Abstract Background 2.2 billion people live with visual impairment (VI) worldwide and face orientation and mobility challenges in various aspects of their lives. Despite technological advancements, the most used mobility solutions for VI are still the walking cane and the guide dog. The objective of this research is to assess the system usability of an AI-based independent pedestrian navigation device (.lumen glasses), designed for blind people. Methods During 31st of October and 2nd of November 2023, 27 visually impaired people living in Bucharest, Romania, tested the .lumen glasses for 1-3 hours during an outdoor navigation task. The glasses use AI to recognize the user’s environment and haptic and audio feedback to guide them. The System Usability Scale (SUS), a 10-item instrument, was used to evaluate the level of usability the participants ascribe to the .lumen glasses. Qualitative feedback was collected as part of the post-test survey and analyzed using thematic analysis. Data were triangulated to identify usability issues. Results The mean age of the participants was 30.3 years old (SD = 12.07, min=21 max =56, range: 48), 55.6% (N = 15) of the participants were male, 96,3% (N = 26) were completely blind, and 81.5% were using a white cane for orientation and mobility. Our findings reveal a mean SUS score of 83.65 (SD = 15.23, range 47.5, min=52.5, max=100) indicating high usability. The thematic analysis revealed 5 themes: (1) auditive and (2) haptic feedback in navigation, (3) hardware (adjustment system & buttons), (4) tutorial & presentation of how the device works and (5) other aspects (usage in combination with other assistive technologies etc.). The participants declared that the glasses are intuitive to use and promote the feeling of safety and independence. Conclusions Data suggest that the .lumen glasses area promising assistive technology for the mobility of VI. Findings are currently used to steer the development and implementation of the AI-based system. Key messages • According to participants’ feedback, .lumen glasses are a scalable AI-based mobility solution that can make navigation and orientation easier for visually impaired individuals. • .lumen glasses designed for the visually impaired individuals are one of the current and limited assistive technology improving the mobility and orientation.