Mean Platelet Volume In Children Research Articles

Evaluation of Mean Platelet Volume in Children with Hypertension.

Childhood hypertension, a disease with increasing prevalence, can lead to severe health problems. With the increased pressure on the vascular endothelium in hypertension, lesions in the endothelium result in endothelial activation and a process of inflammation, which causes platelet activation and in the bone marrow the release of platelet precursor cells into the peripheral blood stream. During inflammation, changes in the number and size of platelets are observed. With the release of platelet precursors into the peripheral blood stream due to platelet activation, an increase in mean platelet volume (MPV) is also seen. Our aim in this study is the evaluation of MPV changes in the hemogram of children suffering from hypertension, a condition causing severe cardiovascular problems. Material and Methods. This research is a descriptive retrospective cross-sectional study. It consists of a patient group diagnosed with hypertension and a control group of children presenting for routine check-ups with no diagnosed hypertension. Demographic characteristics, arterial pressure values, and hemogram parameters have been evaluated. A total of 90 cases were enrolled in the study, including a patient group of 45 cases with hypertension (19 females, 26 males) and a control group of 45 cases (27 females, 18 males). The median age was 15 years in the hypertension group and 13 years in the control group. In the hypertension cases, the thickness of the carotis intima media was statistically significantly greater than in the control group (p < 0.001). Echocardiographic findings (IVSd, LVDd, LVPWd, IVSs, LVDs, LVPWs, and LV mass) were significantly higher in the hypertension group compared to the control group (p < 0.001). A statistically significant difference in platelet count and MPV values between the groups was not found (p = 0.151, p = 0.405, respectively). While MPV is hypothesized to be higher in hypertensive individuals, there was no statistically significant difference between the hypertensive and non-hypertensive groups in this study.

Mean platelet volume in children with Kawasaki disease

Mean platelet volume in children with Kawasaki disease

A Case Control Study to Determine the Effectiveness of Mean Platelet Volume (MPV) in Acute Appendicitis Diagnosis among Children

Aim: To access the diagnostic value of the mean platelet volume in children with acute appendicitis. Study design: A case control study Place and duration: In the Surgical department of Bilawal Medical College for Boys LUMHS, Jamshoro and Sheikh Zayed Medical College/ Hospital Rahim Yar Khan for six-months duration from July 2021 to December 2021. Methods: 150 total patients were selected with the WHO formula with SD 1.09, 80% power, 5% significance level with cases to control ratio of 1:1 and expected populace 7.55. The patients were selected with simple random technique of sampling (lottery method). The continuous variables of both groups were compared by means of the t-test. To determine the association of MPV with other variables; correlation test was applied. Results: The study included 150 patients; 35 (46.7%) are men and 40 (53.3%) are women in the study group and 34 (45.3%) men and 41 (54.7%) women in the control group. 8.21 ± 3.51 (1-15 years) was the mean age of the patients in the study group and the mean age of the controls was 8.69 ± 3.51 (1-15 years). The specificity for raised neutrophil and WBC values was 91% and 89%, and the sensitivity was 77% and 84%, respectively. The sensitivity and specificity to MPV reduction was 87% and 54%. Conclusion: The increase in the leukocytes and neutrophils is significantly associated with acute appendicitis diagnosis. It is less costly and less time-consuming which cause more attention to MPV values during complete blood counts in the acute appendicitis diagnosis among pediatric patients. The low MPV levels are encountered in children with acute appendicitis. Keywords: High white blood cell count, acute appendicitis, specificity, mean platelet volume (MPV).

Evaluation of serum sodium levels and mean platelet volume in children with community-acquired pneumonia

Background and aim Community-acquired pneumonia (CAP) is one of the frequent causes of hospital admission, whereas hyponatremia (HN) is a common electrolyte abnormality in hospitalized patients and is associated with considerable morbidity and mortality. Mean platelet volume (MPV) may be a useful predictor for the diagnosis of CAP but not in disease severity. The purpose of this study was to evaluate serum levels of sodium and MPV in a child with CAP. Patients and methods This is a case–control study that has been carried out in a Malawi General Hospital. The total (100) participants included in the study were classified into two groups as follows: group I which is the case group included 50 children with clinical and laboratory evidence of pneumonia ranging from 1 month to 3 years. Group II which is the control group included 50 children (apparently healthy control) who attended for nonchest problem or serious medical condition. Serum sodium levels, hemoglobin levels, MPV, platelet count, total leukocyte count, and C-reactive protein were done to all children. Results HN was present in 82% of patients with CAP (41 out of 50). Patients with CAP had lower MPV than their healthy counterparts (7.11±0.42 vs. 9.14±1.04 fl; P&lt;0.001). There was a statistically significant negative correlation between the grade of respiratory distress and the level of serum sodium and a positive correlation between the grade of respiratory distress and MPV (P&lt;0.001). Conclusion HN is common among hospitalized children with CAP and MPV may be a useful predictor for the diagnosis of CAP.

Platelet counts and adenoid hypertrophy: a neglected relationship.

The increase in resistance of the respiratory nasal caused by adenoid hypertrophy can condition changes in pulmonary ventilation and translate into a risk of cardiopulmonary diseases. The mean platelet volume is a marker of platelet function, associated with indicators of platelet activity - a greater volume indicates the presence of larger platelets and greater hemostatic reactivity, associated with a propensity for thrombosis. Retrospective study of 200 patients who presented to the otolaryngology outpatient clinic of our hospital, divided in two group-s : chAil dren with adenoid hypertrophy, B - children without adenoid hypertrophy. The age, hemoglobin levels, platelet counts were compared between the two groups. The Mean Platelet Volume levels in patients with Adenoid Hypertrophy were significantly higher than those in the control group (p<0.001). White blood cells, hemoglobin, and platelet levels were not significantly different between the 2 groups (P > 0.05). Adenoid hypertrophy is associated with higher mean platelet volume in children. Measurement of mean platelet volume and platelet count can be considered as quick, safe, and reliable guide for the assessment of clinical consequences of adenoid hypertrophy.

Mean platelet volume in children with systemic lupus erythematosus.

Platelets are heterogeneous in size, density, metabolic, functional, and biochemical properties. Mean platelet volume (MPV) is a measure of the average size of platelet in a blood sample. We aimed to evaluate the mean platelet volume as a marker for disease activity in children with systemic lupus erythematosus. This was a prospective case-control study, which included 50 patients with SLE and 50 age and sex, matched healthy controls. All subjects were subjected to history taking, physical examination and laboratory parameters in active and remission phases of the diseases. The MPV value in the SLE group was significantly higher than control group (9.6 ± 1.3 fL, 9.1 ± 0.57 fL, respectively, p = 0.04). There was a significant increase of weight, blood pressure, urea, creatinine, proteinuria, CRP, ESR, cholestrol, MPV values, SLEDAI-2K scores and significant decrease of HB, albumin, C3, mean platelet volume (MPC) in the active stage than in the remission stage. There was a significant negative correlation between MPV and MPC in active stage of the disease but the correlation was insignificant in remission stage. MPV increased in active phase of patients with SLE and can be an easy, rapid, inexpensive and simple method to assess disease activity in children with SLE.

Study of the Mean Platelet Volume in Children with Chronic Renal Diseases

Background: The mean platelet volume (MPV), which is a readily available indicator of platelet activation and function, is considered as a promising predictive and prognostic biomarker of cerebrovascular and cardiovascular diseases in several studies. The larger platelets tend to aggregate and produce larger amounts of adhesion molecules than small ones. Objective: To investigate the relationship between MPV levels and the glomerular filtration rate (GFR) in pediatric patients with Chronic Kidney Disease (CKD). Patients and Methods: A prospective case-control study was carried out at the Nephrology Unit in the pediatric department of Zagazig University Children Hospitals.40 children participated in study 20 of them having chronic kidney disease as a case group and a similar number of control children comparable with case group. We reviewed the medical records of patients between May 2018 and February 2019. Results: In this study, there was a positive significant correlation between MPV with Red cell Distribution Width (RDW) and creatinine and a negative correlation between MPV and eGFR in the CKD group. There was a statistically significant difference between case and control groups as regard serum creatinine, urea, and eGFR. There was a highly significant difference between the two groups regarding Hemoglobin, MPV, and RDW. There was a statistically significant difference between the two groups regarding systolic blood pressure (SBP) and diastolic blood pressure (DBP). There was a significant difference between the two studied groups as regard weight. MPV was significantly increased with the progression of CKD. Thus the lower the results of eGFR reflecting poor stage and prognosis of chronic kidney disease accompanied by higher values of MPV. Conclusion: The useful estimation of MPV provides a promising Cheap Biomarker in the monitoring of the course of progression in Chronic Kidney Diseased Children.

Relationship between the severity of Helicobacter pylori infection and neutrophil and lymphocyte ratio and mean platelet volume in children.

HP causes local inflammation in the stomach and a systemic humoral immune response. No relationship was found in adult studies investigating the association between HP infection and neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV). To our knowledge, there is no study in children. We aimed to evaluate the association between NLR and MPV values with HP infection, severity classification, and pre- and post-treatment status. Patients with dyspepsia aged between 2-18 years and without any chronic diseases undergoing gastroduodenoscopy were included in the study. Endoscopic mucosal biopsy was performed, HP presence and infection severity were determined according to Sydney Classification. 153 patients with HP positivity and 211 patients with HP negativity were included in the study, the mean age of them was 13.3 ± 3.4 years and 13.1 ± 3.5 years, respectively. No statistically significant difference was found between patients with HP positive and negative patients and also between severity subgroups of HP positive patients in terms of NLR and MPV (p > 0.05). There was no association between NLR and MPV values with HP infection, severity classification, or pre- and post-treatment status.

An evaluation of inflammation with mean platelet volume in children with celiac disease

Aim: The purpose of this study was to evaluate mean platelet volume and platelet distribution width in children with celiac disease.Material and Methods: Fifty children with celiac disease (18 boys, 32 girls) and 63 healthy volunteer children (23 boys, 40 girls) were included in the study. Demographic features such as age, and gender and laboratory values such as platelet count, mean platelet volume, and platelet distribution width were recorded from the patients’ files.Results: Fifty children with celiac disease (18 boys, 32 girls) and 63 healthy volunteer children (23 boys, 40 girls) were included in the study. No statistically significant differences were determined between the celiac disease group and the healthy control group in terms of platelet counts (275,418±70,657/mm3 and 280,888±61,290/mm3, respectively, p=0.661), platelet distribution width (19.27±1.14 fL and 19.16±1.13 fL, respectively, p=0.670) or mean platelet volume (7.31±1.36 fL and 7.38±1.45 fL, respectively, p=0.779). At ROC analysis, a cut off value was determined for platelet distribution width of 18.2 fL with 24.00% sensitivity and 87.30% specificity (AUC: 0.504, 95% Cl: 0.408-0.599 and p=0.947). A cutoff value for mean platelet volume of 0.74 was calculated with 72.00% sensitivity and 44.44% specificity (AUC: 0.520, 95% Cl: 0.424-0.615 and p=0.708).Conclusions: Mean platelet volume values in children with celiac disease were no different to those of the healthy control group. We think that the absence of any change in mean platelet volume, values in children diagnosed with celiac disease may be related to a short duration of inflammation.

Altered mean platelet volume in children with Henoch-Schonlein purpura and its association with disease activity.

Background Henoch-Schonlein purpura is a systemic small-vessel vasculitis that occurs mainly in children. A review of the literature has suggested a correlation between mean platelet volume and several inflammatory disorders. However, to the best of our knowledge, any potential correlation between mean platelet volume and Henoch-Schonlein purpura has not been reported in the literature. Therefore, our study aimed to evaluate the role of mean platelet volume concentrations in patients with Henoch-Schonlein purpura. Methods This study included 97 children with Henoch-Schonlein purpura and 120 healthy individuals as controls. Results Mean platelet volume concentrations were found to be significantly lower in Henoch-Schonlein purpura patients compared with healthy controls (8.1 ± 0.86 vs. 9.4 ± 0.81, P < 0.001). Similarly, significant negative correlations were observed between mean platelet volume and neutrophil count, platelet count and erythrocyte sedimentation rate in patients with Henoch-Schonlein purpura (r=-0.327, P = 0.001; r=-0.419, P < 0.001; r=-0.255, P = 0.012). Interestingly, mean platelet volume was significantly lower in the acute phase compared with the convalescent phase of Henoch-Schonlein purpura patients (7.8 ± 0.86 vs. 8.3 ± 0.77, P = 0.002). A cut-off value for mean platelet volume was 7.85 with area under the curve of 0.726 to identify acute phase vs. convalescent phase in patients with Henoch-Schonlein purpura. Mean platelet volume was independently associated with Henoch-Schonlein purpura in logistic regression analysis (odds ratio = 0.114, 95% confidence interval = 0.053-0.243, P < 0.001). Conclusions Our results suggest that mean platelet volume is inversely associated with disease in patients with Henoch-Schonlein purpura, and mean platelet volume may be a useful marker to identify active disease in Henoch-Schonlein purpura patients.

Mean Platelet Volume in Children with Chronic Spontaneous Urticaria

Objective: It has been suggested that mean platelet volume can be used as a marker of inflammation in some inflammatory diseases. This marker has not been investigated adequately in children with allergic disease. The aim of this study was to evaluate mean platelet volume in children with chronic spontaneous urticaria. Materials and Methods: Fifty-four children with chronic spontaneous urticaria (26 boys and 28 girls, mean age 13.70±3.66 years) were included in this retrospective study. The demographic characteristics, complete blood count, serum total IgE, erythrocyte sedimentation rate, and skin prick tests results of the patients were recorded. Sixty healthy children were included as the control group. Only complete blood count results of the control group were recorded. Platelet count, mean platelet volume, platelet distribution width, leukocyte count, and hemoglobin values were compared between the two groups. Correlations between mean platelet volume with age, disease duration, atopy, serum total IgE, and erythrocyte sedimentation rate were analyzed in the patient group. Results: There was no statistically significant difference in terms of age and sex between the two groups (p=0.09, p=0.60, respectively). Mean platelet volume and platelet count in the patient group were significantly higher than those in the control group (p=0.005, p=0.01, respectively). Platelet distribution widths in the patient group were significantly lower than those in the control group (p 0.05). Mean platelet volumes in the patient group were not correlated with age, disease duration, atopy, serum total IgE, and erythrocyte sedimentation rate. Conclusion: Mean platelet volumes and platelet counts are increased in children with chronic spontaneous urticaria. However, the mean platelet volume does not appear to be associated with the erythrocyte sedimentation rate and atopy.

Assessment of red blood cell distribution width and mean platelet volume in children with epistaxis

ObjectiveThis study aimed to investigate whether there is a relationship between red blood cell distribution width, mean platelet volume and epistaxis in children. MethodsBetween January 2015 and July 2016, 105 children who were referred to our clinic with epistaxis and 100 sex- and age-matched controls were retrospectively analyzed. Red blood cell distribution width (RDW) and mean platelet volume (MPV) values were determined in both groups. ResultsRDW values were found significantly (P < 0.05) lower in the group with epistaxis than in the control group (11.95 ± 1.31 vs. 12.74 ± 1.21). MPV was 7.49 ± 1.33 in the group with epistaxis and 7.23 ± 1.06 in the control group, and there was no significant difference between the groups (p > 0.05). ConclusionWe found no difference between MPV values of both groups and significantly lower RDW values in children with epistaxis. Decreased RDW values were considered as an accompanying marker rather than a result of epistaxis. In addition, it may be thought that low RDW values may increase the bleeding tendency by disrupting the thrombotic activities. Further studies are needed to validate the relation of these parameters with epistaxis and its mechanisms.

Mean platelet volume in children with hepatitis A.

BackgroundMean platelet volume (MPV), which is commonly used as a measure of platelet size, indicates the rate of platelet production and platelet activation. We aimed to evaluate the mean platelet volume in children with hepatitis A.MethodsIn this retrospective case-controlled study, the study population consisted of 62 children with hepatitis A and 62 healthy control subjects.ResultsMPV values, aspartate transaminase (AST), and alanine transaminase (ALT) levels on admission were significantly increased in patients with hepatitis A when compared to controls whereas white blood cell (WBC) counts were significantly lower. Two weeks after admission, the MPV values showed a significant decrease from 9.47 ± 1.62 to 8.84 ± 1.48 fL in patients with hepatitis A, but these values were still significantly higher than the controls. There was a significant difference in terms of MPV, WBC, AST, and ALT values between the controls and the patient group 2 weeks after admission.ConclusionsThis study is the first to evaluate the MPV levels in children with hepatitis A. MPV values were found to be increased in children hospitalized with hepatitis A.

The Importance of Mean Platelet Volume in Children with Nephrotic Syndrome

The Importance of Mean Platelet Volume in Children with Nephrotic Syndrome

Serum interleukin-6 and mean platelet volume in pediatric pneumonia

Background In pneumonia, interleukin (IL)-6 is released in response to inflammation. Interleukin-6 stimulates megakaryocyte maturation, leading to larger platelets being released into the circulation. Platelet size is measured as mean platelet volume (MPV). The MPV may also be affected by nutritional status and smoking.Objective To assess for a possible relationship between serum IL-6 concentration and MPV, including smoking and nutritional status as confounding factors, in children with pneumonia.Methods An analytic, observational study with cross-sectional design and consecutive sampling of children aged 2 to 59 months with a clinical diagnosis of pneumonia was conducted from November 2013 to March 2014 in Dr. Hasan Sadikin General Hospital and two network hospitals. All patients underwent routine complete blood counts including MPV and measurement of serum IL-6 concentration using an enzyme-linked immunosorbent assay (ELISA) technique. Regression linear analysis was used to assess the relationship between MPV and IL-6, passive smoking, and nutritional status.Results There were 67 patients enrolled in the study. Subjects’ mean serum IL-6 concentration was 49.3 (SD 78.3) pg/mL, and mean MPV was 9.2 (SD 0.9) fL. The regression model for MPV was 7.531 + 0.662 (passive smoking) + 0.276 (weight per age) + 0.009 (IL-6).Conclusion There was a relationship between IL-6 serum concentration and MPV in children with pneumonia.

Reduction in mean platelet volume in children with acute bronchiolitis.

Platelets which are known to play a role in inflamation change their shapes when they are activated and this change is reflected in mean platelet volume and platelet distribution width values. Therefore, the mean platelet volume and platelet distribution width values are considered to be beneficial parameters for the diagnosis and treatment of many inflammatory diseases. The aim of the study was to evaluate platelet volume indices in children with acute bronchiolitis. A total of 514 infants who were below the age of 2 years old were evaluated in this study. Three hundred thirteen of these infants were diagnosed with acute bronchiolitis patients and 201 were healthy children. The patients were separated into four groups as mild, moderate, severe bronchiolitis and the control patient group. The groups were evaluated in terms of significant differences in the values of mean platelet volume and platelet distribution width. A p value of <0.05 was considered statistically significant for all results. The mean platelet volume was found to be 6.8±0.6 fL in the patients with mild bronchiolitis attack, 6.7±0.6 fL in the patients with moderate bronchiolitis attack, 6.5±0.5 fL in the patients with severe bronchiolitis attack and 7.3±1.1 fL in the control group. The mean platalet volume was statistically significantly lower in the mild, moderate and severe bronchiolitis attack groups compared to the control group (p=0.000). The platelet distribution width was found to be 17.2%±0.83 in the mild bronchiolitis attack group, 17.1%±0.96 in the moderate bronchiolitis attack group, 17.3%±0.87 in the severe bronchiolitis attack group and 16.9±1.6% in the control patient group. This difference was not statistically significant (p=0.159). The platelet count was statistically significantly higher in the mild, moderate and severe bronchiolitis attack groups compared to the control group (p=0.000). The mean platalet volume is decreased in patients with acute bronchiolitis. It is not a useful criterion in determining the severity of bronchiolitis attack. It is important that clinicians evaluating hemogram results to also interprete this variable.

Increased mean platelet volume in children with sepsis as a predictor of mortality.

Our aim is to investigate the correlation between the mean platelet volume (MPV) levels and platelet counts of the septic children with 28-day mortality risk. MPV at admission (MPV < sub > adm < /sub > ), MPV at 72 < sup > nd < /sup > hour (MPV < sub > 72h < /sub > ) and the difference between these two parameters (ΔMPV < sub > 72h-adm < /sub > ) and platelet counts were recorded retrospectively. The control group consisted of 100 healthy children matched for age, gender, and ethnicity. One hundred eighty six children were enrolled into the study. The study group had significant higher MPV values than those of control group. There were 156 survivors and 32 nonsurvivors in study group with a mortality rate of 17%. Nonsurvivors had significantly higher MPV < sub > adm < /sub > (p: 0.001), MPV < sub > 72h < /sub > (p: 0.001), ΔMPV < sub > 72h-adm < /sub > (p < 0.001) and lower platelet count (p: 0.002) than survivors. MPVadm (OR 2.39), MPV < sub > 72h < /sub > (OR 4.23), ΔMPV < sub > 72h-adm < /sub > (OR 6.4), platelet count (OR 7.3), and need for mechanical ventilation support (OR 9.76) had significant effect on 28-day mortality risk at logistic regression analysis. At the receiver operating characteristic analysis (ROC) the cutoff values for MPV < sub > adm < /sub > , MPV < sub > 72h < /sub > , and ΔMPV < sub > 72h-adm < /sub > were found to be 9 fL, 9.86 fL, and 0.79, respectively. Kaplan-Meier analysis and log-rank test proved that these cutoff values were significantly associated with the time of survival. Septic children who had high MPV levels at admission and whose MPV levels increased during follow up had higher risk of mortality. With the results of further researches targetting large groups of pediatric patients, MPV < sub > adm < /sub > , MPV < sub > 72h < /sub > , and ΔMPV < sub > 72h-adm < /sub > values can be fast and reliable markers for early diagnosis of sepsis and mortality prediction.

Mean Platelet Volume in Children with Acute Gastroenteritis Caused by Entamoeba histolytica

Mean platelet volume (MPV) is a marker of platelet activation, which is a determinant of inflammation. The first aim of the present study was to investigate the MPV levels in children with amebiasis and compare the MPV levels with healthy controls. The second aim of this study was to evaluate the relationship between MPV and other acute phase reactants. Seventy six patients with amebic gastroenteritis (mean age 2.64 ± 0.23 years) and 53 healthy controls (mean age 2.35 ± 0.28 years) were enrolled in the study. Entamoeba histolytica was determined in stool using rapid antigen test. Complete blood count and C-reactive protein (CRP) levels were assessed for all children. MPV levels of patients with amebiasis were significantly higher than those of control children (8.79 ± 0.09 vs. 7.87 ± 0.09 fL, p = 0.000). Leukocyte and eosinophil counts, C-reactive protein and creatinine levels of the patients were higher than controls. Leukocyte count was positively correlated with MPV (r = 0.192, p < 0.05), platelet count (r = 0.278, p < 0.01), and CRP level (r = 0.205, p < 0.05). In this MPV levels were significantly higher in children with amebiasis compared to controls. MPV can be used as an acute phase reactant in children with Entamoeba histolytica gastroenteritis.

Mean platelet volume in children with Reye-like syndrome

Reye-like syndrome (RLS) is considered to be a systemic disorder in which the cytokine storm plays a major role. Mean platelet volume (MPV), which is commonly used as a measure of platelet size, indicates the rate of platelet production and platelet activation. We aimed to study MPV in children with RLS. The study population consisted of 30 children with RLS and 30 healthy control subjects. White blood cell (WBC) count, aspartate transaminase (AST) and alanine transaminase (ALT) values were significantly higher and MPV values were significantly lower in patients with RLS at an early stage of illness when compared to controls. Erythrocyte sedimentation rate (ESR), C-reactive protein, AST and ALT values were significantly decreased in patients with RLS after the treatment when compared to baseline whereas MPV values were increased. MPV values were negatively correlated with ESR and WBC. In conclusion, at an early stage of RLS MPV values were lower when compared to controls.

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

BackgroundFamilial Mediterranean fever (FMF) is an inflammatory disease, which is suggested to be associated with increased risk of atherosclerosis. Epicardial adipose tissue (EAT) thickness and the mean platelet volume (MPV) are parameters used in prediction of atherosclerotic risk in various conditions. These parameters were evaluated in children with FMF and compared with healthy controls.MethodsForty-five patients with FMF and 54 age- and gender-matched healthy controls were assessed. Duration of symptoms, age at diagnosis, duration of delay in diagnosis, frequency and duration of FMF attacks, disease severity scores, response to colchicine therapy, MEditerraneanFeVer (MEFV) gene mutations, and MPV values were recorded. EAT thicknesses were measured by echocardiography.ResultsEpicardial adipose tissue thicknesses of the children with FMF were found to be significantly greater than that of controls (5.1 ± 1.4 vs. 4.5 ± 0.9 mm, p = 0.036). FMF patients had significantly higher MPV values compared with the controls (7.8 ± 1.1 vs. 7.3 ± 1.4 fl, p = 0.044). Age at diagnosis, duration of delay in diagnosis, and MPV values were found to be correlated with EAT thickness in the patient group (r = 0.49, p = 0.001 for the former parameters and r = 0.32, p = 0.04 for MPV).ConclusionEpicardial adipose tissue thickness and MPV values seem to be increased in children with FMF. These findings may indicate an increased risk of atherosclerosis in FMF patients.