Mean Age Of Menarche Research Articles

Correlation Between HbA1c and Fibrocystic Breast Disease Among Polycystic Ovary Syndrome

Objective: The aim of this study is to investigate whether Hemoglobin A1c (HbA1c) levels in polycystic ovary syndrome (PCOS) can predict the risk of fibrocystic breast disease in women applied to the GynecologyO 25.7 ± 1.44). 50.6 % had the risk of fibrocystic breast disease. The mean age of menarche was 11.36 ± 0.97, and the mean level of HbA1c was 5.57 ± 0.37. FSH (p 6 in the control group. Conclusions: It was concluded that HbA1c cannot be used for assessment of the fibrocystic breast disease in the PCOS women but can predict the fibrocystic breast disease in healthy women. There may be a need for additional diagnostic tests for the PCOS women to assess the fibrocystic breast disease for early treatment.

Local Usage of Nigella sativa Oil as an Innovative Method to Attenuate Primary Dysmenorrhea: A Randomized Double-blind Clinical Trial

ObjectivesWe sought to determine the effect of topical application of Nigella sativa (black seed) oil, on the primary dysmenorrhea intensity.MethodsWe conducted a randomized, double-blind clinical trial on 124 female students, 18–22 years old, living in the dormitories of Sabzevar Universities. After a primary assessment, participants were randomly divided into two groups. The first group rubbed two drops of N. sativa oil, and the second group rubbed liquid olive oil, as the placebo. Massage was performed on the fontanel lobe 3, at night, three days before menstruation, for eight consecutive days (about five days after menses). This procedure was repeated for three menstrual cycles. After three cycles, pain severity was measured by the visual analog scale. Data analysis was carried out using the Mann-Whitney U test and analysis of covariance (ANCOVA).ResultsThis study was conducted on 124 female students. The mean age of students, mean age of first menarche, body mass index, and pain severity were not significantly different in the two groups (p > 0.050). No adverse effects were observed during the study. The results of ANCOVA showed that pain intensity in N. sativa oil group was significantly decreased compared to that of the placebo group (0.6 score; p < 0.050).ConclusionsN. sativa could be a promising, safe, and easily available analgesic supplement in women suffering from primary dysmenorrhea.

The mean age of menarche among Chinese schoolgirls declined by 6months from 2005 to 2014.

This study assessed the trends in the age at menarche in Chinese schoolgirls from the majority Han group and 21 ethnic minorities from 2005 to 2014. We also compared the group differences during the study period. A total of 344230 girls aged 9-18years were extracted from the 2005, 2010 and 2014 Chinese National Survey on Students' Constitution and Health. The age at menarche for each subgroup was estimated by probit analysis. The chi-square test and Z-test were used to compare the differences between the groups. The overall average age at menarche in Chinese schoolgirls decreased from 12.8years in 2005 to 12.3years in 2014. The Han girls and girls from 17 ethnic minorities showed decreasing trends in the age at menarche, while four ethnic minorities demonstrated fluctuating increasing trends over time. The gaps in age at menarche between the Han group and 14 of the ethnic minorities became smaller over the study period and were similar by 2014. The overall findings were a decrease in the age at menarche in China and smaller gaps between the majority Han group and ethnic minority groups. Ethnic-specific public health policies are urgently needed on issues such as contraception.

ADOLESCENT DISMENORE PREVALENCE IN WEST JAVA, INDONESIA: PRELIMINARY STUDY

Menstruation is an important life cycle for women. Many teenage girls experience pain during menstruation/dysmenorrhea. This often causes adolescent activities to be disrupted. The purpose of this study was to determine the prevalence of adolescent dysmenorrhea in West Java, Indonesia. The research design used is descriptive-analytic. The number of respondents who took part was 166 teenagers, in the West Java region. The results showed dysmenorrhea occurred in respondents as much as 98.8%, with a mean age of respondents 17.7 years, mean age of menarche 12.5 years. Dysmenorrhea often occurs at the beginning of menstruation (the first and second days of menstruation 83.13%), the pain is felt to disappear, dysmenorrhea affects the activity of respondents to be limited. How to handle dysmenorrhea done by respondents with rest/sleep as much as 56.6%. This research is a preliminary study, as a basis for conducting further research on how to effectively manage dysmenorrhea.

OR31-02 Diagnostic Criteria for Polycystic Ovary Syndrome in Adolescents: Impact on Prevalence and Longitudinal Body Mass Index Trajectories

Background: Polycystic ovary syndrome (PCOS) is characterised by oligo-anovulation (OA), hyperandrogenism (HA) and polycystic ovary morphology (PCO). While the Rotterdam criteria (defined as 2 out of 3 features) are the most widely used criteria in adults, controversy remains for the diagnostic criteria in adolescents as many PCOS features overlap with normal pubertal physiological changes. The 2018 international evidence-based PCOS guideline recommends modified Rotterdam criteria (OA and HA) in adolescents based on expert consensus. We aimed to 1) compare the prevalence of PCOS using original and modified Rotterdam criteria in an unselected adolescent cohort and 2) explore the association between diagnostic phenotypes and long-term body mass index (BMI) trajectories. Methods: 227 adolescent females of the Western Australian Pregnancy Cohort (Raine) Study undertook detailed PCOS assessment at the mean age of 15.3 years (mean age of menarche 12.4 years). Detailed anthropometric measurements were collected from birth until age 22 years. T-test was used for group BMI comparisons and longitudinal BMI was analysed using Generalised Estimating Equations with PCOS by time and PCOS phenotypes by time as interaction terms. Results: PCOS was diagnosed in 66 (29.1%) participants using original Rotterdam criteria versus 37 (16.3%) participants using modified Rotterdam criteria. Using modified Rotterdam criteria, participants with PCOS had higher mean group BMI than participants without PCOS from age 5 years onwards. Significant interaction was detected between PCOS and time (p<0.001) on longitudinal BMI gain where higher BMI gain was observed in participants with PCOS from age 14 years onwards. Only the modified criteria phenotype was significantly associated wth long-term BMI gain whereas other PCOS phenotypes had similar BMI trajectories as participants without PCOS (p<0.001). Conclusions: Our findings validate the PCOS guideline recommendation as modified Rotterdam criteria reduce over-diagnosis of PCOS in adolescents and accurately identify the phenotype at risk of long-term weight gain. The BMI trajectories of females with and without PCOS diverge from early childhood suggesting that metabolic dysfunction in PCOS commences early in the pre-pubertal period. Disclosures: Nothing to disclose. Funding: PCOS CRE scholarship and Research Training Program Scholarship awarded to CT; NHMRC Medical Research Future fund awarded to HT; National Heart Foundation Future Leader Fellowship awarded to LM; NHMRC early career fellowship awarded to AJ.

Association between age at menarche and age at menopause among women of an indigenous population of North Bengal, India.

Menarche and menopause are two major components of a woman's reproductive life. Ages at menarche and menopause vary widely between and within populations and are influenced by various factors, both genetic and environmental. The present community-based cross-sectional investigation aimed to assess the association between ages at menarche and natural menopause among women belonging to the indigenous Rajbanshi population of North Bengal, India. The investigation was carried out from January 2015 to May 2015 among 510 Rajbanshi women aged between 45 and 55 years residing in the district of Darjeeling, West Bengal, India. A structured schedule was used to collect data on ages at menarche and natural menopause, marital status, parity, education, age of first and last pregnancies, duration of breastfeeding, nature of occupation, health status, smoking and monthly family income. Anthropometric measurements of height and weight were recorded and Body Mass Index (BMI) calculated. The statistical analyses, which included descriptive statistics and binary logistic regression (BLR), were done using SPSS. The women's mean age of menarche and median age of natural menopause were 12.52 years and 50 years, respectively. The BLR analysis indicated that education, age at first pregnancy had significant effects on the age at natural menopause among women who experienced menarche at <12 years of age (p<0.05). In the case of women who attained menarche at ≥12 years of age, marital status, age at last pregnancy, parity, education, duration of breastfeeding, smoking, occupation, monthly income and BMI had a greater influence on age at natural menopause. There appears to be an indirect association between age at menarche and age at natural menopause, along with different predictor variables, among the Rajbanshi women.

Demographic, clinical and hormonal characteristics of patients with premature ovarian insufficiency and those of early menopause: data from two tertiary premature ovarian insufficiency centers in Greece

The aim of the study was to compare demographic, hormonal and clinical parameters in patients with premature ovarian insufficiency (POI) and women with early menopause in Greece. One hundred thirty-nine women of Greek origin, aged 14–45 years, referring for oligomenorrhea and having elevated FSH concentrations were divided into three groups regarding the age of menstrual disturbances onset [POI1: </=30 years (n = 42); POI2: 31–39 years (n = 36); early menopause: 40–45 years (n = 61)]. The mean age of menstrual disturbances onset and that of diagnosis in all POI and early menopause patients were 28.7 years (28.7 ± 7.7) versus 42.1 years (42.1 ± 1.5) and 33.8 years (33.8 ± 7.2) versus 43.3 years (43.3 ± 1.4), respectively. POI patients and women with early menopause were diagnosed, respectively, five years and approximately four to six months later than the age of menstrual disturbances onset. Moreover, FSH2 (second confirmatory FSH measurement at 4-to-6-weeks interval) was greater in all POI patients than in early menopause women (55.4 ± 33.9 vs. 32.4 ± 19.4; p < .05) whereas mean age of menarche was greater in early menopause women than in POI patients (13 ± 1.3 vs. 12 ± 2.2; p < .05). Furthermore, FSH2 was increased in all POI and decreased in early menopause patients.

REPRODUCTIVE ASPECTS IN BRAZILIAN CELIAC WOMEN.

Celiac disease (CD) is a chronic enteropathy in response to ingestion of gluten. CD was associated with gynecological disorders. In this retrospective study, we aimed to investigate the age of menarche, age of menopause, number of pregnancies and abortions in Brazilian celiac patients. We studied 214 women diagnosed with CD and as control group 286 women were investigated. Regarding the mean age of menarche, a significant difference was found (12.6±1.40 in CD and 12.8±1.22 years in healthy group; P=0.04). Regarding abortions, in CD women 38/214 (17.8%) and 28/286 (9.8%) in the control group reported abortion (P=0.0092, OR:1.98; CI95%=1.1- 3.3). There was no significant difference in the mean age of menopause nor number of pregnancies per woman. In this study, we found that celiac women had a higher mean age of menarche and higher risk of spontaneous abortions.

Social determinants of menstrual hygiene among school-going girls in a rural area of Southern Haryana, India

Introduction: Several factors associated with menstrual hygiene are modifiable and if such factors are identified and addressed, it can go a long way in promoting good menstrual hygiene practice among adolescent girls. The present study was conducted with an aim to investigate the social determinants for menstrual hygiene-related knowledge and practices among rural school-going girls. Methods: This cross-sectional study included 649 school-going girls (12–19 years) from two government schools. A pretested, predesigned, standardized questionnaire was prepared which included demographic details such as age, sociodemographic characteristics, knowledge regarding menstruation, restrictions practiced, absenteeism during menstruation, the practice of menstrual hygiene. Multiple logistic regression model at a significant level of 0.05 was used. Results: The mean age of menarche in the study population was 12.8 ± 1.73 years. Mother's education and family socioeconomic status showed a trend with poor menstrual hygiene. The study participants belonging to the age group of 12–14 years were nearly 2.3 times more likely to have poor hygiene practices than the study participants belonging to the age group of 18 years or more. Absence of sanitary latrines (adjusted odds ratio [OR]: 2.34, 95% confidence interval [CI]: 1.65–3.31, P = 0.000), lower class in school (adjusted OR: 11.65, 95% CI: 7.19–18.86, P = 0.010), and joint families (adjusted OR: 2.19, 95% CI: 1.42–3.32, P = 0.022) also showed a high positive association with the odds of practicing poor menstrual hygiene. Conclusion: This study reveals that adolescent girls in rural area had ignorance, false perceptions, and unsafe practices regarding menstruation. Thus, the above findings reinforce the need to encourage safe and hygienic practices among the adolescent girls and bring them out of the traditional beliefs, misconceptions, and restrictions regarding menstruation.

A cross-sectional study to investigate the impact of focused group discussion on menstrual hygiene among rural school girls of Southern Haryana, India.

INTRODUCTION:Menstruation is a natural phenomenon among women who experience shedding of blood for 1–7 days every month which usually starts between age 11 and 14 years and continues until menopause at about 51 years of age. It is important to maintain menstrual hygiene, as poor practices increase vulnerability to reproductive and urinary tract infections. The present study was conducted with an aim to investigate the impact of focused group discussion (FGD) compared to didactic lectures (DLs) on the menstrual hygiene knowledge and practices.METHODS:The present cross-sectional study was conducted among 649 school girls during January to August 2019 using a convenience sampling technique. After collecting baseline information using a pretested, predesigned, standardized questionnaire, the participants in the control and intervention groups were exposed for the DLs and FGD, respectively, and 1 month after such intervention, the same questionnaire was again self-administered by participants. All tests were performed at a 5% level of significance using SPSS (version 22.0).RESULTS:The baseline characteristics of both the groups such as participants' mean age, mean age of menarche, mother's literacy status, religion, type of family, and socioeconomic status were comparable. There was a difference in the knowledge and practice mean score of participants in the control group for pre- and postintervention, which was highly statistically significant (P < 0.001).CONCLUSIONS:This study reveals that menstrual hygiene is far from satisfactory among most of the school girls. The DLs and FGD have improved the menstrual hygiene knowledge and practices among school girls.

Epidemiological profile of aged women with breast cancer in a private clinic in Criciúma/sc

Objectives: Breast cancer is the most common cancer among women, gradually increasing its incidence in the aged population. This study aims to analyze the epidemiological characteristics of patients over 60 years of age with breast cancer in a private clinic in the city of Criciúma, Santa Catarina. Methods: This is a retrospective observational study, with collection of primary and secondary data and a quantitative approach. The sample was obtained through the analysis of 76 medical records and questionnaires, between 2014 and 2018. Results: The mean age of the patients was 70.39 years. The mean age of menarche and menopause was 13.23 and 49.48 years, respectively. Regarding the body mass index, 38.4% had some degree of obesity. Most elderly women (81.8%) were non-smokers. Evenly, 92.3% were non-alcoholics. Most cancers were detected by mammography (39.3%). Conservative surgery was predominant (74.2%). The association between radiotherapy and hormone therapy was the predominant adjuvant therapy (48.7%). Neoadjuvance was performed in 15 patients, 9 of whom underwent neoadjuvant chemotherapy (60.0%). The most used hormone therapy was anastrozole (88.9%). The most common side effects related to hormone therapy were isolated muscle pain (35.7%) and associated hot flushes (21.4%). There was a predominance of invasive ductal carcinoma (59.2%) and Luminal A subtype (43.6%). Conclusion: Aged patients usually present with smaller and less aggressive tumors, mostly submitted to less aggressive treatments.

Benign breast tumors: epidemiological profile and therapeutic conduct at the escola paulista de medicina

Introduction: Breasts represent an important site for the development of diseases. It is known that 80% of the palpable masses of the breast are of benign origin. Benign breast diseases range from inflammatory to neoplastic processes. Objectives: to evaluate the clinical and epidemiological characteristics of patients diagnosed with benign breast tumor at the Mastology outpatient clinic of the Universidade Federal de São Paulo (UNIFESP). Methods: 1,532 medical records, available on the electronic platform PEP-HUHSP through the ICD D24 (benign breast cancer) and N63 (unspecified breast nodule), of patients referred to the service between July 2008 and July 2017 were reviewed. After applying exclusion criteria, 403 medical records were submitted to data collection and tabulation in Excel, followed by statistical analysis using the IBM SPSS Statistics 23 software. The study in question was approved by the Research Ethics Committee of UNIFESP (CEP UNIFESP), in the Teaching and Research Coordination of Hospital São Paulo – Hospital Universitário/UNIFESP (CoEP of HSP-HU/UNIFESP) and exempted from the application of the Informed Consent by the same organs. Results: In the 9-year period, the following results were obtained: mean age was 39.3 years. Comorbidities: smoking (16.4%), SAH (16.8%) and dyslipidemia (6.3%). Family history of breast and/or ovarian cancer accounted for 16.6%. Mean age of menarche and menopause, respectively, were 12.7 and 42.5 years. Causes of referral: "alteration in image examination" (38.3%), "lump in the breast" (33.3%), "follow-up due to previous nodules" (16.5%). Anatomopathological report: fibroadenoma (41%), breast cysts (16%), phylloid tumors (3%), and papilloma (1%). Mean number of consultations per patient until discharge or abandonment of follow-up: three. Choice behavior: expectant (85.2%). Conclusion: The epidemiological profile of patients referred to the UNIFESP tertiary mastology service was mainly composed of women of childbearing age and nulliparous women, whose main comorbidities were smoking and SAH, in the great majority with no family history of breast cancer. Regarding the consultation, the main reason for referral is the findings on imaging exams, and, specially, patients would bring their breast USG along, which surpassed mammography by 34.1%. The choice for biopsy was restricted, present in approximately 1/3 of the cases, but pointed out that the most prevalent nodule is fibroadenoma, followed by phylloid and papilloma tumors. Nevertheless, there was a predilection for expectant conduct. On average, there were regular follow-ups for 1.5 years, followed by a significant dropout rate.

Menopause Symptoms, Complications and Preventive Methods: An Exploratory Assessment of Awareness Among 40 to 60 Years Age Women in District Hattian Bala

This study shows to identify the awareness level regarding symptoms and complications of menopause among Women and to determine their knowledge regarding prevention of complications of menopause. It also identify the gaps if any, in their knowledge regarding prevention of complications of menopause and give viable recommendations for creating awareness about menopause and its management in women. It was Descriptive cross-sectional study and conducted over a period of 6 months, from August 2018 to January, 2019 in the villages of District Hattian Bala. Data was collected through structured questionnaire which contain both open and close ended questions. The questions were used for the assessment of awareness of respondent regarding menopause, its symptoms, complications and preventive methods among the women in menopause age group 40-60 years. Sample was collected by using multistage probability sampling method. SPSS was used for Statistical analysis of the data. The mean age of women was, (49.59±5.712) years, the mean age of menarche was, (14.32±.474) years, the mean age at menopause was, (42.54±1.191) years. Majority of respondent had known about menopause. 297 (99%) knew about menopause, those women who knows about the preventive and curative measures about menopause were 261 (87%). (70%) women of menopausal age group were aware regarding the common medical complications associated with menopause. 117 (39.0), of respondent get information from lady health workers, 39 (13.3%) from lady health visitor, 44 (14.67%) from friends / relatives and 38 (12.7%) from electronic media. The results show that awareness regarding menopause and its symptoms has significant positive correlation with awareness regarding common medical complications associated with menopause (r=.34, p<.01) and significant positive correlation also with awareness among respondents regarding preventive methods to overcome the complications (r=.18, p<.01). The values of Pearson Product Moment Correlation also indicate that strong positive correlation exist between awareness regarding common medical complications associated with menopause and awareness among respondents regarding preventive methods to overcome the complications (r=.23, p<.01). It is concluded that menopause is a natural process and it is not a disease, but it has pestiferous effects on women who are in the menopause age due to the destitution of knowledge and awareness. To abate these effects among postmenopausal women, education and medical discussion is necessary. By the results of our study which shows that most of the respondent had a knowledge regarding menopause its symptoms, complications and preventive methods. Education level also had a strong positive correlation exist between awareness regarding menopause its symptoms complications and preventive methods.

Trend of Menarcheal Age among Korean Girls.

BackgroundMenarcheal age has been decreasing worldwide. However, few recent studies have observed trends in menarcheal age in larger populations, and the cutoff age for early menarche remains unclear. Therefore, we aimed to analyze recent trends of menarcheal age and to determine the cutoff age of early menarche based on nationally representative data.MethodsWe conducted a cross-sectional study of 351,006 Korean girls aged 12–18 years who were born in 1988–2003 based on the data of the 2006–2015 Korea Youth Risk Behavior Survey. We identified the distribution of age at menarche using the complex sample Cox regression model. Trends in the prevalence of early menarche were determined using the complex sample linear model.ResultsNinety-five percent of all the participants reported they had experienced menarche. The mean menarcheal age was 13.0 years (95% confidence intervals [CIs], 12.92–13.04) for girls born in 1988 and decreased to 12.6 years (95% CI, 12.54–12.61) for girls born in 2003. The cutoff age (the 3rd percentile value) for early menarche was 10.5 years during the study period. The prevalence of early menarche significantly increased from 1.8% in 2006 to 3.2% in 2015 (P-for-trend < 0.001). Downward trends of menarcheal age were noted across all body mass index groups, and this trend was most prominent in the obese group.ConclusionWe reported an ongoing downward trend in menarcheal age in Korean girls born in 1988–2003, decreasing by 0.4 years over the 15 years.

‘Oh Bulan’ Pilot Project: Sanitary Pad Usage and School Absenteeism During Menstruation Among Adolescent Girls in Rural Kelantan

Introduction: Menstruation is the sign of menarche for female adolescents. Previous finding had reported a need for education to improve the knowledge on menstrual hygiene among adolescent girls living in rural Kelantan. However, the access of sanitary pads and the effect of menstruation on school attendance among this population have not been reported elsewhere.Objectives: To determine the prevalence of sanitary pads usage and school absenteeism among adolescent girls in rural Kelantan.Methods: This is a cross-sectional study conducted among female students of Sekolah Kebangsaan Kampung Dangar in Pasir Mas, Kelantan between February and March 2019. Data were collected using a structured questionnaire in Bahasa Malaysia, which were administered by the school counselor.Results: A total of 172 respondents filled the questionnaires, with a mean age of 15 years (s.d. 1.4, range 13 to 17). Nearly half of them (n=78, 45.3%) are the daughters of laborers. Majority of them have fathers and mothers with the highest education level of SPM/STPM, while 7% have fathers with no proper schooling. Their mean age of menarche is 12. Majority of them claimed to use disposable sanitary pad (n=148, 87.2%) and would be wearing it every time during menstruation (n=148, 86.0%), while 4.7% used cloth pad. 40 (23.3%) of respondents would only stay at home during menstruation, mainly because they felt uncomfortable (5.8%) or having period pain (4.1%). 25 (14.5%) of the respondents used to be absent from school during menstruation, mainly due to period pain (12.2%).Conclusion: Disposable sanitary pad usage is highly prevalent among adolescents in this rural area, while menstruation have caused some of them to be absent from school.International Journal of Human and Health Sciences Supplementary Issue: 2019 Page: 49

SPORT WORKOUT AND PARTICIPATION ASSOCIATED MENSTRUAL PROBLEMS AMONG ADOLESCENT ATHLETES OF ALIGARH

Background: Menstruation and related problems are issues of great importance for adolescent athletes. The concern becomes more crucial when it comes to the sports participation of athletes. The social and cultural setup in India leaves very less space for adolescent athletes to talk freely about menstruation. This raises a great concern regarding menstruation from health perspective. Objectives: To study sport workout and participation associated menstrual problems among adolescent athletes. Materials and Methods: A questionnaire based survey study was carried out during open sports meet 2017 in Aligarh, India. A sample of 158 girl athletes participated in this study. Data was collected using a 23-item semi structured questionnaire. Data collection lasted for two weeks and analysis was done using descriptive statistics, percentages and proportions. Results: Showed that the mean age of menarche was 13.5 years. 37.19% had irregular menstrual cycle. 73.23% (20.11% severe and 53.12% mild) athletes had abdominal pain and cramping during menstruation. While, mere, 7.98% athletes seek any medical practitioner or OB-GYN about their menstruation problems. 56.97% athletes think that sports training and participation effect their menstrual periods. 49.78% reported that diet provided to them was not well balanced and 59.09% reported that imbalanced diet had caused many problems like that of irregular menstrual periods, dizziness, sleeping difficulties, mood swings, constipation and feelings of depression to them. Conclusion: The knowledge of the participants of this study about the menstruation and related problems was very weak and did not know the safe maintenance procedures. They also have the ill faith that sports participation hampers the menstrual periods. Besides this the significant weight loss could be due to training load and dietary imbalances. This seems to have had played major role in the irregularity of the menstrual cycles.

Diagnosis, management, and outcome of obstructed hemivagina and ipsilateral renal agenesis (OHVIRA syndrome): Is there a correlation between MRI findings and outcome?

AimTo review the experience of a single tertiary center with obstructed hemivagina and ipsilateral renal agenesis (OHVIRA syndrome) and evaluate if MRI findings correlate with outcome. MethodsPatients (n = 32) diagnosed with OHVIRA syndrome between 2001 and 2019 were analyzed. Presenting symptoms, age of menarche, age at operation, MRI findings, management, and outcome were reviewed. In sagittal MRI planes, distance from hematocolpos to perineum was measured. Measurements were compared among patients who underwent single-stage vaginoplasty and hemihysterectomy. ResultsMean age at diagnosis and mean age of menarche was 16.8 ± 6.4 (10−33) and 12.8 ± 1.0 (10–15). Main presenting complaints were abdominal pain/dysmenorrhea. Eighteen anomalies (56.3%) were on right side. Twenty-eight had ipsilateral renal agenesis, 3 patients had normal renal anatomy and one had unilateral multicystic dysplastic kidney. In MRI, 21 patients had hematocolpos, 11 patients had both hematocolpos and hematometra. 28 patients underwent single-stage vaginoplasty and vaginal septum resection. One had hemihysterectomy due to sepsis at presentation. Three patients had hemihysterectomy due to proximal vaginal septum and impossibility of vaginoplasty. During follow-up, 7 cases (21.9%) had married and 5 of these (71.4%) were pregnant or had delivered. Five patients had reoperation during follow-up. MRI images of 19 patients indicated mean distances from hematocolpos to perineum whom underwent vaginoplasty or hemihysterectomy were 33.9 ± 18.1 mm (10–79 mm) and 87.3 ± 11.0 mm (80–100), respectively (p = .009). ConclusionsGold standard treatment of OHVIRA syndrome is single-stage vaginoplasty. Distance from hematocolpos to perineum in MRI may correlate with surgical outcome. Hemihysterectomy may be an alternative for extreme proximal vaginal septum or infectious complications.

Identification of Mutation in Exon11 of BRCA1 Gene in Bangladeshi Patients with Breast Cancer.

Background:Worldwide, breast cancer is the leading cause of cancer death in female, in Bangladesh breast cancer is the second leading cancer in both sexes, and in women it occupied the top position. Highly penetrant mutations in BRCA1 gene constitute high risk of breast cancer. The spectrum of BRCA1 gene mutations varies in different population. The objective of this study was to identify mutation in exon11 of BRCA1 gene in Bangladeshi breast cancer patients. Methods:Genomic DNA was extracted from the histopathologically diagnosed formalin fixed paraffin embedded (FFPE) breast cancer tissues of 65 adult female patients. Two regions of exon11 of the BRCA1 gene were amplified and the amplicons were sequenced using Sanger sequencing. The sequenced nucleotides were analyzed and blast using NCBI nucleoblast. Selected demographic, reproductive and medical histories were collected and analyzed using SPSS version 20. Results:The mean age of the patients was 46 years and the mean age at diagnosis was 44.64 years. The patients were married and had 2.65 ± 1.22 children except one was nulliparous, the mean age of menarche was 12.67 years. All patients had children, breastfed the babies for an average 1.5 years. Only 13.6% of the patients had hypertension and the rest had no comorbidity. The family history for cancer (breast and other cancer) was negative. Three novel mutations were found in a patient. Two among the three mutant sequences had effect on amino acid coding (DNA sequence change g.852G>C and g.709G>A and amino acid changes p.Gln284His and p.Glu237Lys respectively). Conclusion:We found three novel mutations in Bangladeshi breast cancer patients. This finding indicates the necessity to study the mutation profile of whole BRCA1 gene in our population for cancer risk prediction.

COMPARISON OF BENIGN AND MALIGNANT BREAST DISEASE-RISK FACTORS AND FREQUENCIES IN SAMPLES REFERRED TO PATHOLOGY LABORATORY OF AHWAZ UNIVERSITY OF MEDICAL SCIENCES FROM 2006 TO 2017

Breast cancer is the most common malignancy in women contributing to about 18% of all cancers worldwide. There are many well-known risk factors for breast cancer, and identifying these risk factors will help to reduce the mortality rate. This study is aimed to compare risk factors and the frequencies in women with benign and malignant breast tumor. This case-control study, was done with 60 women with benign breast tumors as controls and 60 women with malignant breast tumors as case They were randomly selected and checklist was made. Based on the information in the forms of pathology or from medical records or patient contact, data was completed. Data analysis was conducted using SPSS-16 statistical software. The results showed that the mean age at diagnosis (p_value=0.033), the frequency of positive family history of cancer (p_value=0.028) and the mean age at menarche (p_value=0.01) in the two groups was statistically significant difference. However, the frequency of having an abortion (p_value=0.391), the mean age of first child birth (p_value=0.641), the mean months of breastfeeding (p_value=0.281) and the frequency of having a perfect pregnancy (p_value=0.58) did not show significant difference between the two groups. The mean age at diagnosis and the frequency of positive family history of tumors in the case group, and the mean age of menarche in the control group is higher implication

To determine age of appearance of secondary sexual character and age of menarche in working girls of urban slum area

Introduction: Adolescence is the developmental phase between childhood and adulthood with specific psychological attributes. In normal girl evidence of sexual maturation characteristically appears not at four or forty, but at 8 or 10 or 12 years of age. At that time, most healthy girls begin to have physical manifestation of the changes in ovarian function that are associated with reproductive maturity. Their breasts start to bud, and hair appears in the pubic and axillary regions. The timely appearance of the menarche gives assurance that the other less recognizable feature of puberty and early adolescence are processing normally or about to be initiated. Method: A cross sectional survey was done by door to door visit in three randomly selected slums of Bilaspur, Chhattisgarh, India. Data was collected on predesigned and pretested pro-forma with the answer to questionnaire regarding various aspects. SMR staging done by taking consent from guardian of minor adolescents and consent from their selves in those who are above 18 years. Result: Out of 696 girls who were examined, it was found that the maximum number (45.40%) of adolescents were in 10-13 years age group and minimum number (27.01%) were in 17-19 years age group. In 14-16 years 27.58% girls. In SMR staging of 10-13 years age group max girls (39.8%) were in B1 and 55.6%in P1 and no one in B5 and P5.In 14-16 years age group max (45.8%) in B4, and only 1.0% in B1 and max in P3 and minimum in P1 that is 38.5% and 5.2% respectively. In 17-19 years, age group max has reached stage B5 with 94.6% and P5 72.3%. The Mean age of menarche for all age group was 13.19 years. Conclusion: Nutritional, socioeconomic status, climate, genetic makeup affects age of menarche and pubertal changes knowing the fact that working adolescent from slum will have more nutritional deprived thus can be concluded that poor nutrition and lower socioeconomic status might be responsible for this delay.