Backgrounds and objectives: Loss of any maxillofacial subunit will certainly pose a functional, esthetic, and psychological problems. In addition, the mode of fixation of prosthesis is of major concern. This research aimed to study the role of dental implant in fixing maxillofacial prosthesis. Method: A retrospective hospital-based study was designed from June 2019 to January 2023. Maxillofacial prosthetic unit is the only center in the region treating patients with lost maxillofacial subunits. Inclusion criteria were, 18 years old or above, patients who lost facial structure unit/s (mandible, maxilla, orbit, nose, auricle, etc...). Cone beam CT was used for implant site planning. All the surgeries of implant placement were done under local anesthesia through full thickness skin flaps. Implants were placed 1cm away from each other for hygienic purposes and at least 7mm away from hairy skin. Result: A total of 28 implants were used for prosthetic rehabilitation of 10 patients (7 males and 3 females) with age range of 27-70 years. All the implants passed the period of healing and the follow up period after prosthetic rehabilitation successfully with 0% failure. No unwanted sequel like skin infection or peri implantitis or pain is reported. Conclusion: Dental implant considered the best mode of fixation in maxillofacial rehabilitation with best functional, esthetic and psychological outcomes. Keywords: dental implant, rehabilitation, prosthesis, maxillofacial defects.