Objective: This study investigated the frequency of anatomic variations in the sinonasal region with septal deviation and the relationship of these anatomic variations with the developmental direction of the maxilla in cone-beam computed tomography images. Material and Methods: Forty-eight patients who underwent orthognathic surgery were included in this study. These patients were divided into 3 groups: normal maxilla (n=16), prognathic maxilla (n=16), and retrognathic maxilla (n=16) by determining the position of the maxillae in relation to the skull base on lateral cephalometric radiographs. The anatomic variations of the sinonasal region and the presence of maxillary sinus ostium (MSO) obstruction were studied in all groups. The relationship between the anatomical variations and the different developmental aspects of the maxilla was analyzed. Results: The most common anatomical changes in all patients were: hypertrophy of the inferior turbinate (68.8%), deviation of the nasal septum (66.7%), and concha bullosa (62.5%). No statistically significant difference was found between the groups with different skeletal deformities based on the position of the maxilla in relation to the skull base (p>0.05). While there was a statistically significant difference between gender distribution and hypertrophy of the middle concha (p=0.016), no statistically significant difference was found between other anatomical variations and gender distribution (p>0.05). Conclusion: In conclusion, in this study, we investigated the relationship between the anatomical variations of the sinonasal region and the direction of maxillary growth. There was no significant relationship between the above anatomical variations and MSO obstruction between the groups.
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