Maxillary Sinus Carcinoma Research Articles

Multidisciplinary therapy consisting of minimally invasive resection, irradiation, and intra‐arterial infusion of 5‐fluorouracil for maxillary sinus carcinomas

Current goals for the treatment of maxillary sinus carcinoma include the preservation of vision, eating, communication, and appearance, as well as the achievement of a cure. Japanese patients (n = 121) with maxillary sinus carcinoma were analyzed retrospectively. All patients underwent multidisciplinary therapy including minimally invasive resection, 20 Gy irradiation, and intra-arterial infusion of 5-fluorouracil. The 5- and 10-year overall survival rates were 73% and 68%, respectively. In 97 patients with squamous cell carcinoma (SCC), the 5- and 10-year overall survival rates were 76% and 70%, respectively. All 29 patients with orbital invasion retained the orbital contents, and 21 of these patients demonstrated adequate visual acuity. There were 16 complications, including trismus (5 patients), double vision (5 patients), fistula formation (3 patients), and cataract (3 patients). A multidisciplinary therapy, consisting of minimally invasive resection, irradiation, and regional chemotherapy, can yield good patient prognosis and quality of life after treatment.

The functional significance of microRNA-375 in human squamous cell carcinoma: aberrant expression and effects on cancer pathways

MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules consisting of 19-22 nucleotides that are involved in a variety of biological processes, including development, differentiation, apoptosis and cell proliferation. In cancer research, a growing body of evidence has indicated that miRNAs are aberrantly expressed in many types of human cancers and can function either as tumor suppressors or oncogenes. Bioinformatic predictions suggest that miRNAs regulate more than 30% of protein-coding genes. Aberrant expression of miRNAs in cancer cells causes destruction of miRNA-regulated messenger RNA networks. Therefore, the identification of miRNA-regulated cancer pathways is important for understanding the molecular mechanisms of human cancer. Searching for the aberrant expression of miRNAs in cancer cells is the first step in the functional analysis of miRNAs in cancer cells. Genome-wide miRNA expression signatures can rapidly and precisely reveal aberrant expression of miRNA in cancers. The miRNA expression signatures of human cancers have revealed that miR-375 is significantly downregulated in cancer cells. Our recent data on maxillary sinus, hypopharyngeal and esophageal squamous cell carcinomas have suggested that miR-375 is frequently downregulated and functions as a tumor suppressor that targets several oncogenic genes in cancer cells. In this review, we focus on several types of human squamous cell carcinoma and describe the aberrant expression of miRNAs and the cancer pathways they regulate in these diseases.

Neoadjuvant chemotherapy followed by definitive local treatment in locally advanced carcinoma maxillary sinus.

5585 Background: Locally advanced carcinoma of maxillary sinus has been historically reported to have poor prognosis. We evaluated the role of neoadjuvant chemotherapy in improving the outcome in these patients. Methods: 41 patients with locally advanced borderline resectable (stage IVa) or unresectable maxillary carcinoma (stage IVb) were treated with induction chemotherapy between 2008 and 2011. The protocol included 2 cycles of chemotherapy, response assessment and multidisciplinary clinic review for definitive local treatment. The demographic profile, response to induction therapy, toxicity of chemotherapy, definitive treatment received, time to treatment failure (TTF) and overall survival (OS) were analysed. Univariate and multivariate analysis was performed to determine factors associated with response, TTF and OS. Results: The cohort of 41 patients had a median age of 48 years (22-71) with male preponderance (80.5%). The chemotherapy included two drugs (platinum and taxane) in 34 patients (82.9%) and three drugs (platinum, taxane and 5 FU) in 7(17.1%) The taxane utilized was docetaxel in 22 patients (53.7%) and paclitaxel in 19 patients (46.3%). There was no complete response, stable disease in 18 (43.9%), partial response in 16 (39%), and progression in 7 (17.1%) patients. All patients competed two cycles of chemotherapy, adequate dose intensity was maintained in 33 patients (78%) and there were no deaths. Post-induction, the treatment planned included surgery in 12 (29.3%), CT-RT in 24 (58.5%), radical RT in 1 (2.4%), palliative RT in 1 (2.4%) and palliative chemotherapy in 3 ( 7.3%) patients. Overall, the median TTF was 10.2 months. With 16 deaths, the median OS was not reached. Only response post-induction was significantly associated with better TTF (p=0.02). Grade 3 tumor (p=0.04) and baseline serum albumin more than 4 mg/dl (p=0.02) were associated with better OS. Grade 3-4 neutropenia, febrile neutropenia and loose motions were seen in 21.1%, 23.8% and 15.8% respectively. Conclusions: In unresectable maxillary carcinoma, induction chemotherapy has clinically significant benefit with acceptable toxicity. Response to induction was the only significant factor for improved TTF.

Myoepithelial Carcinoma in Maxilla: A Rare Case Report

ABSTRACT Myoepithelial carcinoma (MC) is an extremely rare neoplasm of salivary gland. It is usually found in parotid gland. Here, we report a rare case of myoepithelial carcinoma of maxillary sinus along with discussion of clinical, histopathological and immunohistochemical characteristics of this rare disease. How to cite this article Das C, Singh MK, Majumder A, Das S, Hazra TK. Myoepithelial Carcinoma in Maxilla: A Rare Case Report. Clin Rhinol Int J 2012;5(1):35-37.

Bladder Metastasis From Maxillary Sinus Undifferentiated Carcinoma: A Rare Case

We report the rare case of a 72-year-old woman with maxillary sinus undifferentiated carcinoma with metachronous metastasis localized to the bladder. Bladder metastases and maxillary sinus carcinoma are rare tumors. The bladder is not 1 of the usual sites of distant extension for parasinus tumors. To our knowledge, no data have been reported regarding bladder metastasis originating from a maxillary sinus carcinoma.

Unusual spinal metastases from an adenoid cystic carcinoma of the maxillary sinus

Adenoid cystic carcinoma (ACC), the second most common cancer occurring in the sinonasal tract, is an aggressive malignancy with a poor five-year survival rate. Spinal metastases to the vertebral column related to this cancer are rare. This report presents a patient with maxillary sinus carcinoma with vertebral metastases at the thoracic level and compression of the spinal cord seven years after surgical resection of the primary tumor. Eleven years after detection of the primary tumor the patient is still able to walk. The role of decompression and/or fusion in spinal metastases with neurologic deficits is still under debate, although recent studies have confirmed the beneficial role of surgical intervention in selected patients. This report represents an example of modern individual treatment of an aggressive tumor in a palliative situation. The epidemiology, clinical findings, treatment and outcome of this atypical distant metastasis in long-term survivors are presented.

Late temporal lobe necrosis after conventional radiotherapy for carcinoma of maxillary sinus

Cerebral radiation necrosis is a serious late complication after conventional radiotherapy that can present with focal neurologic deficits or with more generalized signs and symptoms of increased intracranial pressure, depending on the location. The incidence and severity of radionecrosis are dose-volume dependent. We report a case of cerebral radiation necrosis 5years after radiotherapy for a maxillary sinus carcinoma.

Well-differentiated squamous cell carcinoma of maxillary sinus

Well-differentiated squamous cell carcinoma of maxillary sinus

High-grade mucoepidermoid carcinoma of maxillary sinus

Malignant tumors of the paranasal sinus are uncommon, constituting less than 1% of all malignancies and 3% of all head and neck cancers. Nonsquamous cancers of the maxillary sinus are even rarer as is evident from the limited data available on the clinical characteristics and outcomes. Mucoepidermoid carcinoma accounts for 13% of all malignancies occurring in maxillary sinus. We report a rare case of high-grade mucoepidermoid carcinoma of maxillary sinus in a 45-year-old female along with review of the literature.

Water-filled balloon in the postoperative resection cavity improves dose distribution to target volumes in radiotherapy of maxillary sinus carcinoma

Postoperative radiotherapy is a major treatment for patients with maxillary sinus carcinoma. However, the irregular resection cavity poses a technical difficulty for this treatment, causing uneven dose distribution to target volumes. In this study, we evaluated the dose distribution to target volumes and normal tissues in postoperative intensity-modulated radiotherapy (IMRT) after placing a water-filled balloon into the resection cavity. Three postoperative patients with advanced maxillary sinus carcinoma were selected in this trial. Water-filled balloons and supporting dental stents were fabricated according to the size of the maxillary resection cavity. Simulation CT scans were performed with or without water-filled balloons, IMRT treatment plans were established, and dose distribution to target volumes and organs at risk were evaluated. Compared to those in the treatment plan without balloons, the dose (D98) delivered to 98% of the gross tumor volume (GTV) increased by 2.1 Gy (P = 0.009), homogeneity index (HI) improved by 2.3% (P = 0.001), and target volume conformity index (TCI) of 68 Gy increased by 18.5% (P = 0.011) in the plan with balloons. Dosimetry endpoints of normal tissues around target regions in both plans were not significantly different (P > 0.05) except for the optic chiasm. In the plan without balloons, 68 Gy high-dose regions did not entirely cover target volumes in the ethmoid sinus, posteromedial wall of the maxillary sinus, or surgical margin of the hard palate. In contrast, 68 Gy high-dose regions entirely covered the GTV in the plan with balloons. These results suggest that placing a water-filled balloon in the resection cavity for postoperative IMRT of maxillary sinus carcinoma can reduce low-dose regions and markedly and simultaneously increase dose homogeneity and conformity of target volumes.

Utility of intraoral washing cytology as a diagnostic technique in maxillary sinus carcinoma with oral invasion

CytopathologyVolume 24, Issue 1 p. 67-69 Correspondence Utility of intraoral washing cytology as a diagnostic technique in maxillary sinus carcinoma with oral invasion Y. Nishimura, Y. Nishimura Division of Clinical Cytology, Department of Medical Laboratory, School of Allied Health Sciences, Kitasato University, Kanagawa, JapanSearch for more papers by this authorM. Hattori, M. Hattori Division of Clinical Cytology, Department of Medical Laboratory, School of Allied Health Sciences, Kitasato University, Kanagawa, JapanSearch for more papers by this authorM. Ohbu, M. Ohbu Division of Clinical Cytology, Department of Medical Laboratory, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan Division of Pathology, Department of Medical Laboratory, School of Allied Health Sciences, Kitasato University, Kanagawa, JapanSearch for more papers by this authorM. Kobayashi, M. Kobayashi Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, Kanagawa, JapanSearch for more papers by this authorH. Konishi, H. Konishi Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, Kanagawa, JapanSearch for more papers by this authorH. Miyazaki, H. Miyazaki Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, Kanagawa, JapanSearch for more papers by this authorE. Kubota, E. Kubota Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, Kanagawa, JapanSearch for more papers by this authorN. Kubota, N. Kubota Department of Diagnostic Pathology, Kanagawa Dental College Hospital, Kanagawa, JapanSearch for more papers by this author Y. Nishimura, Y. Nishimura Division of Clinical Cytology, Department of Medical Laboratory, School of Allied Health Sciences, Kitasato University, Kanagawa, JapanSearch for more papers by this authorM. Hattori, M. Hattori Division of Clinical Cytology, Department of Medical Laboratory, School of Allied Health Sciences, Kitasato University, Kanagawa, JapanSearch for more papers by this authorM. Ohbu, M. Ohbu Division of Clinical Cytology, Department of Medical Laboratory, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan Division of Pathology, Department of Medical Laboratory, School of Allied Health Sciences, Kitasato University, Kanagawa, JapanSearch for more papers by this authorM. Kobayashi, M. Kobayashi Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, Kanagawa, JapanSearch for more papers by this authorH. Konishi, H. Konishi Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, Kanagawa, JapanSearch for more papers by this authorH. Miyazaki, H. Miyazaki Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, Kanagawa, JapanSearch for more papers by this authorE. Kubota, E. Kubota Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, Kanagawa, JapanSearch for more papers by this authorN. Kubota, N. Kubota Department of Diagnostic Pathology, Kanagawa Dental College Hospital, Kanagawa, JapanSearch for more papers by this author First published: 25 October 2011 https://doi.org/10.1111/j.1365-2303.2011.00933.xCitations: 1 Y. Nishimura, Division of Clinical Cytology, Department of Medical Laboratory, School of Allied Health Sciences, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan Tel.: +81-42-778-9633; Fax: +81-42-778-9648; E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume24, Issue1February 2013Pages 67-69 RelatedInformation

A case of carcinoma of maxillary sinus treated by multidisciplinary therapy

A case of carcinoma of maxillary sinus treated by multidisciplinary therapy

Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus: A Retrospective Study

Squamous cell carcinoma of the maxillary sinus is locally infiltrating tumors, and most tumors are diagnosed at a locally advanced stage after the involvement of adjacent structures. Therefore, local control is the most important factor in obtaining a cure. The purpose of this study was to assess the efficacy radiation therapy for Squamous cell carcinomas of the maxillary sinus at Kobe University Hospital retrospectively.

8566 POSTER Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus – a Retrospective Study

8566 POSTER Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus – a Retrospective Study

Pulmonar collision tumor: Metastatic adenoid cystic carcinoma and lung adenocarcinoma

We report an extraordinary case of collision tumor consisting of a lung adenocarcinoma and a metastatic adenoid cystic carcinoma in a 56 year-old man. He was diagnosed with a pulmonary nodule 11 years after treatment of an adenoid cystic carcinoma of the right maxillary sinus. A non-small cell carcinoma was observed when a transbronchial biopsy was performed. The other component of the nodule was only diagnosed with pathological examination of the resection specimen.

Adenoid cystic carcinoma of maxillary sinus: diagnosis, treatment and prognostic factors

To study the clinical characters, the outcomes of treatments and the factors affecting long-term treatment results of adenoid cystic carcinoma (ACC) of the maxillary sinus. The clinical data of 80 patients with ACC of the maxillary sinus treated initially were analyzed retrospectively. Survival rate, local recurrence and distant metastasis were analyzed using Kaplan-Meier method. Prognosis factors were analyzed by Log-rank test and Cox regression. The 5-, 10- and 15-year cumulative overall survival rates were 65.2%, 37.1%, 26.3% respectively and 5-, 10-, and 15-year disease-free survival rates 50.7%, 30.7% and 24.5% respectively. The 5-, 10- and 15-year cumulative local control rates were 68.5%, 47.3% and 47.3% respectively and the cumulative distant metastasis rate were 32.8%, 48.8% and 48.8% respectively. Prognostic factors affecting survival included T stage, pathologic grade and the modes of treatment (P < 0.05). Patients with combined therapy composed of surgery and radiation had a better local control, compared with surgery or radiation alone (χ(2) = 18.33, P < 0.01), and surgery combined with postoperative radiation was prior to preoperative radiation combined with surgery (χ(2) = 6.64, P < 0.05). Patients treated with surgery combined with preoperative radiation, either with doses of ≥ 60 Gy or with negative margins, had a better local control, compared with doses < 60 Gy and with positive margins (χ(2) = 5.06, P < 0.05). The most of patients (62.8%) died of local recurrence. The most of failure was due to recurrence. Combined therapy composed of surgery and radiation improves the local control and survival in patients with ACC of the maxillary sinus, compared with surgery or radiation alone. Surgery combined with postoperative radiation provides the best overall survival and local control and should be the first choice of treatments.

A colliding maxillary sinus cancer of adenosquamous carcinoma and small cell neuroendocrine carcinoma - a case report with EGFR copy number analysis

BackgroundSmall cell neuroendocrine carcinoma (SNEC) of maxillary sinus is a rare and aggressive malignancy. A tumor with squamous cell carcinoma, adenocarcinoma and SNEC co-existence is extremely rare.Case presentationWe present a colliding tumor of squamous cell, adenocarcinoma and SNEC in maxillary sinus. The clinical features, diagnosis and EGFR flourescence in situ hybridization (FISH) study are presented. A 52-year-old female had a 1-month history of progressing left cheek swelling and purulent rhinorrhea. Magnetic resonance imaging showed a tumor involving left maxilla and orbital floor. Excision of tumor was done and the defect was reconstructed with free flap. The pathology revealed a malignant tumor composed of squamous cell carcinoma, adenocarcinoma and SNEC components. EGFR FISH study showed no gene amplification in 3 components of this tumor. The tumor progressed rapidly and the patient expired at 8 months after surgery.ConclusionA colliding tumor of squamous cell, adenocarcinoma and neuroendocrine carcinoma in maxillary sinus was aggressive in behavior and the treatment response was poor due to the complexity of tumor.

Definitive Radiotherapy With or Without Chemotherapy for T3-4N0 Squamous Cell Carcinoma of the Maxillary Sinus and Nasal Cavity

To evaluate the efficacy and toxicity of definitive radiotherapy with or without chemotherapy for T3-4 squamous cell carcinoma of maxillary sinus and nasal cavity. Forty-two patients with T3-4N0 squamous cell carcinoma of maxillary sinus (n = 30) and nasal cavity (n = 12) received definitive radiotherapy. Chemotherapy was used in 34 patients and elective neck irradiation was not used. The 5-year overall survival/local control rates were 34%/29% for maxillary sinus cancer and 50%/52% for nasal cavity cancer. For maxillary sinus cancers, a performance status of Eastern Cooperative Oncology Group >or=2 (P = 0.012), biologically equivalent dose <68 Gy (P = 0.011) and no use of chemotherapy (P = 0.037) were significant worse predictors for overall survival on log-rank analysis. Biologically equivalent dose <68 Gy was independently associated with poor local control (hazard ratio, 3.32; 95% confidence interval, 1.38-7.97; P = 0.007) and overall survival (hazard ratio, 2.94; 95% confidence interval, 1.23-7.01; P = 0.015). Regional recurrence occurred in only 1 of 30 patients with maxillary sinus cancer and 4 of 12 patients with nasal cavity. Two radiation necrosis in brain, one osteoradionecrosis, and one retinopathy and optic neuropathy occurred. The treatment outcome was poor and local control was a major problem. High radiation dose, effective chemotherapy and elective neck irradiation for advanced nasal cavity cancers may improve disease control.

Results of Treatment of Squamous Cell Carcinoma of Maxillary Sinus: A 26-Year Experience.

BackgroundFive-year survival in squamous cell carcinoma of maxillary antrum is low. This article examines the results of various approaches to treatment as given in our hospital in past 26 years.MethodsFrom 1979 to 2005, 379 patients with squamous cell carcinoma of maxillary antrum managed with curative intent were studied. Twenty-eight patients had T2, 237 patients had T3, and 114 had T4 tumors. The N classification was N0 in 316 patients, N1 in 21 patients, N2a in 28 patients and N2b in 14 patients. Treatment to the primary site comprised of surgery (Sx) and radiation therapy (RT) in 284 patients, RT alone in 57 patients and chemotherapy (CTx) with radiotherapy in 38 patients.ResultsThere was a difference in survival between patients who underwent Sx with RT compared with patients who received RT alone or CTx with RT. The most common pattern of recurrence was in the primary site, 187 (49.3%) patients. Local control at 3 and 5 years was 71% and 63.8% respectively in Sx with RT, 31.6% and 28% respectively in RT, and 28.9% and 26% in CTx with RT group.ConclusionsThe type of treatment to the primary site is an important determinant of survival and local control. Surgery with radiation is a better treatment option.

上顎洞癌に対する超選択的動注化学療法併用放射線療法の検討

1998年より2008年まで当科に入院し放射線同時併用超選択的動注化学療法を施行した上顎洞扁平上皮癌14例に対して一次治療効果，有害事象について検討を行った。対象は年齢が43歳から79歳（中央値61歳），男性10例，女性4例であった。Seldinger法により超選択的動注化学療法を施行し，CDDPを総計200mg/m2動注した。day 2からday 5まで5-FU 800mg/m2の全身投与を併用した。また，放射線治療はday 2より同時併用とした。予定された超選択的動注化学療法併用放射線療法が終了した4週間後に肉眼所見，画像所見，病理組織検査所見を参考に判定を行った。一次治療効果はCR 57.1%（8例），PR 42.9%（6例），奏功率は 100%であった。有害事象ではgrade 4の脳梗塞が1例出現した。しかし，それ以外は全て可逆性で重篤な有害事象はみられなかった。安全性に関して許容範囲内であると考えられた。今後は症例と経過を重ねることで治療成績を検討していく予定である。