In case of surgical interventions requiring significant modifications of the bone crest or the removal of all the teeth, with alteration of the soft tissues, it is difficult to have accurate and stable landmarks to match the pre-surgical and the post-surgical digital impressions taken to prepare a fixed full-arch prosthesis on immediate loading dental implants. Therefore, the purpose of this study was to introduce a reliable method to overcome such a problem and realize a fixed full-arch prosthesis on immediate loading dental implants by the use of a complete digital workflow. Prior to the surgical procedure and the digital impressions, two unique skeletal scan bodies, each one combined with a mini-implant, are positioned distally in the dental arch (one left and one right) where the dental implants are placed, to provide distinctive landmarks that remain unchanged after surgery. Such procedure allows a perfect matching between the pre-surgical and post-surgical scans, maintaining the information of the patient's habitual occlusion in maximum intercuspation. The use of the skeletal scan bodies enables the oral surgeon to add the data of the patient's maxillo-mandibular relationship to the digital workflow. The present protocol allows to achieve the position of the implants and the patient's maxillo-mandibular relationship in maximum intercuspation in the three dimensions with a single digital scan.