During nuclear reactor severe accident, the input of external passive containment cooling system will result in significant aerosol thermophoresis deposition in reactor building, which plays important factor affecting the safety assessment of nuclear reactor. Ratio of aerosol particles radius and gas molecule mean free path (Kn number) in reactor building is not greater than 2, corresponding to the near-continuous medium zone and transition zone. Firstly the typical thermophoretic force equations for these zones are evaluated. Combined with key influencing factors analysis, the correction factor connected to Kn number is introduced to address the deviation in the prediction for the transition zone of the current equations. The modified thermophoretic force equation obviously improves the underestimation of the original equation and is then used to obtain the thermophoresis deposition coefficient. According to experimental validation, the obtained coefficient is more accurate than the model that is widely employed in analysis codes in predicting the thermophoresis deposition of aerosol particles. Finally, fluid continuity, momentum, energy and particle continuity equations are established with deduced thermophoresis deposition coefficient and solved numerically. The thermophoresis deposition model considering natural convection (CT model) is established by theoretical derivation and fitting with the numerical solutions. By introducing the effects of natural convection on temperature distribution and aerosol concentration distribution the CT model could accurately describe the aerosol thermophoresis deposition behavior under natural convection conditions for Kn number is not greater than 2, which can be applied to aerosol thermophoresis deposition prediction in reactor building.