Background: The treatment for staghorn stones is known as mini-percutaneous nephrolithotomy (mini-PNL), which is a minimally invasive surgical procedure. Despite its shorter duration, reduced morbidity, and lower blood loss when compared to standard nephrolithotomy, it may offer similar results. This study aims to compare the safety and efficacy of mini-PNL versus conventional nephrolithotomy for the treatment of staghorn stones. Objectives: To evaluate the clinical effectiveness (stone-free rate and complication rate) and safety (time to stone clearance, perioperative and postoperative morbidity, hospital stay, and blood loss) of mini-percutaneous nephrolithotomy (PNL) in comparison to standard nephrolithotomy for the management of staghorn stones. Study design: A randomized controlled trial Duration and place of study: Department of Urology, Sahiwal Teaching Hospital, Sahiwal, from January 2021 to August 2021 Methodology: We performed a randomised controlled experiment from January 2021 to August 2021 at the Department of Urology, Sahiwal Teaching Hospital, Sahiwal, to ascertain the stone-free rate among patients with staghorn stones. Two years were dedicated to the study. A total of seventy-five patients were split into two groups for the regular PCNL and mini-PCNL procedures during the study. In this study, In this study, one of these procedures was randomly assigned to each patient-- half received traditional PCNL and half had mini-PCNL surgery. Data were gathered for hospital stays, complications and pain during filming. 81 patients participated in the research, ranging in age from 20 to 90 years old. Results : The mean age was 53 02 years old. There were 78 men and 13 women among these subjects taken as 'normal' statistics. In the miniperc and normal PCNL groups, the success rates were 91.2% and 96.8%, respectively (p=0.05). The mean operating time and duration of hospital stay in mini-PCNL group were significantly shorter than those in normal group (81.1±3.3 and 03.3 days respectively; t=3.728,5), p=0.001. Compared with regular PCNL, mini-PCNL has a higher rate of mum less thick stone (25% compared to 13%; p = 0.036) Conclusion : the mini-PCNL group experienced far less postoperative discomfort (p-0.001). Therefore, minimally invasive PCNL emerges as a more effective treatment for staghorn stones. It offers a number of benefits compared to standard-PCNL, such as reducing operating room time, shortening hospital stays and lower pain after surgery. As a result of these advantages, it has become increasingly favored in practice for treating staghorn stones Keywords: Staghorn stones, PCNL, stone-free rate, hospital stay, complications, postoperative pain