Background: COVID-19 pandemic led to the emergence of mental health problems such as depression and the use of maladaptive coping strategies among nursing students. This study is planned to assess the prevalence of depression and coping strategies adopted by nursing students after the second wave of the COVID-19 pandemic. Methods: A descriptive cross-sectional survey was carried out among 164 nursing students in a selected nursing institution in a rural area of Northern India. Depression was assessed using the patient health questionnaire-9, whereas coping was assessed by the brief-coping orientation of problem experienced scale. Results: Mean age of the participants was 20.80±2.35 years. The mean depression score of nursing students was 6.43±4.28. Majority of the nursing students had mild depression (43.9%) and belonged to the non-depressed group (78.7%) with a PHQ-9 score <9. Maladaptive coping mechanisms were chiefly utilized by male nursing students. Coping mechanisms substance use (β=0.223, p<0.013) had more impact on depression, after controlling for sociodemographic variables and COVID-19-related information of nursing students. Conclusions: Minimal or mild depression is common among nursing students after the second wave of the unprecedented pandemic with adaptive coping strategies more commonly used.