To compare the maximum occlusal force in endodontically treated teeth and their vital contralateral counterparts and to evaluate the intraoral factors affecting them. Thirty adult participants presented with an endodontically treated tooth and its vital contralateral counterpart were recruited, with 15 males and females in each group. Maximum occlusal forces were measured using a wireless sensor network occlusal force recorder, and the mean maximum occlusal force of endodontically treated teeth was compared with that of their vital contralateral counterparts. Multiple-factor ANOVA was used to examine the association between various clinical factors and maximum occlusal force. The mean maximum occlusal force for endodontically treated teeth was significantly higher than their vital counterparts (215.44 ± 74.11N and 202.40 ± 70.67N, respectively) (P < 0.001). Among the clinical factors, the maximum occlusal forces were significantly influenced by the location of teeth (P < 0.01) and the crown root ratio (P = 0.01). Upon further analysis of endodontically treated teeth and control groups, the location of teeth was identified as a sole factor associated with maximum occlusal force, with P < 0.05. The maximum occlusal forces for endodontically treated teeth were statistically significantly higher than those of their corresponding vital contralateral teeth.