Participants who had recovered from COVID-19 showed a non-glaucomatous neuropathy trend pattern. We found differences closer to the classic description of the “bow-tie” observed in other neurological as compressive neuropathies at the chiasma location. OCT assessment also showed an increase in choroidal thickness as a result of vascular changes.

Barbell Technique: A Novel Approach for Bidirectional Bone Augmentation: Clinical and Tomographic Study.

Horizontal bone augmentation is a common surgical procedure used in implant therapy to achieve adequate bone volume to permit dental implant placement. However, most current techniques are focused on unidirectional bone reconstruction (grafting only on the buccal side). This study was carried out to validate a new device that will permit bidirectional bone augmentation. Ten patients of both sexes (7 women and 3 men), with ages ranging from 29 to 62 years, who needed a bidirectional horizontal bone augmentation in maxilla were separated in accordance with the horizontal alveolar change (HAC) classification published by Pelegrine et al (2018). The patients classified as HAC 3 (ie, containing remaining cancellous bone at the recipient bed) received the Barbell device with xenogeneic biomaterial and a collagen membrane, whereas HAC 4 patients (ie, with no remaining cancellous bone at the recipient bed) received the Barbell device with a mixture of autogenous bone chips and xenogeneic biomaterial covered by a collagen membrane. For each patient, two computerized tomography scans were performed (T0 at baseline and T1 at 6 months postoperative examinations). Mean bone thickness (T0) in the studied sites were 3.25 ± 0.35 in HAC 3 and 1.98 ± 0.5 in HAC 4 patients. The mean bone thickness achieved after 6 months was 7.70 ± 0.89 mm and 8.62 ± 0.89 in HAC 3 and 4, respectively. All grafted sites were able to receive dental implants in adequate prosthetic positions. Based on these results, the use of this novel device permits bidirectional horizontal bone augmentation.

Morphometric Analysis of Dry Human Patella – A Cross-Sectional Observational Study from Kashmir, North India

Background: The kneecap, also called the patella, is located in front of the knee joint and protects it from injury. It is the most prominent sesamoid bone of the body and is embedded in the quadriceps tendon. The purpose of this study is to perform a detailed morphometric examination of the patella and compare it to specimens from the right and left sides of the patella. Methods: In this cross-sectional observational study, 40 dried patellae were collected from the Department of Anatomy, Government Medical College, Srinagar, of which 21 were right-sided and 19 were left-sided specimens. Height, width, and thickness of the patella; length and width of the articular facets on the medial and lateral sides; and length of the central ridge were among the parameters examined in the study. Results: The mean height, width, and thickness of the patella specimens were 4.10 cm, 2.01 cm, and 4.10 cm, respectively, according to morphometric analysis. The dimensions of the articular facet on the lateral side were found to be statistically different from the dimensions of the articular facet on the medial side, with P = 0.05 considered statistically significant. According to Koyunco's classification, 87.5% of the patella specimens belonged to type B. Conclusion: The morphometric analysis of the patella in this study may help to design implants for reconstruction and guide orthopedic surgeons in reconstructive and fixation surgery of the patella.

Neovascular Age-Related Macular Degeneration in a Predominantly Black Population.

We intend to study the characteristics and outcomes of an understudied patient population with neovascular age-related macular degeneration (nAMD). This retrospective study evaluated presenting features and outcomes in a predominantly Black patient population with nAMD. A multivariate regression explored baseline characteristics predictive of 1-year vision. Sixty-three eyes were included. The median (interquartile range) baseline vision was 20/300 (20/80 to counting fingers). Patients' baseline optical coherence tomography findings showed a mean central subfield thickness of 336 µm; 80% (n = 35) and 41% (n = 18) had fluid and central scarring, respectively. The primary predictor for vision at year-one was baseline vision (P = 0.03, 95% CI: 0.04 to 0.91). All of those who gained ≥ 3 lines of vision lacked central scarring at baseline. Further studies are needed to investigate how to improve earlier detection and treatment of nAMD in this patient population. [Ophthalmic Surg Lasers Imaging Retina 2023;54:580-584.].

Evaluation of the thickness of coronary calcium by 60-MHz intravascular ultrasound: head-to-head comparison with optical frequency domain imaging.

The region behind the coronary calcium could not be visualized by intravascular ultrasound (IVUS) because of acoustic shadow. However, some pathological studies have shown that IVUS delineated the vessel border behind thin coronary calcium sheets. This study aimed to reveal whether recent IVUS can visualize the region behind thin coronary calcium sheets. Using 534 cross-sectional optical frequency domain images (OFDI), including severe calcified coronary lesions, calcium sheet thickness was measured by every 1°. Accordingly, the visibility of the vessel border behind the coronary calcium sheet was evaluated using 60-MHz IVUS images, which were longitudinally linked with OFDI ones. After carefully coordinating with the axial position, the association between the IVUS-derived permeability of the coronary calcium sheet and calcium thickness was evaluated. The maximum and mean calcium thickness by OFDI was 0.88 ± 0.39 and 0.62 ± 0.30mm, respectively. By 60-MHz IVUS, 12.1% of the coronary calcium sheets had permeable segments. Comparing between OFDI and IVUS images, 48.6% of the coronary calcium sheets with maximum thickness ≤ 0.3mm were sometimes permeable by 60-MHz IVUS, whereas most > 0.5mm thick calcium sheets were impermeable. In the receiver operating characteristic curve analysis, the best cutoff values for the maximum and mean thickness of permeable calcium were 0.48 and 0.31mm, respectively. Thus, 60-MHz IVUS can occasionally visualize the region behind a thin coronary calcium sheet. When using 60-MHz IVUS, this finding may be a predictive marker of calcium sheet with a thickness of < 0.5mm.

Correlation of Dose Volume Parameters with Dysphagia and Pharyngeal Constrictor Muscle Thickness in Dysphagia Optimized IMRT

Reduced radiation dose to the pharyngeal constrictor muscles (PCM) using dysphagia optimized intensity-modulated RT (DO-IMRT) is associated with improved swallowing outcomes in oropharyngeal cancers (OPCs). Purpose was to evaluate the relationship between dose of radiation delivered and acute dysphagia in patients with OPC treated with IMRT, after delineation of PCM. Twenty-five patients with newly diagnosed OPC who underwent definitive IMRT with concurrent cisplatin were included in the study. PCM mean dose < 50 Gy was used as the dose constraint. Target volume was divided into high, intermediate and low risk areas receiving doses in the range of 60-66 Gy, 54-58 Gy, 51-56 Gy in 30-33 fractions over 6-6.5 weeks, respectively. PCM dose-volume parameters were collected and logistic regression was used to analyze these data relative to percent weight loss during RT and duration of feeding tube use. Thickness of constrictor muscle in pre-treatment and 3 months post-therapy CT scan were assessed. Weekly assessment of dysphagia was based on RTOG toxicity gradings. Aim of the study was to evaluate the correlation between dysphagia grades with dose-volume parameters and PCM thickness. Median age was 55.0 years (mean 54.3) with 24 males and stage II:III-16:9 patients. Dmean to PCM was 49.86 Gy (range 48.22 -57.63) with median Dmax of 70.24 Gy. For patients with dysphagia (grade ≥1), V50 ranged from 48.2-57.23%, while in those with no dysphagia, it ranged from 47.92-52.18 % (Mean 51.36%). Nine patients needed feeding tube after RT end. Median feeding tube duration was 64 days. The correlation between Dmean ≥ 50 Gy and dysphagia at 1st, 2nd, 3rd and 6th month was found statistically significant (p < 0.01). Table 1 shows the Pearson correlation and P-value of the dosimetric parameters with dysphagia. The correlation of V50 was found statistically significant with grade of dysphagia at 3rd and 6th month post-treatment (p<0.001). The mean thickness range and median thickness of constrictors before and 3 months after treatment were 1.8-3.2 mm, 2.4 mm, and 2.8-6.2 mm,4.1 mm, respectively. The increase in thickness of constrictor muscle correlated significantly (p<0.05) with dysphagia grades and also with V50, V60 and Dmean (p<0.001) but no statistical significance was seen with Dmax (p = 0.232). With a median follow-up of 18 months (range 7-24), 1-year actuarial local control was 92%. DO-IMRT may prove beneficial in the OPC by preventing dysphagia and aspiration post therapy and hence improving the quality of life of patients. Dmean ≥ 50Gy, V50 > 51.4% and V60 > 35.5% are the parameters correlating significantly with dysphagia (p<0.001) and change in mean thickness of PCM (p<0.001).

Morphometry of pyramidalis muscle and its role in reconstructive surgeries: A cadaveric study in South Indian population.

The pyramidalis muscle is a tiny triangular-shaped muscle that is located in the anterior abdominal wall, which originates from the body of the pubis and pubic symphysis and is inserted into linea alba. This study aimed to measure the different parameters of the pyramidalis muscle in adult cadavers. This study was carried out on 31 adults (26 males and five females) 10% formalin embalmed cadavers of both sexes from the Department of Anatomy at Kasturba Medical College, Manipal. The mean length of the right pyramidalis muscle was 64.44 ± 12.52 mm and the left pyramidalis muscle was 64.73 ± 12.81 mm. The mean width of the muscle was 15 ± 4.18 mm and 15.03 ± 3.52 mm on the right and left sides, respectively. The mean thickness of the muscle was 1.32 ± 0.55 mm and 1.4 ± 0.80 mm on the right and left sides, respectively. The distance between the umbilicus to pubic symphysis ranged from 130-192 mm and their mean was calculated to be 159.77 ± 15.36. The distance between the umbilicus and the apex of the muscle ranged from 72-123 mm. The measured parameters like length, width and thickness may help the surgeons to locate the muscle during infra umbilical surgeries.

Influence of Parity on Placenta Thickness and Diameter Among Pregnant Women in Usman Danfodio Teaching Hospital Sokoto

The management of pregnancy requires knowledge of the gestational age. It is usually estimated by ultrasound using parameters like femur length, bi-parietal diameter, and abdominal circumference. A healthy placenta is crucial for fetal well-being, growth, development and neonatal survival. Fetal Sonographic biometric parameters are crucial in obstetric decision making, the placenta’s weight is important in detecting functioning after birth, as placenta’s gross examination could shed light on the new-born’s weight and any pregnancy-related complication fetus .The purpose of the study determine The Influence of Parity on Placenta Thickness and Diameter Among Pregnant Women in Usmanu Danfodiyo University Teaching Hospital Sokoto. A cross-sectional study design was conducted among 72 pregnant women who were between 24 to 40 weeks of gestational age and came for an ultrasound in the Radiology department at Usmanu Danfodiyo University Teaching Hospital, Sokoto. Data were collected using proforma. Data was processed using IBM® SPSS version 25 and analysed using descriptive and inferential statistics. The finding of the results reveals majority of the respondents were in the age group 25-29 years. The majority of the mothers were multigravida 60(83.3%) and about 84% of the respondent was multipara. The mean placental diameter and thickness were 14.10 ? 1.4cm and 4.58 ? 4.2cm respectively. The placental thickness and diameter all rise linearly with increased gestational age (r = 0.422, P&lt;0.001, r=0.24, p=0.044, respectively. Placental thickness and diameter are positively correlated with parity and gestational age. (r=0.24, p=0.044 and r=0.24, p=0.040, respectively).it is recommended Placenta thickness and diameter is an index. it is recommended to incorporated measurement of placenta thickness and diameter as a routine into conventional fetal biometric for fetal age estimation and weight during antenatal ultrasound.

Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration

BackgroundSignificant diurnal fluctuation of optical coherence tomography (OCT)-based macular fluid occurs in patients with several macular conditions including diabetic macular edema (DME) and cystoid macular edema due to retinal venous occlusion (RVO). OCT imaging and analysis of macular fluid status plays a central role in clinical management of exudative age-related macular degeneration (eAMD), however diurnal variation of eAMD OCT findings has not yet been formally studied. Herein, we investigate whether clinically meaningful fluctuation of OCT-based macular fluid occurs in patients with eAMD.MethodsProspective observational study. Patients with eAMD and intra- and/or sub-retinal fluid on early AM OCT were enrolled to receive two consecutive OCT scans at least four hours later. Retinal layers were manually segmented on all OCT rasters and AM-to-PM and PM-to-PM image pairs were analyzed for total retinal and neurosensory retinal volume changes within the central 1 and 3 mm ETDRS subfields. Finally, two masked retinal specialists analyzed all OCT image pairs for qualitative differences that may impact clinical management.Results21 patients with eAMD and fluid on OCT were recruited between January 2020 and November 2021. There was no mean difference between AM and PM central 3 mm total retinal volume (p = 0.56), central 3 mm neurosensory retinal volume (p = 0.25), central 1 mm total retinal mean thickness (p = 0.96), or central 1 mm neurosensory retinal mean thickness (p = 0.63), nor were any differences identified in PM-to-PM control comparisons. Qualitative analysis by two masked experts identified no clinically significant differences between any AM-to-PM OCT image pairs.ConclusionsNo significant diurnal variation in OCT-based macular fluid or thickness was identified in patients with eAMD, either quantitatively or qualitatively.

The use of ultrasonography as an effective screening tool for chronic posterior cruciate ligament injuries

PurposeWe aimed to explore the applicability and validity of ultrasonography for diagnosing chronic posterior cruciate ligament (PCL) injuries.MethodsPCL thickness was measured at 2 cm proximal to the tibia insertion site. Using the same ultrasonography image, the angle tangent to the PCL from the tibia insertion site was also measured. These data were analyzed by plotting the receiver operating curve (ROC), and the sensitivity and specificity were calculated according to the optimal cut-off point. Ultrasonography data from the PCLinjured knee were compared with those from the contralateral uninjured knee of the same patient.ResultsTwelve men and six women, with a mean age of 28.8 ± 14.0 years, were included in this study. The mean time from injury to medical examination was 10.0 ± 6.7 months. The mean thickness of the PCL was 8.1 ± 1.9 mm on the affected side and 5.8 ± 1.2 mm on the uninjured side, with the affected side being significantly thicker. ROC analysis revealed that the optimal cut-off value for the thickness of chronic PCL injuries was 6.5 mm (sensitivity 83.3%, specificity 77.8%, area under the curve [AUC] = 0.87). The optimal cut-off value for the angle was 20° (sensitivity 88.9%, specificity 94.4%, AUC = 0.96).ConclusionUltrasonography is useful as a screening tool for chronic PCL injuries. The optimal cut-off point was 6.5 mm for thickness and 20° for angle.Level of evidenceIV.

Holocene marine deposits in the Bohai Sea: Depocenters, sediment sources, and oceanic and tectonic influences

The Bohai Sea is a semi-enclosed shallow shelf sea that has undergone a unique sediment source-to-sink process in the past. Despite this, our knowledge about the sediment budget, existence of depocenters and the factors controlling depocenter formation during the Holocene remains limited. This paper aims to address these gaps by estimating the Holocene marine deposit thickness and sediment budget in the Bohai Sea using high-resolution subbottom profiles. The results reveal that the mean thickness of Holocene marine deposits is approximately 7.8 m and a maximum thickness of 28 m was found in Jinzhou Bay. The Highstand System Tracts (HST) have a mean thickness of approximately 5.4 m and a maximum thickness of 25 m observed in the Jinzhou Bay. On the other hand, the Transgressive System Tracts (TST) have a mean thickness of approximately 2.5 m and a maximum thickness of 7 m in the north of the Laizhou Bay. The total accumulation in the Bohai Sea is estimated to be ∼713.97 × 109 tons, consisting of 489.28 × 109 tons from the HST and 224.69 × 109 tons from the TST. Three deposit centers were identified and estimated to be approximately 299 × 109 tons, accounting for approximately 42 % of the total Bohai Sea sediments. The development of Holocene marine deposit centers was mainly influenced by the Tanlu Fault zone and water circulations. Based on preliminary estimates, it is suggested that roughly half of the sediments dispersed from the estuaries are preserved on the Bohai Sea shelf since the maximum flooding (∼7000 cal yr BP). This research provides valuable insights for the post-glacial sedimentary and geomorphic evolution of the Bohai Sea.

Evaluation the effect of dietary vitamin E, sesamin and thymoquinone bioactive compounds on immunological response, intestinal traits and MUC-2 gene expression in broiler Japanese quails (Coturnix japonica)

The current study was performed to determine the effect of dietary vitamin E, sesamin and thymoquinone bioactive lignans derived from sesame and black seed on immunological response, intestinal traits and Mucin2 gene expression in broiler quails. Three hundred and fifty (one days-old) quails were allotted to seven dietary treatments with five replicates as an experimental randomized design study. Treatments were basal diet as a control, control +100 and +200 mg of vitamin E, sesamin and thymoquinone per each kg of diet respectively. At 35 d of age, two quails from each pen were chosen, weighted, slaughtered, eviscerated and lymphoid organ relative weights were measured. Anti-body titers against Newcastle disease (ND), Sheep red blood cell (SRBC), and infectious bronchitis virus (IBV) and Avian influenza (AI) vaccination were determined. The serum activities of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and serum antioxidant activates such as superoxide dismutase (SOD),glutathione peroxidase(GPX), catalase (CAT) and total antioxidant capacity (TAC) were examined. The cell mediated immunity by dinitrochlorobenzene (DNCB) and phytohemagglutinin (PHA) challenges were assessed. The microflora populations of ileum, morphological traits of jejunum and mucin2 gene expression were analyzed. Data showed that the lymphoid organ (thymus, spleen and Bursa) relative weights and antibody titer against HI, AI, SRBC and IB vaccination were increased compared to the control (p ≤ 0.05). Serum activities of ALP, ALT and AST were decreased under influences of dietary treatments (p ≤ 0.05). The serum antioxidant activates of GPX,SOD,CAT and TAC were increased and Increasing in mean skin thickness after DNCB challenge and decrease wing web swelling response to PHA mitojen injection were observed (p ≤ 0.05). Salmonella enterica, E-coli and Coliforms colonies were decrease and Lactobacillus colonies increased instead (p ≤ 0.05). The villus height and surface, crypt depth and goblet cells density were increased compared to the control (p ≤ 0.05). The expression of MUC2 gene increased under influnces of vitamin E, sesamin and thymoquinone supplemented diets (p ≤ 0.05).

Ganglion Cell Layer, Inner Plexiform Layer, and Choroidal Layer Correlate Better with Disorder Severity in ADHD Patients than Retinal Nerve Fiber Layer: An Optical Coherence Tomography Study

Aim: To assess the thickness of the choroidal layer, inner plexiform layer (IPL), ganglion cell layer (GCL), and retinal nerve fiber layer (RNFL) in individuals with attention-deficit/hyperactivity disorder (ADHD).&#x0D; Material and Methods: In this retrospective study, we used a spectral optical coherence tomography (OCT) device. The CPRS-48 was performed to the ADHD group. &#x0D; Results: Both groups consisted of 60 subjects. There were significant differences in NS segment of RNFL (right p=0.039; left p=0.035). The mean right choroidal thickness of ADHD group was significantly lower than the control group (p=0.015). The left GCL and IPL volumes of ADHD group were significantly lower than the control group (p

Analysis of experimental injuries to obese occupants with different postures in frontal impact

The objective of the present study was to analyze injuries and their patterns to obese occupants in frontal impacts with upright and reclined postures using experimental data. Twelve obese post-mortem human subjects (PMHS) were positioned on a sled buck with seatback angles of 250 or 450 from the vertical, termed as upright and reclined postures. They were restrained with a seat belt and pretensioner. Frontal impact tests were conducted at 8.9 or 13.9 m/s, termed as low and high velocities. After the test, x-rays and CTs were taken, and an autopsy was conducted. The Maximum AIS (MAIS) and Injury Severity Score (ISS) were calculated, and injury patterns were analyzed. The mean age, stature, total body mass, and body mass indexes were 67 years, 112 kg, and 1.7 m, and 38 kg/m2. None of these parameters were statistically significantly different between any groups. The mean thickness of the soft tissues in the left anterior lateral, central, and right anterior lateral aspects were 44 mm, 24 mm, and 46 mm. In the low-velocity tests, the ISS data were 9, 18, and 9 for the upright, and 9, 9, and 4 for the reclined specimens, and in the high velocity tests, they were 29, 17, and 27 for the upright, and 27, 13, and 27 for the reclined postures. Other data are given in the paper. For both postures at the low velocity, injuries were concentrated at one body region, and the ISS data were in the mild category; in contrast, at the high velocity, other body regions also sustained injuries, and the ISS data were in the major trauma category. From MAIS perspectives, injuries to obese occupants did not change between postures and were independent of the energy input to the system. The association of chest with pelvis injuries in upright and reclined postures to obese occupants may have additional consequences following the initial injury to this group of our population.

Surgical Anatomy of Transversus Abdominis Muscle for Transversus Abdominis Release: A CT-Based Study in Three Patient Groups.

The anatomy of the transversus abdominis muscle and its aponeurosis is important in transversus abdominis release surgery. We studied the CT anatomy of the transversus abdominis muscle medial to the linea semilunaris at different levels in the abdomen and measured the thickness of this muscle. In this retrospective study, we analysed 150 abdominal computed tomography at L1, L3, and L5 vertebral levels corresponding to subxiphoid, umbilical, and suprapubic regions, respectively. The patients were divided into three groups based on age and sex: women aged 15-20 years (nulliparous), women aged 30-60 years (multiparous), and men aged 15-60 years, with each group having 50 patients. We compared the thickness of the TA muscle at the L1 level between men and women and between nulliparous and multiparous women. Transversus abdominis muscle was consistently present medial to the linea semilunaris at L1 vertebral level in the subxiphoid region (150/150). At the L3 vertebral level in the mid-abdomen, only eight patients had the transversus abdominis muscle there (8/150, 5%). At the L5 vertebral level in the suprapubic region, no patient had the transversus abdominis muscle medial to the linea semilunaris. The mean thickness of the transversus abdominis muscle at the L1 level was 3.4 mm, and at the L3 level, it was 1.6 mm. There was no statistically significant difference in the transversus abdominis muscle thickness between the men and women; however, a significant difference was found between the nulliparous and multiparous women, with thinner TA muscle in later. There is good transversus abdominis muscle bulk medial to the linea semilunaris for doing transversus abdominis muscle division in the upper abdomen. However, as we move towards the mid-abdomen, we have TA aponeurosis or rarely TA muscle of little bulk.

Preoperative Frontal and Parietal Bone Thickness Assessment to Predict Blood Loss and Transfusion During Extended Suturectomy for Isolated Sagittal Craniosynostosis.

To predict the morbidity of sagittal suturectomy using preoperative computer tomographic measurement of frontal and parietal bone thickness in osteotomy sites. Retrospective analysis. Tertiary children's hospital. Fifty infants with nonsyndromic, isolated sagittal craniosynostosis who underwent extended sagittal suturectomy from 2015-2022. Mean thickness of the frontal and parietal bone in regions of osteotomies were determined for each patient from preoperative CT images obtained within 30 days prior to suturectomy. The relationship between bone thickness (mm) and estimated blood loss (mL) was evaluated using Spearman's correlation and a multivariable model that adjusted for patient weight and surgery duration. The association between bone thickness and perioperative blood transfusion was evaluated using a multivariable logistic model controlling for patient weight and surgery duration. Estimated blood loss, perioperative blood transfusion. Frontal and parietal bone thickness in the region of osteotomies were positively correlated with estimated blood loss (p < 0.01). After adjusting for patient weight and duration of operation, both parietal and frontal bone thickness were associated with intraoperative blood loss (R2 = 0.292, p = 0.002 and R2 = 0.216, p = 0.026). Thicker frontal and parietal bone in the line of osteotomies resulted in significantly higher odds of blood transfusion. Bone thickness in the line of parietal osteotomies was 76% accurate at identifying patients who would require blood transfusion (p = 0.004). Frontal and parietal bone thickness in the line of osteotomies is associated with blood loss and perioperative blood transfusion for sagittal suturectomy operations.