Mean Oxford Knee Score Research Articles

Radiological grading of osteoarthritis on Rosenberg view has a significant correlation with clinical outcomes after medial open-wedge high-tibial osteotomy.

To determine the classification scheme for osteoarthritis severity grading that most closely correlates with postoperative clinical outcomes and to identify the positive and negative prognostic factors for medial open-wedge high-tibial osteotomy (OWHTO). Seventy-nine consecutive patients with primary varus osteoarthritis were treated using OWHTO. Arthritic grading was determined by arthroscopic assessment according to the modified Outerbridge classification and by radiographic classification according to the Kellgren-Lawrence (KL) grading scale on standing anteroposterior (AP) and 45° posteroanterior (PA) flexion weight-bearing radiography. Clinical outcome was assessed using the Oxford Knee Score (OKS), which was evaluated both preoperatively and at the postoperative 2-year follow-up after OWHTO. Multivariate regression analyses were used to explore and quantify the influence of baseline patient demographics, variables related to arthroscopic and radiological grades of arthritis, as well as postoperative alignment changes on the OKS. At the 2-year follow-up, the mean OKS had improved from 20 ± 4 to 39 ± 5 points (p < 0.001). The average mechanical femorotibial and mechanical medial proximal tibial angle (MPTA) changed from 6.9°±3.4° to valgus 2.7° ± 2.8° and from 85.6°±2.4° to 92.9°±3.7° (all p < 0.001). The osteoarthritis severity grade based on the KL scale was 2.4 ± 0.9 on standing AP radiography, 2.8 ± 0.9 on 45° PA flexion weight-bearing radiography (p = 0.003), and 3.4 ± 0.7 according to the modified Outerbridge classification. In the multivariate analyses, the KL grade on 45° PA flexion weight-bearing radiography (p = 0.01) and postoperative MPTA (p = 0.01) showed significant negative correlations with postoperative OKS at the 2-year follow-up. The KL grading system based on 45° PA flexion weight-bearing radiography showed the strongest significant negative correlation with postoperative OKS after the OWHTO procedure using three different common OA classification schemes, which should be considered to determine the surgical indication of HTO. The KL grading system based on 45° PA flexion weight-bearing radiography showed the strongest correlation with high-tibial osteotomy-surgical indications and the counselling of patients with advanced osteoarthritis. IV.

Outcomes of a Fixed-Bearing, Medial, Cemented Unicondylar Knee Arthroplasty Design: Survival Analysis and Functional Score of 460 Cases

BackgroundUnicompartmental knee arthroplasty (UKA) is an alternative to total knee arthroplasty in isolated medial osteoarthritis (OA). However, despite satisfactory reports on the clinical performance, UKA revision rates are still concerning. This retrospective study reports on the long-term survivorship, functional outcomes, and reasons for revision in fixed-bearing UKA implant. MethodsBetween 2005 and 2013, 460 consecutive patients were treated with medial UKA in one center using a fixed-bearing UKA system. All patients were evaluated clinically and radiographically before surgery, and postoperatively at 6 weeks and 1 year. Between February and April 2016, all patients were reevaluated using the Oxford Knee Score. ResultsMean follow-up was 5.5 (range, 2-11) years. The mean Oxford Knee Score was 43.3 (7-48), with 94.6% patients showing excellent or good outcomes. Eleven revisions (2.4%) occurred. The survivorship was 97.2% (95% confidence interval, 96.2%-99.2%) and 94.2% (95% confidence interval, 86.8%-97.5%) at 5 and 10 years, respectively, with revision of any implant component for any reason as the end point. The causes for revision were infection (4 cases, 0.9%); lateral pain due to overload (2 cases, 0.4%); progression of OA in the lateral compartment (2 cases, 0.4%); patellar pain with patellar chondropathy (2 cases, 0.4%); and severe synovitis (1 cases, 0.2%). There were no reoperations or revisions for component loosening, instability, component wear, or periprosthetic fracture. ConclusionA fixed-bearing UKA system is a good treatment option for medial end-stage OA. Satisfactory functional results were achieved with low incidence of complications and revisions.

Ten-Year Results of the Press Fit Condylar Sigma Cobalt-Chrome Total Knee Replacement.

Total knee arthroplasty (TKA) is reliant on safe and effective implants. The Press Fit Condylar Sigma Cobalt-Chrome (PFCSCC) was introduced in 2006, but no reports have examined long-term failure rates and patient-reported outcome measures (PROMs). The primary aim of this study was to assess survival outcomes of the PFCSCC at 10 years after implantation. Prospective data collection was performed on all patients undergoing primary TKA in one orthopaedic department using this prosthesis exclusively from February 1, 2006, to January 31, 2007. Follow-up was at 10 years. Survival analysis was performed using two primary outcome measures: (1) all-cause joint revision and (2) aseptic revision. Secondary outcomes measures included the American Knee Society Score (AKSS) and Oxford Knee Score (OKS). In total, 249 knees of 233 patients underwent primary TKA. Mean patient age was 66.7 years (range 34-80), and mean body mass index (BMI) was 30 kg/m2 (20.7-40.1). Reviewing all causes of revisions, 14 joints (5.6%) of 14 patients required reoperation. Of these, nine were for deep infection, including six in the first year. Four (1.6%) underwent aseptic revision. Mean AKSS changed from 47.6 to 90.4 (n = 140; p < 0.001) at 10 years, and mean OKS changed from 38.3 to 23.2 (n = 149; p < 0.001). Prospective analysis of consecutive TKA cases using this design of prosthesis demonstrated high survival rates of 94.4% (all-cause revision) and 98.4% (aseptic revision) at 10 years. Postoperative gains in PROMs were sustained at 10 years. These real-world data represent a substantial extension to previous reports for the PFCSCC and suggest that it is not prone to late mechanical failure.

Does Orthopaedic Training Compromise the Outcome in Knee Joint Arthroplasty?

This study investigates knee joint arthroplasty and compares the outcomes between attending (consultant) orthopedic surgeons and resident (trainee) surgeons. Retrospective review and comparison of knee joint arthroplasty outcomes between 4 surgeon groups (attending, supervised senior and junior residents, and unsupervised senior residents). Measured outcomes were implant survival (revision rate) and patient reported functional outcomes, measured by Oxford knee score (OKS). New Zealand arthroplasty service. Seventeen years of knee joint arthroplasty data from the New Zealand Joint Registry (NZJR) was reviewed. The New Zealand Joint Registry (NZJR) data showed 79,671 total knee arthroplasties (TKA) and 8854 unicompartmental knee arthroplasties (UKA) performed between 1999 and 2016. Attending surgeons performed 90% and 97% of TKA and UKA, respectively. The number and proportion of resident performed knee joint arthroplasty has decreased. Faster operation times was observed in the attending surgeon group. Attending surgeon revision rate was 0.49 and 1.19/100 component years for TKA and UKA, respectively, this was not significantly increased in resident surgeon groups. Postoperative OKS was 37.7 and 39.7 for attending surgeon performed TKA and UKA, respectively. Mean OKS were less than 2 points worse in resident groups (resident range: 36.3-36.9) compared to attending colleagues for TKA, but for UKA scores were up to 11 points worse (resident range: 28.9-38.8). New Zealand has a high rate of attending surgeon performed TKA and UKA. Revision rates were not increased in resident surgeon groups. Postoperative function was not reduced by a clinically significant amount in TKA in any of the resident surgeon groups but was reduced in supervised junior resident and unsupervised senior resident surgeon groups for UKA.

Total Knee Arthroplasty in a Low-Income Country: Short-Term Outcomes from a National Joint Registry.

Background:We describe our 10-year experience with total knee arthroplasty in patients who are included in the Malawi National Joint Registry.Methods:A total of 127 patients underwent 153 total knee arthroplasties (TKAs) between 2005 and 2015. The mean duration of follow-up was 4 years and 3 months (range, 6 months to 10 years and 6 months). The study group included 98 women and 29 men with a mean age of 65.3 years (range, 24 to 84 years). Nine patients were human immunodeficiency virus (HIV)-positive.Results:The primary indication for surgery was osteoarthritis (150 knees), and the mean preoperative and postoperative Oxford Knee Scores were 16.81 (range, 4 to 36) and 45.61 (range, 29 to 48), respectively. Four knees (2.6%) were revised because of early periprosthetic joint infection (1 knee), aseptic loosening (1 knee), and late periprosthetic joint infection (2 knees). There were no perioperative deaths. In the group of 9 patients who were HIV-positive, there were no early or late complications and the mean Oxford Knee Score was 47 (range, 42 to 48) at the time of the latest follow-up.Conclusions:This study demonstrated good short-term results following 153 primary TKAs performed in a low-income country.Level of Evidence:Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Ten-year survival and patient-reported outcomes of a medial unicompartmental knee arthroplasty incorporating an all-polyethylene tibial component

IntroductionBiomechanical studies have suggested that proximal tibial strain is elevated in UKAs incorporating all-polyethylene tibial components with concern that this leads to premature failure. This study reports minimum 10-year outcomes for a UKA incorporating an all-polyethylene tibial component to determine whether these concerns were realised.Materials and methods109 fixed bearing UKAs (97 patients, mean age 68 (range 48–87), 54/97 (56%) female) with all-polyethylene tibial components were followed up for ≥ 10 years with Oxford Knee Scores, Forgotten Joint Scores and Kaplan–Meier analysis. 106/109 implants were 7 mm, 3 were 9.5 mm.ResultsTen-year survival was 85.5% (78.6–92.4 95% CI) with the end-point failure for any reason. Unexplained pain was the commonest mode of failure (6/17) followed by lateral compartment osteoarthritis (5/17) and tibial subsidence/loosening (4/17). Revision rate was highest at 2–5 years due to revisions for unexplained pain. Ten-year survival was worse in patients < 65 years old (p = 0.035), in those with BMI > 30 (p = 0.017) and in those with postoperative increases in medial tibial sclerosis (p < 0.001 log-rank). Implant malalignment was not significantly associated with failure. Radioisotope bone scans in 16 patients all remained “hot” at mean 6.1 years (range 2.1–11.5). Relative risk of failure in patients < 65 years was 2.9 (1.2–7.0 95% CI) and when BMI > 30 was 2.9 (1.2–6.9 95% CI). In those with intact UKAs at 10 years, mean Oxford Knee Score was 34.8 ± 10.7, Forgotten Joint Score was 37.9 ± 26.7 and 96% were satisfied with their knee.ConclusionThe high rate of early failure between 2 and 5 years in this all-polyethylene tibial component UKA did not persist in the long term. Though medial proximal tibial metabolic changes appear to persist they are not necessarily symptomatic. BMI > 30 and age < 65 years were significant risk factors for revision.

Mid-term survivorship and clinical outcomes of the Avon patellofemoral joint replacement

BackgroundWe present the largest series of Avon patellofemoral joint (PFJ) replacements outside of the design centre. There is discussion over its efficacy and usefulness. We report an independent opinion of its indications, survivorship and outcomes. MethodsWe prospectively collected demographic data and patient reported outcome measures (PROM's) on our cohort of Avon Patellofemoral replacements since its adoption in our unit in 2003 until 2014. We performed a retrospective review of radiographs. ResultsWe performed 103 PFJ replacements in 85 patients, 36 were male (mean age 61 - range 34 to 78) and 67 female (mean age 60 - range 38 to 82), mean follow up time was 5.6years (range 2.9 to 14.2years) with 93 implants still in situ. Their mean post-operative Oxford Knee Score was 36 (range seven to 48). There were nine conversions to TKR for disease progression and one revision of a femoral component for trochlear malpositioning. Mean time to revision was 2.9years (1.0 to 6.0years). Radiographic evidence of progression on Kellgren and Lawrence score in the un-replaced compartments was demonstrated in 23% of cases with imaging available.The Avon PFJ replacement delivers reproducible and effective pain relief and function to patients with isolated patellofemoral osteoarthritis. We believe PFJ replacement has an important role to play, and we will continue to perform this procedure for a carefully selected group of patients. Conversion to TKR does not and should not be regarded as failure of the index operation.

Tibial component sizing and alignment of TKR components does not significantly affect patient reported outcome measures at six months. A case series of 474 participants

ObjectivesTotal knee replacement (TKR) is an effective means of alleviating the symptoms of end stage osteoarthritis. However, 20% of patients report dissatisfaction one year post-operatively. Previous literature has demonstrated contradictory evidence regarding the relationship between alignment and tibial component sizing with patient reported outcome measures (PROMs). We aim to investigate the association between alignment of TKR components and effect of tibial component sizing on PROMs. MethodA prospective, multicentre case series was performed at six centres. Baseline characteristics were collected at recruitment. Coronal and sagittal plain films were taken day one post-operatively. Trained medical professionals blinded to outcome measured the alignment and degree of over/underhang of the tibial component in the coronal and sagittal place, with Oxford Knee Score (OKS) measured six months post-operatively. Results474 patients were recruited. Malaligned TKRs caused no significant difference in mean OKS change at six months (independent t-test) (p > 0.05). A multivariate regression model taking into account age, gender, body mass index and baseline OKS also demonstrated no significant difference (p > 0.05). With regards to tibial component sizing, 125 (27%) of patients had appropriately sized tibial components, 120 (26%) had overhang and 219 (53%) had underhang with no significant difference in OKS between the groups (p > 0.05). ConclusionTibial component sizing and alignment does not significantly affect short-term function, as measured by OKS, after total knee replacement. Dissatisfaction after TKR is likely due to other factors other than alignment of implant.

Outcomes of Primary Total Knee Arthroplasty in Patients With Parkinson's Disease

BackgroundParkinson's disease is a degenerative disorder causing rigidity, bradykinesia, and tremor of the motor system. There is significant paucity of evidence regarding whether total knee arthroplasty (TKA) is of benefit in patients with both Parkinson's disease and osteoarthritis. We aimed to compare outcomes and complications of TKA between patients with Parkinson's disease and those without. MethodsA cohort of 43 knees from 35 patients with Parkinson's disease who received a primary TKA between January 2004 and December 2015 were retrospectively extracted from a private clinical database held by 2 surgeons and compared to an age and gender-matched control group of 50 knees from 41 patients. TKAs were performed by 2 surgeons at 1 tertiary private hospital.The indication for TKA in both groups was osteoarthritis. Difference between preoperative and 1-year range of movement (ROM) and 12-point Oxford Knee Score (OKS) was assessed using Student's unpaired t-test. Postoperative complications and revision procedures were also recorded during the follow-up period. The minimal clinically important difference for OKS at 1-year follow-up, defined as improvement of ≥6, was also assessed. ResultsIn the Parkinson's group, mean ROM improvement was 14° (100° preoperatively to 114° at 12 months), compared to 12° in the control group (102°-114°, respectively). Mean OKS improvement was 15 in the Parkinson's group (23 preoperatively to 38 at 12 months) compared to 17 in the control group (23 and 40, respectively.) No significant difference was identified between the 2 groups for either ROM (P = .96) or OKS (P = .45.) All Parkinson's patients achieved the minimal clinically important difference at 1-year follow-up. There were no mortalities during the study follow-up period and no significant difference in complication rates between the 2 groups (P = .41). ConclusionParkinson's disease was not associated with poorer functional outcomes or increased complications compared to controls in our study. We suggest that Parkinson's disease is not an absolute contraindication to TKA.

Adverse Events in the Treatment of Periprosthetic Fractures Around the Knee - a Clinical and Radiological Outcome Analysis.

The incidence of periprosthetic fractures associated with total knee arthroplasty (PpFxK) has been reported to be 0.3 - 5.5%. 40% of all cases are related to revision TKA. The most common localisation is the distal femur. Classification is performed according to Rorabeck (RB). RB I - II fractures are usually treated with locked plating and retrograde intramedullary nailing, whereas RB III fractures are an indication for revision arthroplasty using a hinged endoprosthesis. PpFxK of the patella can be classified according to Goldberg and PpFxK of the proximal tibia can be grouped as in Felix. Interprosthetic fractures can be regarded as a special type of PpFx. Due to the increasing numbers of TKA being performed, increasing numbers of adverse events in arthroplasty can be expected. Adverse events in the treatment of PpFxK occur in up to 41% of patients according to the literature and revision is needed in approximately 29% of all cases. Risk factors are age, osteoporosis, infection, malalignment, osteolysis/loosening of the implant and status post revision. A clinical and radiographic follow-up was performed with 50 patients (14 men, 36 women) treated for PpFxK of the femur, tibia and patella between 2011 and 2015 at the department of arthroplasty at a level 1 trauma center in Europe. The follow-up of all patients was 68%, with an average of 19.1 ± 14.6 (1 - 49) months between PpFxK and clinical follow-up. 16% of the patients were allocated for further treatment or revision surgery from other hospitals. The patients' median age was 78.0 ± 8.8 (55 - 94) years. Most patients were affected by several orthopaedic and internal medical comorbidities. PpFxK classified as RB II were the most common fractures (60%, n = 30). PpFxK usually occurred 5.0 ± 4.8 (0 - 20) years after index TKA (primary or revision TKA), mostly in patients with CR-retaining endoprosthesis, whereas PpFxK according to Felix occurred significantly earlier and mostly in hinged TKAs. Patients achieved on average a mean Oxford Knee Score of 31.1 ± 9.9 (14 - 46) points. The functional Knee Society Score (KSS) was 52.6 ± 24.4 (20 - 100) and the mean KSS was 58.7 ± 26.8 (0 - 99) points (n = 25). Radiographic evaluation of the RB I - II patients showed frontal and sagittal malalignment in 20.6% of all cases after reduction and plate fixation. The overall rate of surgical adverse events was 50%; 44% of all RB patients needed revision surgery. Adverse events comprised non-union, failure of osteosynthesis, infection, wound healing disorders and re-fractures in the RB II and the Felix subgroup. PpFxK are severe injuries and are associated with a high rate of adverse events related to treatment. Patients often have a complex background and a history of revision surgery or periprosthetic joint infection. The treatment of PpFxK should therefore take place at a centre with expertise in traumatology as well as in revision arthroplasty. Preoperative infection diagnostic testing as well as adequate imaging (X-rays and CT) are essential. We furthermore advise early evaluation of revision arthroplasty, especially in elderly patients suffering from PpFxK with insufficient bone quality around the TKA and closeness between fracture and TKA. In the case of plate fixation, it is important to give attention to correct reduction - to prevent non-union, loosening of the implant and failure of the osteosynthesis - as well as to consider double plating.

Cardiovascular Phenotypic Heterogeneity in Marfan Syndrome

To evaluate the clinical efficacy and safety of an intra-articular injection of bone marrow aspirate concentrate (BMAC) as a treatment option for osteoarthritis (OA) of the knee.Between June 2014 and February 2017, data from 233 patients with knee osteoarthritis treated with BMAC injection at a single center, were retrospectively evaluated. Only patients with idiopathic osteoarthritis were included. Exclusion criteria were post-traumatic osteoarthritis, previous knee surgery, age less than 50 years old or more than 85 years old, active infection, uncontrolled diabetes mellitus, rheumatological or other systemic disease, malignancy, or treatment with immunosuppressive drugs. Bone marrow from the iliac crest was aspirated/concentrated with a standardized technique using a single-spin manual method. Patients were evaluated before and after the procedure, using the numeric pain scale (NPS) and Oxford knee score (OKS). Mean follow-up period was 11 months, range (6–30 months).A total of 121 of 233 patients had completed data as previously defined and were included in the statistical analysis. There were 85 females and 36 males, with mean age 70 years (range 50–85). Compared to baseline, the mean NPS decreased from 8.33 to 4.49 (p < 0.001) and the mean OKS increased from 20.20 to 32.29 (P < 0.001) at final follow-up. There were no complications.A single intra-articular injection of BMAC is a safe and reliable procedure that results in clinical improvement of knee OA.

Mid-term results of lateral unicondylar mobile bearing knee arthroplasty: a multicentre study of 363 cases.

The aim of this independent multicentre study was to assess the mid-term results of mobile bearing unicondylar knee arthroplasty (UKA) for isolated lateral osteoarthritis of the knee joint. We retrospectively evaluated 363 consecutive, lateral UKAs (346 patients) performed using the Oxford domed lateral prosthesis undertaken in three high-volume knee arthroplasty centres between 2006 and 2014. Mean age of the patients at surgery was 65 years (36 to 88) with a mean final follow-up of 37 months (12 to 93) RESULTS: A total of 36 (10.5%) patients underwent revision surgery, giving a survival rate of 90.1% at three years (95% confidence intervals (CI) 86.1 to 93.1; number at risk: 155) and 85.0% at five years (95% CI 77.9 to 89.9; number at risk: 43). Dislocation of the mobile bearing occurred in 18 patients (5.6%) at three years (95% CI 1.0 to 16.4; number at risk: 154) and in 20 patients (8.5%) at five years (95% CI 1.0 to 27.0; number at risk: 42). There were no significant differences in the dislocation rate between the participating centres or the surgeons. We were not able to identify an effect of each surgeon's learning curve on the dislocation rate of the mobile bearing. The clinical outcome in patients without revision surgery at final follow-up was good to excellent, with a mean Oxford knee score of 40.3 (95% CI 39.4 to 41.2), a mean Tegner activity score of 3.2 (95% CI 3.1 to 3.3) and a mean University of California, Los Angeles score of 5.7 (95% CI 5.5 to 5.9). Our data, which consists of a high number of patients treated with mobile bearing UKA in the lateral compartment, indicates a high revision rate of 15% at five years with dislocation of the mobile bearing being the main reason for implant failure. Despite the good functional and clinical results and the high patient satisfaction in our study group, we therefore discontinued using mobile-bearing lateral UKA in favour of a fixed-bearing component. Cite this article: Bone Joint J 2018;100-B:42-9.

Results with nine years mean follow up on one hundred and three KAPS® uni knee arthroplasties: eighty six medial and seventeen lateral.

The purpose of this study was to present the results of the KAPS® uni knee arthroplasty system, both mobile and fixed bearing with reference to function, alignment and complications in 103 implants with a mean follow-up of nineyears. This was a retrospective study of 103 unicompartimental knee arthroplasties in 89 patients operated on between March 2005 and March 2010. The population was composed of 50 males and 39 females, with a mean age of 70.5 ± 7.5years (41 - 90). Eighty-seven patients had a genu varum deformity (84.5%), one of whom had an osteoid osteoma of the lateral tibial plateau and 16 patients had a genu valgum (15.5%). Eighty-six medial prostheses were implanted (82 mobile bearings and 4 fixed bearings) and 17 lateral prostheses (all fixed bearings) including the osteoid osteoma. At a mean follow-up of 107.5months (73-138), 72 knees (58 patients) were reviewed (70%). The mean IKS score was of 173 ± 31 points (58 - 200). The mean Oxford knee score was 21 ± 8 points (12 - 50). The cumulated survival rate at a follow up of 132months was 98.2%. The KAPS® unicompartmental knee arthroplasty gives efficacious and safe outcomes in the majority of cases at a mean follow-up of nineyears. The availability of both fixed and mobile bearings with the same instrumentation, allowing to choose the right implant intra-operatively, is a great advantage in order to avoid the occurrence of some complications, specific to mobile bearing prostheses (dislocation and over-correction).

Surgically treated Hoffa Fractures with poor long-term functional results

IntroductionHoffa fractures are rare injuries and usually involve the lateral condyle. There are few published studies of large series of isolated coronal plane fractures of the femoral condyle. The aim of the study to determine the long-term functional outcomes and complications in surgically treated Hoffa fractures. Patients and methodsA retrospective review was made of 13 consecutive patients who were treated surgically for an isolated coronal plane fracture of the distal femur posterior condyle. The patients were evaluated with physical examination, PA and lateral radiographs and CT at the final follow-up examination. Functional outcome was evaluated with the OXFORD knee scoring system and Knee Society Score (KSS). Pain at rest and in activity was assessed using a Visual Analog Scale (VAS). ResultsThe patients comprised 11 males and 2 females with an average age at surgery of 27.5 years. The mean follow-up period was 93 months (range, 62–134 months). Mean time to fracture healing was 10 weeks (range, 8–12 weeks). The mean ROM was determined as 110°, mean KSS 78,4 and mean Oxford knee score 38,2. The mean KSS was 66,5 for medial Hoffa fracture patients and it was 83,8 for lateral Hoffa fracture patients. The mean Oxford knee score was 33,2 for medial Hoffa fracture patients and it was 40,4 for lateral Hoffa fracture patients. The mean VAS at rest and in activity was 1,1 and 2,9, respectively. Osteoarthritis was seen in 7 (54%) patients and avascular necrosis in 2 (15.4%). Varus instability was determined in 1 patient and valgus instability in 1 patient. ConclusionHoffa fractures may easily be overlooked if the radiological examination is not made carefully. Screw fixation was seen to provide enough biomechanical stability until the fracture healed. Arthrosis is a frequent long-term complication which worsens the functional results. Medial Hoffa fractures tend to have worse functional results than lateral Hoffa fractures. Level of evidence: Therapeutic Level IV retrospective case series.

Prospective, Multicenter, Randomized, Crossover Clinical Trial Comparing the Safety and Effectiveness of Cooled Radiofrequency Ablation With Corticosteroid Injection in the Management of Knee Pain From Osteoarthritis.

Background and ObjectivesOsteoarthritis (OA) of the knee affects the aging population and has an associated influence on the health care system. Rigorous studies evaluating radiofrequency ablation for OA-related knee pain are lacking. This study compared long-term clinical safety and effectiveness of cooled radiofrequency ablation (CRFA) with intra-articular steroid (IAS) injection in managing OA-related knee pain.MethodsThis is a prospective, multicenter, randomized trial with 151 subjects with chronic (≥6 months) knee pain that was unresponsive to conservative modalities. Knee pain (Numeric Rating Scale [NRS]), Oxford Knee Score, overall treatment effect (Global Perceived Effect), analgesic drug use, and adverse events were compared between CRFA and IAS cohorts at 1, 3, and 6 months after intervention.ResultsThere were no differences in demographics between study groups. At 6 months, the CRFA group had more favorable outcomes in NRS: pain reduction 50% or greater: 74.1% versus 16.2%, P < 0.0001 (25.9% and 83.8% of these study cohorts, respectively, were nonresponders). Mean NRS score reduction was 4.9 ± 2.4 versus 1.3 ± 2.2, P < 0.0001; mean Oxford Knee Score was 35.7 ± 8.8 vs 22.4 ± 8.5, P < 0.0001; mean improved Global Perceived Effect was 91.4% vs 23.9%, P < 0.0001; and mean change in nonopioid medication use was CRFA > IAS (P = 0.02). There were no procedure-related serious adverse events.ConclusionsThis study demonstrates that CRFA is an effective long-term therapeutic option for managing pain and improving physical function and quality of life for patients with painful knee OA when compared with IAS injection.Clinical Trial Registration: ClinicalTrials.gov (NCT02343003).

Clinical Outcome of Massive Endoprostheses Used for Managing Periprosthetic Joint Infections of the Hip and Knee

BackgroundEndoprosthetic replacement (EPR) is an option for management of massive bone loss resulting from infection around failed lower limb implants. The aim of this study is to determine the mid-term outcome of EPRs performed in the treatment of periprosthetic joint infection (PJI) and infected failed osteosyntheses around the hip and knee joint and identify factors that influence it. MethodsWe retrospectively reviewed all hip and knee EPRs performed between 2007 and 2014 for the management of chronic infection following complex arthroplasty or fracture fixation. Data recorded included indication for EPR, number of previous surgeries, comorbidities, and organism identified. Outcome measures included PJI eradication rate, complications, implant survival, mortality, and functional outcome (Oxford Hip or Knee Score). ResultsSixty-nine EPRs (29 knees and 40 hips) were performed with a mean age of 68 years (43-92). Polymicrobial growth was detected in 36% of cases, followed by coagulase-negative staphylococci (28%) and Staphylococcus aureus (10%). Recurrence of infection occurred in 19 patients (28%): 5 were treated with irrigation and debridement, 5 with revision, 1 with above-knee amputation, and 8 remain on long-term antibiotics. PJI eradication was achieved in 50 patients (72%); the chance of PJI eradication was greater in hips (83%) than in knees (59%) (P = .038). The 5-year implant survivorship was 81% (95% confidence interval 74-88). The mean Oxford Hip Score and Oxford Knee Score were 22 (4-39) and 21 (6-43), respectively. ConclusionThis study supports the use of EPRs for eradication of PJI in complex, multiply revised cases. We describe PJI eradication rate of 72% with acceptable functional outcome.

Assessment of Unloading Effects After Open Wedge High Tibial Osoteotomy Using Quantitative Bone Scintigraphy

Open wedge high tibial osteotomy (OWHTO) led to a significant decrease in bone tracer uptake (BTU) of the medial compartment, which correlated well with knee pain and postoperative mechanical alignment. Despite shifting the weight bearing line to the lateral compartment, no increased postoperative BTU was found in the lateral compartment. Bone scintigraphy is known to reflect the loading pattern of the knee. In addition, it is reported that bone tracer uptake (BTU) correlates with mechanical alignment and knee pain [1-3]. However, there are few studies to evaluate the unloading effect after open wedge high tibial osteotomy (OWHTO) by using quantitative bone scintigraphy. The purpose of this study was to assess changes of BTU in OWHTO and to evaluate whether BTU correlates clinical symptoms, postoperative alignment and cartilage regeneration after OWHTO. Fifty-six knees in 53 patients who underwent OWHTO for medial compartment OA were enrolled in this study between 2010 and 2015. All patients were assessed preoperatively and at plate removal using bone scintigraphy. The mean interval from surgery and plate removal was 16.9 ± 4.9 months. Clinical outcomes using the visual analogue scale (VAS) for pain, Oxford Knee Score (OKS), Knee Injury and Osteoarthritis Outcome Score (KOOS) and radiographic analysis of alignment (weight bearing line ratio: WBLR) were assessed preoperatively and at plate removal. In addition, cartilage regeneration was assessed arthroscopically with the ICRS grading system. Region of interest (ROI) was positioned on medial and lateral compartment as well as femoral shaft. The ratio between BTU of each compartment and femoral shaft was calculated for quantification and was defined as bone scintigraphy score (BSS). The changes of BSS of each compartment after OWHTO were assessed. In addition, the correlations between BSS of medial component and all parameters (VAS, OKS, KOOS, WBLR and cartilage regeneration after OWHTO) were analyzed. Postoperatively, all outcome measurements significantly improved: mean VAS 64.2 ± 14.9 to 11.1 ± 9.3, mean OKS 28.0 ± 7.9 to 41.7 ± 4.3, mean KOOS 55.8 ± 13.6 to 83.7 ± 9.7, mean WBLR 23.3 ± 9.7 to 70.9 ± 9.4. Cartilage regeneration was found in 39 knees (70.0%) at the second-look arthroscopy. While BSS of the medial compartment was significantly decreased from 3.6 ± 1.5 to 1.4 ± 0.4 (p<0.01) after OWTHO, BSS of the lateral compartment did not change postoperatively. Postoperative BSS of the medial compartment significantly correlated with VAS, KOOS and WBLR. No statistical significant associations between BTU and cartilage regeneration were found. OWHTO led to a significant decrease in BTU of the medial compartment, which correlated well with knee pain and postoperative mechanical alignment. Despite shifting the weight bearing line to the lateral compartment, no increased postoperative BTU was found in the lateral compartment. This observation demonstrated that OWHTO does not cause overloading in the lateral compartment.

Columbus® computer navigated total knee arthroplasty: Gap balancing versus measured resection

BackgroundThe aim of this study was to compare the medium term functional outcome and patient satisfaction of gap balanced (GB) with measured resection (MR) total knee arthroplasty (TKA) using computer navigation. MethodsA cohort of 144 consecutive computer navigated TKA were retrospectively identified from an arthroplasty database. Functional assessment using the Oxford Knee Score (OKS) and patient satisfaction were obtained from 113 patients at a mean follow-up of 5.4 (range four to seven) years. There were 44 patients in the GB group and 69 patients in the MR group. ResultsThe mean OKS for the GB group was 36.9 (SD 9.2) and for the MR was 33.6 (SD 9.8), with a difference of 3.3 (95% CI 0.3 to 6.3) points, which was statistically significant (p=0.01). Linear regression analysis confirmed the independent effect of surgical technique when adjusting for confounding factors and surgeon, with the GB group achieving a greater post-operative OKS (R2=0.39, 3.0 points, 95% CI 1.2 to 4.8, p=0.001). There was a greater rate of patient satisfaction in the GB group (88.6%, n=39/44) compared to the MR group (81.1%, n=56/69), but this was not statistically significant (odds ratio 1.8, 95% CI 0.6 to 5.5, p=0.31). ConclusionComputer navigated Columbus® TKA using a GB technique results in a statistically significantly greater functional outcome but no significant difference in patient satisfaction in the medium term compared to patients undergoing a MR technique.

Does Calipered Kinematically Aligned TKA Restore Native Left to Right Symmetry of the Lower Limb and Improve Function?

BackgroundKinematically aligned total knee arthroplasty (KA TKA) strives to restore the native left to right symmetry of the lower limb; however, the reproducibility of achieving this target is unknown. The present study determined the proportion of patients with left to right symmetry and the improvement in patient-reported function after calipered KA TKA. MethodsA review of 562 postoperative scanograms identified 102 patients (53 women) with a KA TKA in one limb, no other skeletal abnormalities in either limb, and symmetrical rotation between limbs on the scanogram. All patients were treated with primary TKA that used caliper measurement of the thicknesses of the femoral bone and tibial bone resections to kinematically align the components. The hip-knee-ankle (HKA) angle, distal lateral femoral angle (DLFA), and proximal medial tibial angle (PMTA) were measured. Patient-reported Oxford Knee Score (OKS) measured preoperative and postoperative functions. ResultsThe proportion of patients with a difference in the HKA angle, DLFA, and PMTA between limbs within ±3°, >3° varus, and <−3° valgus was 95%, 2%, and 3%, respectively, for the HKA angle; 97%, 1%, and 2%, respectively, for the DLFA; and 97%, 2%, and 1%, respectively, for the PMTA. The mean OKS improved from 20 preoperatively to 44 points (range 18-48 points) at 15 months postoperatively. ConclusionCalipered KA TKA restored native left to right symmetry of the HKA angle, DLFA, and PMTA in nearly all patients with negligible risk of varus alignment of the tibial component with respect to the native tibial joint line. The mean postoperative OKS indicated clinically important improvement in patient-reported function.

Functional outcome of Schatzker type V and VI tibial plateau fractures managed with open reduction internal fixation using dual plates

&lt;p class="abstract"&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;span lang="EN-IN"&gt;Complex tibial plateau fractures remain a challenge to even the most experienced surgeons. These injuries usually affect the young population in their productive years thereby causing socioeconomic impact. We performed a retrospective study to evaluate the functional outcome of of Schatzker type V and VI managed through open reduction and internal fixation.&lt;/span&gt;&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Methods:&lt;/strong&gt; &lt;span lang="EN-IN"&gt;26 patients with Schatzker type V and type VI tibial plateau fractures treated with open reduction and internal fixation using plates were included in the study. Three patients were lost to follow up, 23 patients were evaluated in the final analysis. The preoperative, intraoperative data was noted from the indoor files.The final evaluation was done using Oxford knee score and VAS score&lt;/span&gt;.&lt;strong&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Results:&lt;/strong&gt; &lt;span lang="EN-IN"&gt;There were nine Schatzker type V fractures and 14 patients with Schatzker type VI fractures. The mean duration of follow-up was 68.32 months ranging from 41 months to 126 months. The mean Oxford knee score was 39.78. Patients with Schatzker type VI had mean OKS of 37.7.The mean MPTA and mean PPTA were 88.75 degrees and 7.35 degrees respectively. Average VAS Score was 2.8 ranging from 1 to 3.9. All patients returned to their pre-injury level of activity and employment. There were no patients of deep infection. &lt;/span&gt;&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; &lt;span lang="EN-IN"&gt;We conclude that open reduction and internal fixation of high-energy tibial plateau fractures gives excellent to good functional outcome with minimal soft tissue complications. The complications can be minimized with proper patient selection and soft tissue dissection.&lt;/span&gt;&lt;/p&gt;