The present study evaluated the optimal force for orthodontic intrusive mechanics of a tooth with different levels of periodontal support reduction using a finite element analysis (FEA) approach. An anatomical 3D model was constructed representing a second unirradicular premolar inserted into a maxillary bone segment. Based on the control model, three horizontal bone resorption conditions were simulated with alveolar bone height loss of 2 mm, 4 mm, and 6 mm (R2, R4, and R6, respectively). An 25 cN intrusive force was used for the two simulated mechanics: bilateral mini-implant intrusion and conventional intrusion. A root resorption risk index (RRRi) was calculated by dividing the maximum compressive hydrostatic stress in the periodontal ligament by the hydrostatic stress of the capillaries (4.7 kPa). It was assumed that the optimal intrusive force of reduced periodontal premolars was reached when the compressive hydrostatic stress distributions pattern of the reduced models was similar to those found in the control models of the corresponding mechanics. The FEA optimal force values for each model were compared with those obtained by the analytical formula (Force = stress x area). A linear trendline was observed between the control force reduction percentage and the bone loss height for both mechanics. For each millimeter of bone height loss, the control force had to be reduced by 9% for conventional intrusion, and by 8% for bilateral mini-implant intrusion. The root resorption risk index and the optimal intrusive force depends not only on the remaining root area with ligament support, but also on the intrusive mechanics used. The use of bilateral mini-implants in orthodontic intrusion reduced the external apical root resorption risk index and increased the optimal intrusive force. The proposed FEA strategy provided an easy, precise and feasible approach to suggest the optimum force in a clinical situation.