Matters Arising Research Articles

Matters Arising

Ophthalmic and Physiological OpticsVolume 20, Issue 4 p. 348-348 Matters Arising Christos N. Serpetopoulos, Christos N. Serpetopoulos Athens, GreeceSearch for more papers by this author Christos N. Serpetopoulos, Christos N. Serpetopoulos Athens, GreeceSearch for more papers by this author First published: 01 July 2000 https://doi.org/10.1046/j.1475-1313.2000.00501.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume20, Issue4July 2000Pages 348-348 RelatedInformation

Matters Arising

Ophthalmic and Physiological OpticsVolume 20, Issue 4 p. 348-348 Matters Arising Christos N. Serpetopoulos, Christos N. Serpetopoulos Athens, GreeceSearch for more papers by this author Christos N. Serpetopoulos, Christos N. Serpetopoulos Athens, GreeceSearch for more papers by this author First published: 01 July 2000 https://doi.org/10.1046/j.1475-1313.2000.00501.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume20, Issue4July 2000Pages 348-348 RelatedInformation

Matters Arising Extracellular Glucose Concentrations in the Brain

Journal of NeurochemistryVolume 73, Issue 5 p. 2222-2222 Free Access Matters Arising Extracellular Glucose Concentrations in the Brain First published: 04 October 2002 https://doi.org/10.1046/j.1471-4159.1999.02222.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume73, Issue5November 1999Pages 2222-2222 RelatedInformation

MATTERS ARISING: Geny replies:

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Matters Arising: A Cross‐Phase Photography Residency

Journal of Art & Design EducationVolume 15, Issue 1 p. 41-45 Matters Arising: A Cross-Phase Photography Residency TERRY TAYLOR, TERRY TAYLORSearch for more papers by this author TERRY TAYLOR, TERRY TAYLORSearch for more papers by this author First published: February 1996 https://doi.org/10.1111/j.1476-8070.1996.tb00647.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume15, Issue1February 1996Pages 41-45 RelatedInformation

MATTERS ARISING: Cavanagh replies:

Cortical reorganization occurring in multiple sclerosis (MS) patients is thought to play a key role in limiting the effect of structural tissue damage. Conversely, its exhaustion may contribute to the irreversible disability that accumulates with disease progression. Several aspects of MS-related cortical reorganization, including the overall functional effect and likely modulation by therapies, still remain to be elucidated. The aim of this work was to assess the extent of functional cortical reorganization and its brain structural/pathological correlates in Dark Agouti rats with experimental autoimmune encephalomyelitis (EAE), a widely accepted preclinical model of chronic MS. Morphological and functional MRI (fMRI) were performed before disease induction and during the relapsing and chronic phases of EAE. During somatosensory stimulation of the right forepaw, fMRI demonstrated that cortical reorganization occurs in both relapsing and chronic phases of EAE with increased activated volume and decreased laterality index versus baseline values. Voxel-based morphometry demonstrated gray matter (GM) atrophy in the cerebral cortex, and both GM and white matter atrophy were assessed by <i>ex vivo</i> pathology of the sensorimotor cortex and corpus callosum. Neuroinflammation persisted in the relapsing and chronic phases, with dendritic spine density in the layer IV sensory neurons inversely correlating with the number of cluster of differentiation 45-positive inflammatory lesions. Our work provides an innovative experimental platform that may be pivotal for the comprehension of key mechanisms responsible for the accumulation of irreversible brain damage and for the development of innovative therapies to reduce disability in EAE/MS. <b>SIGNIFICANCE STATEMENT</b> Since the early 2000s, functional MRI (fMRI) has demonstrated profound modifications in the recruitment of cortical areas during motor, cognitive, and sensory tasks in multiple sclerosis (MS) patients. Experimental autoimmune encephalomyelitis (EAE) represents a reliable model of the chronic-progressive variant of MS. fMRI studies in EAE have not been performed extensively up to now. This paper reports fMRI studies in a rat model of MS with somatosensory stimulation of the forepaw. We demonstrated modifications in the recruitment of cortical areas consistent with data from MS patients. To the best of our knowledge, this is the first report of cortical remodeling in a preclinical <i>in vivo</i> model of MS.

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MATTERS ARISING: Antiganglioside antibodies in the CSF of patients with motor neuron diseases and Guillain-Barre syndrome

MATTERS ARISING: Antiganglioside antibodies in the CSF of patients with motor neuron diseases and Guillain-Barre syndrome

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