Maximum Compliance Research Articles

Rheological and Thermal Studies of Euglena/Konjac Glucomannan Composite Gel as a New Resource Food Matrix

ABSTRACTNatural konjac glucomannan is an ideal candidate for hydrogels due to its excellent gel‐forming abilities, though its limited nutritional value somewhat restricts its applications. This project primarily explored the thermal and rheological properties of composite hydrogels formed by combining konjac glucomannan with Euglena. The hydrogels were created using a Euglena suspension processed through hydration, high‐speed shearing, and ultrasonic homogenization. This is the first report to document the creation of composite gels using konjac glucomannan and Euglena. This novel combination enhanced the thermal stability of the gels to 258.7°C, improved frost resistance to −19.9°C, increased the maximum activation energy to 24,179.6 J/mol, and raised maximum creep compliance to 0.6259 1/Pa. These characteristics significantly expand their potential for food preservation and active nutrient delivery while also offering new strategy for developing nutritionally rich gel foods and new resource food matrices.

Neonatal Hearing Screening Using Wideband Absorbance and Otoacoustic Emissions Measured Under Ambient and Pressurized Conditions.

The objective was to analyze wideband acoustic absorbance and transiently evoked otoacoustic emissions (TEOAEs) from newborns without risk indicators of hearing loss and test the effectiveness of measuring TEOAEs under pressurized ear canal conditions. Evaluation of 102 newborns from a maternity hospital, who stayed in the well-baby nursery and did not have risk indicators for hearing loss. The procedures involved wideband tympanometry and TEOAEs performed at ambient pressure (AP) and at a pressure corresponding to maximum compliance (PP). Newborns were then divided into three groups according to their AP and PP results: G1 (PASS/PASS), G2 (FAIL/PASS), and G3 (FAIL/FAIL). Comparing the three groups, pressurization improved the pass rate for G2 only. For wideband absorbance, differences were statistically significant for frequencies of 2, 3, and 6 kHz, with lower values under the AP condition. For TEOAEs, the differences were statistically significant in all bands, with lower values under the AP condition. Pressurization was effective in detecting more TEOAEs in G2, thus reducing the number of failures in neonatal hearing screening and reducing the need to return for retesting.

Improving midwives' management of occiput-posterior fetal positions: a best practice implementation project.

The occiput-posterior (OP) fetal position is the most frequent form of labor dystocia. This position has been associated with delaying the second stage of labor and adverse outcomes. This project aimed to improve the quality of intrapartum care provided by midwives for OP fetal positions during the second stage of labor. This best practice implementation project was conducted at the Río Hortega University Hospital in Valladolid, Spain. The project followed the JBI Evidence Implementation Framework, which is based on an audit, feedback, and re-audit process. Current practices were compared against best practices in a baseline audit using 13 audit criteria. Barriers to compliance with best practices were identified and improvement strategies were implemented. An initial follow-up audit was carried out after 4 months to avoid secondary bias. After another 4 months, a second follow-up audit was conducted. Data were collected and compared using the JBI Practical Application of Clinical Evidence System (JBI PACES). The results revealed an improvement in all structure criteria (1-3), five of the process criteria (4-6, 8, 10), and all results criteria (11-13). One process criterion (8) reached maximum compliance in all audits. A key finding was the inadequate recording of upright positions (criterion 7) and the interpretation of cardiotocography (criterion 9). Evidence-based interventions for managing OP labor improved the quality of care and underlined the importance of ongoing training for midwives. Additional studies are required on positions and fetal monitoring during labor. http://links.lww.com/IJEBH/A279.

Review on Monoclonal Antibodies (mAbs) as a Therapeutic Approach for Type 1 Diabetes.

Monoclonal antibodies have been successfully utilized in a variety of animal models to treat auto-immune illnesses for a long time. Immune system responses will either be less active or more active depending on how the immune system is operating abnormally. Immune system hypoactivity reduces the body's capacity to fight off various invading pathogens, whereas immune system hyperactivity causes the body to attack and kill its own tissues and cells. For maximal patient compliance, we will concentrate on a variety of antibody therapies in this study to treat Type 1 diabetes (an autoimmune condition). T-cells are responsible for the auto-immune condition known as T1D, which causes irregularities in the function of β-cells in the pancreas. As a result, for the treatment and prevention of T1D, immunotherapies that selectively restore continuous beta cellspecific self-tolerance are needed. Utilizing monoclonal antibodies is one way to specifically target immune cell populations responsible for the auto-immune-driven disease (mAb). Numerous mAbs have demonstrated clinical safety and varied degrees of success in modulating autoimmunity, including T1D. A targeted cell population is exhausted by mAb treatments, regardless of antigenic specificity. One drawback of this treatment is the loss of obtained protective immunity. Immune effector cell function is regulated by nondepleting monoclonal antibodies (mAb). The antigenfocused new drug delivery system is made possible by the adaptability of mAbs. For the treatment of T1D and T-cell-mediated autoimmunity, different existing and potential mAb therapy methods are described in this article.

Urodynamic and Frequency-Volume Chart Parameters Influencing Anticholinergic Resistance in Patients With Neurogenic Detrusor Overactivity.

Neurogenic detrusor overactivity (NDOA) is characterized by involuntary detrusor muscle contractions during bladder filling in patients with neurological disorders. Anticholinergic therapy is the primary treatment; however, the reasons for treatment resistance in NDOA are not well understood. This study aimed to identify predictors of treatment failure by comparing urodynamic and frequency-volume chart data between patients with NDOA who respond and patients who do not respond to anticholinergic therapy. We reviewed the records of 362 patients presenting with lower urinary tract symptoms and selected 85 who had NDOA and were on anticholinergic therapy. Ultimately, 67 patients were analyzed. We categorized these individuals into responders (group R) and nonresponders (group NR) based on clinical and urodynamic improvements. Three-day frequencyvolume charts and urodynamic study results were retrospectively reviewed. Of the 85 initial patients, 12 refused medication, and 6 were lost to follow-up. Pre- to posttreatment changes differed significantly between groups in the number of urgency urinary incontinence (UUI) episodes per 24 hours (P=0.001), maximum cystometric capacity (mL, P=0.003), NDOA frequency (P=0.004), and bladder compliance (mL/cm H2O, P=0.003). Multivariate analysis revealed that NDOA frequency (P=0.014) and UUI episodes per 24 hours (P=0.002) were significant factors associated with treatment failure. NDOA varies according to underlying neurological conditions. The frequencies of UUI episodes and NDOA in urodynamic studies can predict resistance to initial anticholinergic treatment.

Humor dalam Buku Komik ‘Lawak Kampus’: Analisis Teori Grice

This research aims to find out the hidden meanings found in the comic book 'Lawak Kampus' by Keith. The research questions are, (1) What maxims exist in the ‘Lawak Kampus’ comic? and (2) Does the comic 'Lawak Kampus' have maximum compliance with the principle of cooperation or vice versa? The objectives of this study are (1) To identify the implied meaning behind the four-part comic 'Lawak Kampus', (2) To analyze the maxims of the principle of cooperation found in the comic 'Lawak Kampus' and (3) To classify the maxims of the principle of cooperation as categorized in Grice's theory (1975). This study uses a qualitative method which is a descriptive type. In producing this study, three methods were used, namely the library method, the data collection method and the data analysis method. The data taken is from a comic book 'Lawak Kampus Kompilasi Mantap 3' Malay version. The selection of data is random by selecting 20 data from the comic book that has humor for each story. This study only focuses on the humor in the comic book. Next, the results of the 20 data that have been selected will be analyzed one by one by explaining the implicature used in each title whether there is compliance or violation of the maximum principle of cooperation in the comic or vice versa. As a result of the study, there are four maxims of the principle of cooperation in the comic book. In addition, this study uses the theory from Grice (1975). Therefore, this study looks in terms of the hidden meanings found in the comic.

Effectiveness of mHealth intervention for trismus exercise in patients with head and neck cancer undergoing proton and heavy ion therapy: a randomized control trial.

This study aimed to compare the effects of a mobile health intervention based on social cognitive theory with standard care on maximal mouth opening, exercise compliance, and self-efficacy in patients receiving proton and heavy ion therapy for head and neck cancer. This open-label, parallel-group, randomized, superiority trial involved a self-developed "Health Enjoy System" intervention. We assessed maximal mouth opening, exercise compliance, and self-efficacy at baseline (T0), post-treatment (T1), and at 1 month (T2) and 3 months (T3) after radiotherapy. Generalized estimating equations were used to analyze differences between the groups over time, with results reported as P values and 95% confidence intervals (CIs). The study included 44 participants. At T3, the intervention group showed a 6 mm greater increase in maximal interincisal opening than the control group (mean difference = 6.0, 95% CI = 2.4 to 9.5, P = 0.001). There was also a significant difference in exercise compliance between the groups (mean difference = 31.7, 95% CI = 4.6 to 58.8, P = 0.022). However, no significant difference in self-efficacy was found between the groups. This study demonstrated that an mHealth intervention incorporating behavior change theory could effectively enhance or maintain maximal mouth opening in patients undergoing proton and heavy ion therapy for head and neck cancer in China. This approach provides valuable support during and after treatment. ChiCTR: ChiCTR2300067550. Registered 11 Jan 2023.

Optimal configurations for stiffness and compliance in human & robot arms.

Research in neurophysiology has shown that humans are able to adapt the mechanical stiffness at the hand in order to resist disturbances. This has served as inspiration for optimising stiffness in robot arms during manipulation tasks. Endpoint stiffness is modelled in Cartesian space, as though the hand were in independent rigid body. But an arm is a series of rigid bodies connected by articulated joints. The contribution of the joints and arm configuration to the endpoint stiffness has not yet been quantified. In this paper we use mathematical optimisation to find conditions for maximum stiffness and compliance with respect to an externally applied force. By doing so, we can retroactively explain observations made about humans using these mathematically optimal conditions. We then show how this optimisation can be applied to robotic task planning and control. Experiments on a humanoid robot show similar arm posture to that observed in humans. This suggests there is an underlying physical principle by which humans optimise stiffness. We can use this to derive natural control methods for robots.

Selection and integration of adjustable load in multiple scenarios

In the context of the “carbon peaking and carbon neutrality goals”, the new electricity systems are evolving towards source-load friendly interactions. At the same time, the increasing necessity for adjustable loads to participate in the power balance of the new electricity systems is highlighted. Consequently, a large-scale source-grid-load design scheme is proposed. It employs three independent communication channels to facilitate communication between users and intelligent grid-load terminals. Based on analysis of the individual loads and equipment characteristics of each user, principles for user shunt load access principle and adjustable loads are formulated by combining the maximum duration, frequency constraints, and compliance costs. Furthermore, it proposes construction plans for both the customer side in a single distribution room and the customer side distributed across different locations. According to the experimental analysis of 245 users, the response time of the experimental system is less than 600 ms. These advancements enhance the emergency response speed and responsiveness, contributing to the advancement of precise, real-time, and lean management of the demand side of the power grid.

Когнитивное и речевое развитие детей дошкольного возраста, зачатых путем вспомогательных репродуктивных технологий

<p style="text-align: justify;"><strong>Objectives. </strong>The mental health of children conceived using assisted reproductive technologies (ART) is a growing concern for parents and professionals. With a maximum compliance with the conditions for using reproductive technologies, the birth of a healthy child is expected. But some children conceived through artificial insemination have developmental problems, speech and/or cognitive problems. A pilot study was conducted on the cognitive and speech development of children from 3 to 8 years old with the aim of a comparative analysis of children from induced pregnancy with children conceived naturally, to determine the possible impact of ART methods on children's health.</p> <p style="text-align: justify;"><strong>Methods.</strong> The cognitive and speech functions of 115 children aged 3 to 8 years were studied: 54 children from induced pregnancy were included in the experimental groups (EG 1 and EG 2) and 61 children from natural conception were included in the control groups (CG 1 and CG 2). The method of neuropsychological diagnostics of children of L.S. Tsvetkova and methods of speech therapy examination (assessment of the state of facial and articulatory muscles, breathing, prosodic speech, general speech development) were used. The results were processed through the qualitative and quantitative assessment of the correspondence of the child’s cognitive and speech development to normative ontogenesis.</p> <p style="text-align: justify;"><strong>Results. </strong>It has been determined that children conceived through ART have a high percentage of perinatal risk: 35% of children (n=54) conceived through ART have: mental disorders (autism, intellectual disability) and various speech disorders in 77% of cases, — which has a negative impact on the development of cognitive activity. In children conceived naturally (n=61), the percentage of disorders was lower: in 47% of cases, cognitive disorders were noted, and in 60% of children, speech disorders of mild to moderate severity were identified.</p> <p style="text-align: justify;"><strong>Conclusions</strong>. The hypothesis about the possible influence of the fertilization methods used, the characteristics of the procedure, the health status of the parents before conception, the course of the mother’s pregnancy and other prenatal factors on the occurrence of developmental disorders in children conceived through ART is supported. An interdisciplinary approach to organizing research will allow a comprehensive study of the developmental features of children from induced pregnancy and the timely identification of possible dysontogenetic risk factors.</p>

Effects of hydrocolloids on mechanical properties, viscoelastic and microstructural properties of starch-based modeling clay

The effects of various hydrocolloids (guar gum, xanthan gum, and carboxymethyl cellulose) on the texture, rheology, and microstructural properties of modeling clay prepared with cassava starch were investigated. Notably, incorporation of 3 % guar gum and 4 % xanthan gum into starch-based modeling clay resulted in enhancements of 94.12 % and 77.47 % in cohesiveness, and 64.70 % and 66.20 % in extensibility, respectively. For starch-based modeling clay with added guar gum and xanthan gum, compared to formulations without hydrocolloids, the linear viscoelastic range exceeded 0.04 %, and the frequency dependence of both maximum creep compliance (Jmax) and storage modulus (G′) was significantly reduced. This indicates a more stable network structure and enhanced resistance to deformation. Results from Fourier Transform Infrared (FTIR) spectroscopy and X-ray diffraction (XRD) confirmed that the physical interactions between starch and various hydrocolloids, along with the addition of these hydrocolloids, inhibited the degradation effect of thermomechanical processing on the crystalline structure of starch. With the addition of guar gum, it is observed that a continuous and dense network structure forms within the starch-based modeling clay, and starch particles are distributed uniformly. In conclusion, hydrocolloids enhances the properties of starch-based modeling clay, introducing an innovative solution to the modeling clay sector.

Design and analysis of three-dimensional chiral metamaterials for enhanced torsional compliance

Three-dimensional (3D) chiral structures are a subset of mechanical metamaterials known for their distinctive deformation characteristics, including the presence of auxetic and compression–torsion coupling behaviors. In this study, a novel 3D chiral metamaterial with high torsional compliance was designed. A gammadion-shaped chiral cell comprising inclined ligaments was incorporated into the chiral structure for enhanced torsional compliance. Finite element analyses (FEAs) were performed to demonstrate that the proposed chiral structure outperformed other chiral structures in terms of torsional compliance. Furthermore, FEAs were performed to investigate the influence of the slenderness ratio and ligament diameter of the chiral structure, on attaining a maximum torsional compliance of 18.6° N−1. These 3D chiral structures were fabricated using additive manufacturing techniques, and experimental validations were performed to observe and confirm the compression–torsion coupling behaviors. To further expand the utility of these 3D chiral structures, statistical analyses were conducted to establish regression models for effective density and torsional compliance, as functions of the slenderness ratio and ligament diameter. These regression models can enhance the applicability of the proposed chiral structures in the development of versatile functional components that require compression–torsion coupling behaviors.

Individualised flow-controlled ventilation reduces applied mechanical power and improves ventilation efficiency in a porcine intra-abdominal hypertension model

BackgroundAim of this study was to evaluate feasibility and effects of individualised flow-controlled ventilation (FCV), based on compliance guided pressure settings, compared to standard of pressure-controlled ventilation (PCV) in a porcine intra-abdominal hypertension (IAH) model. The primary aim of this study was to investigate oxygenation. Secondary aims were to assess respiratory and metabolic variables and lung tissue aeration.MethodsPigs were randomly assigned to FCV (n = 9) and PCV (n = 9). IAH was induced by insufflation of air into the abdomen to induce IAH grades ranging from 0 to 3. At each IAH grade FCV was undertaken using compliance guided pressure settings, or PCV (n = 9) was undertaken with the positive end-expiratory pressure titrated for maximum compliance and the peak pressure set to achieve a tidal volume of 7 ml/kg. Gas exchange, ventilator settings and derived formulas were recorded at two timepoints for each grade of IAH. Lung aeration was assessed by a computed tomography scan at IAH grade 3.ResultsAll 18 pigs (median weight 54 kg [IQR 51–67]) completed the observation period of 4 h. Oxygenation was comparable at each IAH grade, but a significantly lower minute volume was required to secure normocapnia in FCV at all IAH grades (7.6 vs. 14.4, MD − 6.8 (95% CI − 8.5 to − 5.2) l/min; p < 0.001). There was also a significant reduction of applied mechanical power being most evident at IAH grade 3 (25.9 vs. 57.6, MD − 31.7 (95% CI − 39.7 to − 23.7) J/min; p < 0.001). Analysis of Hounsfield unit distribution of the computed tomography scans revealed a significant reduction in non- (5 vs. 8, MD − 3 (95% CI − 6 to 0) %; p = 0.032) and poorly-aerated lung tissue (7 vs. 15, MD − 6 (95% CI − 13 to − 3) %, p = 0.002) for FCV. Concomitantly, normally-aerated lung tissue was significantly increased (84 vs. 76, MD 8 (95% CI 2 to 15) %; p = 0.011).ConclusionsIndividualised FCV showed similar oxygenation but required a significantly lower minute volume for CO2-removal, which led to a remarkable reduction of applied mechanical power. Additionally, there was a shift from non- and poorly-aerated lung tissue to normally-aerated lung tissue in FCV compared to PCV.

Compliance with the WCRF/AICR Recommendations in Qualitative Adaptation and the Occurrence of Breast Cancer: A Case-Control Study.

The aim of the study was twofold: (1) the qualitative adaptation of the 2018 WCRF/AICR (QAd-WCRF/AICR) score, and (2) the assessment of the association between the level of compliance with the WCRF/AICR recommendations and the occurrence of breast cancer in peri- and postmenopausal women. This case-control study involved 420 women, aged 40-79 years, from northeastern Poland, including 190 newly diagnosed breast cancer cases. Data related to the WCRF/AICR recommendations were collected in face-to-face interviews with 409 women, including 179 women with breast cancer. The frequency of food consumption data were collected using the FFQ-6® and KomPAN® questionnaires. Body weight, height, and waist circumference were measured. The QAd-WCRF/AICR score (range: 0-8 points) was calculated on the basis of eight components, including two components from to the WCRF/AICR recommendations: (1) body mass index (BMI), and (2) waist circumference, with six components expressed qualitatively: (3) overall physical activity, as well as the frequency of the consumption of (4) vegetables/fruits/whole grains/nuts/seeds/legumes, (5) highly processed foods, including fast foods/sweets/instant soups, (6) red/processed meat, (7) sweetened/energy drinks, and (8) alcohol. Logistic regression analysis was performed to assess the occurrence of breast cancer. The moderate (4-5 points) and maximal (6-8 points) compliance with the qualitative adaptation of the WRCF/AICR recommendations reduced the odds of breast cancer by 54% and 72%, respectively, compared to the results noted for minimal compliance (≤3 points). Lower odds of breast cancer were associated with moderate or high physical activity, consumption of a minimum of four serving per day of vegetables/fruits/whole grains/nuts/seeds/legumes, and limiting the consumption of highly processed food/fast foods and red/processed meat to a maximum of 1-3 times/month. Higher odds of breast cancer were associated with a higher waist circumference and alcohol abstinence. These findings may prove useful in establishing cancer prevention recommendations based on simple suggestions regarding the frequency of food consumption.

Study of Antibacterial Drugs’ Nephrotoxicity in the RPTEC Cell Line

The created cell line of human proximal renal tubules RPTEC/TERT1 showed maximum compliance with primary human RPTEC, which makes it optimal for use in studies of the nephrotoxic properties of xenobiotics. Transepithelial resistance measurement (TEER) is a valuable non-invasive method that can be used to quantify the integrity of the cell barrier at various stages of cell growth and differentiation, as well as to predict the toxicity and permeability of drugs.The aim of the study was to examine the dynamics of changes in transepithelial resistance in the model of the RPTEC/TERT1 cell line during incubation with drugs with nephrotoxic effects.Material and methods. The human proximal renal tubule cell line RPTEC/TERT was obtained from the ATCC cell culture bank. Cells at passage 14 were used in the experiment. The following drugs were studied: cisplatin: 2.5 mcg/ml; vancomycin: 50 mcg/ml; doripenem — 20mcg/ml; cefepim — 150mcg/ml. 4–5 repetitions were performed for each concentration of the drug in the experiment. THEER measurements were carried out 4–5 times for each well.Results. Cisplatin, vancomycin, doripenem, and cefepim in the concentrations used do not show a cytotoxic effect on the RPTEC cell line according to TEER dynamics.

POWER AND TRUST: A MEDIATOR IN THE RELATIONSHIP BETWEEN PROCEDURAL JUSTICE AND TAX COMPLIANCE IN INDONESIA

This study analyses the connection between procedural justice, trust and power concerning tax compliance in Indonesia and investigates the mediating influence of trust and power tax authorities hold in this relationship. While various factors play a role in tax compliance behaviour in Indonesia, the country still struggles to achieve maximum compliance, falling short of international standards in terms of tax ratio. Only half of Indonesians have confidence in the tax system, and procedural justice is closely linked to power and trust. This study is groundbreaking as it is the first to investigate these three factors simultaneously in Indonesia. A quantitative approach was employed, with data gathered from 371 taxpayers and analyzed using the PLS-SEM method. The findings indicate that legitimate power and trust are positively associated with voluntary tax compliance and function as mediators between procedural justice and tax compliance. However, no correlation was found between procedural justice and tax compliance or between coercive power and tax compliance. To enhance taxpayer compliance in Indonesia, it is recommended to bolster trust in the tax authority and its jurisdictions. This study addresses a gap in the tax compliance literature. It enhances the theoretical framework, providing valuable practical insights for compliance improvement strategies, particularly for the Indonesian Directorate General of Taxes. The findings support developing more effective policies, improving tax education, and promoting transparency to strengthen public trust and compliance.

ДИНАМИКА ПОКАЗАТЕЛЕЙ ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ ОРГАНА СЛУХА И СОСТАВА МИКРОФЛОРЫ ЛОР-ОРГАНОВ ЧЕЛОВЕКА В УСЛОВИЯХ НАЗЕМНОГО МОДЕЛИРОВАНИЯ ЭФФЕКТОВ МИКРОГРАВИТАЦИИ

Functioning of hearing organs and ENT microflora composition were investigated in 10 healthy male subjects (25–36 y.o.) who volunteered for a 7-day dry immersion as a model of the physiological effects of microgravity. The functional state of the hearing organs was assessed with the registration of distortion product oto-acoustic emission (DPOAE), and tympanometry. Specifically, assessed were the signal-to-noise ratio (SNR) of the oto-acoustic response (dB), middle ear pressure (daPa) and tympanogram maximal compliance (ml). To identify and count ENT microbial cultures, samples were gathered from the nasal and pharyngeal membranes and external skin of the auditory meatus. The eubiotic index was used to detect changes in the microflora composition. Changes in the hearing organ functioning included a SNR decrease in DPOAE of the low-frequency band (p ≤ 0.05), increase of the middle ear pressure (p ≤ 0.05) and an obvious downward trend of the maximal compliance. Dynamic microbiocenosis assessment discovered several negative changes such as a reduction in the number of protective microorganisms and growth of the number of opportunistic groups. The eubiotic index value was below one. These changes demonstrate a potential negative effect of modeled microgravity on the ENT microflora functioning and composition. Methods of dynamic assessment and control of the hearing organ and ENT microbiocenosis would be appropriate for use in monitoring of cosmonauts' health.

Formulation, Analytical Method Development and Validation of an Emulsion of Multi-enzyme with Carminative Oils

Introduction:: Indigestion leading to Flatulence is a common problem for infants, and tackling it is tedious for the parents. So, addressing the issue with an ideal formulation should likely have a combination of digestive enzymes and carminatives. Methods: A formulation containing enzymes like Fungal Diastase (Amylase) and Papain (Protease) for the digestion of Carbohydrates and Protein, respectively, along with aromatic, volatile, carminative oils like Dill Oil, Anise Oil, and Caraway Oil can serve the purpose to mitigate problems associated with infant indigestion and flatulence with maximum compliance. Results: The stability of multi-enzyme and analysis of carminative oil mixtures still need to be improved due to their inherent characteristics. Enzymes are very likely susceptible to changes in temperature and pH, while the solubility of carminative oils is minimal in the aqueous phase. Also, each enzyme is stable in different pH ranges. Nine emulsions were developed using a suitable buffer system and analyzed by HPLC method. Conclusion:: The optimum pH range was found, and analytical method validation was done for the method's accuracy, precision, and repeatability. The optimum pH was 6-6.5, and the active pharmaceutical ingredients (API) assay was found within the acceptable limit of NLT, 90% for enzymes and 90-110% for carminative oils.

Relational enforcement

A principal incentivizes an agent to maintain compliance and to truthfully announce any breaches of compliance. Compliance is imperfectly controlled by the agent's private effort choices, is partially persistent, and is verifiable by the principal only through costly inspections. We show that in principal‐optimal equilibria, the principal enforces maximum compliance using deterministic inspections. Periodic inspection cycles are suspended during periods of self‐reported noncompliance, during which the agent is fined. We show how commitment to random inspections would benefit the principal, and discuss possible ways for the principal to overcome her commitment problem.

Patient-centered health care planning in acute inpatient mental health settings: a best practice implementation project.

The current project aimed to improve the quality of health care by promoting evidence-based practice (EBP) regarding mental health care planning (MHCP) for adult inpatients. The implementation of the best evidence in the process of developing and documenting nursing care plans is currently an important legal requirement that contributes to increasing the quality of care. This implementation project was based on the JBI evidence implementation approach and included a baseline audit of seven criteria, implementation of strategies, and a follow-up audit. The project was conducted in an acute psychiatric setting at a university hospital in Bucharest, Romania. The sample included 17 nurses and 30 ward patients. The baseline audit revealed low compliance (33%-37%) for criterion 3 (a comprehensive care plan) and criterion 4 (patient involvement); moderate compliance (55%) for criterion 1 (care plan for all patients); and increased compliance (97%-100%) for criterion 2 (assessment of patient's needs), criterion 5 (education of patients/caregivers), criterion 6 (providing a copy at discharge), and criterion 7 (education of professionals). As a result of implementing the most appropriate strategies, the maximum improvement (100%) was observed across all five audit criteria that were found to be deficient in the baseline audit. The development and implementation of strategies adapted to specific care need to play a key role in the implementation of EBP. In this case, educating nurses, facilitating nurses' access to EBP for care planning, and improving procedures proved effective in achieving maximum compliance with all the audit criteria.