Background: It is rare to encounter a gall bladder stones in the paediatric age group. In Saudi Arabia, sickle cell disease (SCD) is common with incidence reach to 19.7%in some provinces. Cholecystitis is responsible for significant morbidity in SCD patients. Laparoscopic cholecystectomy (LC) is now considered as the procedure of choice for treating such cases. Over a period of 3 years, a total of 21 children with sickle cell anemia (SCA) had cholecystectomy. We exclude 3 patients who had splenectomy and cholecystectomy in the same time, the remaining 18 patients (6 males and 12 females) had LC only. Their age ranged from 4 years to 13 years (mean of 7.45±1.94 years). Methods: LC was the standard procedure performed in all the children in our study group. The mean duration of operation was 92.17±27.31 minutes (range from 62-167 minutes). Results: The mean post-operative stay after operation was 2.167±0.5 days (range from 1-3 days). One patient required conversion to open cholecystectomy (OC) because of severe adhesions, there were no immediate postoperative complications in the other 17 patients of our study group. Conclusions: In conclusion, elective LC in well prepared patients, is feasible and safe in children with SCA and should be the treatment of choice for both symptomatic and asymptomatic cholelithiasis. ERCP is a valuable diagnostic and therapeutic investigation both preoperatively and postoperatively.