Maximum Accommodation Research Articles

Development of Student Worksheet through Deep Questions with Physics Comics to Train High Order Thinking Skill in High School Students in Optical Instrument Lup for Maximum Accommodation Eyes

Student Worksheet (LKPD) was developed with comic strips and through integrating deep questions in them. Comic strips were taken from the WHY Science Comics series? LIGHT AND SOUND. Comics Strip are written in LKPD to stimulate and provide information and basic concepts of optical devices to students. LKPD through deep questions approach consists of 4 sub-activities, where each activity contains the main sub-questions. In addition, 4 activities in LKPD are arranged systematically through the most basic sub-questions to the high-level sub-questions. In-depth questions integrated in LKPD provide a stimulus for thinking of students so that they practice high-level thinking skills and gain depth in learning. The systematic learning process using LKPD is proven to promote deep learning and can train students’ high-level thinking skills. Physical comics provide basic information about physics concepts and give a good impression to motivate student learning. LKPD is applied to two classes through different discussion models. The result show that student-centered discussion model will be more effective to be applied in learning with LKPD.

Sensitivity Analysis on the Inter-regional Accommodating Capability of Renewable Energy Based on Time Sequential Simulations

To realize the maximum accommodation of renewable energy of two regions, the paper has studied many influencing factors including renewable energy theoretical output curve, load characteristics, operation constraints of units and operation characteristics of UHV line. The weekly renewable energy inter-regional accommodation model is proposed based on time sequential simulation, considering the reserve of system, maintenance of units, trading power of two regions, power plan of conventional units and so on. An inter-regional system consisting of two IEEE 30 bus systems is used as an example. The sensitivity of influencing factors is analysed to prove the effectiveness and rationality of the proposed model. The research results could be available for dispatching agency to formulate the dispatching plan.

Accommodation in Early Presbyopes Fit with Bilateral or Unilateral Near Add.

When fit with monovision, most early presbyopes (aged 40 to 50 years) accommodated to near objects by focusing the distance corrected eye, leaving the near corrected eye myopically defocused with reduced image quality. A few were able to switch focus to the near corrected eye retaining a consistently focused image in one eye over a wider range of distances. The aim of this study was to examine accommodation behavior, pupil responses, and resultant image quality of early presbyopes fit with either bilateral or unilateral (monovision) near adds. Accommodative response and pupil size of 19 subjects (27 to 60 years), including 13 early presbyopes (40 to 50 years), were measured using an aberrometer as a binocularly viewed 20/40 letter E was moved from 2 m to 20 cm. Each subject was fit with different refractive strategies: bilateral distance correction, bilateral +2 diopters (D) near add, and unilateral +2 D near add placed over the measured right eye or unmeasured left eye. Monochromatic image quality was quantified using the Visual Strehl ratio metric. With bilateral +2 D near add, all early presbyopes mostly refrained from accommodating (gain = 0.22 D/D) until the target approached closer than the 50-cm far point, and they then accommodated accurately until their maximum accommodative amplitude was reached. With monovision, most (10 of 13 early presbyopes) accommodated to focus the distance corrected eye, leaving the near corrected eye myopically defocused with reduced image quality. As stimulus distance became closer than their distance corrected eye's near point, they continued to exert maximum accommodation. Only two early presbyopes relaxed their accommodation to "switch" focus to the near corrected eye as target distance was reduced, and these two did not experience bilateral drop in image quality as stimulus distance became closer than the near point of the distance corrected eye. Our data suggest that many early presbyopes will not initially adopt an accommodation strategy that optimizes image quality with monovision, but consistently accommodate to focus the distance corrected eye.

Risk–Based Admissibility Analysis of Wind Power Integration into Power System With Energy Storage System

The increasing high penetration of wind power will further increase the uncertainty in power systems, and three key issues should be addressed: 1) determining the maximum accommodation level of wind power without sacrificing system reliability; 2) quantifying the potential risk when the wind generation realization is beyond the prescribed uncertainty sets; and 3) how to reduce the risk loss. Motivated by these, a risk-based two-stage robust unit commitment (RUC) model is proposed to analyze the admissibility of wind power. In this model, the electricity storage system (ESS) is utilized for managing the wind power uncertainty to reduce the risk loss. Different from a determined uncertainty set in the previous RUC, the proposed method can flexibly adjust the uncertainty set by optimizing the operational risks including the wind spillage risk and load shedding risk. Conditional Value-at Risk (CVaR) is adopted to describe the risk loss when the real wind power output is beyond the predefined uncertainty set. Meanwhile, the low-probability, high-influence events are taken into the account based on CVaR to determine the optimal acceptable wind generation considering the tradeoff between reliability and economics. The proposed model is solved effectively by the modified column and constraint generation method. Case studies on two benchmark systems illustrate that the ESS can reduce the risk loss of power system and improve the ability to accommodate the uncertainty of wind generation.

Influence of Gravity on Ocular Lens Position.

We determined whether human ocular lens position is influenced by gravity. Anterior chamber depth (ACD) and lens thickness (LT) were determined with a Haag-Streit Lenstar LS900 for right eyes of participants in two age groups, with a young group of 13 participants aged 18 to 21 years (mean, 21 years; SD, 1 year) and an older group of 10 participants aged 50 to 63 years (mean, 58 years; SD, 4 years). There were two sessions for each participant separated by at least 48 hours, with one session for the usual upright head position and one session for a downwards head position. In a session, testing was done for minimum accommodation followed by testing at maximum accommodation. A drop of 2% pilocarpine nitrate was instilled, and testing was repeated after 30 minutes under minimum and maximum accommodation conditions. Gravity, manipulated through head posture, affected ACD for young adult and older adult groups but mean effects were only small, ranging from 0.04 to 0.12 mm, and for the older group required the instillation of an accommodation-stimulating drug. Gravity had a weakly significant effect on LT for the young group without accommodation or a drug, but the effect was small at 0.04 ± 0.06 mm (mean ± SD, P = 0.04). There is a small but real effect of gravity on crystalline lens position, manifested as reduction in ACD at high levels of accommodative effort with the head in a downwards position. This provides evidence of the ability of zonules to slacken during strong accommodation.

Stretch‐dependent changes in surface profiles of the human crystalline lens during accommodation: A finite element study

BackgroundA non‐linear isotropic finite element (FE) model of a 29‐year‐old human crystalline lens was constructed to study the effects of various geometrical parameters on lens accommodation.MethodsThe model simulates dis‐accommodation by stretching of the lens and predicts the change in surface profiles of the lens capsule, cortex and nucleus at select states of stretching/accommodation. Multiple regression analysis (MRA) is used to develop a stretch‐dependent mathematical model relating the lens sagittal height to the radial position of the lens surface as a function of dis‐accommodative stretch. A load analysis is performed to compare the finite element results to empirical results from lens stretcher studies. Using the predicted geometrical changes, the optical response of the whole eye during accommodation was analysed by ray‐tracing.ResultsAspects of lens shape change relative to stretch were evaluated, including change in diameter, central thickness and accommodation. Maximum accommodation achieved was 10.29-D. From the multiple regression analysis, the stretch‐dependent mathematical model of the lens shape related lens curvatures as a function of lens ciliary stretch well (maximum mean‐square residual error 2.5 × 10‐3 μm, p < 0.001). The results are compared with those from in vitro studies.ConclusionsThe finite element and ray‐tracing predictions are consistent with Ex Vivo Accommodation Simulator (EVAS) studies in terms of load and power change versus change in thickness. The mathematical stretch‐dependent model of accommodation presented may have utility in investigating lens behaviour at states other than the relaxed or fully accommodated states.

Changes in the objective amplitude of accommodation with pupil size.

We evaluate the effect of pupil size on objectively measured amplitude of accommodation (AA). Pupil diameter and wavefront aberrometry were obtained in 15 eyes when stimulus swept across the range of clear vision in steps of 0.5 diopters. Wavefront refraction techniques were used to compute objective AA as the maximum refractive change. Measurements were obtained monocularly under low and high ambient room lighting conditions with a fixed luminance of the fixation target. Amplitude of accommodation computations were performed taking into account just paraxial rays (paraxial AA) or including the effects of the change of spherical aberration during accommodation (minRMS AA). Mean pupil size values at low light level were 6.26 mm (relaxed) and 4.15 mm (maximum accommodation), whereas at the high light level, those values became 4.74 and 3.04 mm, respectively. The effects of both light level on accommodation were significant (p < 0.001), and accommodative miosis was slightly larger at low light levels. Mean minRMS and paraxial AA were always greater by more than 1 diopter in high than in low ambient lighting conditions (p < 0.01), indicating a significant impact of pupil size on AA. The influence of the ambient lighting on the objective AA is not only attributed to the increased effects of spherical aberration as the pupil dilates but mostly attributed to a decrease in the paraxial accommodation as pupil dilates.

Accommodation-induced variations in retinal thickness measured by spectral domain optical coherence tomography.

To research retinal stretching or distortion with accommodation, accommodation-induced changes in retinal thickness (RT) in the macular area were investigated in a population of young adults (n = 23) by using a dual-channel spectral domain optical coherence tomography (SD-OCT) system manufactured in-house for this study. This dual-channel SD-OCT is capable of imaging the cornea and retina simultaneously with an imaging speed of 24 kHz A-line scan rate, which can provide the anatomical dimensions of the eye, including the RT and axial length. Thus, the modification of the RT with accommodation can be calculated. A significant decrease in the RT (13.50 ± 1.25 μm) was observed during maximum accommodation. In the 4 mm × 4 mm macular area centered at the fovea, we did not find a significant quadrant-dependent difference in retinal volume change, which indicates that neither retinal stretching nor distortion was quadrant-dependent during accommodation. We speculate that the changes in RT with maximum accommodation resulted from accommodation-induced ciliary muscle contractions.

Evaluation of proximal gastric function in functional dyspepsia and its subtypes

Objective To evaluate proximal gastric function in patients with functional dyspepsia (FD) met Rome Ⅲ criteria and its subtypes.Methods Thirty FD patients were enrolled,including 15 patients with postprandial distress syndrome (PDS) and 15 patients with epigastric pain syndrome (EPS).A total of 30 healthy volunteers were recruited as control.All the subjects received barostat examination.Minimal distending pressure (MDP),pressure and volume of thresholds for first sensation and maximal tolerance for gastric sensitivity were recorded.When the pressure level was MDP+2 mmHg (1 mmHg=0.133 kPa),average volume at 30 minutes before meal,averaged volume at 60 minutes after meal and maximum accommodation volume after meal were recorded,and receptive diastolic volume was calculated.The gastric hypersensitivity and impaired accommodation were observed.Student's t test or x2 test was performed for statistical analysis.Results MDP,pressure of first-sensation,maximum sensation pressure,volume of first sensation and maximal sensation volume of FD group were (6.17 ±1.95) mmHg,(8.44±2.01) mmHg,(14.62±3.72) mmHg,(123.59±53.26) mL and (451.26±140.44) mL,respectively; which were lower than those of healthy control group ((9.27±1.99) mmHg,(12.04±2.66) mmHg,(19.74±4.18) mmHg,(168.41±73.06) mL and (556.89±124.07) mL),and the differences were statistically significant (t=-6.080,-5.900,-5.011,-2.723 and-2.995,all P＜0.01).The averaged volume at 30 minutes before meal and 60 minutes after meal was (212.19±120.82) mL and (333.97±121.86) mL while those of healthy control group was (191.69±66.19) mL and (385.58±83.05) mL,and there were no significant differences between the two groups (both P＞0.05).The maximum postprandial accommodation volume and receptive diastolic volume of FD group were (405.10±111.29) mL and (190.16±97.22) mL,which were lower than those of healthy control group ((461.10±87.60) mL and (262.83±78.39) mL),and the differences were statistically significant (t=-2.599 and-3.187,both P＜0.05).The maximum postprandial accommodation volume of FD patients was at 15 to 20 minutes after meal and in healthy control it was at five to ten minutes after meal.Among the 30 FD patients,12 patients (40 ％) had gastric hypersensitivity,including eight PDS patients and four EPS patients,and there was no significant difference in the ratio between two groups (P＞0.05) ;nine patients (30 ％) had impaired accommodation,including five PDS patients and four EPS patients,and there was no significant difference in the ratio between two groups (P＞ 0.05).Conclusions Gastric hypersensitivity and impaired accommodation often appear in FD patients,and there is no significant difference between PDS and EPS subtypes.FD patients with different pathophysiologic mechanisms cannot be efficiently distinguished according to Rome Ⅲ criteria. Key words: Functional dyspepsia; Visceral hypersensitivity; Gastric accommodation

Linked sequence stratigraphy and tectonics in the Sichuan continental foreland basin, Upper Triassic Xujiahe Formation, southwest China

Intracontinental subduction of the South China Block below the North China Block in the Late Triassic resulted in formation of the transpressional Sichuan foreland basin on the South China Block. The Upper Triassic Xujiahe Formation was deposited in this basin and consists of an eastward-tapering wedge of predominantly continental siliciclastic sedimentary rocks that are up to 3.5km thick in the western foredeep depocenter and thin onto the forebulge and into backbulge depocenters.Five facies associations (A–E) make up the Xujiahe Formation and these are interpreted, respectively, as alluvial fan, transverse and longitudinal braided river, meandering river, overbank or shallow lacustrine, and deltaic deposits. This study establishes a sequence stratigraphic framework for the Xujiahe Formation which is subdivided into four sequences (SQ1, 2, 3 and 4). Sequence boundaries are recognized on the basis of facies-tract dislocations and associated fluvial rejuvenation and incision, and systems tracts are identified based on their constituent facies associations and changes in architectural style and sediment body geometries. Typical sequences consist of early to late transgressive systems tract deposits related to a progressive increase in accommodation and represented by Facies Associations A, B and C that grade upwards into Facies Association D. Regionally extensive and vertically stacked coal seams define maximum accommodation and are overlain by early highstand systems tract deposits represented by Facies Associations D, E and C. Late highstand systems tract deposits are rare because of erosion below sequence boundaries. Sequence development in the Xujiahe Formation is attributed to active and quiescent phases of thrust-loading events and is closely related to the tectonic evolution of the basin. The Sichuan Basin experienced three periods of thrust loading and lithospheric flexure (SQ1, lower SQ2 and SQ3), two periods of stress relaxation and basin widening (upper SQ 2 and SQ3) and one phase of isostatic rebound (SQ4). Paleogeographic reconstruction of the Sichuan Basin in the Late Triassic indicates that the Longmen Mountains to the west, consisting of metamorphic, sedimentary and pre-Neoproterozoic basement granitoid rocks, was the major source of sediment to the foredeep depocenter. Subordinate sediment sources were the Xuefeng Mountains to the east to backbulge depocenters, and the Micang Mountains to the northwest during the late history of the basin. This study has demonstrated the viability of sequence stratigraphic analysis in continental successions in a foreland basin, and the influence of thrust loading on sequence development.

Comparison between carbachol iontophoresis and intravenous pilocarpine stimulated accommodation in anesthetized rhesus monkeys

Rhesus monkeys are an animal model for human accommodation and presbyopia and consistent and repeatable methods are needed to stimulate and measure accommodation in anesthetized rhesus monkeys. Accommodation has typically been pharmacologically stimulated with topical pilocarpine or carbachol iontophoresis. Intravenous (i.v.) pilocarpine has recently been shown to produce more natural, rapid and reproducible accommodative responses compared to topical pilocarpine. Here, i.v. pilocarpine was compared to carbachol iontophoresis stimulated accommodation. Experiments were performed under anaesthesia on five previously iridectomized monkeys aged 10–16 years. In three monkeys, accommodation was stimulated with carbachol iontophoresis in five successive experiments and refraction measured with a Hartinger coincidence refractometer. In separate experiments, accommodation was stimulated using a 5 mg/kg bolus of i.v. pilocarpine given over 30 s followed by a continuous infusion of 20 mg/kg/hr for 5.5 min in three successive experiments with the same monkeys as well as in single experiments with two additional monkeys. Refraction was measured continuously using photorefraction with baseline and accommodated refraction also measured with the Hartinger. In subsequent i.v. pilocarpine experiments with each monkey, accommodative changes in lens equatorial diameter were measured in real-time with video-image analysis. Maximum accommodation of three monkeys with carbachol iontophoresis (five repeats) was (mean ± SD; range) 14.0 ± 3.5; 9.9–20.3 D and with i.v. pilocarpine stimulation (three repeats) was 11.1 ± 1.1; 9.9–13.0 D. The average of the standard deviations of maximum accommodation from each monkey was 0.8 ± 0.3 D from carbachol iontophoresis and 0.3 ± 0.2 from i.v. pilocarpine. The average latency to the start of the response after carbachol iontophoresis was 2.5 ± 3.9; 0.0–12.0 min with a time constant of 12.7 ± 9.5; 2.3–29.2 min. The average latency after i.v. pilocarpine was 0.31 ± 0.03; 0.25–0.34 min with a time constant of 0.19 ± 0.07; 0.11–0.31 s. During i.v. pilocarpine stimulated accommodation in five monkeys, lens diameters decreased by 0.54 ± 0.09; 0.42–0.64 mm with a rate of change of 0.052 ± 0.002; 0.050–0.055 mm/D. Accommodative responses with i.v. pilocarpine were more rapid, consistent and stable than those with carbachol iontophoresis. The accommodative decrease in lens diameter with i.v. pilocarpine as a function of age was consistent with previous results using constant topical pilocarpine. Intravenous pilocarpine stimulated accommodation is safe, more consistent and more rapid than carbachol iontophoresis and it requires no contact with or obstruction of the eye thus allowing continuous and uninterrupted refraction and ocular biometry measurements.

Facies, sequence stratigraphy and reservoir/seal potential of a Jilh Formation outcrop equivalent (Wadi Sahtan, Triassic, Upper Mahil Member, Sultanate of Oman)

ABSTRACT The investigated Middle to Upper Triassic Upper Mahil Member, representing a Jilh outcrop equivalent in the Northern Oman Mountains, illustrates the proximal portion of a flat epeiric carbonate ramp. A sedimentological study of well-exposed outcrops in Wadi Sahtan may serve as a reference section for a sequence-stratigraphic framework and detailed facies description of the Upper Mahil Member. It also provides an insight into the seal and reservoir potential of carbonates in a low-accommodation inner ramp setting. Outcrop observations and thin section analyses yielded 14 different lithofacies types ranging from a supratidal marsh to high-energy subtidal shoal environment. Vertical facies stacking patterns show three basic small-scale cycle motifs (fifth-order). While mud-rich backshoal cycles with claystone intercalations and rooted/bioturbated mud-/wackestones illustrate potential baffles and seal units around the center of the Upper Mahil, potential reservoir units occur stratigraphically in the upper part of the formation. There, a few meter-thick trough cross-bedded oolitic-/peloidal-rich grainstone depicts maximum accommodation within backshoal to shoal cycle types below the erosional base-Jurassic unconformity. The investigated outcrop section in Wadi Sahtan was subdivided into nine almost complete third-order sequences. Two to four of these sequences are further stacked into three second-order super-sequences which are well reflected in the gamma-ray pattern. The highest reservoir potential occurs around second-order maximum floodings. Internal seals can be observed at third-order sequence boundaries where shales and muddy carbonates are up to 20 m thick. A regional correlation with subsurface data from Yibal and Lekhwair in Oman shows that the apparent thickness changes in the Upper Mahil (Jilh) are mainly determined by the Late Triassic/Early Jurassic erosional truncation. The occurrence of thick anhydrite units in the subsurface indicates a more proximal setting towards the southwest.

Reproducibility of carbachol stimulated accommodation in rhesus monkeys

Approaches are being explored to restore accommodation to the presbyopic eye. Some of these approaches can be tested in monkeys by stimulating accommodation in various ways including using carbachol iontophoresis. Knowledge of the repeatability of carbachol iontophoresis stimulated accommodation in the monkey phakic eye is necessary to understand the variability of this method of evaluating accommodation. Data from 9 to 10 separate carbachol iontophoresis experiments performed on phakic eyes from 8 monkeys were retrospectively analyzed. For each experiment, carbachol was applied iontophoretically to the eyes of anesthetized monkeys and refraction generally measured every two minutes until accommodation reached a plateau. Repeated experiments were performed in each monkey over periods ranging from 10 to 18 months. Maximum accommodation measured for each monkey ranged from 11.1 D to 18.3 D with standard deviations from 0.8 D to 2.1 D and differences in accommodative amplitude varying from 2.2 D to 7.5 D. Time to reach maximum accommodation ranged from 18 to 64 min in individual experiments. Averaged time-courses indicate that maximum accommodation is generally achieved between 10 and 20 min after carbachol administration. Although carbachol iontophoresis is considered a reliable method to stimulate maximum accommodation in anesthetized monkeys, the amplitude achieved typically varies by more than 2 D. Presbyopia treatments evaluated in this way in phakic monkeys would need to show an increase in accommodation of over 2 D to clearly demonstrate that the treatments work when being tested with carbachol iontophoresis stimulation.

Fallstricke bei der Bestimmung von Nahbrillen

People in the second half of their lives often require reading glasses. A basic requirement for determining suitable reading glasses is measurement of the patient's accommodation, which describes the change in the eye's optical power caused by the attempt to clearly focus on an object at a certain distance. The maximum accommodation performance of a person already begins to decline from the age of 40 onwards. When it becomes increasingly difficult to adjust to the typical reading distance of 40 cm, one speaks of presbyopia: age-related farsightedness. This contribution describes two appropriate methods for determining the strength of reading glasses: determination of the maximum accommodation performance by measuring the near point distance and determination of the maximum accommodation effort by measuring the relative positive and negative accommodation. Optimal reading glasses enable the patient to focus sharply on something from the working distance that is closer but also on something that is further away.

Facies evolution and sequence chronostratigraphy of a “mid”-Cretaceous shallow-water carbonate succession of the Apulia Carbonate Platform from the northern Murge area (Apulia, southern Italy)

The “mid”-Cretaceous carbonate succession of the Apulia Carbonate Platform cropping out in northern Murge area (Apulia, southern Italy) is composed of shallow-water carbonate rocks and is over 400 m in thickness. This paper focuses on the lithofacies analysis of this carbonate succession, its paleoenvironmental interpretation, and its sequence-chronostratigraphic architecture. Lithofacies analysis permitted to identify deposits which can be grouped into the following three facies belts: (1) terrestrial facies belt formed by: intraclast-supported paleosoils; solution-collapse breccias; (2) restricted facies belt made up of lithofacies deposited in protected peritidal environments; (3) normal-marine facies belt made up of lithofacies formed in moderate- to high-energy subtidal environments. The detailed study both in outcrops and in thin-sections revealed that, at the bed scale, lithofacies are cyclically arranged and form shallowing-upward small-scale depositional sequences comparable to parasequences and/or simple sequences. The following three small-scale sequence types have been distinguished: (1) subtidal sequences mostly made up of lithofacies formed in the normal-marine open subtidal domain; (2) peritidal sequences made up of lithofacies formed in the restricted peritidal domain; (3) peritidal sequences showing a cap formed by paleosoils. Small-scale sequences are not randomly arranged in the compiled succession but form discrete packages, or sets, that alternate in the sedimentary record. The repetition of such small-scale sequence packages in the succession has been the key to recognize large-scale sequences comparable to third-order depositional sequences. Although sedimentological data are often fragmentary due to late dolomitization, four large-scale sequences have been distinguished. The data support a generalized landward-backstepping of facies belts during transgression, which implies a gradual gain of accommodation culminating with the deposition of a package of small-scale sequences formed by normal-marine subtidal deposits. These mark periods of maximum accommodation space and form the maximum-flooding zones of large-scale sequences. A gradual seaward progradation of facies belts is recorded during highstand conditions, which implies a gradual loss of accommodation culminating with the deposition of a package of peritidal small-scale sequences capped by paleosoils or by solution-collapse breccias. The occurrence of terrestrial deposits marks periods of minimum accommodation on the platform and determines the sequence boundary of large-scale sequences. The large-scale sequences identified in this study fit with the main transgressive/regressive cycles published in the sequence-chronostratigraphic chart of European basins. As a consequence, it is interpreted that changes of the sea level recorded at the scale of European basins played an important role in determining the sequence-stratigraphic architecture of the studied succession. In spite of this, the occurrence of solution-collapse breccias, which implies a significant gap in carbonate sedimentation in between Early and Middle Cenomanian times, may also have an alternative interpretation. In particular, this deposit may represent the local fingerprint of the well-known tectonic phase which, during Late Albian-Early/Middle Cenomanian times, determined the subaerial exposure of large parts of Periadriatic carbonate platforms producing a marked regional unconformity.

Analysis and applications of accommodative lenses for vision corrections

Analysis and applications of vision correction via accommodating intraocular lens (AIOL) are presented. By Gaussian optics, analytic formulas for the accommodation rate function (M) for two-optics and three-optics systems are derived and compared with the exact numerical results. In a single-optics AIOL, typical value of M is (0.5-1.5) D∕mm, for an IOL power of (10-20) diopter. For a given IOL power, higher M is achieved in positive-IOL than negative-IOL. In the dual-optics AIOL, maximum accommodation is predicted when the front positive-optics moves toward the corneal plan and the back negative-optics moves backward. Our analytic formulas predict that greater accommodative rate may be achieved by using a positive-powered front optics, a general feature when either front or back optics is mobile. The M function is used to find the piggy-back IOL power for customized design based on the individual ocular parameters. Many of the new features demonstrated in this study can be easily realized by our analytic formulas, but not by raytracing method.

PLURALIST CONSTITUTIONALISM

AbstractThis essay explores the ways in which a broadly pluralist outlook can help illuminate longstanding issues of constitutional theory and practice. It begins with a common-sense understanding of pluralism as the diversity of observed practices within a general category (section 2). It turns out that many assumptions Americans and others often make about constitutional essentials are valid only locally but not generically. The essay then turns to pluralism in a more technical and philosophical sense—specifically, the account of value pluralism adumbrated by Isaiah Berlin and developed by his followers. Section 3 sketches this version of pluralism, and section 4 brings it to bear on a range of familiar constitutional issues. In the process, a distinction emerges between, on the one hand, areas of variation among constitutions and, on the other, some general truths about political life that define core constitutional functions. The essay concludes (section 5) with some brief reflections on the normative thrust of pluralist constitutional theory—in particular, a presumption in favor of the maximum accommodation of individual and group differences consistent with the maintenance of constitutional unity and civic order.

Lithostratigraphy, sedimentation and evolution of the Volta Basin in Ghana

We present a revised lithostratigraphy for the Voltaian Supergroup of Ghana, based on a review of existing literature, interpretations of remotely sensed data and reconnaissance field survey of the Volta Basin. These strata thicken eastwards, to a maximum of between 5 and 6 km adjacent to the Pan-African Dahomeyide orogen. They began to accumulate some time after about 1000 Ma, along the margin of an epicontinental sea. Initial sedimentation, comprising the age-equivalent Kwahu and Bombouaka Groups, shows a cyclical mode of deposition controlled by eustatic changes in sea-level that produced a range of nearshore marine, littoral and terrestrial environments. A major erosional interval was followed by deposition of the 3–4 km thick Oti-Pendjari Group. Basal tillites and associated sandy diamictons are correlated with the Marinoan (end-Cryogenian) glaciation, indicating a maximum depositional age of about 635 Ma. The overlying cap carbonates and tuffs were deposited within a shallow epeiric sea bordered by a volcanically active rift system. The main part of the group records the transition from a rifted passive margin to a fully developed foreland basin receiving marine flysch in the form of argillaceous strata interbedded with highly immature wacke-type sandstones and conglomerates. Maximum accommodation space was developed within a foredeep adjacent to the Dahomeyide belt. Towards the end of the orogenic phase, the foredeep succession became partially inverted and then was buried under coarse terrestrial, red-bed molasse of the Obosum Group.

Influence of Amplitude, Starting Point, and Age on First- and Second-Order Dynamics of Edinger-Westphal–Stimulated Accommodation in Rhesus Monkeys

In humans, accommodative and disaccommodative dynamics depend on response amplitude and starting point. The purpose of this study was to determine the influence of amplitude and starting point on open-loop accommodative dynamics in Edinger-Westphal (EW)-stimulated, anesthetized rhesus monkeys of different ages. One eye each of two younger and two older iridectomized rhesus monkeys, (aged 6.8, 8.9, 15.0, and 16.3 years) were studied. The experiment was repeated in one eye of one younger monkey. Lens thickness changes were recorded by dynamic ultrasound biometry at 100 Hz. Stimuli used produced accommodative responses: (1) starting from baseline with increasing amplitudes; (2) from increasing starting points to maximum accommodation; and (3) from increasing starting points with a constant amplitude of 1 D. The lens thickness measurements were converted into accommodation and velocities and accelerations of the responses were determined by using a two-point difference algorithm. Maximum accommodative amplitudes ranged from 4.68 to 6.37 D in the older monkeys and 9.33 to 11.59 D in the younger monkeys. The peak velocity of accommodation and disaccommodation increased linearly with response amplitude. Peak velocity and peak acceleration of accommodation and disaccommodation were independent of the response starting point. Subtle variations in disaccommodative response peak velocities were found to vary with age. The results suggest that, in anesthetized rhesus monkeys, disaccommodative rather than accommodative dynamics may be more sensitive to age-related changes and that, unlike in conscious human subjects, the starting configuration of the accommodative plant has little influence on accommodative dynamics.

Topical and intravenous pilocarpine stimulated accommodation in anesthetized rhesus monkeys

Many studies have used pilocarpine to stimulate accommodation in both humans and monkeys. However, the concentrations of pilocarpine used and the methods of administration vary. In this study, three different methods of pilocarpine administration are evaluated for their effectiveness in stimulating accommodation in rhesus monkeys. Experiments were performed in 17 iridectomized, anesthetized rhesus monkeys aged 4–16 years. Maximum accommodation was stimulated in all these monkeys with a 2% pilocarpine solution maintained on the cornea for at least 30 min in a specially designed perfusion lens. In subsequent topical pilocarpine experiments, baseline refraction was measured with a Hartinger coincidence refractometer and then while the monkeys were upright and facing forward, commercially available pilocarpine (2, 4, or 6%) was applied topically to the cornea as 2 or 4 drops in two applications or 6 drops in three applications over a five minute period with the eyelids closed between applications. Alternatively, while supine, 10–12 drops of pilocarpine were maintained on the cornea in a scleral cup for 5 min. Refraction measurements were begun 5 min after the second application of pilocarpine and continued for at least 30 min after initial administration until no further change in refraction occurred. In intravenous experiments, pilocarpine was given either as boluses ranging from 0.1 mg/kg to 2 mg/kg or boluses followed by a constant infusion at rates between 3.06 mg/kg/h and 11.6 mg/kg/h. Constant 2% pilocarpine solution on the eye in the perfusion lens produced 10.88 ± 2.73 D (mean ± SD) of accommodation. Topically applied pilocarpine produced 3.81 D ± 2.41, 5.49 D ± 4.08, and 5.55 D ± 3.27 using 2%, 4%, and 6% solutions respectively. When expressed as a percentage of the accommodative response amplitude obtained in the same monkey with constant 2% pilocarpine solution on the eye, the responses were 34.7% for 2% pilocarpine, 48.4% for 4% pilocarpine, and 44.6% for 6% pilocarpine. Topical 4% and 6% pilocarpine achieved similar, variable accommodative responses, but neither achieved maximum accommodation. IV boluses of pilocarpine achieved near maximal levels of accommodation at least ten times faster than topical methods. Doses effective for producing maximum accommodation ranged from 0.25 mg/kg to 1.0 mg/kg. IV pilocarpine boluses caused an anterior movement of the anterior lens surface, a posterior movement of the posterior lens surface, and a slight net anterior movement of the entire lens. Considerable variability in response amplitude occurred and maximum accommodative amplitude was rarely achieved with topical application of a variety of concentrations of commercially available pilocarpine. Intravenous infusion of pilocarpine was a rapid and reliable method of producing a nearly maximal accommodative response and maintaining accommodation when desired.