Molecular docking studies are efficient tools to study the biopharmaceutical and pharmacokinetic parameters of drug compounds. The present study aimed to determinethe anti-cancer activity of Neolamarckia Cadamba (Roxb.) stem bark extract and to perform molecular docking on selected phytocompounds. The dried bark extracted successively by Soxhlet apparatus using n-Hexane, Dichloromethane and 80%Ethanol which was confirmed by visualization of spots on TLC using UV chamber. The extracted compounds subjected to Insilico study such as molecular docking using AUTODOCK 4.2.6 on the active sites of VEGFR2, HER2(erbB2) and EGFR Proteins. The docking results reveal among all the 3 phytoconstituents that are extracted from the Neolamarckia Cadamba bark 4-hydroxy-beta- ionone has maximum binding affinity at the active sites of HER2, VGERF2 and EGFR. The target proteins show good anti-cancer activity in response towards 4-hydroxy-betaionone. Keywords- Neolamarckia Cadamba, Molecular docking, Cancer, GC-MS, In-silico analysis