Poor weight status in nursing home residents is associated with increased morbidity, mortality and costs. Aggressive nutrition therapy may remediate the abnormality if inadequate nutrition is the primary cause, but may be futile if progressive disease is the primary cause. A pilot study examined factors associated with weight change over three months in newly admitted undernourished patients (n=43). Absence of urinary tract infection (UTI) was significantly (p<.05) associated with weight gain in both males (r=.45) and females (r=.63). To further explore this relationship the weight status of 78 nursing home residents (63 females, and 16 males) who had contracted at least 1 UTI was monitored over a six-month period using medical record data. Females with 3 or more UTIs on average lost weight, whereas those with only 1 UTI did not. Mean percent weight change ±std.dev. in females in the 3+UTI group was −3.5±6.8%, and was significantly different (t-test, p<.03) than that of the 1 UTI group which was +0.4±3.8%. No significant associations with frequency of UTI were found with percent change of weight in men or with final body mass index in either gender.