An increase in the nonlinearity of the bridge will lead to a more obvious vehicle–bridge interaction effect and affect the vehicle response and driving comfort as the span increases. This paper establishes a refined finite element model of vehicle–bridge coupling for the 575 m long-span concrete-filled steel tubular arch bridge, Pingnan Third Bridge. Coupling vibration responses under different vehicle speeds, vehicle weights and road conditions of this bridge is analyzed. Then its comfort is assessed according to the comfort criterion. The results show that the vehicle–bridge coupling model has good agreement with the field test. The dynamic response of the bridge within the speed limit has no significant linear relationship with the magnitude of the vehicle speed without considering the pavement class. When the vehicle exceeds the speed limit, the dynamic response increases sharply with the increase in speed. The increase in vehicle weight leads to an increase in the maximum dynamic deflection of the bridge and a decrease in the impact coefficient, but the actual total response of the bridge does not decrease. The worse the road surface condition, the more dramatic the dynamic response of the bridge structure, taking into account the road surface level.
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