Maturity-onset Diabetes Of The Young Patients Research Articles

High prevalence of maturity-onset diabetes of the young (MODY) among Indians.

This article describes the high prevalence of maturity-onset diabetes in the young (MODY) in an Indian clinic population of diabetic patients. MODY appears to be more common among Indians than among Caucasians. Only 27% of MODY patients had definite autosomal-dominant inheritance. In 73% the mode of inheritance was not definite. Microvascular complications were common and macrovascular complications rare. The high prevalence of MODY in this diabetes clinic might suggest an ethnic variation in diabetes.

C-Peptide responses to glucose load in maturity-onset diabetes of the young (MODY).

Pancreatic beta cell responses were measured in obese and nonobese maturity-onset diabetes of the young (MODY) patients by estimating serum immunoreactive insulin (IRI) and C-peptide (CP) during oral glucose tolerance testing (OGTT). The serum CP responses were generally low in MODY patients and more pronounced in obese patients. The IRI responses were heterogenous; some patients had normal and others low responses. It was observed that in several patients there was a relatively higher IRI concentration in comparison with the CP values, as indicated by low CP and normal IRI values. This is suggestive of altered metabolic fates of insulin and CP in the MODY patients.

Heterogeneity of insulin responses in maturity-onset type diabetes (MOD) and in maturity-onset type diabetes of young people (MODY).

Previously we presented evidence for heterogeneity among maturity-onset diabetes of the young (MODY) pedigrees, particularly in regard to occurence of vascular disease. It is the purpose of this presentation to present evidence for heterogeneity of insulin responses to orally administered glucose in patients with MODY and maturity-onset diabetes (MOD) diabetes. (1,2,3) Our initial studies suggested that MODY or MOD diabetes is characterized by subnormal insulin responses to glucose as compared to healthy control subjects (4) while other investigators have reported increased insulin responses in latent or chemical diabetic patients. (1) When data for 25 MODY patients, age 9 to 17 years at diagnosis, were compared with results of 125 control subjects, mean concentration of plasma glucose for the two groups showed significant differences from fasting through three hours. (3) The diabetics showed a significantly delayed and subnormal insulin response to glucose.