Heat injection well reaches temperatures above 400 ◦C during the process of heat injection, Heat injection is essential for oil shale in-situ conversion technology. The downhole of the and part of the high-temperature gas dissipates through the wellbore annulus. Consequently, in addition to causing energy loss, the dissipation causes thermal damage to the casing and wellhead. To avoid dissipation, components that are suitable for high-temperature environments should be sealed and used during heat injection while mining. Therefore, this study presents the design of a packer composed of elastic graphite rubber and a high-temperature-resistant material. The influence of numerous factors, such as downhole temperature, working load, and height of rubber, on the reliability of the packer was analyzed. Subsequently, the numerical simulation analysis of the packer reliability in in-situ conversion mining under high temperature and pressure environments was performed. The results indicate that when the operating temperature is stable, the operating load has the most obvious influence on the sealing reliability of the packer, whereas the change in the height of the rubber has the least significant effect on the maximum contact stress between the casing and rubber. The change in the operating temperature has the least significant effect on the overall sealing performance of the packer. Moreover, the rise of the temperature will increase the sealing reliability of the packer, and on the contrary, the drop in the temperature will decrease it. Cited as: Guo, W., Shui, H., Liu, Z., Wang, Y., Tu, J. Reliability analysis of elastic graphite packer in heat injection well during oil shale in-situ conversion. Advances in Geo-Energy Research, 2023, 7(1): 28-38. https://doi.org/10.46690/ager.2023.01.04