This paper presents the results obtained by the implementation of an artificial immune algorithm to optimize standard multi-axis tool-paths applied to machine free-form surfaces. The investigation for its applicability was based on a full factorial experimental design addressing the two additional axes for tool inclination as independent variables whilst a multi-objective response was formulated by taking into consideration surface deviation and tool path time; objectives assessed directly from computer-aided manufacturing environment A standard sculptured part was developed by scratch considering its benchmark specifications and a cutting-edge surface machining tool-path was applied to study the effects of the pattern formulated when dynamically inclining a toroidal end-mill and guiding it towards the feed direction under fixed lead and tilt inclination angles. The results obtained form the series of the experiments were used for the fitness function creation the algorithm was about to sequentially evaluate. It was found that the artificial immune algorithm employed has the ability of attaining optimal values for inclination angles facilitating thus the complexity of such manufacturing process and ensuring full potentials in multi-axis machining modelling operations for producing enhanced CNC manufacturing programs. Results suggested that the proposed algorithm implementation may reduce the mean experimental objective value to 51.5%