For the study on the propagation–attenuation rule of the blasting vibration wave in the deep mining roadway of Shizishan copper mine, and the analysis of the influences of different maximum explosive charges and different underground systems on the propagation of blasting vibration signals, blasting vibration monitoring of the two different situations has been carried out respectively. Firstly, the Sadov’s Formula has been applied to analyzing the monitoring results of the mining roadway, and thus the value of its excavation blasting vibration attenuation index K and \(\alpha \) and its corresponding regression formula were attained; then, the appropriate regression formula was used to calculate the maximum explosive charge which could ensure the safety of the principal chambers underground the mine. Meanwhile, on the basis of the HHT analysis method, the rule of vibration wave propagation under these two different situations was analyzed. And the results indicated that, whether with an increase in the single charge, or with an increase in the number of the underground systems to cross, blasting seismic wave had a tendency for spreading to the low-frequency band. Through the regression analysis of the Sadov’s Formula and the HHT Method, the results provided a reliable basis for the safe and efficient production of the mine.